PRODUCT PROSPECTUS. Probiotics and Prebiotics

Transcription

1 PRODUCT PROSPECTUS Probiotics and Prebiotics

2 2 PURITY POTENCY PERFORMANCE

3 PROBIOTICS AND PREBIOTICS Table of Contents The Klaire Labs Story 4-5 Section 1: Probiotics Reference Guide 6-7 Section 2: Probiotics Ther-Biotic Complete 8 Ther-Biotic Children s Chewable 9 Ther-Biotic for Infants Powder 10 Ther-Biotic Women s Formula 11 Ther-Biotic Metabolic Formula 11 Ther-Biotic Senior Formula 12 Ther-Biotic Detoxification 12 Ther-Biotic Factor 1 13 Ther-Biotic Factor 6 13 Target gb- 14 Target b 2 15 LactoPrime Plus 15 BioSpora 16 ABx 17 Saccharomyces Boulardii 17 Section 3: Prebiotics Galactomune 18 BiotaGen 19 How to Purchase 19 3 PRODUCT PROSPECTUS TABLE OF CONTENTS Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of reach of children.

4 4 PRODUCT PROSPECTUS THE KLAIRE LABS STORY The Klaire Labs Story According to all who knew her, Claire Farr was a tireless crusader, genuine humanitarian, and dynamic entrepreneur with a commitment to excellence for the nutritionally aware. In 1969, driven by a personal struggle with severe food allergies and environmental sensitivities, Claire Farr set out on a mission to formulate and manufacture the highest quality, hypoallergenic nutritional supplements possible. As many dedicated entrepreneurs do, Claire set up shop in her own home in Carlsbad, California and Klaire Labs was born. In her quest to develop a line of nutraceuticals that sensitive individuals could reliably tolerate, Claire initially focused on single ingredient formulations. Unlike most nutritional supplement manufacturers at the time, Claire purchased only pharmaceutical grade raw ingredients selected specifically for maximum purity and bioavailability. She avoided the use of fillers and synthetic ingredients, while focusing on natural and synergistic constituents. The medical community began to take notice. By this time, demand was growing for environmental, nutrition-focused, and integrative medical practitioners. As such, Claire and her unique products gained the attention and respect of a number of prestigious complementary medicine proponents. Word of consistently reliable outcomes spread, allowing Claire s home-based start-up to grow into a new manufacturing facility, expanding her capabilities to include bottling and custom formulations. Ther-Biotic The original hypoallergenic probiotic offering tailored formulations for more personalized performances.

5 5 In 2004, Klaire Labs was sold to ProThera, Inc. ProThera, Inc. was in turn acquired by Soho Flordis International (SFI) in SFI s philosophy to empower healthcare providers with better, natural options aligned quite naturally with that of Claire Farr. Having dedicated their lives work to similar goals, the SFI founders represented a renewed commitment to, and a tangible investment in, Claire s founding principles. In 2017, SFI USA (comprised of the three originating companies: ProThera, Inc., Klaire Labs, and Complementary Prescriptions) christened a new >75,000 square foot, state-of-the-art manufacturing facility, including expanded scientific and support resources, advanced quality tools, and modernized processes. Although SFI has acquired several exceptionally discriminating, independent nutraceutical manufacturers across the globe in recent years, shared values are the common thread. In the spirit of honoring the past as we embrace the future, all products manufactured at SFI USA in Reno, Nevada are now unified under the Klaire Labs brand and guiding philosophy. #1 Best Seller PRODUCT PROSPECTUS THE KLAIRE LABS STORY It was not until 1983 that Claire introduced her first probiotic, a product category that ultimately became her most successful. Klaire Labs Ther-Biotic formulations remain a leading professional brand to this day.

6 6 SECTION 1 PROBIOTICS REFERENCE GUIDE Probiotics Reference Guide General Use Suggested Age Range TB Complete Comprehensive Gut Microbiota TB Children s Chewable GI, Immune, Oral Health TB for Infants GI, Immune, Metabolic Ther-Biotic Line TB Women s Formula GI, Genitourinary TB Metabolic GI, Metabolic TB Senior Formula GI, Immune TB Detoxification Detoxification Protocol 2 years 2 years 6 months puberty puberty 60 years 18 years CFU 25B, 100B 25B 5B 25B 25B 25B 50B Prebiotic Base Inulin Inulin Inulin Inulin Cellulose Inulin Cellulose Dose Form Capsules, Powder Chewable Tablet Powder Capsules Capsules Capsules Capsules Storage Refrigerated Refrigerated Refrigerated Refrigerated Refrigerated Refrigerated Refrigerated Hypoallergenic Yes Yes Yes Yes Yes Yes Yes B. animalis B. bifidum B. breve B. bulgaricus B. infantis B. lactis B. longum L. acidophilus L. brevis L. bulgaricus L. casei L. fermentum L. gasseri L. paracasei L. plantarum L. rhamnosus L. salvarius Lc. lactis S. boulardii S. thermophilus B. coagulans B. subtilis

7 7 Ther-Biotic Line Target Line Antibiotic TB Factor 1 TB Factor 6 Target gb- Target b 2 ABx S. Boulardii LactoPrime Plus BioSpora GI, Immune, Genitourinary GI, Intensive Gut Barrier Gut-Brain Axis, Healthy Mood, GI Breast Health, Lactation, Infant Immunity Probiotic for Antibiotic Probiotic for Antibiotic GI, FODMAP Diet GI, Immune puberty puberty 1 year 1 year 1 year > 1 year 1 year 10 years 20B 100B 5B 3B 10B 3B 25B 2B Inulin Cellulose Inulin Cellulose Inulin Cellulose Cellulose Cellulose SECTION 1 PROBIOTICS REFERENCE GUIDE Capsules Capsules Sachets (powder) Capsules Capsules Capsules Capsules Capsules Refrigerated Refrigerated Shelf Stable Shelf Stable Refrigerated Refrigerated Refrigerated Shelf Stable Yes Yes Yes Sourced from human breast milk Yes Yes Yes Soy and dairy free

8 8 SECTION 2 PROBIOTICS Probiotics Ther-Biotic Complete Our most comprehensive, maximum-support probiotic formula Ther-Biotic Complete is a robust, broad-spectrum, hypoallergenic blend of 12 probiotic species in a base of inulin. Designed to supply a complete component of synergistic and complementary species, each capsule provides 25 billion CFU and each 0.25 teaspoon (1 gram) provides 100 billion CFU protected by our proprietary InTactic technology for maximum viability throughout the intestinal tract. Maximum probiotic support with colonizing and transient strains Clean and hypoallergenic for optimal results Available in 25B CFU capsules or 100B CFU powder #1 Best Seller Capsules SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (25 billion CFU) in a base of inulin (derived from chicory root) Bifidobacterium bifidum Lactobacillus acidophilus Lactobacillus casei Lactobacillus plantarum Lactobacillus salivarius Bifidobacterium longum Streptococcus thermophilus Lactobacillus bulgaricus Lactobacillus paracasei Bifidobacterium lactis Bifidobacterium breve Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. V vegetarian capsules V vegetarian capsules 6.0 billion CFU* 5.0 billion CFU* 3.0 billion CFU* 2.5 billion CFU* 2.0 billion CFU* 2.0 billion CFU* 1.0 billion CFU* 1.0 billion CFU* 1.0 billion CFU* 0.5 billion CFU* 0.5 billion CFU* 0.5 billion CFU* 280 mg* Powder SUGGESTED USE: Adults: 1/4 teaspoon daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Serving Size 1/4 Teaspoon (Approx. 1 gram) Servings Per Container 60 Amount Per 1/4 Teaspoon Probiotic Blend (100 billion CFU) 1 g* in a base of inulin (derived from chicory root) and InTactic proprietary polysaccharide complex Bifidobacterium bifidum Lactobacillus acidophilus Lactobacillus casei Lactobacillus plantarum Lactobacillus salivarius Bifidobacterium longum Streptococcus thermophilus Lactobacillus bulgaricus Lactobacillus paracasei Bifidobacterium lactis Bifidobacterium breve Other ingredients: None. K-TCP 2.25 oz. (64 grams) powder 24.0 billion CFU* 20.0 billion CFU* 12.0 billion CFU* 10.0 billion CFU* 8.0 billion CFU* 8.0 billion CFU* 4.0 billion CFU* 4.0 billion CFU* 4.0 billion CFU* 2.0 billion CFU* 2.0 billion CFU* 2.0 billion CFU*

9 9 Ther-Biotic Children s Chewable High-CFU, multispecies chewable probiotic Ther-Biotic Children s Chewable is a broad-spectrum, hypoallergenic probiotic supplement designed for children 2 years of age and older. Our 25 billion CFU formulation, in a base of inulin, contains 8 total Lactobacillus and Bifidobacterium species which have been intensively researched and clinically shown to support gastrointestinal health and immune function in children. The pleasant natural flavor makes daily supplementation easy. SECTION 2 PROBIOTICS Broad spectrum gastrointestinal and immune support Potent daily 25B CFU probiotic blend for anyone preferring a chewable option Sweet, natural flavor is ideal for children SUGGESTED USE: For children 2 years of age and older: Chew 1 tablet daily preferably 30 to 60 minutes following a meal or as directed by a healthcare professional. Not recommended for children less than 2 years of age. Serving Size 1 Tablet Amount Per Tablet Probiotic Blend (25 billion CFU) in a base of inulin (derived from chicory root) Lactobacillus species Lactobacillus casei Lactobacillus salivarius Lactobacillus paracasei Bifidobacterium species Bifidobacterium infantis Bifidobacterium bifidum Bifidobacterium longum Bifidobacterium breve Other ingredients: ylitol, natural cherry flavor, natural vanilla flavor, silicon dioxide, stearic acid, magnesium stearate, and natural licorice extract. K-TCC 60 chewable tablets 17 billion CFU* 8 billion CFU* 224 mg*

10 10 SECTION 2 PROBIOTICS Ther-Biotic for Infants Powder A multispecies probiotic formula to meet the special needs of infants Ther-Biotic for Infants and children is a 10-species probiotic blend, in a base of inulin, designed to safely meet the metabolic, intestinal, and immune support needs of infants and young children. This formula supports a normal infant microbiota that can be easily disrupted by cesarean section delivery, formula feedings, medications, environmental exposures, or maternal diet. Each scoop (0.5 gram) provides 5 billion CFU. Safe gastrointestinal, metabolic, and immune support. Developed specifically for infants and young childrens developmental needs Clean and hypoallergenic for optimal results Available in 5B CFU powder that can be mixed with breast milk, formula, or food SUGGESTED USE: For children over 12 months: 1 scoop, once or twice daily. For infants 6 to 12 months: 1 scoop daily. Mix product in infant formula, milk, juice, or sprinkled on food such as yogurt, apple sauce or cereal, or as recommended by your healthcare professional. For breastfeeding mothers, product can be added to expressed milk, or small amounts at a time can be dispensed by placing on nipple or finger. Serving Size 1 Scoop (Approx. 0.5 gram) Servings Per Container 120 Amount Per Sccop Proprietary Probiotic Blend (5 billion CFU) Other ingredients: None. K-TIF 2.33 oz. (66 grams) powder 500 mg % Daily Value Lactobacillus species 2.5 billion CFU 150 mg in a base of inulin (derived from chicory root) * Lactobacillus casei * Lactobacillus paracasei * Lactobacillus gasseri * Lactobacillus salivarius * Bifidobacterium species 2.5 billion CFU 350 mg in a base of inulin (derived from chicory root) Bifidobacterium infantis * Bifidobacterium bifidum * Bifidobacterium longum * Bifidobacterium breve * Bifidobacterium lactis * CAUTION: DO NOT feed powder directly to infants or children. If the infant or child has a medical condition, taking prescription drugs, or under the age of 6 months, consult your healthcare professional before using this product. Keep out of reach of children.

11 Ther-Biotic Women s Formula s genitourinary microbiota health Ther-Biotic Women s Formula is a hypoallergenic blend of 10 species specifically designed to support a woman s genitourinary system. Lactobacilli modulate the mucosal immune response to undesirable microorganisms, secrete biosurfactants to block their adherence and disrupt biofilm formation, and produce lactic acid to promote a healthy vaginal ph. Each capsule provides 25 billion CFU protected by our proprietary InTactic technology for maximum viability. Concentrated probiotic support for women Clean, hypoallergenic formula Available in 25B CFU capsules 11 SECTION 2 PROBIOTICS SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (25 billion CFU) in a base of inulin (derived from chicory root) Lactobacillus species Lactobacillus acidophilus Lactobacillus brevis Lactobacillus gasseri Lactobacillus casei Lactobacillus salivarius Lactobacillus plantarum Bifidobacterium species Bifidobacterium bifidum Bifidobacterium breve Bifidobacterium longum Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. K-TWF 60 vegetarian capsules 20 billion CFU* 5 billion CFU* 300 mg* Ther-Biotic Metabolic Formula Multispecies probiotic supports healthy weight and energy metabolism Ther-Biotic Metabolic Formula is a blend of 7 select probiotic species, in a base of cellulose, designed to increase intestinal diversity and support healthy metabolism and weight management. Each capsule provides 25 billion CFU. s healthy energy homeostasis and glucose metabolism Clean, hypoallergenic, and FODMAPS compliant Available in 25B CFU capsules SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (25 billion CFU) Lactobacillus acidophilus Lactobacillus plantarum Bifidobacterium lactis Lactobacillus gasseri Bifidobacterium breve Bifidobacterium longum 113 mg* Other ingredients: Cellulose and vegetarian capsule (hydroxypropyl methylcellulose, water). K-MBS 60 vegetarian capsules

12 12 SECTION 2 PROBIOTICS Ther-Biotic Senior Formula s a healthy gut microbiota in aging individuals Ther-Biotic Senior Formula is a synergistic blend of 10 probiotic species, in a base of inulin, designed to support a balanced and diverse microbiota, and normal gastrointestinal and immune function for individuals over 60 years of age. Each capsule provides 25 billion CFU protected by our proprietary InTactic technology for maximum viability throughout the intestinal tract. Maximum probiotic support for individuals over 60 Clean and hypoallergenic for optimal results Available in 25B CFU capsules SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (25 billion CFU) in a base of inulin (derived from chicory root) Bifidobacterium species Bifidobacterium infantis Bifidobacterium longum Bifidobacterium breve Bifidobacterium bifidum Bifidobacterium lactis Lactobacillus species Lactobacillus acidophilus Lactobacillus gasseri Lactobacillus casei Lactobacillus plantarum 18 billion CFU* 7 billion CFU* 300 mg* Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. K-TSR 60 vegetarian capsules Ther-Biotic Detoxification High-strength, 50 billion CFU Ther-Biotic Detoxification is a concentrated 3-species blend specifically designed to complement detoxification protocols. Selected species support endotoxin digestion and toxin uptake reduction through tight junction intestinal barrier support. Each capsule provides 50 billion CFU protected by our proprietary InTactic technology for maximum viability throughout the intestinal tract. Potent, probiotic detoxification support Clean, hypoallergenic, and FODMAPS-compliant Available in 50B CFU capsules SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (50 billion CFU) Lactobacillus casei Bifidobacterium bifidum Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. V vegetarian capsules 20 billion CFU* 20 billion CFU* 10 billion CFU* 265 mg*

13 Ther-Biotic Factor 1, 20 billion CFU Ther-Biotic Factor 1 is a concentrated, 20 billion CFU strain in an inulin base. An extensively researched species, L. rhamnosus has been recognized for robust L(+) lactic acid production and immune support as well as genitourinary health. Each capsule provides 20 billion CFU protected by our proprietary InTactic technology for maximum viability throughout the intestinal tract. Concentrated L. rhamnosus formulation Clean and hypoallergenic for optimal results Available in 20B CFU capsules 13 SECTION 2 PROBIOTICS SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend in a base of inulin (derived from chicory root) Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. V vegetarian capsules 20 billion CFU* 220 mg* Ther-Biotic Factor 6 Ultra-strength, 100 billion CFU formula Ther-Biotic Factor 6 is a high potency, hypoallergenic probiotic blend, in a cellulose base, designed for individuals at high risk for occasional diarrhea and compromised gut barrier function. Each capsule provides 100 billion CFU protected by our proprietary InTactic technology for maximum viability throughout the intestinal tract. High-potency gastrointestinal support Clean, hypoallergenic, and FODMAPS-compliant Available in 100B CFU capsules SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (100 billion CFU) in a base of cellulose Bifidobacterium longum Lactobacillus acidophilus Bifidobacterium bifidum Bifidobacterium lactis Lactobacillus paracasei Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), InTactic proprietary polysaccharide complex, and L-leucine. K-TF6 60 vegetarian capsules 595 mg*

14 14 SECTION 2 PROBIOTICS Target gb- A targeted probiotic blend clinically demonstrated to support mood Target gb- is a probiotic supplement specifically designed to support positive mood by influencing the gut-brain axis. It is powered by Ecologic BARRIER, a 5 billion CFU blend of 9 probiotic strains, that has been clinically shown to decrease overall cognitive reactivity to sad mood, rumination, negative thinking, and aggressive thoughts. 1 Heightened cognitive reactivity to sad mood is an established risk factor for more serious mood alterations in otherwise healthy individuals, and is therefore considered an important target for interventions. Powered by Ecologic BARRIER, a 5B CFU blend of 9 probiotic strains Protected by PROBIOACT Technology for optimal efficacy and shelf-stability Hypoallergenic, non-gmo powder offered in convenient, single serving sachets SUGGESTED USE: Dissolve the contents of 1 sachet in approximately 3-4 oz. of lukewarm water or mix with a dairy product such as milk or yogurt. Gently stir before consuming. Take on an empty stomach in the morning, before bed, or as directed by a healthcare professional. Suitable for children from the age of 1 year. Caution: When antibiotics are used, wait 2-3 hours before using this product. If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of the reach of children. Serving Size 1 Sachet (Approx. 2 g) Servings Per Container 30 Amount Per Sachet Calories 5 % Daily Value Total Carbohydrate 2 g <1%** Sodium 70 mg 3% Potassium (as potassium chloride) 35 mg <1% Ecologic BARRIER Probiotic Blend (5 billion CFU) Lactobacillus casei W56 * Lactobacillus acidophilus W37 * Lactobacillus brevis W63 * Lactococcus lactis ssp. lactis W58 * Bifidobacterium animalis ssp. lactis W52 * Lactococcus lactis ssp. lactis W19 * Lactobacillus salivarius W24 * Bifidobacterium bifidum W23 * Bifidobacterium lactis W51 * **Percent Daily Values are based on a 2,000 calories diet. Other ingredients: Maize starch, maltodextrin, inulin, polydextrose, vegetable protein, magnesium sulfate, and manganese sulfate. GB 30 sachets 2 g Target gb- Formulation Function L. casei W56 L. acidophilus W37 L. brevis W63 Lc. lactis W58 B. lactis W52 Lc. lactis W19 L. salivarius W24 B. bifidum W23 B. lactis W51 Epithelial barrier function strengthening Cytokine modulation Mast cell integrity support Circulating lipopolysaccharide suppression

15 Target b2 A targeted probiotic clinically demonstrated to support lactation comfort and infant immune health Target b2 with Hereditum Lc40 is a targeted probiotic designed to extend the benefits of breastfeeding and support overall infant immune health. This strain of Lactobacillus fermentum (CECT5716) is clinically demonstrated to support breast health and resolve discomfort associated with mammary dysbiosis. 2,3 As many as one third of lactating women experience significant discomfort resulting in premature cessation of breastfeeding. Studies have shown that lactic acid bacteria isolated from human milk may prevent and resolve lactation-associated mammary dysbiosis. The Target b 2 strain was isolated from colonizing Lactobacillus in healthy breast milk and specifically selected for safety, antimicrobial and immunomodulary properties. One capsule per day in the third trimester through cessation of breast feeding is recommended. For more intensive support, increase to one capsule three times per day or as recommended by the healthcare professional. 15 SECTION 2 PROBIOTICS Suggested use: 1 capsule, 1 to 3 times daily (3 to 9 billion CFU) or as directed by a healthcare professional. Serving Size 1 capsule Lactobacillus fermentum 3 billion CFU CECT5716 (Hereditum Lc40) Other ingredients: Microcrystalline cellulose, silicon dioxide, vegetarian capsule (hydroxypropyl methylcellulose, water), maltodextrin, sucrose, calcium carbonate, and sodium ascorbate. Hereditum is a registered trademark of Biosearch, S.A., Spain. CONTAINS MILK. TB2 90 capsules 30 mg* LactoPrime Plus 25 bilion CFU, multispecies formula This broad-spectrum, 12-strain blend of 7 Lactobacillus and 5 Bifidobacterium species is provided in a base of purified plant cellulose. This formula is free of inulin and other prebiotics and polysaccharides making it suitable for those who have dietary restrictions such as a FODMAP diet. SUGGESTED USE: Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (25 billion CFU) in a base of cellulose Lactobacillus species Lactobacillus acidophilus Lactobacillus brevis Lactobacillus casei Lactobacillus plantarum Lactobacillus salivarius Lactobacillus paracasei Bifidobacterium species Bifidobacterium bifidum Bifidobacterium infantis Bifidobacterium longum Bifidobacterium lactis Bifidobacterium breve 19 billion CFU* 6 billion CFU* 240 mg* Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) and L-leucine. K-LPP 60 vegetarian capsules

16 16 SECTION 2 PROBIOTICS BioSpora A combination of two spore-forming probiotics BioSpora is a powerful blend of genetically certified Bacillus coagulans and B. subtilis species formulated to provide unique probiotic support of healthy gastrointestinal and immune function. Spore-forming bacilli have often been referred to as soil-based microorganisms because of their ubiquitous presence in the earth. Although found in the human GI tract, spore-forming bacilli have long been considered incidental, transient bacteria. However, research shows that Bacillus species are present in the GI tract in numbers higher than can be explained by ingestion alone. Germination of Bacillus spores within the human small intestine and transient colonization is now thought to be part of the normal life cycle of human-associated Bacillus species providing specific stimuli for healthy GI and immune system development and function. Each capsule of BioSpora supplies a total of 2 billion CFU of B. coagulans and B. subtilis spores positively identified through independent 16S ribosomal RNA gene sequencing. The spores are resistant to extremes of heat, ultraviolet radiation, solvents, hydrogen peroxide, and enzymes. The spores withstand stomach acid and germinate in the small intestine within 6 hours of ingestion. Ingested B. coagulans and B. subtilis reside in the human GI tract for up to 7 days following consumption. BioSpora is recommended for enhanced support of normal GI and immune function. It is certified free of casein, gluten, and soy. BioSpora does not require refrigeration. SUGGESTED USE: 1 capsule daily or as directed by a healthcare professional. Probiotic Blend (2 billion CFU) in a base of cellulose Bacillus coagulans Bacillus subtilis 260 mg* Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) and coconut oil powder. K-BSP vegetarian capsules

17 ABx Powerful intestinal microbiota support during antibiotic therapy ABx is a carefully researched blend of the non-pathogenic yeast Saccharomyces boulardii with, Bifidobacterium bifidum, and Bifidobacterium breve, probiotic microorganisms which have been shown in numerous controlled clinical trials to reinforce the commensal gut bacteria during antibiotic therapy. S. boulardii has versatile gastrointestinal effects. It stimulates intestinal brush border enzymes to maintain normal digestive functions. It stimulates D-glucose and sodium absorption and produces short-chain fatty acids that nourish colon mucosa. Additonally, the ABx species enhance innate and acquired immunity, decrease T cell proliferation, induce helper (CD4+) T cell hypo-responsiveness, increase phagocytic activity in peripheral white blood cells and killing activity in natural killer cells, and support inflammation metabolism. This hypoallergenic formulation is provided in vegetarian capsules in bottles of 28 capsules, a convenient 14-day supply for concurrent use during antibiotic therapy, or larger bottles of 60 capsules to continue to support GI after antibiotic therapy. 17 SECTION 2 PROBIOTICS SUGGESTED USE: Adults: 1 capsule twice daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional. Probiotic Blend (10 billion CFU) in a base of inulin (derived from chicory root) Saccharomyces boulardii Bifidobacterium bifidum Bifidobacterium breve Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water). K-AB 28 vegetarian capsules K-AB vegetarian capsules 5.0 billion CFU* 2.5 billion CFU* 1.25 billion CFU* 1.25 billion CFU* 400 mg* Saccharomyces Boulardii A powerful transient yeast probiotic Saccharomyces boulardii is a nonpathogenic, transient yeast long used to support normal bowel transit time. It is a hardy, acid-resistant, temperature tolerant microorganism that is not affected by antibacterial agents. S. boulardii is genetically and functionally distinct from brewer s yeast (S. cerevisiae) and different from pathogenic Candida species. SUGGESTED USE: 1 capsule twice daily with meals or as directed by a healthcare professional. Probiotic Blend in a base of cellulose Saccharomyces boulardii Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) and L-leucine. V vegetarian capsules V vegetarian capsules 3 billion CFU* 320 mg*

18 18 SECTION 3 PREBIOTICS Prebiotics Prebiotic fiber goes through the small intestine undigested and is fermented by gut bacteria when it reaches the colon. This fermentation process by gut bacteria feeds beneficial Galactomune Targeted prebiotic support for healthy intestinal microflora Galactomune provides a synergistic blend of two well-researched prebiotic fibers, galactooligosaccharides (GOS) and betaglucan, formulated to nourish and support growth of beneficial Bifidobacterium and Lactobacillus species. The microbiota is comprised of hundreds of bacterial species, that support a wide variety of body functions from digestion and metabolism to immunity and mental health. Prebiotics such as GOS and betaglucans contribute to soluble fiber intake, essential to commensal organism health and normal bowel function. The galactooligosaccharides (derived from lactose) and betaglucans (derived from Saccharomyces cerevisiae) in Galactomune powder and capsules are extensively purified. for healthy intestinal microflora Clean and hypoallergenic formula s probiotic supplementation bacteria colonies (including probiotic bacteria) and helps to increase the number of desirable bacteria in our digestive systems that support health. Capsules SUGGESTED USE: 1 capsule twice daily with food or as directed by a healthcare professional. Galactomune Prebiotic Blend Galactooligosaccharides Beta-Glucan (purified from Saccharomyces cerevisiae) Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), L-leucine, and cellulose. CONTAINS MILK AND FISH (BONITO). K-GALC 60 vegetarian capsules K-GALC1 120 vegetarian capsules 550 mg* Powder SUGGESTED USE: 1 scoop, 1 to 2 times daily with food or as directed by a healthcare practitioner. Mix powder in cold, warm, or hot foods or beverages as desired. Serving Size 1 Scoop (Approx. 1 teaspoon or 5 grams) Servings Per Container 30 Amount Per Scoop Calories 5 % Daily Value Total Carbohydrate 5 g 2%** Dietary Fiber 4 g 16%** Galactomune Prebiotic Blend Galactooligosaccharides * Beta-Glucan (purified from Saccharomyces cerevisiae) * **Percent Daily Values are based on a 2,000 calorie diet. Other ingredients: None. CONTAINS MILK AND FISH (BONITO). K-GAL 5.3 oz. (150 grams) powder WARNING: This product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to 5 g

19 BiotaGen A comprehensive prebiotic formula BiotaGen is a combination of prebiotic fibers formulated with a unique blend of inulin, arabinogalactan, and beta-glucan. Human digestive enzymes are not able to break down most fibers found in complex carbohydrates and plant polysaccharides. Instead, these fibers act as prebiotics that nourish the gut microbiota. Through the fermentation process, commensal organisms use these fibers to generate the short-chain fatty acids (SCFAs) instrumental in colon cell nourishment, intestinal barrier integrity, and other systemic functions. BiotaGen also contains the prebiotic arabinogalactan, derived from Larix occidentalis. Arabinogalactan may help aid the immune system by supporting normal macrophage activity and healthy immune cell function within the body. Beta-glucan, isolated from Saccharomyces cerevisiae, also supports healthy immune system cells, including monocytes, macrophages, and natural killer cells. Three prebiotic fibers in one formula Available in capsule and powder format s health of gut microbiota species and host immune system 19 SECTION 3 PREBIOTICS Capsules SUGGESTED USE: 4 capsules, 1 to 2 times daily or as directed by a healthcare professional. Serving Size 4 Capsules Amount Per 4 Capsules Calories 5 % Daily Value Total Carbohydrate 3 g 1%** Dietary Fiber 2 g 7%** BiotaGen Prebiotic Blend 3 g * Inulin (derived from chicory root) Beta-Glucan (purified from Saccharomyces cerevisiae) Arabinogalactan (Larix laricina), (larch tree wood) (water-soluble polysaccharide extract) **Percent Daily Values are based on a 2,000 calorie diet. Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) and L-leucine. K-BTGC 120 vegetarian capsules Powder SUGGESTED USE: 1 scoop, 1 to 2 times daily. Mix with water, juice or food, or as directed by a healthcare professional. Serving Size 1 Scoop (Approx. 1 teaspoon or 5 grams) Servings Per Container 30 Amount Per Scoop Calories 5 % Daily Value Total Carbohydrate 5 g 2%** Dietary Fiber 4 g 16%** BiotaGen Prebiotic Blend 5 g * Inulin (derived from chicory root) Beta-Glucan (purified from Saccharomyces cerevisiae) Arabinogalactan (Larix laricina), (larch tree wood) (water-soluble polysaccharide extract) **Percent Daily Values are based on a 2,000 calorie diet. Other ingredients: None. K-BTG 5.3 oz. (150 grams) powder WARNING: This product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to Contact us and order today klaire.com Available through licensed healthcare professionals.

20 PRODUCT PROSPECTUS 1. Steenbergen L, et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactvity to sad mood. Brain Behav Immun Aug;48: Jiménez E, et al. Oral administration of Lactobacillus strains isolated from breast milk as an alternative for treatment of infectious mastitis during lactation. Appl Environ Microbiol. 2008,74(15): Arroyo R, et al. Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk. Clin Infect Dis. 2010;50(12): SFI USA 795 Trademark Drive Reno, NV USA P F TF klaire.com Copyright 2018 SFI USA Reno, NV All rights reserved. PPPROS062218