COGNAGEN SUPPORTS BRAIN FUNCTION. The SMART Choice for Brain Health!

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1 COGNAGEN SUPPORTS BRAIN FUNCTION The SMART Choice for Brain Health! 1.

2 COGNAGEN SUPPORTS BRAIN FUNCTION COGNITIVE NEEDS THROUGHOUT THE LIFESPAN Brain health is one of the major public health concerns at all ages. Children and students today are growing up in a very competitive academic environment and parents are committed to supporting their mental performance and helping them achieve the highest academic results. Adults are looking for a way to keep their brain healthy and well-nourished in order to enable their brain to work at top capacity, and seniors seek to lessen loss of cognitive skills and abilities as part of the aging process. Clinical studies have demonstrated that phosphatidylserine () supplementation may improve mental performance and contribute to maintaining a healthy life style. Seniors Healthy Lifestyle Adults Maximizing potential and achievements Children & Students Supporting brain health and development 2.

3 The SMART Choice for Brain Health! A unique blend of phosphatidylserine and organic blueberry powder Supports memory and cognitive health Improves memory, mood, and learning Slows/reverses age-related memory loss Enhances overall quality of life Usage: One capsule three times a day or as recommended by healthcare provider After maximum effect is achieved, the dosage can reportedly be reduced to 100 mg (one capsule) daily without losing benefit Can be taken with or without meals Each Capsule Contains: Sunflower Phosphatidylserine Complex (Helianthus annuus) (seed) (standardized to 60% phosphatidylserine) mg Organic Blueberry Powder mg Non-GMO sources of sunflower and blueberry Suitable for vegans Soy free 3.

4 COGNAGEN SUPPORTS BRAIN FUNCTION The SMART Choice for Brain Health! Phosphatidylserine () Phosphatidylserine () is one of the body s essential building blocks. is naturally found in the cell membrane and particularly abundant in the brain 1. The brain is a very metabolically active organ and is one of the richest organs in lipid content 2. is a well-researched, scientifically-validated brain health nutrient. In numerous clinical trials, has been shown to alleviate stress, improve mood, and positively impact focus, memory and cognition. Phosphatidylserine Composition of Human Tissues 1 (as a % of total phospholipids) 18% of the brain 3% of the heart 3% of the liver Phosphatidylserine () and the brain Human brain cell membranes are highly enriched with. Nerve cells depend on healthy membrane function for normal neurotransmitter metabolism and nerve signal transmission. Adequate levels ensure membrane fluidity, structure, and therefore, function. Maintaining brain levels has been associated with: 4. normal and efficient signal transduction processes efficient glucose consumption normal and healthy cognitive and mental functions

5 Cognitive Support Throughout the Lifespan! Biological Overview of phosphatidylserine is a major component of brain cell tissues. mediates nerve-signal transduction processes. maintains brain cell membrane activity. SERINE PHOSPHATE GLYCEROL 1 2 FATTY ACID CELL INTERIOR is a natural lecithin-derived substance. CELL EXTERIOR Why do we use Sharp- Green? Sharp Green is one the most revolutionary and innovative new products in the field of brain health. Sharp- Green is: Clinically validated and proprietary Comprised of phosphatidylserine from a vegetarian source Free from soy allergens, and is non GMO and eco-friendly Helps maintain and restore memory and mental performance Grown in temperate, not tropical climes, to preclude deforestation practices Benefits of Supplementing with health benefits have been proven in over 30 clinical studies addressing the entire human life cycle, from seniors 3, adults 4 to children 5,6. was found to significantly improve: Concentration Memory Learning Attention Behavior Stress Management 5.

6 Blueberries and Brain Health Over the last 10 years, there has been increasing scientific interest in flavonoid polyphenols (abundant in blueberries) for their ability to increase brain protection and possibly decrease age-related cognitive and motor decline7. The majority of evidence is from human population studies correlating flavonoid rich diets to brain health, and from animal models where the animals consumed a blueberry supplemented diet 8. improves Memory & Attention Following 12 weeks of supplementation with 300 mg/day of in elderly subjects, the reversal of the aging process amounted to nearly 14 years. Improvements were exhibited in other capacities as well, including learning and remembering written information, recognition of people, and memory of numbers YEARS OF IMPROVEMENT Remembering names after introduction Learning & remembering written information. Recognizing someone previously seen Dialing 10-digit phone no. from memory Improvement in years following a 12 week 300mg/day supplementation of in different cognitive abilities in an elderly population 9. 6.

7 improves Memory & Attention (Continued) Another study demonstrated that soybean-derived (SB-) may have favorable effects on cognitive function in elderly subjects with memory complaints. The participants received supplementation with 300 mg/day of with meals for 12 weeks 10. supplementation significantly increased the following cognitive parameters: memory recognition, memory recall, executive functions, and mental flexibility. Another assessment test indicated that, following SB- administration, total learning and immediate memory recall improved significantly 10. Phosphatidylserine is Safe is a common structural component of biological membranes of plants, animals and other life forms 11,12. Human studies provide evidence that is safe even at high levels: no significant effects were observed in safety parameters, blood pressure, heart rate or adverse events subsequent to supplementation of 600 mg daily for 12 weeks 11,12. safety is further supported by the absence of reports of adverse reactions in the published literature 11,12. 7.

8 COGNAGEN SUPPORTS BRAIN FUNCTION References: 1. White, D. The phospholipid composition of mammalian tissue, Woods et al, AA Journal, Richter et al, Clinical Interventions in Aging. 2013; 8: Yong, T., Chongqing Medicine, 2011, 30: , Manor, I., European Psychiatry, 2012, 27(5): Hirayama, S., Journal of Human Nutrition and Dietetics, 2014, 27 (Suppl. 2): Psychopharmacology (Berl) Oct;223(3): PLoS One May 28;8(5):e Nutr Neurosci. 2001;4(2): Clin Interv Aging. 2013;8: Jorissen et al. (2002) Nutr Neurosci. 5: Cenacchi et al. (1987) Clin Trials J. Neurosci. 24: These statements have not been evaluated by the Food and Drug Administration.These products are not intended to diagnose, treat, cure or prevent any disease. 8. [ LL]