An Optimum Prosthesis Combination of Low Risk TKR Options in All Five Primary Categories of Design Results in a 60% Reduction in Revision Risk
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1 An Optimum Prosthesis Combination of Low Risk TKR Options in All Five Primary Categories of Design Results in a 60% Reduction in Revision Risk Christopher Vertullo Andrea Peng Stephen Graves Peter Lewis DR CHRISTOPHER VERTULLO MBBS PhD FRACS GCORE Menzies Health Institute Gold Coast, Australia
2 Decades of design innovation in TKR have resulted in a selection dilemma for the fives Primary TKR prosthesis design categories of Fixation, Posterior stability, Bearing mobility, Bearing surface, Patella resurfacing Typically these are regarded in isolation, however, it is more pragmatic to regard their effects on revision risk in combination, as their effects are often cumulative
3 Cemented Non-Cemented Hybrid Fixation Posterior stability Bearing mobility Bearing surface Patella resurfacing 96 possible combinations Posterior Stabilized Minimally Stabilized Fixed Bearing Mobile Bearing Crosslinked Polyethylene Non-Crosslinked Polyethylene Cobalt Chrome Oxinium Patella Resurfaced Patella Non-Resurfaced
4 This paper introduces the concept of the Optimum Prosthesis Combination where the lowest risk option in each category is utilised. Paucity of clinical data on the long-term revision risk for patients who undergo a TKR with the lowest revision risk option in each category
5 Aims 1 To identify the Optimum Prosthesis Combination 2 To compare the revision risk of the OPC to the Alternative PC Methods Australian Orthopaedic Assoc National Joint Replacement Registry data for Patients with Osteoarthritis Two cohorts - OPC vs APC APC = patients who received a higher risk options in one or more categories Kaplan-Meier estimates of survivorship to estimate the time to the first revision Hazard ratios adjusted for age & sex Demographics for each cohort were obtained
6 Results The OPC was a TKR with Cemented or hybrid fixation, Minimally stabilised, Fixed bearing, XLPE Bearing and a Resurfaced patella, representing 4 of the possible 96 prosthesis category options. There were 482,373 Primary TKR in the study, 9% OPC and 91% APC
7 Results The OPC Cohort s Cumulative Percent Revision at 13 years 2.8% (95% CI 2.4, 3.4) compared to 6.7% (95% CI 6.5, 6.8) for the APC The Top 5 OPC and Top 5 APC were not the same Top 5 OPC -Nexgen CR, Nexgen CR Flex, Triathlon CR, Natural Knee Flex, Scorpio NRG CR Top 5 APC - BalanSys, Legion PS, Nexgen CR, Nexgen CR Flex, Natural Knee Flex
8 Results: Revision Risk 6.7% 2.8% All groups based on age <65 or > 65 years and gender had increased risk with APC APC had151% increased revision risk after 3 years
9 Results: Reasons for Revisions Loosening most common in APC Infection most common in OPC, but less than the APC
10 Results The demographics of each cohort were essentially similar *BMI from 2015 & ASA from 2012
11 Discussion The OPC identified in this analysis represented 4 of the possible 96 possible primary option combinations with a 61% lower revision risk.
12 Discussion Some options have not fulfilled their original design rationale and represent either developmental dead-ends and or evidence-utilization incongruity The OPC concept represents a pragmatic manufactureragnostic alternative comparator methodology assessment
13 References 1. Vertullo CJ, Lewis PL, Peng Y, Graves SE, de Steiger RN. The Effect of Alternative Bearing Surfaces on the Risk of Revision Due to Infection in Minimally Stabilized Total Knee Replacement: An Analysis of 326,603 Prostheses from the Australian Orthopaedic Association National Joint Replacement Registry. The Journal of Bone and Joint Surgery. 2018;100(2): doi: /jbjs Vertullo CJ, Graves SE, Peng Y, Lewis PL. An optimum prosthesis combination of low-risk total knee arthroplasty options in all five primary categories of design results in a 60% reduction in revision risk: a registry analysis of 482,373 prostheses. Knee Surgery, Sports Traumatology, Arthroscopy. August doi: /s z 3. Vertullo CJ, de Steiger RN, Lewis PL, Lorimer M, Peng Y, Graves SE. The Effect of Prosthetic Design and Polyethylene Type on the Risk of Revision for Infection in Total Knee Replacement: An Analysis of 336,997 Prostheses from the Australian Orthopaedic Association National Joint Replacement Registry. The Journal of Bone and Joint Surgery. 2018;100(23): doi: /jbjs Vertullo CJ, Graves SE, Peng Y, Lewis PL. The effect of surgeon s preference for hybrid or cemented fixation on the long-term survivorship of total knee replacement: An analysis of 39,623 prostheses from the Australian Orthopaedic Association National Joint Replacement Registry. Acta Orthopaedica. 2018;89(3): doi: / Vertullo CJ, Lewis PL, Lorimer M, Graves SE. The Effect on Long-Term Survivorship of Surgeon Preference for Posterior-Stabilized or Minimally Stabilized Total Knee Replacement: An Analysis of 63,416 Prostheses from the Australian Orthopaedic Association National Joint Replacement Registry. The Journal of Bone and Joint Surgery. 2017;99(13): doi: /jbjs Vertullo CJ, Lewis PL, Graves S, Kelly L, Lorimer M, Myers P. Twelve-Year Outcomes of an Oxinium Total Knee Replacement Compared with the Same Cobalt-Chromium Design: An Analysis of 17,577 Prostheses from the Australian Orthopaedic Association National Joint Replacement Registry. J Bone Joint Surg Am. 2017;99(4): doi: /jbjs Vertullo CJ, Grimbeek PM, Graves SE, Lewis PL. Surgeon s Preference in Total Knee Replacement: A Quantitative Examination of Attributes, Reasons for Alteration, and Barriers to Change. The Journal of Arthroplasty. 2017;32(10): doi: /j.arth
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