Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend

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1 Bio Pro 365 Prebiotic Probiotic Blend Product Summary Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend specifically designed to protect and enhance all aspects of the digestion process. Seven unique probiotic strains are combined with prebiotic and digestive blends, to better re-calibrate the body to efficiently use the nutrients in our food. And maybe most important, it helps us feel better all day long as we enjoy the physical, mental, and emotional benefits of healthy digestion. Key Benefits: Re-calibrates the body for healthy digestion. Helps improve better absorption of nutrients from food* Improves overall mood and symptoms of anxiety* Improves mental cognition and heart health* Ingredients Probiotic Blend contains seven scientifically proven strains at a potency of 25 billion colony-forming units, with proven survival in the human digestive tract. This blend works to ensure your body is absorbing key nutrients from your diet while helping lessen minor abdominal discomfort and bloating. It also works to provide support against inflammation and allergies and helps to improve your heart health by lowering blood pressure and cholesterol levels. This blend has also been proven to significantly increase mental cognition and improve mood. 30 Prebiotic Blend boosts the vitality and survivability of the probiotic blend in the digestive tract for maximum effectiveness. It also works synergistically with the probiotic to help minimize symptoms caused by food sensitivities S. Union Park Center, Suite 140 Salt Lake City, UT Tele *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 1

2 Digestive Blend is a potent blend of digestive enzymes specially formulated to aid in proper digestion of a typical modern diet. This includes helping to increase absorption of key nutrients and minimizing the abdominal pain, bloating and general discomfort associated with food sensitivities. Product Background Human diets have changed significantly over the centuries foods and ingredients that are common today were not available hundreds of years or even decades ago. With all the factors associated with the production of food (soil conditions, chemicals, bio-engineering, processing, packaging, preservatives, etc.), the body s ability to digest and effectively use food has drastically changed. As a result, we re seeing more and more evidence of food-based, digestive problems, including allergies and intolerance to gluten and lactose, among others. To put it simply, more and more people do not feel good after they eat. Gastrointestinal difficulties not only make us feel bad, it effects the rest of our health as well. Recent research suggests that the health of the human biome in the gut, where up to 90% of the serotonin found in the body is produced and used, also directly affects serotonin production in the brain and is extremely important in supporting overall positive mood. As our food becomes more processed, the importance of good digestion becomes paramount we need help! Bio Pro 356 combats the stress and strain that a modern food supply (particularly the typical American diet) puts on the digestive system. Influenced by traditional Chinese medicine that has been proven to work for centuries, Bio Pro 365 helps to re-calibrate the body to use the nutrients in the food we eat. And maybe most importantly, it helps us feel better not only after we eat, but all day long as we enjoy the physical, mental, and emotional benefits of healthy digestion. Benefits and Features Promotes healthy digestion* Helps improve absorption of nutrients from food and supplements* Helps reduce occasional diarrhea or constipation* Fights hypersensitivity, allergies and inflammation* Provides colon health support* Supports a healthy immune system* Fights and prevents infection* 2

3 Improves overall mood and helps alleviate symptoms of anxiety* Improves cardiovascular health as blood pressure and cholesterol are lowered* Promotes healthy blood sugar levels* Improves mental cognition* Formulation influenced by centuries of wisdom in traditional Chinese medicine* What Makes This Product Unique? Bio Pro 365 is guaranteed to contain 25 billion live CFUs by the end of the product shelf life. It contains seven clinically tested strains as well as prebiotics to ensure the effectiveness and survivability of these strains in the gut. Made with veggie caps, it has a 1-year shelf life. No refrigeration needed. Who Should Take this Product? Anyone with acute gastrointestinal complaints or wishing to achieve better digestion and benefits from the food they eat should take this product. Only those over the age of 16 should use this product. FAQs Q: Why do I feel bad after I eat? A: Irritants, chemicals, food allergies and sensitivities contribute to us feeling bloated, gassy, and uncomfortable after we eat. Bio Pro 365 is meant to help alleviate the general discomfort associated with eating. Changes in how you feel when you start a probiotic are normal, any initial feelings of being bloated or gassy should quickly fade. Q: Does this change my digestion permanently? A: There are many things that affect digestion on a day to day basis including, but not limited to, the foods you eat and your physical health. Bio Pro 356 has been designed to positively affect your digestion while you take it. Going off of the product could result in a return of your previous digestive issues. Suggested Use Take 1 capsule daily with food and eight (8) ounces of water. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 3

4 Guarantee Bio Pro 365 is guaranteed to contain 25 billion live CFUs by the end of the product shelf life of one year. Fact Panel Supplement Facts Serving Size: 1 Capsule Servings Per Container: 30 Amount Per Serving %DV Proprietary Probiotic Blend 25 billion viable organisms Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium lactis, and Bifidobacterium bifidum Proprietary Digestive and Immune Blend Astragalus Root Extract DigeSEB Dong Quai Root FOS (fructooligosaccharides) *Daily Value Not Established 200 mg Other ingredients: Vegetable Cellulose (capsule), Magnesium Stearate, Microcrystalline Cellulose, and Silica Gluten Free Key Studies 1. Dimidi E., et al. The effect of probiotics on functional constipation in adults: a systematic review and metaanalysis of randomized controlled trials. American Journal of Clinical Nutrition Oct; 100(4): Guarino A., et al. Probiotics as Prevention and Treatment for Diarrhea. Current Opinion in Gastroenterology. 2009; 25(1): O Mahony L., et al. Lactobacillus and Bifidobacterium in Irritable Bowel Syndrome: Symptom Responses and Relationships to Cytokine Profiles. Gastroenterology. 2005; 128: Yoon JS, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double- blind, placebo-controlled trial. Journal of Gastroenterology and Hepatology Jan; 29(1): Kundalini S., et al. Probiotics for prevention and treatment of diarrhea. Journal of Clinical Gastroenterology Nov; 45 Suppl: Sisson G., et al. Randomised clinical trial: A liquid multi-strain probiotic vs. placebo in the irritable bowel syndrome-a 12 week double-blind study. Aliment Pharmacol Ther 2014 Jul; 40(1):

5 7. Huey-Shi L.., et al. The Improvement of Hypertension by Probiotics: Effects on Cholesterol, Diabetes, Renin, and Phytoestrogens. Int. Journal of Molecular Sciences. 2009, 10; Naruszeqicz M., et al. Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. American Journal of Clinical Nutrition Vol. 76 no. 6: Khalesi S., et al. Effect of Probiotics on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials. Hypertension: American Heart Association. 2014; 64: Tsai, C. et al. Cholesterol Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism In vitro and In vivo. The Scientific World Journal. 2014, Article ID , 10 pages. 11. Sanchez M., et al. Effect of Lactobacillus rhamnosus CGMCC supplementation on weight loss and maintenance in obese men and women. British Journal of Nutrition. 2014; 111: Shida K, Nomoto K. Probiotics as efficient immunopotentiators: Translational role in cancer prevention. Indian J Med Res Nov; 138(5): Roxas M., et al. The Role of Enzyme Supplementation in Digestive Disorders. Altern Med Rev Dec; 13(4): Quinten T., et al. Can the supplementation of a digestive enzyme complex offer a solution for common digestive problems? Archives of Public Health. 2014; 72(Suppl 1): P Paineau D., et al. Effects of seven potential probiotic strains on specific immune responses in healthy adults; a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol Jun; 53(1): Mikhail S. et al. The role of Probiotics in allergic diseases. Allergy, Asthma and Clinical Immunology. 2009, 5: Gill H.S., et al. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). British Journal Nutrition Feb; 83(2): Cummings J.H., Macfarlane G.T. Gastrointestinal effects of prebiotics. British Journal of Nutrition May; 87 Suppl 2: S Ruan Y., Sun J., He J., Chen F., Chen R., Chen H. (2015) Effect of Probiotics on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials. PLoS ONE 10(7): e doi: /journal.pone Steenbergen L., et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behavior Immunity. Vol; 96, Published 2015/04/07, 5

6 21. Carabotti M., et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology (28): Reid G., et al. Oral Probiotics can resolve urogenital infections. FEMS Immunology and Medical Microbiology (30): Reid G., et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunology and Medical Microbiology (35): Bezkorovainy A., et al. Probiotics: determinants of survival and growth in the gut. The American Journal of Clinical Nutrition Vo. 73, no. 2, Diop L., et al. Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Journal of Nutrition Research ; Matkovic Z., Zivkovic V., Korica M., et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 2010; 24: Auyeung K.K., et al. Astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. Am Journal Chin Med. 2016; 44(1):