Nurse and Technician Forum Part II Critical Limb Ischemia: Optimal care, an interdisciplinary challenge
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1 L E I P Z I G I N T E R V E N T I O N A L C O U R S E 2017 Nurse and Technician Forum Part II Critical Limb Ischemia: Optimal care, an interdisciplinary challenge Markus Haumer Landesklinikum Baden-Mödling Austria
2 Disclosure Disclosure Speaker name: Markus Haumer, MD I have the following potential conflicts of interest to report: Consulting Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Peripheral Arterial Disease Grading of Severity Fontaine Stage I IIa IIb III IV Rutherford Category Ankle Pressure [mmhg] (70) 0 Ankle Brachial Index Asympt. Claudication Critical Limb Ischemia
4 Consensus Definitions from Peripheral Academic Research Consortium (PARC) Patel MR et al. JACC 2015;65: Critical Limb Ischemia Fontaine Stage III IIa Definitions Rutherford Clinical Category Ischemic Rest Pain Ankle pressure <70mmHg Toe pressure <50mmHg TcPO 2 <40mmHg Skin perfusion pressure <40mmHg Ischemic Ulceration Ankle pressure <50mmHg Toe pressure <30mmHg TcPO 2 <20mmHg Skin perfusion pressure <30mmHg IV Ischemic Gangrene Ankle pressure <50mmHg Toe pressure <30mmHg TcPO 2 <20mmHg Skin perfusion pressure <30mmHg
5 René Magritte (1934) La Modèle Rouge Critical Limb Ischemia Definition and Perspective Definition Critical limb ischemia (CLI) is equated with a need for limb salvage. Perspective Arterial reconstruction and / or major amputation are the therapies ultimately available to such patients.
6 René Magritte (1934) La Modèle Rouge Critical Limb Ischemia Definition and Perspective Definition Critical limb ischemia (CLI) is equated with a need for limb salvage. Perspective Arterial reconstruction and / or major amputation are the therapies ultimately available to such patients.
7 Treatment of Critical Limb Ischemia Network of Aims and Options Survival Death Limb Salvage Quality of Life ABI
8 Treatment of Critical Limb Ischemia Network of Aims and Options Revascularisation Survival Death Quality of Life Wound Management Best Medical Treatment Limb Salvage ABI
9 Treatment of Critical Limb Ischemia Network of Aims and Options Revascularisation Survival Death Quality of Life Wound Management Best Medical Treatment Limb Salvage ABI
10 Treatment of Critical Limb Ischemia Guidelines I Ila Ilb III IV Lifestyle Modification Best Medical Treatment Exercise Revascularisation Prostanoids Local Therapy, Control of Infection, Amputation
11 ESC Guidelines 2011 doi: /eurheartj/ehr211 Treatment of Critical Limb Ischemia Guidelines I Ila Ilb III IV Pain Control Treatment of Infection Revascularisation Wound-Management Risk-Modification Prostanoids, Amputation ESC Guidelines 2011 doi: /eurheartj/ehr211
12 Prompers L et al. [Eurodiale Study] Diabetic Med 2008;25: Vascular imaging 14-68% in patients with ABPI <0.5 or persistent ulcer (i.e. >1yr) or after major amputation; revascularization in 43%. Footulcers in Diabetic Patients Delivery of Care in Daily Practice in Europe Referral 6-55% late referral (i.e. >3 months) to a dedicated foot clinic Pressure off-loading 0 68% casting in plantar fore- or midfoot ulcers
13 Critical Limb Ischemia Still poor outcomes and lack of guideline adherence Primary Amputation is still common! Retrospective data ( ) from largest German healthcare provider hospitalisations due to PAD 49% Critical Limb Ischemia (n=20.685) 10% Amputations (n=4.298) Reinecke H et al. Eur Heart J 2015;36:932-8.
14 Critical Limb Ischemia Time Issues René Magritte The Anger of Gods (1960) Acute limb ischemia, dissection, hemorrhage, infarction and stroke are emergencies. Chronic critical limb ischemia is an urgency. Time is tissue. Helping fast is helping twice. Keep patients on a fast track for vascular imaging and (repeat-) revascularization.
15 Critical Limb Ischemia Time Issues Timeline Development of clinical disease: days / years
16 Critical Limb Ischemia Time Issues Timeline Development of clinical disease: days / years Patient care / Wound care: weeks / months
17 Critical Limb Ischemia Time Issues Timeline Development of clinical disease: days / years Patient care / Wound care: weeks / months Hemodynamic evaluation, vascular imaging and revascularisation: minutes / hours Consider repeat-imaging and -intervention!
18 49% 26% 25% Critical Limb Ischemia An Interdisciplinary Approach LINC 2016 (n ~ 5.000) Interdisciplinary Core Vascular medicine physicians Interventional cardiologists Interventional radiologists Vascular surgeons ~80% of 120 (140) sites enrolling in BEST-CLI Trial have multidisciplinary CLI Teams [Endovascular Today 11/2015] Complementary Disciplines Podiatrist, wound manager, diabetologist; microbiologist, plastic / orthophedic surgeon, prosthetist...
19 Modif. After Rogers LC, Armstrong DL: Podiatry Care, Chapter 113, Rutherford's Vascular Surgery, 7 th Edition. Elsevier Inc, 2010 Perfusion Critical Limb Ischemia An Interdisciplinary Approach Toe-Team Whole Patient-Team NURSES AND TECHNICIANS Flow-Team Probability of Healing
20 Critical Limb Ischemia An Interdisciplinary Approach Teamwork matters Even an excellent revascularisation can be futile if it is not embedded in an optimal environment of patient care and follow-up. Sisyphos at work
21 Isambard Kingdom Brunel ( ) Critical Limb Ischemia An Interdisciplinary Approach A chain is only as strong as ist weakest link! The patient is in a weak position! The patient needs a dedicated case-manager! The case-manager needs a dedicated team! Communicate! If needed, every good team-player can be a good team-leader! Enforce the team; if necessary, expand the team!
22 Vincent van Gogh Sunflowers (1889) Critical Limb Ischemia An Interdisciplinary Approach Identification of CLI Suspicion of ischemia Hemodynamic evaluation Anatomical evaluation
23 Vincent van Gogh Sunflowers (1889) Critical Limb Ischemia An Interdisciplinary Approach Identification of CLI Suspicion of ischemia Hemodynamic evaluation Anatomical evaluation Identification of comorbidities Contributors to tissue loss Diabetes, neuropathy, infection, vessel pathology, malnutrition... Contributors to strategy CAD; CHD; HTN; HLP; CVD; CKD
24 Critical Limb Ischemia Diagnostic Approach ABI TcPO 2 Toe Pressure DUS CTA MRA SPP iadsa
25 Critical Limb Ischemia Diagnostic Approach ABI TcPO 2 Toe Pressure DUS CTA MRA SPP iadsa
26 Mills JL et al. J Vasc Surg 2014;59: Critical Limb Ischemia Diagnostic Approach CLI, first defined in 1982, was intended to delineate a subgroup of patients with a threatened lower extremity primarily because of chronic ischemia. Perfusion is only one determinant of outcome.. Risk stratification is based on three major factors that impact amputation risk and clinical management: Wound, Ischemia, and foot Infection (WIfI)
27 Mills JL et al. J Vasc Surg 2014;59: Critical Limb Ischemia Diagnostic Approach CLI, first defined in 1982, was intended to delineate a subgroup of patients with a threatened lower extremity primarily because of chronic ischemia. Perfusion is only one determinant of outcome.. Risk stratification is based on three major factors that impact amputation risk and clinical management: Wound, Ischemia, and foot Infection (WIfI)
28 Critical Limb Ischemia Non-angiographic Workup Rutherford 5 Rutherford 5 (6?) Rutherford 6 Ischemic wound Ischemic toe Ischemic limb Mild infection Ankle pressure 70mmHg Ankle pressure >200mmHg Toe pressure 0 (30) mmhg Ankle pressure 30mmHg Toe Pressure 0mmHg
29 Mills JL et al. J Vasc Surg 2014;59: Critical Limb Ischemia Risk stratification according to WIfI Estimate risk of amputation at 1 year for each combination Estimate likelihood of benefit of / requirement for revascularization (assuming infection can be controlled first) W...Wound; I...Ischemia; fi...foot Infection; VL...Very Low; L...Low; M...Moderate; H...High
30 Critical Limb Ischemia Non-angiographic Workup Rutherford 5 Rutherford 5 (6?) Rutherford 6 Ischemic wound Ischemic toe Ischemic limb Mild infection Ankle pressure 70mmHg Ankle pressure >200mmHg Toe pressure 0 (30) mmhg Ankle pressure 30mmHg Toe Pressure 0mmHg WIfI 121 / Stage 3 WIfI 320 / Stage 4 WIfI 330 / Stage 4
31 Critical Limb Ischemia Validation of risk stratification according to WIfI Distribution of WIfI clinical stages 1 to 4 among amputation and limb salvage cohorts Incidence of major amputation and 1-yr amputation-free survival (AFS) among WIfI clinical stages 1 to 4 Zhan LX et al. J Vasc Surg 2015;61:
32 Critical Limb Ischemia Cost Issues Amputation There is no evidence for the cost-effectiveness of primary amputation. [Yost ML Endovascular Today 2014(5); Barshes NR et al. J Vasc Surg 2012;56: ] Total hospital cost of distal arterial revascularisation for limb salvage is significantly less than that of primary amputation. [Panayiotopoulos YP et al. Diab Med 1997;14: ]
33 Yusuf S Lancet 2002;360:2-3. Fonarow GC et al. Am J Cardiol 2000;85:10A-17A. Chronic Limb Ischemia Modification of Risk Medical Principles I Ila Ilb III IV Lifestyle Modification Best Medical Treatment Cumulative Relative Risk-Reduction Therapy RRR MACE/10a 40% Smoking 50% 20% Antiplatelets 25% 15% Statins 30% 10% LDL-C % 8% ACE-I / ARB 25% 6% ß-Blocker 25% 5%
34 Critical Limb Ischemia Conclusions Cosmas ( 303 AD) Damian ( 303 AD) Early recognition matters! Early revascularisation matters! Teamwork matters! Keep the foot in the shoe! There is only one single case-report of a successful leg-transplantation in the literature! [The Miracle of Cosmas and Damian]
35 L E I P Z I G I N T E R V E N T I O N A L C O U R S E 2017 Nurse and Technician Forum Part II Critical Limb Ischemia: Optimal care, an interdisciplinary challenge Markus Haumer Landesklinikum Baden-Mödling Austria
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