46 in humans 23 from mom 23 from dad

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Earl McGee
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1 July 3, 2000

2 46 in humans 23 from mom 23 from dad

3 1) Genes: The DNA. (the hardware of the phone) 2)Epi: on 3) Epigenetics the study of changes in organisms caused by modification of gene expression rather than alteration of the DNA. (app) Genes Epigenetics is the software genes are the hardware of the iphone 6

4 Methylation: The modification of a strand of DNA after a methyl (CH 3 ) group is added. We giving a name to the app. (CH3) Methyl Methyl App 2)Epi: on 3) Epigenetics the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.

5 What methyl groups do to mice

6 Agouti mean brown

7 Choline, folic acid, betaine and B12

9 Jan. 11, 1999

10 Jan. 18, 2010

13 Methylation Cycle

14 Methylation Cycle Methyl Naked-B12 Folate B9 Methyl-B12

15 Green= both good genes Yellow=1 bad gene from mom or dad Red=2 bad genes from mom and dad

17 46 in humans 23 from mom 23 from dad

19 Nutrients: acting as methyl donors (folate, vitamin B12, and choline) collard greens, Brussels sprouts, broccoli, Swiss chard, cauliflower, and asparagus, diet, inflammation,

20 12 Tips to Optimize Your Methylation Process Just as there are many causes of poor methylation, there are lots of things that support its proper functioning. Here s how to maximize methylation and prevent conditions like heart disease, cancer, dementia, depression, and more. 1) Eat more dark, leafy greens You want to eat l cup a day of vegetables like bok choy, escarole, Swiss chard, kale, watercress, spinach, or dandelion, mustard, collard, or beet greens. These are among the most abundant sources of the nutrients needed for optimal methylation 2) Get more B s in your diet Good food sources include sunflower seeds and wheat germ (vitamin B6); fish and eggs (vitamin B6 and B12); cheese (B12); beans and walnuts (vitamin B6 and folate); leafy dark green vegetables; asparagus, almonds, and whole grains (folate); and liver (all three) 3) Minimize conventional animal protein, sugar, and saturated fat Animal protein directly increases homocysteine. Sugar and saturated fat deplete your body s vitamin stores

21 4) Avoid processed foods and canned foods These are depleted in vitamins 5) Avoid caffeine Excess amounts can deplete your B vitamin levels 4) Avoid processed foods and canned foods These are depleted in vitamins 5) Avoid caffeine Excess amounts can deplete your B vitamin levels 6) Limit alcohol to 3 drinks a week More than this can deplete your B vitamin levels 7) Don t smoke As noted above, smoking inactivates vitamin B6 8) Avoid medications that interfere with methylation See notes on this above

22 9) Keep the bacteria in your gut healthy Take probiotic supplements and use other measures to make sure the bacteria in your gut are healthy so you can properly absorb the vitamins you do get 10) Improve stomach acid Use herbal digestives (bitters) or taking supplemental HCl 11) Take supplements that prevent damage from homocysteine Antioxidants protect you from homocysteine damage. Also make sure you support methylation with supplements like magnesium and zinc Functional less than ) Supplement to help support proper homocysteine metabolism Talk to your doctor to determine the best doses and forms for you. Here are a few suggestions: Folate (folic acid): Amounts can vary based on individual needs from 200 mcg to 1 mg. Some people may also need to take preformed folate (folinic acid or 5 formylthf) to bypass some of the steps in activating folic acid

23 13) Vitamin B6: Take 2 to 5 mg a day. Some people may need up to 250 mg or even special active B6 (pyridoxyl-5-phosphate) to achieve the greatest effect. Doses higher than 500 mg may cause nerve injury 14) Vitamin B12: Doses of 500 mcg may be needed to protect against heart disease. Oral vitamin B12 isn t well absorbed; you may need up to 1 or 2 mg daily. 15) Betaine: This amino acid derivative is needed in doses from 500 to 3,000 mg a day, depending on the person

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