New Devices Pedro Pinto Cardoso

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1 New Devices Pedro Pinto Cardoso HSM, CHLN, CALM

2 for CTOs Guidewires Microcatheters Radiofrequency Pharmacotherapy Pedro Pinto Cardoso, Serviço de Cardiologia HSM CHLN

3 New Guidewires SENTAI family Samurai Fighter Hornet Asahi SION blue ES Suoh 03 Pedro Pinto Cardoso, Serviço de Cardiologia HSM CHLN

4 SENTAI Family SENTAI Frontline MARVEL SAMURAI Guidewires Specialty Crossing SAMURAI RC FIGHTER HORNET HORNET 10 HORNET 14 IC AA JAN2016 Boston Scientific Corporation. All Rights Reserved. Pedro Pinto Cardoso, HSM CHLN, CALM

5 Samurai Technology Good tip strength, tip flexibility, and reduced whipping. Samurai Inner Coil Technology (ICT) Inner coil Coil Core wire Inner Coil Coil Core wire Ease of shaping Good shape retention Superior operability during a Side Branch Approach

6 Samurai RC Technology New generation crossing wire with moderate support Key Points Easy-to-shape, atraumatic tip Inner Coil Technology (ICT) 1:1 torqueability Full coil-length hydrophilic coating Moderate rail support Coil Length(24cm) / Hydrophilic Coating(24cm) Radiopaque (4 cm) inch* Hydrophilic Coating 4.5g PTFE Coating Name Diameter* (inch/ mm) Length (cm) Coil (cm) Radiopaque SAMURAI RC 0.014/ (cm) Tip Load (gf) Core Material Tip Shape Coating 1.2 Stainless Steel Straight Hydrophilic (Full Length)

7 Fighter Technology Small knuckle wire Fielder like wire Key Points Tapered tip Clear polymer jacket Hydrophilic coating Ideal prolapse wire Moderate rail support Polymer (Coil) Length (18cm) inch* inch** Radiopaque (3.5 cm) Hydrophilic 4.5gCoating PTFE Coating Name Diameter* (inch/ mm) Tip Diameter** (inch/mm) Length (cm) Coil length (cm) Radiopaque (cm) Tip Load (gf) Core Material Tip Shape Coating FIGHTER 0.014/ / Stainless Steel Straight Polymer Jacket, Hydrophilic

8 Hornet Family New generation penetration wires Key Points^ Tapered tip: lowest tip profile on market (.008 )** Hornet 14: highest tip load on market Hornet 10 & 14: highest penetration force on market Hydrophilic coating Coil Length(15cm) / Hydrophilic Coating inch* inch** Radiopaque (3.5 cm) PTFE Coating Hydrophilic 4.5gCoating Name Diameter* (inch/ mm) Hornet 0.014/ 0.37 Hornet 10 Hornet 14 Tip Diameter** (inch/mm) Total Length (cm) Coil Length (cm) Radiopaque (cm) Tip Load (gf) Penetration Force (gf/mm2 )^^ Core Material Tip Shape Coating 0.008/ Stainless Steel Straight Hydrophilic 0.014/ / Stainless Steel Straight Hydrophilic 0.014/ / Stainless Steel Straight Hydrophilic

9 Asahi SION blue ES New generation extra support wire Atraumatic tip Improved torque Easy navigation Excellent support Improves device delivery Alternative to BHW / Grand Slam

10 Suoh 03 New generation retrograde wire

11 New Microcatheters Asahi Caravel new generation microcatheter Turnpike LP new generation microcatheter FineDuo dual lumen microcatheter Threader microdilatation catheter Pedro Pinto Cardoso, Serviço de Cardiologia HSM CHLN

12 Asahi Caravel New generation microcatheter Tapered tip Highly flexible and atraumatic tip Low profile (two in 6 Fr guide) Improved wire support Improved visibility Managed by pushing and not rotating

13 Turnpike LP New generation microcatheter Lower distal shaft profile Increased flexibility in the distal shaft and tip Improved deliverability

14 FineDuo Dual lumen microcatheter Multifunction Catheter having two Guidewire lumen (RX / OTW) for Side Branch Access; especially helpful for GW manipulation in Bifurcation Stenting procedure

15 Achieves superior crossability Double radiopaque markers Double radiopaque markers are located specifically for better visualization u u u OTW lumen exit port in between both markers 1 mm Distal marker on RX lumen part Distal marker on RX lumen part is located at 0.5 mm 0.5 mm 1.0 mm 0.5 mm 5 mm Double markers facilitate an accurate placement to access SUPPORT Any side branch or collaterals The most distal stent strut

16 Parallel wire technique

17 Parallel wire technique

18 Threader Microdilatation catheter Joins the concept of microcatheter and pre-dilatation balloon 1.2 x 12 mm OTW semi-compliant balloon

19 New Concepts - out of the box tools Radiofrequency PlasmaWire System Pharmacotherapy Collagenase Pedro Pinto Cardoso, Serviço de Cardiologia HSM CHLN

20 PlasmaWire System Radiofrequency PlasmaWire System RF Generator (RFG) Connector Cable Two RF wires (PlasmaWire) FIM results presented at TCT 2016 Plasma ablation in hotdog Plasma ablation in bone (calcium) Approximately 2 mm Approximately inch Clear channel created without charring (electrodes offset by 2 mm) Clear channel created without charring

21 PlasmaWire System Gaia NEXT

22 Potential Indications of PlasmaWire System localized plasma ablation Ablation of proximal fibrous cap break of fibrous cap with ablation Recanalization with CTO exit ablation at CTO exit Antegrade re-entry re-entry from subintima with ablation Retrograde re-entry with or w/o calcium ablation dense calcium channel in calcium FIM of PlasmaWire

23 Potential Indications of PlasmaWire System localized plasma ablation Ablation of proximal fibrous cap break of fibrous cap with ablation Recanalization with CTO exit ablation at CTO exit Antegrade re-entry re-entry from subintima with ablation Retrograde re-entry with or w/o calcium ablation dense calcium channel in calcium FIM of PlasmaWire

24 Potential Indications of PlasmaWire System localized plasma ablation Ablation of proximal fibrous cap break of fibrous cap with ablation Recanalization with CTO exit ablation at CTO exit Antegrade re-entry re-entry from subintima with ablation Retrograde re-entry with or w/o calcium ablation dense calcium channel in calcium FIM of PlasmaWire

25 Potential Indications of PlasmaWire System localized plasma ablation Ablation of proximal fibrous cap break of fibrous cap with ablation Recanalization with CTO exit ablation at CTO exit Antegrade re-entry re-entry from subintima with ablation Retrograde re-entry with or w/o calcium ablation dense calcium channel in calcium FIM of PlasmaWire

26 Potential Indications of PlasmaWire System localized plasma ablation Ablation of proximal fibrous cap break of fibrous cap with ablation Recanalization with CTO exit ablation at CTO exit Antegrade re-entry re-entry from subintima with ablation Retrograde re-entry with or w/o calcium ablation dense calcium channel in calcium FIM of PlasmaWire

27 Intra-Lesional MZ-004 Collagenase for CTOs Bacterial collagenase obtained by fermentation of Clostridium histolyticum collagenase-enabled wire-crossing animal CTO model Circulation 2003;108:1259 First-in-Man experience 20 patients with prior CTO PCI failure mcg delivered into proximal cap 15 of 20 crossed successfully 1 day later Circulation 2012;125:522

28 Thank You Pedro Pinto Cardoso HSM, CHLN, CALM

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