Second Generation of Calcium Antagonists
|
|
- Aubrie Sherman
- 5 years ago
- Views:
Transcription
1 Winifred G. Nayler Second Generation of Calcium Antagonists With 81 Figures and 63 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
2 Contents Foreword Chapter 1 The Second Generation of Calcium Antagonists: What Are They? VII - Rationale for the Development of the Second Generation Calcium Antagonists: Limitations of the First Generation. 2 - Are the Second Generation Calcium Antagonists Needed?. 4 - Summary 7 Chapter 2 The Chemistry of the Second Generation Calcium Antagonists - Derivatives of the Prototype Calcium Antagonists Which Interact with The Alpha i Subunit Binding Sites of the L-Type Ca 2+ Channels 12 - Other New Calcium Antagonists 19 - Novel Calcium Antagonists with Additional Antagonist Activity ', 22 - Summary 23 Chapter 3 The Molecular Biology of the Voltage-Dependent, Calcium Antagonist-Sensitive Calcium Channels - Ca 2+ -Conducting Channels 26 - The Voltage-Sensitive Ca 2+ Channels 26 - The Molecular Biology of the L-type Ca 2+ Channel 27 - The Voltage-Dependent Calcium Antagonist-Sensitive Ca 2+ Channel Complex of Skeletal Muscle T-Tubules: Subunit Structure and Function 28 - The Tissue Specificity of the Alpha! Subunit 34 - Summary 36
3 X Contents Chapter 4 Calcium Antagonists and the Calcium Release Channels of the Sarcoplasmic Reticulum - The General Properties of the Sarcoplasmic Reticulum The General Morphology of the Sarcoplasmic Reticulum (SR): Evidence of Specialization 41 - The Biochemistry of the Sarcoplasmic Reticulum 43 - The Ultrastructure and Chemistry of the SR Feet (The SR Ryanodine Receptor - Ca 2+ Release Channel) Chemistry 46 - The Intraluminal Contents of the Junctional SR 48 - Characteristics of the SR Ryanodine Receptor - Ca 2+ Release Channel Complex 48 - SR Ca 2+ Release Channels in Various Pathologies 50 - The Trigger for SR Ca 2+ Release: Differences Between Skeletal and Cardiac Muscle 52 - Calcium Antagonists and SR Ca 2+ Release 53 - Summary / 54 Chapter 5 "Up" and "Down" Regulation of the Calcium Antagonist Binding Sites - Age-Dependent Changes in Calcium Antagonist Binding Site Density 55 - Cardiomyopathies 56 - Ischaemia as a Cause of "Down" Regulation 58 - Effect of Ischaemia on Other Cardiac Receptors 60 - Effect of Drugs and Chemicals on Calcium Antagonist Binding Site Density 62 - The Effect of Other Physiological Interventions 65 - Summary 65 Chapter 6 Oxyradical-Induced Lipid Peroxidation: Do Calcium Antagonists Provide Any Protection? - Chemistry and Production of the Oxyradicals 68 - Sites of Oxyradical Production 70 - Protective Mechanisms.' 71 - Mode of Action 71 - Evidence of Oxyradical Production in the Heart 73 - Oxyradical-Induced Injury 74 - Oxyradical-Induced Loss of Ca 2+ Homeostasis 77 - Evidence of Excess Oxyradical Production During Myocardial Ischaemia and Post Ischaemic Reperfusion Role of Calcium Antagonists as Protective Agents 79
4 Contents XI - Protection Against Oxyradical-Induced Injury: Are the Calcium Antagonists Effective? 80 - Mode of Action 83 - Summary 83 Chapter 7 Endothelin-1 and the Calcium Antagonists - The Production of Endothelin Agents and Conditions Which Stimulate Endothelin-1 Production 88 - The Endothelin Receptor 88 - The Endothelin-1 Receptor 89 - Endothelin-1 and the Calcium Antagonists 90 - The Involvement of Endothelin-1 in the Maintenance of Vascular Tone 93 - Endothelin-1 and the Coronary Circulation: The Role of the Calcium Antagonists 94 - Endothelin and Hypertension 95 - Endothelin-1 and Atherosclerosis 95 - Summary 95 Chapter 8 Calcium Antagonists and the Stunned Heart - Stunning, Hibernation or Infarction? 97 - The Clinical Relevance of Myocardial Stunning 98 - Animal Models of Myocardial Stunning 99 - The Electrical, Mechanical, Morphological and Biochemical Properties of the Pre-Stunned and Stunned Myocardium Possible Mechanisms of Myocardial Stunning Is Energy Utilization Impaired? Is the Altered Ultrastructure Responsible? Is Perfusion Adequate During Reperfusion? Is There an Abnormal Ca 2+ Influx? Do the Myofibrils Become Relatively Insensitive to Ca 2+? Oxyradical-Mediated Dysfunction: Is this Relevant? The Sarcoplasmic Reticulum: Is it Involved? Myocardial Stunning: A Multifactorial Event Calcium Antagonists and the Stunned Myocardium Summary 116 Chapter 9 Calcium Antagonists and the Hibernating Myocardium - The Hibernating Myocardium Is Myocardial Hibernation an Adaptive Process? The Identification of the Hibernating Myocardium The Hibernating Myocardium: It's Clinical Occurrence
5 XII Contents - The Possible Causes of the Depressed Contractile State Effective Remedial Measures Summary 128 Chapter 10 Second Generation Calcium Antagonists and the Ischaemic Myocardium - Myocardial Infarction The Significance of the Early Rise in Cytosolic Ca The Possible Contribution of Endothelin-1 to Ischaemia-Reperfusion Injury Clinical Evidence of a Protective Role for the Second Generation Antagonists Summary 135 Chapter 11 The Molecular Mechanisms Involved in the Anti-Atherogenic Effect of the Calcium Antagonists - Lesion Formation: Sequence of Events Factors Concerned with the Initiation of Plaque Formation The Mechanism Involved in the Macrophage Accumulation of Low Density Lipoproteins (LDL) The Progression of the Fatty Streak to the Adult Plaque Calcium-Dependent Processes Which Contribute to the Formation of Atherosclerotic Lesions Human Studies Showing an Antiatherosclerotic Effect of Calcium Antagonist Therapy Laboratory Studies Relating to the Antiatherosclerotic Effect of First and Second Generation Calcium Antagonists The Molecular Mechanisms Involved in the Antiatherogenic Effect of the Calcium Antagonists Effect of Calcium Antagonists on Restenosis after PTCA Effect of Calcium Antagonists on Coronary Graft Patency Endothelial Dysfunction Early in the Atherogenic Process Summary 151 Chapter 12 Second Generation Calcium Antagonists: Their Use in Congestive Heart Failure - The Pathophysiology of Congestive Heart Failure The Therapeutic Management of the Failing Heart The Second Generation Calcium Antagonists Summary 161
6 Contents XIII Chapter 13 Second Generation Calcium Antagonists as Blood Pressure Lowering Agents: The Prevention of Cardiac Hypertrophy - Calcium and Vascular Smooth Muscle Contraction The Pathophysiology of Hypertension Calcium Antagonists as Blood Pressure Lowering Agents Mode of Action Summary 172 Chapter 14 Second Generation Calcium Antagonists and the Management of Cerebral Ischaemia - The Ischaemic Brain Causes of Cerebral Ischaemia Ischaemic "Stroke" and Subarachnoid Haemorrhage Aetiology of Acute Cerebral Ischaemia (Stroke) and Subarachnoid Haemorrhage Consequences of Cerebral Ischaemia Protection of the Ischaemically-Injured Brain Efficacy of Second Generation Calcium Antagonists in the Management of Acute Cerebral Ischaemia Clinical Data Mode of Action Subarachnoid Haemorrhage Effect of Second Generation Calcium Antagonists on Recovery After Subarachnoid Haemorrhage Summary 184 Chapter 15 Second Generation Calcium Antagonists and the Coronary Circulation - Coronary Spasm Angina Pectoris Silent Ischaemia Summary 191 Chapter 16 The Second Generation Calcium Antagonists - Improved Tissue Selectivity Relevance of Improved Tissue Selectivity Duration of Action Future Directions 195 References 197
Pathophysiology of Cardiovascular System. Dr. Hemn Hassan Othman, PhD
Pathophysiology of Cardiovascular System Dr. Hemn Hassan Othman, PhD hemn.othman@univsul.edu.iq What is the circulatory system? The circulatory system carries blood and dissolved substances to and from
More informationCardiac Muscle Physiology. Physiology Sheet # 8
15 8 1 We have three types of muscles in our body: 1. Skeletal muscles. 2. Cardiac muscle. 3. Smooth muscles. The cardiovascular system consists of : Heart, cardiac vessels. The wall of the Heart has three
More informationThe Universal Definition of Myocardial Infarction 3 rd revision, 2012
The Universal Definition of Myocardial Infarction 3 rd revision, 2012 Joseph S. Alpert, MD Professor of Medicine, University of Arizona College of Medicine, Tucson, AZ; Editor-in-Chief, American Journal
More informationInvited Review. Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular diseases
Histol Histopathol (2000) 15: 557-571 Histology and Histopathology Cellular and Molecular Biology Invited Review Vascular smooth muscle cell proliferation in the pathogenesis of atherosclerotic cardiovascular
More informationMuscle Cells & Muscle Fiber Contractions. Packet #8
Muscle Cells & Muscle Fiber Contractions Packet #8 Skeletal muscle is attached to bones and is responsible for movement. Introduction Introduction II Skeletal muscle is composed of bundles of muscle fibers
More informationCardiovascular Disorders Lecture 3 Coronar Artery Diseases
Cardiovascular Disorders Lecture 3 Coronar Artery Diseases By Prof. El Sayed Abdel Fattah Eid Lecturer of Internal Medicine Delta University Coronary Heart Diseases It is the leading cause of death in
More informationAcute coronary syndrome. Dr LM Murray Chemical Pathology Block SA
Acute coronary syndrome Dr LM Murray Chemical Pathology Block SA13-2014 Acute myocardial infarction (MI) MI is still the leading cause of death in many countries It is characterized by severe chest pain,
More informationIschemic heart disease
Ischemic heart disease Introduction In > 90% of cases: the cause is: reduced coronary blood flow secondary to: obstructive atherosclerotic vascular disease so most of the time it is called: coronary artery
More informationMyocardial injury, necrosis and infarction
Myocardial injury, necrosis and infarction Harvey White Green Lane Cardiovascular Service and Cardiovascular Research Unit Auckland City Hospital, Auckland, New Zealand Faculty Disclosure In accordance
More informationPathophysiology of Coronary Microvascular Dysfunction
Pathophysiology of Coronary Microvascular Dysfunction Cheol Woong Yu, MD, PhD Cardiology Department Division of Internal Medicine Korea University Anam Hospital. Etiologies of Chest Pain without obstructive
More informationCardiovascular Pathology
Cardiovascular Pathology Duration: 03 Weeks (15 days) Concepts Objectives Activity Time Department Comments 3/SBM-3/01 Introduction to ischaemia, infarction, thrombosis stenosis / occlusion, embolism Atherosclerosis
More informationHeart disease remains the leading cause of morbidity and mortality in industrialized nations. It accounts for nearly 40% of all deaths in the United
Heart disease remains the leading cause of morbidity and mortality in industrialized nations. It accounts for nearly 40% of all deaths in the United States, totaling about 750,000 individuals annually
More informationDrug Treatment of Ischemic Heart Disease
Drug Treatment of Ischemic Heart Disease 1 Categories of Ischemic Heart Disease Fixed "Stable, Effort Angina Variant Angina Primary Angina Unstable Angina Myocardial Infarction 2 3 Secondary Angina Primary
More informationPart 1 Risk Factors and Atherosclerosis. LO1. Define the Different Forms of CVD
Week 3: Cardiovascular Disease Learning Outcomes: 1. Define the difference forms of CVD 2. Describe the various risk factors of CVD 3. Describe atherosclerosis and its stages 4. Describe the role of oxidation,
More informationDOWNLOAD PDF ABC OF HEART FAILURE
Chapter 1 : The ABCs of managing systolic heart failure: Past, present, and future Heart failure is a multisystem disorder which is characterised by abnormalities of cardiac, skeletal muscle, and renal
More informationHealth and Disease of the Cardiovascular system
1 Health and Disease of the Cardiovascular system DR CHRIS MOORE Instructions 2 USE THE ARROWS TO NAVIGATE, OR TAP OUTLINE AT THE TOP TO BRING DOWN A SLIDE MENU Click these where you see them to zoom or
More informationIndex of subjects. effect on ventricular tachycardia 30 treatment with 101, 116 boosterpump 80 Brockenbrough phenomenon 55, 125
145 Index of subjects A accessory pathways 3 amiodarone 4, 5, 6, 23, 30, 97, 102 angina pectoris 4, 24, 1l0, 137, 139, 140 angulation, of cavity 73, 74 aorta aortic flow velocity 2 aortic insufficiency
More informationCommon Codes for ICD-10
Common Codes for ICD-10 Specialty: Cardiology *Always utilize more specific codes first. ABNORMALITIES OF HEART RHYTHM ICD-9-CM Codes: 427.81, 427.89, 785.0, 785.1, 785.3 R00.0 Tachycardia, unspecified
More informationFIBER TYPES - oxidative metabolism is the main form here - ATPase activity is relatively low
Cardiac Muscle Physiology Special characteristics of cardiac muscle - Branching and interdigitating cells - At their ends, they are connected by INTERCALATED DISCS - The discs are always at the Z-lines
More informationBlood and Circulation Module Year 3 Semester 1
Blood and Circulation Module Year 3 Semester 1 Duration: 03 Weeks (15 days) Concepts Objectives Activity Time Department 1. 2006-3/SBM-3/01 Introduction to ischaemia, infarction, thrombosis stenosis /
More informationTopics Covered. Excitation-Contraction (E-C) Coupling.
Topics Covered Excitation-Contraction (E-C) Coupling. - E-C Coupling in Skeletal vs. Cardiac Muscle. - NMJ Transmission. - Membrane Propagation of Action Potential (AP). - Voltage Gated Ca2+ Channels.
More informationDrug Treatment of Ischemic Heart Disease
Drug Treatment of Ischemic Heart Disease Munir Gharaibeh, MD, PhD, MHPE Faculty of Medicine, The University of Jordan November, 2014 Categories of Ischemic Heart Disease Fixed "Stable, Effort Angina Variant
More informationPhysiology sheet #2. The heart composed of 3 layers that line its lumen and cover it from out side, these layers are :
Physiology sheet #2 * We will talk in this lecture about cardiac muscle physiology, the mechanism and the energy sources of their contraction and intracellular calcium homeostasis. # Slide 4 : The heart
More informationIschemic Heart Disease
Ischemic Heart Disease Dr Rodney Itaki Lecturer Division of Pathology University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology General Consideration Results from partial
More information12 Lead EKG Chapter 4 Worksheet
Match the following using the word bank. 1. A form of arteriosclerosis in which the thickening and hardening of the vessels walls are caused by an accumulation of fatty deposits in the innermost lining
More informationBIOCHEMICAL INVESTIGATIONS IN THE DIAGNOSTICS OF CARDIOVASCULAR DISORDERS. As. MARUSHCHAK M.I.
BIOCHEMICAL INVESTIGATIONS IN THE DIAGNOSTICS OF CARDIOVASCULAR DISORDERS As. MARUSHCHAK M.I. Heart attack symptoms Acute MI Measurement of cardiac enzyme levels Measure cardiac enzyme levels at regular
More informationDeclaration of conflict of interest. None to declare
Declaration of conflict of interest None to declare Risk management of coronary artery disease Arrhythmias and diabetes Hercules Mavrakis Cardiology Department Heraklion University Hospital Crete, Greece
More informationFive chapters 1. What is CVD prevention 2. Why is CVD prevention needed 3. Who needs CVD prevention 4. How is CVD prevention applied 5. Where should CVD prevention be offered Shorter, more adapted to clinical
More informationRecommended Evaluation Data Excerpt from NVIC 04-08
Recommended Evaluation Data Excerpt from NVIC 04-08 Purpose: This document is an excerpt from the Medical and Physical Evaluations Guidelines for Merchant Mariner Credentials, contained in enclosure 3
More informationProcess Measure: Screening for Adult Obstructive Sleep Apnea
Process Measure: Screening for Adult Obstructive Sleep Apnea Measure Description Description Type of Measure All patients aged 18 years and older at high risk for obstructive sleep apnea (OSA) with documentation
More informationAngina Pectoris Dr. Shariq Syed
Angina Pectoris Dr. Syed 1 What is Angina Pectoris (AP)? Commonly known as angina is chest pain often due to ischemia of the heart muscle, Because of obstruction or spasm of the coronary arteries 2 What
More informationNerve regeneration. Somatic nervous system
Somatic nervous system Signals from CNS are sent to skeletal muscles. Final result is a muscle contraction. Motor neuron starts in CNS and its axon ends at a muscle cell. Alpha motor neuron Alpha motor
More informationNerve meets muscle. Nerve regeneration. Somatic nervous system
Somatic nervous system Signals from CNS are sent to skeletal muscles. Final result is a muscle contraction. Alpha motor neurons branch into several terminals (can be over 1000), each contacting a separate
More informationHEART HEALTH WEEK 2 SUPPLEMENT. A Beginner s Guide to Cardiovascular Disease ATHEROSCLEROSIS. Fatty deposits can narrow and harden the artery
WEEK 2 SUPPLEMENT HEART HEALTH A Beginner s Guide to Cardiovascular Disease ATHEROSCLEROSIS FIGURE 1 Atherosclerosis is an inflammatory process where cholesterol is deposited in the wall of arteries and
More informationDrug Treatment of Ischemic Heart Disease
Drug Treatment of Ischemic Heart Disease Munir Gharaibeh, MD, PhD, MHPE School of Medicine, The University of Jordan November, 2017 Categories of Ischemic Heart Disease Fixed "Stable, Effort Angina Variant
More informationIn the name of GOD. Animal models of cardiovascular diseases: myocardial infarction & hypertension
In the name of GOD Animal models of cardiovascular diseases: myocardial infarction & hypertension 44 Presentation outline: Cardiovascular diseases Acute myocardial infarction Animal models for myocardial
More informationTracking a Killer Molecule
Tracking a Killer Molecule Mercodia Oxidized LDL ELISA www.mercodia.com Mercodia Oxidized LDL ELISA products Product Catalog No Kit size Oxidized LDL ELISA 10-1143-01 96 wells Oxidized LDL competitive
More informationCh 12: Muscles sarcolemma, t-tubules, sarcoplasmic reticulum, myofibrils, myofilaments, sarcomere...
Ch 12: Muscles Review micro-anatomy of muscle tissue Terminology examples: sarcolemma, t-tubules, sarcoplasmic reticulum, myofibrils, myofilaments, sarcomere... SLOs Differentiate levels of muscle structure:
More informationANGINA PECTORIS. angina pectoris is a symptom of myocardial ischemia in the absence of infarction
Pharmacology Ezra Levy, Pharm.D. ANGINA PECTORIS A. Definition angina pectoris is a symptom of myocardial ischemia in the absence of infarction angina usually implies severe chest pain or discomfort during
More informationChapter 13 The Cardiovascular System: Cardiac Function
Chapter 13 The Cardiovascular System: Cardiac Function Overview of the Cardiovascular System The Path of Blood Flow through the Heart and Vasculature Anatomy of the Heart Electrical Activity of the Heart
More informationChapter 10. Learning Objectives. Learning Objectives 9/11/2012. Congestive Heart Failure
Chapter 10 Congestive Heart Failure Learning Objectives Explain concept of polypharmacy in treatment of congestive heart failure Explain function of diuretics Learning Objectives Discuss drugs used for
More informationFOI CAERS Reports Allegedly Related to Multiple Energy Drinks
FOI 14-17 Reports Allegedly Related to Multiple Energy Drinks Search Terms: Products Listed FDA s Center for Food Safety and Applied Nutrition s (CFSAN s) Adverse Event Reporting System () is a post-market
More informationSkeletal Muscle and the Molecular Basis of Contraction. Lanny Shulman, O.D., Ph.D. University of Houston College of Optometry
Skeletal Muscle and the Molecular Basis of Contraction Lanny Shulman, O.D., Ph.D. University of Houston College of Optometry Like neurons, all muscle cells can be excited chemically, electrically, and
More informationDifficult Scenarios for Myocardial Protection SAHA Gil Bolotin M.D., Ph.D. Rambam Medical Center, Haifa, Israel
Difficult Scenarios for Myocardial Protection SAHA 2017 Gil Bolotin M.D., Ph.D. Rambam Medical Center, Haifa, Israel Difficult Scenarios for Myocardial Protection Stone Heart Nightmare Nightmare of the
More informationCardiac arrhythmias. Janusz Witowski. Department of Pathophysiology Poznan University of Medical Sciences. J. Witowski
Cardiac arrhythmias Janusz Witowski Department of Pathophysiology Poznan University of Medical Sciences A 68-year old man presents to the emergency department late one evening complaining of increasing
More informationA DAYS CARDIOVASCULAR UNIT GUIDE DUE WEDNESDAY 4/12
A DAYS CARDIOVASCULAR UNIT GUIDE DUE WEDNESDAY 4/12 MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY 3/20 - B 3/21 - A 3/22 - B 3/23 - A 3/24 - B 3/27 - A Dissection Ethics Debate 3/28 - B 3/29 - A Intro to Cardiovascular
More informationClinical benefits of trimetazidine in diabetic patients with coronary artery disease
Clinical benefits of trimetazidine in diabetic patients with coronary artery disease Department of Cardiology, Ain Shams University, Cairo, Egypt Correspondence:, Department of Cardiology, Ain Shams University,
More informationSkin supplied by T1-4 (medial upper arm and neck) T5-9- epigastrium Visceral afferents from skin and heart are the same dorsal root ganglio
Cardio 2 ECG... 3 Cardiac Remodelling... 11 Valvular Diseases... 13 Hypertension... 18 Aortic Coarctation... 24 Erythropoiesis... 27 Haemostasis... 30 Anaemia... 36 Atherosclerosis... 44 Angina... 48 Myocardial
More informationPharmacology. Drugs affecting the Cardiovascular system (Antianginal Drugs)
Lecture 7 (year3) Dr Noor Al-Hasani Pharmacology University of Baghdad College of dentistry Drugs affecting the Cardiovascular system (Antianginal Drugs) Atherosclerotic disease of the coronary arteries,
More informationCardiovascular health & Health Promotion HH2602 & HH5607
Cardiovascular health & Health Promotion HH2602 & HH5607 Lecture 2: Microscopic Structure and Function of the Heart 2pm 28-02-17 ESGW Teaching Aims To introduce you to the microstructure of heart muscle.
More informationLecture 8 Cardiovascular Health Lecture 8 1. Introduction 2. Cardiovascular Health 3. Stroke 4. Contributing Factors
Lecture 8 Cardiovascular Health 1 Lecture 8 1. Introduction 2. Cardiovascular Health 3. Stroke 4. Contributing Factors 1 Human Health: What s Killing Us? Health in America Health is the U.S Average life
More informationUnit 1: Human Systems. The Circulatory System
Unit 1: Human Systems The Circulatory System nourish all cells with oxygen, glucose, amino acids and other nutrients and carry away carbon dioxide, urea and other wastes Purposes Transport chemical messengers
More informationCitation for published version (APA): Sivapalaratnam, S. (2012). The molecular basis of early onset cardiovascular disease
UvA-DARE (Digital Academic Repository) The molecular basis of early onset cardiovascular disease Sivapalaratnam, S. Link to publication Citation for published version (APA): Sivapalaratnam, S. (2012).
More informationA Review of Cardiac Pathophysiology and EKG. Jamie Dyson PT, DPT Kathy Swanick PT, DPT, OCS
A Review of Cardiac Pathophysiology and EKG Jamie Dyson PT, DPT Kathy Swanick PT, DPT, OCS Cardiac Pathophysiology Coronary Artery Disease Congestive Heart Failure Valvular Heart Disease Athletic Heart
More information10/8/2018. Lecture 9. Cardiovascular Health. Lecture Heart 2. Cardiovascular Health 3. Stroke 4. Contributing Factor
Lecture 9 Cardiovascular Health 1 Lecture 9 1. Heart 2. Cardiovascular Health 3. Stroke 4. Contributing Factor 1 The Heart Muscular Pump The Heart Receives blood low pressure then increases the pressure
More informationThe organization of skeletal muscles. Excitation contraction coupling. Whole Skeletal Muscles contractions. Muscle Energetics
Muscle and Movement The organization of skeletal muscles Excitation contraction coupling Whole Skeletal Muscles contractions Muscle Energetics The molecular bases of movement Muscular cells use molecular
More informationEFFECT OF NICARDIPINE ON FASTING PLASMA LIPIDS AND APOLIPOPROTEINS IN MALE NEW ZEALAND WHITE RABBITS. Kamsiah Jaarin, Nafeeza MI*
REVIEW ARTICLE Malaysian Journal of Medical Sciences, Vol. 6, No. 2, July 1999 (5-11) EFFECT OF NICARDIPINE ON FASTING PLASMA LIPIDS AND APOLIPOPROTEINS IN MALE NEW ZEALAND WHITE RABBITS Kamsiah Jaarin,
More informationPSK4U THE NEUROMUSCULAR SYSTEM
PSK4U THE NEUROMUSCULAR SYSTEM REVIEW Review of muscle so we can see how the neuromuscular system works This is not on today's note Skeletal Muscle Cell: Cellular System A) Excitation System Electrical
More informationPathology of Cardiovascular Interventions. Body and Disease 2011
Pathology of Cardiovascular Interventions Body and Disease 2011 Coronary Artery Atherosclerosis Intervention Goals: Acute Coronary Syndromes: Treat plaque rupture and thrombosis Significant Disease: Prevent
More informationCLINICAL OUTCOME Vs SURROGATE MARKER
CLINICAL OUTCOME Vs SURROGATE MARKER Statin Real Experience Dr. Mostafa Sherif Senior Medical Manager Pfizer Egypt & Sudan Objective Difference between Clinical outcome and surrogate marker Proper Clinical
More informationPharmacologic Therapy of Coronary Disease
Pharmacologic Therapy of Coronary Disease M. MOHSEN IBRAHIM, MD Prof. of Cardiology- Cairo University President of the Egyptian Hypertension Society Introduction Coronary artery disease (CAD) is possibly
More informationManagement of Headache and Headache Medications
Management of Headache and Headache Medications Lawrence D. Robbins, M.D. Management of Headache and Headache Medications Foreword by Jerome Goldstein, M.D. Springer-Verlag New York Berlin Heidelberg London
More informationPage 1. Introduction Skeletal muscle cells have unique characteristics which allow for body movement.
Anatomy Review: Skeletal Muscle Tissue Graphics are used with permission of: adam.com (http://www.adam.com/) Benjamin Cummings Publishing Co (http://www.awl.com/bc) Page 1. Introduction Skeletal muscle
More informationDoor to Balloon : The Big Deal. Shaiful Azmi Yahaya,, M.D. Consultant Cardiologist Institut Jantung Negara
Door to Balloon : The Big Deal Shaiful Azmi Yahaya,, M.D. Consultant Cardiologist Institut Jantung Negara Lecture Outline Pathophysiology of ACS History Door to balloon -? The big deal Myocardial ischaemia
More informationCoronary heart disease (CHD)
1 Coronary heart disease (CHD) 2 Institute of Pathological Physiology Martin Vokurka mvoku@lf1.cuni.cz Winter Semester 3 CORONARY CIRCULATION AND MYOCARDIAL METABOLISM 4 Blood flow: resting: 250 ml/min
More informationIndex. A Action potential duration, increased, by decreases in sodium current,
Heart Failure Clin 1 (2005) 313 319 Index Note: Page numbers of article titles are in boldface type. A Action potential duration, increased, by decreases in sodium current, 201 202 Adenylyl cyclase, overexpression
More informationTHE BLOOD VESSELS. Manar hajeer, MD University of Jordan Faculty of medicine, pathology department.
THE BLOOD VESSELS Manar hajeer, MD University of Jordan Faculty of medicine, pathology department. Vascular pathology: 1- Narrowing or complete obstruction of vessel lumina, either progressively (e.g.,
More informationManagement of Hypertension
Clinical Practice Guidelines Management of Hypertension Definition and classification of blood pressure levels (mmhg) Category Systolic Diastolic Normal
More informationChapter 10 Muscle Tissue and Physiology Chapter Outline
Chapter 10 Muscle Tissue and Physiology Chapter Outline Module 10.1 Overview of muscle tissue (Figures 10.1 10.2) A. Types of Muscle Tissue (Figure 10.1) 1. The three types of cells in muscle tissue are,,
More information1 Functions of endothelial cells include all the following EXCEPT. 2 Response to vascular injury is characterised by
airns ase Hospital mergency epartment Part 1 FM MQs 1 Functions of endothelial cells include all the following XPT Formation of von-willebrand factor Formation of collagen and proteoglycans Formation of
More informationPathophysiology of Lipid Disorders
Pathophysiology of Lipid Disorders Henry Ginsberg, M.D. Division of Preventive Medicine and Nutrition CHD in the United States CHD is the single largest killer of men and women 12 million have history
More informationAppendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors.
Appendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors. Appendix to: Banks E, Crouch SR, Korda RJ, et al. Absolute risk of cardiovascular
More informationIschaemic heart disease. IInd Chair and Clinic of Cardiology
Ischaemic heart disease IInd Chair and Clinic of Cardiology Definition Syndrome due to chronic insufficient oxygen supply to myocardial cells Nomenclature: ischaemic heart disease (IHD), coronary artery
More informationArteriosclerosis & Atherosclerosis
Arteriosclerosis & Atherosclerosis Arteriosclerosis = hardening of arteries = arterial wall thickening + loss of elasticity 3 types: -Arteriolosclerosis -Monckeberg medial sclerosis -Atherosclerosis Arteriosclerosis,
More informationChapter 10 -Muscle Tissue
Chapter 10 -Muscle Tissue Muscles: 1. Overview of Muscle Tissue A. Review 5 functions of muscle tissue. B. Review the 5 properties of muscle tissue. WHICH do they share with nervous tissue? (2, plus the
More informationIn Vivo Animal Models of Heart Disease. Why Animal Models of Disease? Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison
In Vivo Animal Models of Heart Disease Timothy A Hacker, PhD Department of Medicine University of Wisconsin-Madison Why Animal Models of Disease? Heart Failure (HF) Leading cause of morbidity and mortality
More information1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones?
1Why lipids cannot be transported in blood alone? 2How we transport Fatty acids and steroid hormones? 3How are dietary lipids transported? 4How lipids synthesized in the liver are transported? 5 Lipoprotien
More informationBIOLOGY - CLUTCH CH.49 - MUSCLE SYSTEMS.
!! www.clutchprep.com BIOLOGY - CLUTCH Muscle system organ system that includes skeletal, cardiac, and smooth muscle Muscle tissue capable of contracting through the interaction of actin and myosin proteins
More informationMuscle Tissue- 3 Types
AN INTRODUCTION TO MUSCLE TISSUE Muscle Tissue- 3 Types Skeletal muscle (focus on these) Cardiac muscle Smooth muscle FUNCTIONS OF SKELETAL MUSCLES Produce movement of the skeleton Maintain posture and
More informationMuscle and Muscle Tissue
Muscle and Muscle Tissue Make up about half of total body mass Exerts force by converting chemical energy, ATP, to mechanical energy Muscle tissue is classified based on Shape Number and position of nuclei
More informationBy the end of this lecture, you will be able to: Understand the 12 lead ECG in relation to the coronary circulation and myocardium Perform an ECG
By the end of this lecture, you will be able to: Understand the 12 lead ECG in relation to the coronary circulation and myocardium Perform an ECG recording Identify the ECG changes that occur in the presence
More informationMuscle and Neuromuscular Junction. Peter Takizawa Department of Cell Biology
Muscle and Neuromuscular Junction Peter Takizawa Department of Cell Biology Types and structure of muscle cells Structural basis of contraction Triggering muscle contraction Skeletal muscle consists of
More informationCirculation. Blood Pressure and Antihypertensive Medications. Venous Return. Arterial flow. Regulation of Cardiac Output.
Circulation Blood Pressure and Antihypertensive Medications Two systems Pulmonary (low pressure) Systemic (high pressure) Aorta 120 mmhg Large arteries 110 mmhg Arterioles 40 mmhg Arteriolar capillaries
More informationChapter 50. You re on your own for: Sensory Reception Mechanoreceptors Gravity, Hearing and Equilibrium. Chemoreception taste and smell
1 Sensory and Motor Mechanisms 2 Chapter 50 You re on your own for: Sensory Reception Mechanoreceptors Gravity, Hearing and Equilibrium Chemoreception taste and smell Photoreceptors vision It s interesting.
More informationCardiovascular Diseases and Diabetes
Cardiovascular Diseases and Diabetes LEARNING OBJECTIVES Ø Identify the components of the cardiovascular system and the various types of cardiovascular disease Ø Discuss ways of promoting cardiovascular
More informationThe Cardiovascular System
Chapter 18 Part A The Cardiovascular System 1/19/16 1 Annie Leibovitz/Contact Press Images Similarities of Cardiac and Skeletal Muscle RMP Ion concentration Deploarization Action Potential Repolarization
More informationPrevention of Disease Progression Throughout the Cardiovascular Continuum
Prevention of Disease Progression Throughout the Cardiovascular Continuum Springer-Verlag Berlin Heidelberg GmbH L.E. RYDEN (ED.) Prevention of Disease Progression Throughout the Cardiovaseular Continuum
More informationDRUG CLASSES BETA-ADRENOCEPTOR ANTAGONISTS (BETA-BLOCKERS)
DRUG CLASSES BETA-ADRENOCEPTOR ANTAGONISTS (BETA-BLOCKERS) Beta-blockers have been widely used in the management of angina, certain tachyarrhythmias and heart failure, as well as in hypertension. Examples
More informationSkeletal Muscle. Connective tissue: Binding, support and insulation. Blood vessels
Chapter 12 Muscle Physiology Outline o Skeletal Muscle Structure o The mechanism of Force Generation in Muscle o The mechanics of Skeletal Muscle Contraction o Skeletal Muscle Metabolism o Control of Skeletal
More information2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension.
2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension Writing Group: Background Hypertension worldwide causes 7.1 million premature
More informationBasics of skeletal muscle electrophysiology. Tóth András, PhD
Basics of skeletal muscle electrophysiology Tóth András, PhD Topics Structure Contraction and relaxation Activation Excitation-contraction coupling Action potential Ion channels* Calcium homeostasis Structure
More information1/3/2008. Karen Burke Priscilla LeMone Elaine Mohn-Brown. Medical-Surgical Nursing Care, 2e Karen Burke, Priscilla LeMone, and Elaine Mohn-Brown
Medical-Surgical Nursing Care Second Edition Karen Burke Priscilla LeMone Elaine Mohn-Brown Chapter 26 Caring for Clients with Coronary Heart Disease and Dysrhythmias Coronary Heart Disease (CHD) Leading
More informationInvestigating the Frequency of Atherosclerosis Risk Factors in Patients Suffering from X Syndrome
Available online at www.ijmrhs.com ISSN No: 2319-5886 International Journal of Medical Research & Health Sciences, 2016, 5, 10:84-90 Investigating the Frequency of Atherosclerosis Risk Factors in Patients
More informationTYPE II MI. KC ACDIS LOCAL CHAPTER March 8, 2016
TYPE II MI KC ACDIS LOCAL CHAPTER March 8, 2016 TYPE 2 MI DEFINITION: Acute coronary syndrome (ACS) encompasses a continuum of myocardial ischemia and infarction, which can make the diagnostic and coding
More informationFOCUS ON CARDIOVASCULAR DISEASE
The Consequences of Vitamin D Deficiency: FOCUS ON CARDIOVASCULAR DISEASE Vitamin D deficiency is a global health problem. With all the medical advances of the century, vitamin D deficiency is still epidemic.
More informationβ adrenergic blockade, a renal perspective Prof S O McLigeyo
β adrenergic blockade, a renal perspective Prof S O McLigeyo Carvedilol Third generation β blocker (both β 1 and β 2 ) Possesses α 1 adrenergic blocking properties. β: α blocking ratio 7:1 to 3:1 Antioxidant
More informationDiagnosis and Management of Acute Myocardial Infarction
Diagnosis and Management of Acute Myocardial Infarction Acute Myocardial Infarction (AMI) occurs as a result of prolonged myocardial ischemia Atherosclerosis leads to endothelial rupture or erosion that
More informationCho et al., 2009 Journal of Cardiology (2009), 54:
Endothelial Dysfunction, Increased Carotid Artery Intima-media Thickness and Pulse Wave Velocity, and Increased Level of Inflammatory Markers are Associated with Variant Angina Cho et al., 2009 Journal
More informationCardiology. Objectives. Chapter
1:44 M age 1121 Chapter Cardiology Objectives art 1: Cardiovascular natomy and hysiology, ECG Monitoring, and Dysrhythmia nalysis (begins on p. 1127) fter reading art 1 of this chapter, you should be able
More informationStructure and organization of blood vessels
The cardiovascular system Structure of the heart The cardiac cycle Structure and organization of blood vessels What is the cardiovascular system? The heart is a double pump heart arteries arterioles veins
More information