Osteoporosis & You. What the newest research means for the health of your bones.

Transcription

1 Osteoporosis & You What the newest research means for the health of your bones AdvaCAL Retail Brochure.indd 2 1/15/10 4:56:18 PM

2 It s never too late to build bone, but it is also never too early. According to the National Osteoporosis Foundation: - An estimated 44 million Americans (or 55% of the people over 50 years of age) have Osteoporosis or are at great risk of getting Osteoporosis. - 80% of those affected by Osteoporosis are women. - One in two women over age 50 will have an Osteoporosis related fracture in her remaining lifetime. - An average of 24% of hip fracture patients aged 50 and over die in the year following their fracture. - The number of fractures due to Osteoporosis is expected to rise to more than 3 million by These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life AdvaCAL Retail Brochure.indd 3 1/15/10 4:56:20 PM

3 What is Osteoporosis? Osteoporosis is a disease in which calcium-depleted bones become extremely porous, fragile and weak. Who is susceptible to Osteoporosis? Although anyone can be affected, postmenopausal women have the greatest risk. Bone loss generally begins at age 35 and can accelerate up to 3% per year during menopause. How can I optimize my bone health? 1. Get daily sufficient amounts of calcium and Vitamin D 2. Engage in regular weight-bearing and muscle strengthening exercise 3. Avoid smoking and excessive alcohol 4. Talk to your health care provider about bone health 5. Have a bone density test done regularly Why is calcium important? Bone is largely comprised of calcium. Your body uses calcium continuously to support the heart, brain and muscles. When the calcium absorbed from foods or supplements is inadequate, your body takes calcium from bone, weakening it. If you rob too much calcium from your bones, the supply becomes depleted. That is Osteoporosis. The human body cannot produce calcium on its own. Likewise, Osteoporosis drugs do not supply calcium to the body. It is therefore important to take in and absorb enough calcium through the food we eat or supplements we take. The FDA recommends intakes of 1000 mg daily of calcium; 1200 mg daily for women 50+. There are many types of calcium (such as carbonate, lactate and citrate) available in supplements and foods. Not all calciums are equally well absorbed nor do they all equally benefit bone. Healthy bone Calcium-depleted bone AdvaCAL Retail Brochure.indd 4 1/15/10 4:56:20 PM

4 Can the Type of Calcium Make a Difference? Yes. There are many different types of calcium. The calcium is identical in each case but the salt Calcium Type to which the calcium is attached varies. These different combinations can Carbonate AAACa dramatically affect absorption of calcium. Calcium carbonate, which is used in Gluconate many calcium supplements, Lactate Gluconate is poorly absorbed under certain conditions and can Citrate create stomach gas. Calcium Citrate Malate citrate and calcium hydroxyapatite (from calf bone) Hydroxyapatite are bulky, resulting in a large pill size. Brands* AdvaCAL Tums, OsCal, Caltrate, AlgaeCal, Grow Bone, Coral Calcium, Bone Strength Take Care Various Various Citracal Various Bone-Up, Bone-Builder 4 How do I Choose a Calcium Supplement? Start with the published science. A December 2009 article in the medical journal Osteoporosis International summarized human studies on various calciums since The article reviewed 32 multi-year studies on calcium and bone density in postmenopausal women. A Japanese calcium called AAACa (for Active Absorbable Algal Calcium) reported the highest See chart average increase in bone density among all the studies. *Trademarks are owned by their respective companies. These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life AdvaCAL Retail Brochure.indd 5 1/15/10 4:56:22 PM

5 REPORT FROM OSTEOPOROSIS INTERNATIONAL 1 Multi-Year Calcium Supplement Studies on Bone Density in Postmenopausal Women (750 mg or more of calcium daily) CALCIUM NUMBER OF AVERAGE STUDY LENGTH BONE BONE DENSITY % CHANGE PER YEAR AUTHOR CALCIUM TYPE PER DAY PEOPLE AGE IN YEARS MEASURED VS. BASELINE VS. CONTROLS Fujita 04 AAACa (AdvaCAL) 900 mg Spine Fujita 97 2 AAACa (AdvaCAL) 900 mg Spine Smith 81 Carbonate 750 mg Mid-Radius Ettinger 87 Carbonate 1000 mg Metacarpal Dist. Radius Spine QCT Hansson 87 Carbonate 1000 mg Spine Riis 87 Carbonate 2000 mg Prox Radius Dist. Radius Tot. Body Spine Smith 89 Carbonate 1500 mg Mid-Radius Mid-Ulna Mid-humerus Chevalley 94 Carbonate 800 mg Fem. Shaft Fem. Neck Spine Aloia 94 Carbonate 1200 mg Tot. Body Spine Dist. Radius 0 0 Fem. Neck Ward s Trochanter Recker 96 Carbonate 1200 mg Mid-Forearm Recker 96 Carbonate 1200 mg Mid-Forearm Storm 98 Carbonate 1000 mg Spine Trochanter Fujita 04 Carbonate 900 mg Spine Prince 06 Carbonate 1200 mg Fem Neck Zhu 08 Carbonate 1200 mg Tot. Hip Horsman 77 Gluconate 800 mg Metacarpal Dist. Ulna Dist. Radius Elders 94 Gluconate 1000 mg Spine Metacarpal Elders 94 Gluconate 2000 mg Spine Metacarpal Hannson 87 Gluconate 1000 mg Spine Prince 91 Gluconate 1000 mg Dist. Radius Mid-radius Prox. Radius Prince 95 Lactate Gluconate 1000 mg Trochanter Intertrochantr Fem. Neck Ankle Reid 95 Lactate Gluconate 1000 mg Tot. Body Fem. Neck Ward s Trochanter Spine Riggs 98 Citrate 1600 mg Spine Hip Tot. Body Reid 06 Citrate 1000 mg Spine Tot. Body Hip Strause 94 Citrate Malate 1000 mg Spine Data Excerpted from Nordin B.E.C. The Effect of Calcium Supplementation on Bone Loss in 32 Controlled Trials in Postmenopausal Women Osteoporosis International, (2009) 20: Additional AdvaCAL published study provided for reference (93% women. 7% men) AdvaCAL Retail Brochure.indd 6 1/15/10 4:56:23 PM

6 AdvaCAL: The #1 Bone-Building Calcium. What is AdvaCAL? AdvaCAL is the only line of calcium supplements with AAACa calcium, the #1 bone-building calcium. The AAACa calcium in AdvaCAL has shown statistically significant increases in bone density in four different, published human studies. Participants in that research included women and men in their 60s and women in their 80s. In those studies bone density improvement started as early as 4 months, up to 3 years. Unlike other calciums, AdvaCAL is absorbable with or without food, and does not produce stomach gas. * The capsules are also small and easy to swallow. AdvaCAL is the safe, natural way to fight Osteoporosis harder. Can AdvaCAL help reverse Osteoporosis? Yes. In one study, average bone density of Osteoporosis patients taking AdvaCAL increased 8% over those taking a placebo. Individual results have been even more dramatic (see pages 10-11). How long should I take AdvaCAL before I see a benefit? Clinical research has shown an increase in bone density in as little as 4-6 months. Spinal bone density studies have shown statistically significant increases versus placebo yearly, through 3 years. The best way to monitor your results is to have bone density tests yearly or as recommended by your doctor. Is AdvaCAL more effective with added magnesium? Not necessarily. A study published in the 1999 American Journal of Nutrition suggests that the bone benefit of magnesium results from its alkalinity (i.e. high ph). Because the AAACa calcium in AdvaCAL is already highly alkaline, it likely offers the same alkalinity bone benefit as magnesium. Those who desire to take magnesium with their AdvaCAL should use AdvaCAL Ultra 1000 which contains 600 mg of magnesium per daily serving. Can I take AdvaCAL with prescription Osteoporosis medications? Yes. 6 *We recommend taking AdvaCAL 1000 Ultra with food to improve the absorption of the other bone nutrients. These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life AdvaCAL Retail Brochure.indd 7 1/15/10 4:56:24 PM

7 Which AdvaCAL is right for me? AdvaCAL mg of AdvaCAL Calcium, 1000 IU of Vitamin D3 daily. AdvaCAL Ultra mg of AdvaCAL Calcium, 1000 IU of Vitamin D3 daily, plus other bone nutrients. Smallest Capsule With Magnesium Per Day (6 capsules) AdvaCAL 1000 AdvaCAL Ultra 1000 AAACa Calcium 1000 mg 1000 mg Vitamin D IU 1000 IU Magnesium 600 mg Vitamin C 100 mg Vitamin K2 100 mcg Zinc 12 mg Copper 2 mg Manganese 4 mg Boron 4 mg Directions for use: Take 3 capsules in the morning and at bedtime, preferably with food AdvaCAL Retail Brochure.indd 8 1/15/10 4:56:26 PM

8 AdvaCAL In The News Federal Judge Rules for AdvaCAL Newark, NJ A U.S. District Court Judge Dennis M. Cavanaugh ruled that LaneLabs clearly offered support and substantiation for claims on AdvaCAL, thereby denying FTC charges to the contrary. The judge noted that LaneLabs provided credible medical testimony that the products in question are good products and could have the results advertised... Reference: 20 Years of AdvaCAL Research Waldwick, NJ LaneLabs recently celebrated twenty years of research on the AAACa calcium in AdvaCAL. Dating back to 1988, 30 scientific articles on AAACa or its ingredients have been accepted by leading medical journals. AAACa calcium also has been granted five separate patents in the US or Japan. AdvaCAL Tops Among 32 Calcium Studies Adelaide, Australia A recent report in Osteoporosis International showed the yearly spinal bone mineral density gain from taking AAACa calcium (AdvaCAL) was highest among 79 skeletal measures in 32 different calcium studies on postmenopausal women. AdvaCAL s top score is based on a comparison of average results in each study, not a statistical analysis. Reference Nordin B.E.C. The effect of calcium on bone loss in 32 controlled trials in postmenopausal women Osteoporosis Int. (2009) 20: #3 in Doctor Prescriptions Mumbai, India - A supplement comprised of AAACa calcium, the same calcium in AdvaCAL, now ranks third in prescription generation among all calcium brands in India. Reference: 8 These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life AdvaCAL Retail Brochure.indd 9 1/15/10 4:56:30 PM

9 AdvaCAL Research DR. TAKUO FUJITA, M.D. Founder of Japan s Calcium Research Institute, past president of Japan s Osteoporosis Foundation and author of over 400 scientific papers on calcium To show whether AAACa (AdvaCAL) is really effective against osteoporosis we have to perform bone measurements. Now any studies which are not randomized or placebocontrolled are not considered valid these days, so I did all these procedures with a group of very elderly ladies in their eighties. It took quite a long time and some of these patients dropped out for various reasons. But a good number continued for the full twenty-four months and we found a very impressive increase in bone-mineral density (BMD) in those who received AAACa (AdvaCAL) and a very significant fall of BMD in those who took placebo. Everybody is getting older and losing bone, so we expect such a loss... but there was a significant increase in BMD for AAACa users. This was quite surprising. Smallest Capsule AdvaCAL mg of AdvaCAL Calcium, 1000 IU of Vitamin D3 daily. With Magnesium AdvaCAL Ultra mg of AdvaCAL Calcium, 1000 IU of Vitamin D3 daily, plus other bone nutrients AdvaCAL Retail Brochure.indd 10 1/15/10 4:56:30 PM

10 Success Stories Connie P. Age 70 Connie s Bone Scans improved +6% in her hip and +14% in her spine after 2 years of taking AdvaCAL. AdvaCAL has changed my life because now I have peace of mind. I m not worried about breaking a bone because I know my bones are getting stronger. As an Osteoporosis expert, I appreciate the difference that AdvaCAL offers over other calciums. I recommend it to my patients and I take it myself every day. Martha Gonzalez, M.D. I have a history of severe osteoporosis, I have been seeing an endocrinologist for several years. Last year they did a bone scan and repeated it this year with the same machine, the same technician and the position so exact X-ray could be superimposed on the other. To their surprise, and mine, I had a 6.1% bone increase. The doctor immediately wanted to know what supplements I had been taking. Of course AdvaCAL was at the top of the list. Jean M. The results of my DEXA for 2008 represent one full year on your product AdvaCAL. While the numbers are not dramatic, they do show progress towards rebuilding bone. I only take your product. It works! Many Thanks! Denise S. Denise s Bone Scan showed 6 of 8 bone measures higher after 1 year. Carol B. Age 41 In one year, I had a 11.9% increase in bone density with Fosamax and AdvaCAL. AdvaCAL has improved my quality of life. You brush your teeth to make them feel good. I take AdvaCAL to make my life better. I am writing to thank you for your product. I have done great on your AdvaCAL Ultra. One year ago my bone scan showed Osteoporosis in my spine and one year later it is normal. My doctor told me to take 1,800mg a day of calcium he left the choice up to me. I have had no problems taking your product. My doctor put on my report Bone Density Excellent Markedly Improved. Stay on same vitamins. Thanks again! Jean Y. 10 * Fosamax is a registered trademark of Merck & Company, Inc. These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life AdvaCAL Retail Brochure.indd 11 1/15/10 4:56:33 PM

11 Jean W. Age 80 I had a crash on my bike last Fall. I am quite sure I would have had a broken bone if I hadn t been on AdvaCAL. AdvaCAL works 100%. I ll stay on it the rest of my life. Bone Scan Osteoporosis (t-score -3.2) to Osteopenia (t-score -2.4) in 6 months I feel great! I am energetic and I sleep well and more soundly. I saw results with AdvaCAL immediately. There are absolutely no problems with side effects at all. It s a great product. So far, so good! Barbara R. AdvaCAL Ultra works exactly like LaneLabs says it does! I couldn t be without it! I just love it. Joyce S. A remarkable increase in bone density. Doctor s Report on Jean Y. after one year taking AdvaCAL More success stories at Lauri T. Age 50 I wouldn t take anything else. I really feel that it has made a difference in my energy, my strength and... my whole balance. I feel like I am on an even keel. I m sleeping better. I don t have the PMS that I did. I am absorbing it. I know I am and I can feel the difference. Some individuals received free AdvaCAL as a thank you for their testimonials. In one clinical study, postmenopausal women and men taking AdvaCAL increased their bone density on average by 8% more than those taking a placebo after 3 years. In another study, elderly women taking AdvaCAL increased their bone density on average by 6.6% more than those taking placebo after 2 years. Your results will vary AdvaCAL Retail Brochure.indd 12 1/15/10 4:56:34 PM

12 AdvaCAL: The #1 Bone-Building Calcium Smallest Capsule With Magnesium AdvaCAL 1000 AdvaCAL Ultra 1000 Osteoporosis is preventable. Take the best calcium not the cheapest one. Takuo Fujita M.D. Founder of Japan s Calcium Research Institute, past president of Japan s Osteoporosis Foundation and author of over 400 scientific papers on calcium These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, prevent or cure any disease. Adequate calcium with vitamin D as part of a healthful diet throughout life, along with physical activity, may reduce the risk of osteoporosis in later life. LaneLabs-USA, Inc., 3 North Street, Waldwick, NJ /10 R CTRL BR AdvaCAL Retail Brochure.indd 1 1/15/10 4:56:14 PM