Dept of Internal Medicine, Central Hospital, Kristianstad (Sweden) Dept of Internal Medicine, Central Hospital, Kristianstad (Sweden)

Transcription

1 Curriculum vitae PERSONAL INFORMATION Charles Cline WORK EXPERIENCE June 1984 January 1985 Dept of Internal Medicine, Central Hospital, Kristianstad (Sweden) February 1985 January 1987 Internship Central Hospital, Kristianstad (Sweden) Rotation incl. internal medicine, general surgery, child psychiatry, Ob/Gyn, pediatrics and general practice. February 1987 October 1988 Dept of Internal Medicine, Central Hospital, Kristianstad (Sweden) November 1988 April 1989 Dept of Psychiatry, Lund University Hospital, Lund (Sweden) May 1989 September 1989 Dept of Pulmonary Medicine, Malmö University Hospital, Malmö (Sweden) September 1989 December 1991 Dept of Cardiology, Malmö University Hospital, Malmö (Sweden) January 1992 February 2003 Consultant Cardiologist Dept of Cardiology, Malmö University Hospital, Malmö (Sweden) March 2003 December 2004 Consultant Cardiologist, Head of Heart Failure and Transplant Unit Cardiology Dept, Karolinska University Hospital, Huddinge-Stockholm (Sweden) January 2005 April 2008 Medical Advisor GlaxoSmithKline Sweden (Sweden) CV-disease, Diabetes and Urology April 2008 December 2012 Nordic Medical Director Otsuka Pharmaceuticals Scandinavia (Sweden) September 2013 Present Clinical Assessor Dept for Clinical Trials and Special Permissions, Medical Product Agency (Sweden) Assessment and approval of CTAs and amendments. Scientific advice. Cardiology consultations to other MPA departments, including to Efficacy and Safety, relating to marketing authorisation. June 2015 May 2016 Manager Medical Products Agency (Sweden) 18/9/17 European Union, Page 1 / 5

2 Managing the efficacy and safety group with non-clinical and clinical assessors. June 2016 Present Clinical Assessor Medical Products Agency (Sweden) EDUCATION AND TRAINING January 1979 June 1984 MD Medical Faculty, Lund University (Sweden) 1991 Specialist Cardiology National Board of Health and Welfare (Sweden) 1993 Specialist Internal Medicine National Board of Health and Welfare (Sweden) 1999 PhD Cardiology Medical Faculty, Lund University (Sweden) ADDITIONAL INFORMATION Expertise Cardiac diseases in particular: Acute and chronic heart failure. - Approx. 20 years clinical experience of evaluation (incl. echocardiography) and management of patients referred for specialist care. - Research experience from academic heart faillure studies including treatment compliance, cardiopulmonary exercise testing, echocardiography, health related qualty of life, health economics, patient education and physical training. - Long experience in design and performance of clinical trials in heart failure and CV-disease. Publications 1: Nilsson KA, Cline C. [Incomplete description of effect data in intermittent claudication]. Lakartidningen Sep 1-7;107(35):2021. Swedish. PubMed PMID: : Midgren B, Mared L, Franklin KA, Berg S, Erhardt L, Cline C. Cheyne-Stokes respiration is not related to quality of life or sleepiness in heart failure. Clin Respir J Jan;4(1):30-6. doi: /j X x. PubMed PMID: : Tasevska-Dinevska G, Kennedy LM, Cline-Iwarson A, Cline C, Erhardt L, Willenheimer R. Gender differences in variables related to B-natriuretic peptide, left ventricular ejection fraction and mass, and peak oxygen consumption, in patients with heart failure. Int J Cardiol Jun 16;149(3): doi: /j.ijcard Epub 2010 Mar 3. PubMed PMID: : Tasevska-Dinevska G, Kennedy LM, Cline-Iwarson A, Cline C, Erhardt L, Willenheimer R. Gender aspects on survival among patients admitted to hospital with suspected or diagnosed heart failure. Scand Cardiovasc J Dec;42(6): doi: / PubMed PMID: : Remme WJ, McMurray JJ, Hobbs FD, Cohen-Solal A, Lopez-Sendon J, Boccanelli A, 18/9/17 European Union, Page 2 / 5

3 Zannad F, Rauch B, Keukelaar K, Macarie C, Ruzyllo W, Cline C; SHAPE Study Group. Awareness and perception of heart failure among European cardiologists, internists, geriatricians, and primary care physicians. Eur Heart J Jul;29(14): doi: /eurheartj/ehn196. Epub 2008 May 27. PubMed PMID: : Eskafi M, Cline C, Nilner M, Israelsson B. Treatment of sleep apnea in congestive heart failure with a dental device: the effect on brain natriuretic peptide and quality of life. Sleep Breath Jun;10(2):90-7. PubMed PMID: : Remme WJ, McMurray JJ, Rauch B, Zannad F, Keukelaar K, Cohen-Solal A, Lopez-Sendon J, Hobbs FD, Grobbee DE, Boccanelli A, Cline C, Macarie C, Dietz R, Ruzyllo W. Public awareness of heart failure in Europe: first results from SHAPE. Eur Heart J Nov;26(22): Epub 2005 Aug 31. PubMed PMID: : Eskafi M, Cline C, Israelsson B, Nilner M. A mandibular advancement device reduces sleep disordered breathing in patients with congestive heart failure. Swed Dent J. 2004;28(4): PubMed PMID: : Mared L, Cline C, Erhardt L, Berg S, Midgren B. Cheyne-Stokes respiration in patients hospitalised for heart failure. Respir Res Sep 20;5:14. PubMed PMID: ; PubMed Central PMCID: PMC : Eskafi M, Ekberg E, Cline C, Israelsson B, Nilner M. Use of a mandibular advancement device in patients with congestive heart failure and sleep apnoea. Gerodontology Jun;21(2): PubMed PMID: : Remme W, Boccanelli A, Cline C, Cohen-Solal A, Dietz R, Hobbs R, Keukelaar K, Sendon JL, Macarie C, McMurray J, Rauch B, Ruzyllo W, Zannad F; SHAPE Study. Increasing awareness and perception of heart failure in Europe and improving care--rationale and design of the SHAPE Study. Cardiovasc Drugs Ther Mar;18(2): PubMed PMID: : Eskafi M, Cline C, Petersson A, Israelsson B, Nilner M. The effect of mandibular advancement device on pharyngeal airway dimension in patients with congestive heart failure treated for sleep apnoea. Swed Dent J. 2004;28(1):1-9. PubMed PMID: : Cline C, Boman K, Swedberg K. [A study of primary health care in 15 different countries. Examination and treatment of patients with heart failure should be better]. Lakartidningen Apr 3;100(14): Swedish. PubMed PMID: : Cline C. Nurse-led clinics for heart failure in Sweden-doing the right thing? Eur J Heart Fail Aug;4(4): PubMed PMID: : Cline CM, Boman K, Holst M, Erhardt LR; Swedish Society of Cardiology Working Group for Heart Failure. The management of heart failure in Sweden. Eur J Heart Fail Jun;4(3): PubMed PMID: : Willenheimer R, Rydberg E, Cline C, Broms K, Hillberger B, Oberg L, Erhardt L. Effects on quality of life, symptoms and daily activity 6 months after termination of an exercise training programme in heart failure patients. Int J Cardiol Jan;77(1): PubMed PMID: : Cline CM, Björck-Linné AK, Israelsson BY, Willenheimer RB, Erhardt LR. Non-compliance and knowledge of prescribed medication in elderly patients with heart failure. Eur J Heart Fail Jun;1(2): PubMed PMID: /9/17 European Union, Page 3 / 5

4 18: Cline CM, Willenheimer RB, Erhardt LR, Wiklund I, Israelsson BY. Health-related quality of life in elderly patients with heart failure. Scand Cardiovasc J. 1999;33(5): PubMed PMID: : Andersson F, Cline C, Rydén-Bergsten T, Erhardt L. Angiotensin converting enzyme (ACE) inhibitors and heart failure. The consequences of underprescribing. Pharmacoeconomics Jun;15(6): Review. PubMed PMID: : Willenheimer R, Israelsson B, Cline C, Rydberg E, Broms K, Erhardt L. Left atrioventricular plane displacement is related to both systolic and diastolic left ventricular performance in patients with chronic heart failure. Eur Heart J Apr;20(8): PubMed PMID: : Cline CM, Israelsson BY, Willenheimer RB, Broms K, Erhardt LR. Cost effective management programme for heart failure reduces hospitalisation. Heart Nov;80(5): PubMed PMID: ; PubMed Central PMCID: PMC : Erhardt L, Cline C. Heart failure clinics: a possible means of improving care. Heart Nov;80(5): PubMed PMID: ; PubMed Central PMCID: PMC : Erhardt LR, Cline CM. Organisation of the care of patients with heart failure. Lancet Aug;352 Suppl 1:SI15-8. Review. PubMed PMID: : Willenheimer R, Erhardt L, Cline C, Rydberg E, Israelsson B. Exercise training in heart failure improves quality of life and exercise capacity. Eur Heart J May;19(5): PubMed PMID: : Willenheimer RB, Erhardt LR, Cline CM, Rydberg ER, Israelsson BA. Prognostic significance of changes in left ventricular systolic function in elderly patients with congestive heart failure. Coron Artery Dis Nov-Dec;8(11-12): PubMed PMID: : Willenheimer R, Cline C, Erhardt L, Israelsson B. Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure. Heart Sep;78(3): PubMed PMID: ; PubMed Central PMCID: PMC : Westin L, Carlsson R, Israelsson B, Willenheimer R, Cline C, McNeil TF. Quality of life in patients with ischaemic heart disease: a prospective controlled study. J Intern Med Sep;242(3): PubMed PMID: : Willenheimer RB, Israelsson BA, Cline CM, Erhardt LR. Simplified echocardiography in the diagnosis of heart failure. Scand Cardiovasc J. 1997;31(1):9-16. PubMed PMID: : Willenheimer R, Cline C, Erhardt L. Combined heart failure treatment with ACE inhibition and AT1-receptor blockade. Eur Heart J Nov;17(11): PubMed PMID: : Cline CM, Broms K, Willenheimer RB, Israelsson BA, Erhardt LR. Hospitalization and Health Care Costs Due to Congestive Heart Failure in the Elderly. Am J Geriatr Cardiol Jul;5(4): PubMed PMID: : Israelsson B, Stagmo M, Alm C, Cline C, Westin L, Willenheimer R, Carlsson R. [Need for a long-term program in the follow-up of anti-lipid treatment following coronary artery surgery?]. Nord Med. 1995;110(8-9): Swedish. PubMed PMID: : Erhardt L, Cline C. [Do we neglect the treatment of elderly patients with heart diseases?]. 18/9/17 European Union, Page 4 / 5

5 Projects Memberships Member of the Swedish Society of Cardiology (former board member) Swedish Society of Cardiology Working Group for Heart Failure (former member) Fellow of the European Society of Cardiology Other Relevant Information 18/9/17 European Union, Page 5 / 5