Introduction. mortality 42, SCCM ACCP ESICM PICU
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1 SIRSsepsis B Introduction mortality 42, PICU 19 2 SIRSsepsis SIRSsepsis SIRSsepsis Background Sepsis Septikos Bone sepsis syndrome SCCMACCP SIRS sepsis SIRS SCCMACCP ESICM ATSSIS The International Consensus Conference on Pediatric Sepsis and Organ Dysfunction 2005 Pediatric Critical Care Medicine 8 12 Discussion 1 SIRSsepsis SIRS sepsis SIRS
2 2013 Vol. 25No SIRS 10 SIRS 12 SIRS SIRS bpm bpm 12 SIRS 1 sepsis SIRS SD 3 2 SD or 4 or or10 Severe sepsis Septic shock SepsisSevere sepsis Sepsis SD mlkg 120 mgdl 7.7 mmoll 2 WBC12,000l WBC4,000l 10 CRP 2 SD 2 SD 3 90 mmhg 70 mmhg40 mmhg 2 SD SvO 2 70 CI3.5 lminm 2 4 PaO 2 FiO mlkgh mgdl PTINR1.5 aptt60 10 l 4 mgdl 5 1 mmoll 7 2 SIRS ,000 19,500 or 5,000 17,500 or 5,000 15,500 or 6,000 13,500 or 4,500 11,000 or 4,
3 SIRS HR 10 2SIRS RR 10 SIRS SIRS SIRS Septic shock SIRS 14 1 pediatric septic shock septic shock PALS SIRSsepsis 2 3 SIRSsepsis 3 SIRSsepsis 3 SIRSsepsis PIRO score SIRSsepsis Sepsissevere sepsisseptic shock 16, John C. Marshall TNM PIRO PIRO PredispositionInfectionResponseOrgan dysfunction 4 17 P predisposition COPD
4 2013 Vol. 25No IL1 receptor antagoist TNF Tolllike receptor 1 sepsis I infection 19 R response SIRS 20 O organ dysfunction sepsis PELOD scorepediatric logistic organ dysfunction scorepmod scorepediatric multiple organ dysfunction score MOSF score multi organ system failure score 21 PIRO score VAP sepsis Response Organ dysfunction Moreno study Response Organ dysfunction PIRO score PIRO score PIRO score Conclusion SIRSsepsis Sepsis SIRSsepsis B 1Watson RS, Carcillo JA, LindeZwirble WT, et al The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med , Shime N, et alincidence and risk factors for mortality in paediatric severe sepsisresults from the national paediatric intensive care registry in Japan. Intensive Care Med , Budelmann GHugo Schottmüller, The problem of sepsis. InternistBerl , Geroulanos S, Douka ETHistorical perspective of the wordsepsis.intensive Care Med , Bone RC, et alsepsis syndromea valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med , American College of Chest PhysiciansSociety of Critical Care Medicine Consensus Conference definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med , Levy MM, et al2001 SCCMESICMACCP ATSSIS International Sepsis Definitions Conference. Crit Care Med , Goldstein B, et alinternational pediatric sepsis conferencedefinitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 62 8, Zhao H, et alan evaluation of the diagnostic accuracy of the 1991 American College of Chest PhysiciansSociety of Critical Care Medicine and the 2001 Society of Critical Care MedicineEuropean Society of Intensive Care MedicineAmerican College of Chest PhysiciansAmerican Thoracic SocietySurgical Infection Society sepsis definition. Crit Care Med , 2012
5 Fleming S, et alnormal ranges of heart rate and respiratory rate in children from birth to 18 years of agea systematic review of observational studies. Lancet , Thompson M, et alderiving temperature and age appropriate heart rate centiles for children with acute infections. Arch Dis Child , Nijman RG, et alderivation and validation of age and temperature specific reference values and centile charts to predict lower respiratory tract infection in children with feverprospective observational study. BMJ 345e4224, Van den Bruel A, et alclinicians gut feeling about serious infections in children observational study. BMJ 345e6114, Dellinger RP, et alsepsis Campaigninternational guidelines for management of severe sepsis and septic shock2008. Crit Care Med , Han YY, Carcillo JA, Dragotta MA, et alearly reversal of pediatricneonatal septic shock by community physicians is associated with improved outcome. Pediatrics , Brilli RJ, Goldstein BPediatric sepsis definitionspast, present, and future. Pediatr Crit Care Med 6Suppl.S6S8, PIRO score Angus DC, Burgner D, Wunderink R, et althe PIRO conceptp is for predisposition. Crit Care Med , Vincent JL, Opal S, Torres A, et althe PIRO concepti is for Infection. Crit Care Med , Gerlach H, Dhainaut JF, Harbarth S, et althe PIRO conceptr is for response. Crit Care Med , Vincent JL, Wendon J, Groeneveld J, et althe PIRO concepto is for organ dysfunction. Crit Care Med , Moreno RP, Metnitz B, Adler L, et alsaps 3 Investigators. Sepsis mortality prediction based on predisposition, infection and response. Intensive Care Med , 2008
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