Interactive case session using PredictND tool
|
|
- Emil Ford
- 6 years ago
- Views:
Transcription
1 Interactive case session using PredictND tool AEC 2017, Berlin, Germany Hanneke Rhodius- Meester Clinical geriatrician VUmc Alzheimer Center, Amsterdam
2 Disclosures The Alzheimer Center VUmc has received unrestricted funding from: Aegon, Alzheimer Nederland, VUmc Fonds, Heineken Nederland, Kroonenberg NV, Rabobank Amsterdam, Genootschap tot Steun Alzheimercentrum, Alzheimer Rally, and many others Contract research partners: GE Healthcare, Piramal Imaging, Merck, Nutricia, Probiodrug, EIP Pharma, Roche AG Espria, Combinostics, and Boehringer Ingelheim Grant funding: NWO, ZonMW, CVON, EU-FP7, EU-JPND, EU-IMI, ISAO, Alzheimer Nederland, Dioraphte, Gieskes Strijbis Dr Rhodius receives no personal compensation from any of the above or others except the Vumc; she is appointed on a grant from the European Seventh Framework Program project PredictND under grant agreement
3 Dementia diagnosis. Background
4 Background Dementia diagnosis.complex! Challenge as a clinician How to take into account all information? How to weigh and combine data? And. Literature often about controls vs Alzheimer Clinical practice is about differential diagnosis
5 Background To clinical practice. 73 year old male: History: transient ischemic attack Memory and word finding problems since 3 years, plus subtle hallucinations Mild parkinsonism, MMSE 28/30 Impairment in memory, naming and executive functions, slow MRI: mild atrophy and mild vascular damage No CSF obtained???
6 Background To clinical practice. 73 year old male: History: transient ischemic attack Memory and word finding problems since 3 years, plus subtle hallucinations Mild parkinsonism, MMSE 28/30 Impairment in memory, naming and executive functions, slow MRI: mild atrophy and mild vascular damage No CSF obtained Lewy body dementia? Alzheimer s disease?
7 Aim Could a computer tool help? Combining and visualizing data providing overview Dealing with conflicting data like clinical practice Comparing different dementia types with each other about differential diagnosis clinical practice is Mattila 2012, Antilla 2013, Rhodius- Meester 2016
8 Methods PredictND project computer tool Clinical descision support system: Combines and visualizes data to support clinician Entrance patient data Analyses tool How? Entrance baseline data of 1 patient: - demographics - CSF - cognitive tests - raw MRI images Outcome DSI and fingerprint
9 Methods Automatic MRI analyses Clinical practice: Majority of information hidden in MRI How to extract? With tool: Provides simple overview Highlights important areas Quantitative features, f.e. - hippocampal volumes Entrance patient data Analyses tool Outcome DSI and fingerprint Koikkalainen, NeuroImage Clin 2016
10 Methods Disease state index Compares patient baseline data with dataset Which diagnosis fits the data best? Entrance patient data Analyses tool Results in disease state index (DSI): Value between 0 and 1 cut-off 0.5 xx = 0= resembles f.e. controls xx = 1= resembles f.e. vascular dementia Outcome DSI and fingerprint
11 Methods Fingerprint Combines and visualises all data of 1 patient Size of box: xxxx = large contribution to diagnosis = small contribution Colour of box: xx = towards 0 (f.e. controls) xx = towards 1 (f.e. AD) Entrance patient data Analyses tool Outcome DSI and fingerprint
12 Translation to daily practice
13 Results Back to clinical practice. 73 year old male: History: transient ischemic attack Memory and word finding problems since 3 years, plus subtle hallucinations Mild parkinsonism, MMSE 28/30 Impairment in memory, naming and executive functions, slow MRI: MTA 1/1, GCA 1, Fazekas 1 all mild No CSF obtained Lewy body dementia? Alzheimer s disease?
14 Results 73 year old male tool Ingevoerde gegevens Ruwe MRI beelden Resultaten tool
15 Results 73 year old male Mixed pathology. Amyloïd-PET: positive DLB, with comorbid Alzheimer s pathology
16 Results 58 years old female Since 1 year complaints of forgetfulness, inappropriate behavior and urgency to speak. Interference in daily living No medical history Neuropsychology: MMSE 26/30, impairments in memory and language, difficult to stop MRI brain: atrophy frontal and temporal regions CSF: normal amyloid, tau and p-tau???
17 Results 58 years old female Since 1 year complaints of forgetfulness, inappropriate behavior and urgency to speak. Interference in daily living No medical history Neuropsychology: MMSE 26/30, impairments in memory and language, difficult to stop MRI brain: atrophy frontal and temporal regions CSF: normal amyloid, tau and p-tau FTLD, Alzheimer s disease?
18 58 year old female tool Results
19 Results 58 years old female Results tool DLB DSI 0.74 Behavioural variant of FTD AD DSI 0.59 xx = DLB, xx = AD
20 Results 71 years old female Memory complaints since 4 years, desorientation and apraxia, interference in cooking, shopping and driving. History of hypertension and diabetes medication Neuropsychology: MMSE 20/30, impairment in memory, executive functions, naming and visual functions. MRI brain: moderate hippocampal and parietal atrophy No CSF obtained???
21 Results 71 years old female Memory complaints since 4 years, desorientation and apraxia, interference in cooking, shopping and driving. History of hypertension and diabetes medication Neuropsychology: MMSE 20/30, impairment in memory, executive functions, naming and visual functions. MRI brain: moderate hippocampal and parietal atrophy No CSF obtained Alzheimer s dementia? Vascular dementia?
22 71 year old female tool Results
23 Results 71 years old female Results tool DLB DSI 0.74 Alzheimer s disease AD DSI 0.59 xx = DLB, xx = AD
24 Conclusion Assistance by computer Differential diagnosis of dementia is complex, computer tool can help by: Combining and visualising data provides overview Adding fully automated MRI analyses Multiclass tool daily practice is about differential diagnosis and multiple pathologies Yet, difficult cases will remain difficult: Tool depends on quality of data shows what you enter Can never replace the clinician only supports
25 v
Advances in Alzheimer s diagnosis; implications for clinical practice. Wiesje M. van der Flier Alzheimer Europe Conference Berlin, 4 October 2017
Advances in Alzheimer s diagnosis; implications for clinical practice Wiesje M. van der Flier Alzheimer Europe Conference Berlin, 4 October 2017 Grand Challenge Alzheimer s disease 47 million worldwide
More informationP20.2. Characteristics of different types of dementia and challenges for the clinician
P20.2. Characteristics of different types of dementia and challenges for the clinician, professor Danish Dementia Research Center Rigshospitalet, University of Copenhagen (Denmark) This project has received
More informationDISCLOSURES. Objectives. THE EPIDEMIC of 21 st Century. Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia NONE TO REPORT
Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia DISCLOSURES NONE TO REPORT Freddi Segal Gidan, PA, PhD USC Keck School of Medicine Rancho/USC California Alzheimers Disease
More informationDementia Update. October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada
Dementia Update October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada Outline New concepts in Alzheimer disease Biomarkers and in vivo diagnosis Future trends
More informationForm D1: Clinician Diagnosis
Initial Visit Packet Form D: Clinician Diagnosis NACC Uniform Data Set (UDS) ADC name: Subject ID: Form date: / / Visit #: Examiner s initials: INSTRUCTIONS: This form is to be completed by the clinician.
More informationBrain imaging for the diagnosis of people with suspected dementia
Why do we undertake brain imaging in dementia? Brain imaging for the diagnosis of people with suspected dementia Not just because guidelines tell us to! Exclude other causes for dementia Help confirm diagnosis
More informationNeuro degenerative PET image from FDG, amyloid to Tau
Neuro degenerative PET image from FDG, amyloid to Tau Kun Ju Lin ( ) MD, Ph.D Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital ( ) Department of Medical Imaging
More informationIntroduction, use of imaging and current guidelines. John O Brien Professor of Old Age Psychiatry University of Cambridge
Introduction, use of imaging and current guidelines John O Brien Professor of Old Age Psychiatry University of Cambridge Why do we undertake brain imaging in AD and other dementias? Exclude other causes
More informationDEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER
OVERCOMING THE CHALLENGES OF MANAGING CHRONIC DISEASES IN PERSONS WITH DEMENTIA DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER LEARNING OBJECTIVES Be familiar with the diagnostic criteria for
More informationCommon Forms of Dementia Handout Package
Common Forms of Dementia Handout Package Common Forms of Dementia 1 Learning Objectives As a result of working through this module, you should be better able to: 1. Describe clinical features of 4 major
More information2016 Programs & Information
Mayo Alzheimer s Disease Research Clinic Education Center 2016 Programs & Information BROCHURE TITLE FLUSH RIGHT for Persons & Families impacted by Mild Cognitive Impairment Alzheimer s Disease Dementia
More informationImproving diagnosis of Alzheimer s disease and lewy body dementia. Brain TLC October 2018
Improving diagnosis of Alzheimer s disease and lewy body dementia Brain TLC October 2018 Plan for this discussion: Introduction to AD and LBD Why do we need to improve diagnosis? What progress has been
More informationWhat is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. It has been identified that there are over 200 subtypes of
More informationDEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD
DEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD OBJECTIVES Terminology/Dementia Basics Most Common Types Defining features Neuro-anatomical/pathological underpinnings Neuro-cognitive
More informationThe ABCs of Dementia Diagnosis
The ABCs of Dementia Diagnosis Dr. Robin Heinrichs, Ph.D., ABPP Board Certified Clinical Neuropsychologist Associate Professor, Psychiatry & Behavioral Sciences Director of Neuropsychology Training What
More informationALZHEIMER S DISEASE OVERVIEW. Jeffrey Cummings, MD, ScD Cleveland Clinic Lou Ruvo Center for Brain Health
ALZHEIMER S DISEASE OVERVIEW Jeffrey Cummings, MD, ScD Cleveland Clinic Lou Ruvo Center for Brain Health Prevalence AD: DEMOGRAPHY AND CLINICAL FEATURES Risk and protective factors Clinical features and
More informationNon Alzheimer Dementias
Non Alzheimer Dementias Randolph B Schiffer Department of Neuropsychiatry and Behavioral Science Texas Tech University Health Sciences Center 9/11/2007 Statement of Financial Disclosure Randolph B Schiffer,,
More informationDEMENTIA? 45 Million. What is. WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: 70% Dementia is not a disease
What is PRESENTS DEMENTIA? WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: Memory Reasoning Planning Learning Attention Language Perception Behavior AS OF 2013 There
More informationPart 2: Early detection, assessment and treatment in relation to the new guidelines. Christopher Patterson McMaster University
Part 2: Early detection, assessment and treatment in relation to the new guidelines Christopher Patterson McMaster University C. Patterson MD, FRCPC Division of Geriatric Medicine, McMaster University
More informationAssessing and Managing the Patient with Cognitive Decline
Assessing and Managing the Patient with Cognitive Decline Center of Excellence For Alzheimer s Disease for State of NY Capital Region Alzheimer s Center of Albany Medical Center Earl A. Zimmerman, MD Professor
More informationYin-Hui Siow MD, FRCPC Director of Nuclear Medicine Southlake Regional Health Centre
Yin-Hui Siow MD, FRCPC Director of Nuclear Medicine Southlake Regional Health Centre Today Introduction to CT Introduction to MRI Introduction to nuclear medicine Imaging the dementias The Brain ~ 1.5
More informationOverview. Case #1 4/20/2012. Neuropsychological assessment of older adults: what, when and why?
Neuropsychological assessment of older adults: what, when and why? Benjamin Mast, Ph.D. Associate Professor & Vice Chair, Psychological & Brain Sciences Associate Clinical Professor, Family & Geriatric
More information3/7/2017. Alzheimer s and Dementia Research: An Advanced Discussion. Alzheimer s and Dementia Research: An Advanced Discussion
Alzheimer s and Dementia Research: An Advanced Discussion Brad Boeve, MD Department of Neurology Mayo Clinic Alzheimer s and Dementia Research: An Advanced Discussion Theoretical Constructs in Aging/Dementia
More informationDementia Update. Daniel Drubach, M.D. Division of Behavioral Neurology Department of Neurology Mayo Clinic Rochester, Minnesota
Dementia Update Daniel Drubach, M.D. Division of Behavioral Neurology Department of Neurology Mayo Clinic Rochester, Minnesota Nothing to disclose Dementia Progressive deterioration in mental function
More informationWhat is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. There are over 200 subtypes of dementia, but the five most
More informationDEMENTIA NEWSLETTER FOR PHYSICIANS
Vol. 1, No. 3 DEMENTIA NEWSLETTER FOR PHYSICIANS A Publication of the Ontario Dementia Network Fall 2011 In This Issue... Dementia Interview Guide - Dr. W. B. Dalziel Editorial Committee Dr. Andrew R.
More informationNeuro-Imaging in dementia: using MRI in routine work-up Prof. Philip Scheltens
Neuro-Imaging in dementia: Philip Scheltens Alzheimer Center VU University Medical Center Amsterdam The Netherlands 1 Outline of talk Current guidelines Imaging used to exclude disease Specific patterns
More informationMild Cognitive Impairment (MCI)
October 19, 2018 Mild Cognitive Impairment (MCI) Yonas E. Geda, MD, MSc Professor of Neurology and Psychiatry Consultant, Departments of Psychiatry & Psychology, and Neurology Mayo Clinic College of Medicine
More informationSilent Cerebral Strokes: Clinical Outcomes and Management
Silent Cerebral Strokes: Clinical Outcomes and Management Nagaendran Kandiah Senior Consultant Neurologist, National Neuroscience Institute, Singapore Clinician Scientist, National Medical Research Council,
More informationType 2 Diabetes and Brain Disease in Older Adults. Erin L. Abner, PhD, MPH Asst. Professor University Of Kentucky
Type 2 Diabetes and Brain Disease in Older Adults Erin L. Abner, PhD, MPH Asst. Professor University Of Kentucky Disclosures to Participants Requirements for Successful Completion: For successful completion,
More informationThe Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease
The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease AIBL: Two site collaborative study Study is conducted at two sites: Perth
More informationAlzheimer s Disease Update: From Treatment to Prevention
Alzheimer s Disease Update: From Treatment to Prevention Jeffrey M. Burns, MD Edward H. Hashinger Professor of Medicine Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science
More informationFRONTOTEMPORAL DEGENERATION: OVERVIEW, TRENDS AND DEVELOPMENTS
FRONTOTEMPORAL DEGENERATION: OVERVIEW, TRENDS AND DEVELOPMENTS Norman L. Foster, M.D. Director, Center for Alzheimer s Care, Imaging and Research Chief, Division of Cognitive Neurology, Department of Neurology
More informationClinical Genetics & Dementia
Clinical Genetics & Dementia Dr Nayana Lahiri Consultant in Clinical Genetics & Honorary Senior Lecturer Nayana.lahiri@nhs.net Aims of the Session To appreciate the potential utility of family history
More informationThe frontotemporal dementia spectrum what the general physician needs to know Dr Jonathan Rohrer
The frontotemporal dementia spectrum what the general physician needs to know Dr Jonathan Rohrer MRC Clinician Scientist Honorary Consultant Neurologist Dementia Research Centre, UCL Institute of Neurology
More informationI do not have any disclosures
Alzheimer s Disease: Update on Research, Treatment & Care Clinicopathological Classifications of FTD and Related Disorders Keith A. Josephs, MST, MD, MS Associate Professor & Consultant of Neurology Mayo
More informationClinical Differences Among Four Common Dementia Syndromes. a program of Morningside Ministries
Clinical Differences Among Four Common Dementia Syndromes a program of Morningside Ministries Introduction Four clinical dementia syndromes account for 90% of all cases after excluding reversible causes
More information! slow, progressive, permanent loss of neurologic function.
UBC ! slow, progressive, permanent loss of neurologic function.! cause unknown.! sporadic, familial or inherited.! degeneration of specific brain region! clinical syndrome.! pathology: abnormal accumulation
More informationDiagnosis and Treatment of Alzhiemer s Disease
Diagnosis and Treatment of Alzhiemer s Disease Roy Yaari, MD, MAS Director, Memory Disorders Clinic, Banner Alzheimer s Institute 602-839-6900 Outline Introduction Alzheimer s disease (AD)Guidelines -revised
More informationDementia and Delirium: A Neurologist s Approach to Altered Mental Status. Case 1 4/7/11. Which of the following evaluations is your next step?
Dementia and Delirium: A Neurologist s Approach to Altered Mental Status S. Andrew Josephson, MD Director, Neurohospitalist Program Medical Director, Inpatient Neurology University of California San Francisco
More informationFRONTOTEMPORAL DEMENTIA
FRONTOTEMPORAL DEMENTIA Towards an early diagnosis Yolande A.L. Pijnenburg The studies described in this thesis were carried out in the Alzheimer Center of the Department of Neurology at the VU University
More informationBiomarkers: Translating Research into Clinical Practice
Biomarkers: Translating Research into Clinical Practice AFTD Education Conference San Diego, April 2015 Nadine Tatton, PhD Scientific Director, AFTD HelpLine 866-5507-7222 u info@theaftd.org u www.theaftd.org
More informationDiagnosis before NIA AA The impact of FDG PET in. Diagnosis after NIA AA Neuropathology and PET image 2015/10/16
The impact of FDG PET in degenerative dementia diagnosis Jung Lung, Hsu MD, Ph.D (Utrecht) Section of dementia and cognitive impairment Department of Neurology Chang Gung Memorial Hospital, Linkou, Taipei
More informationWhite matter hyperintensities correlate with neuropsychiatric manifestations of Alzheimer s disease and frontotemporal lobar degeneration
White matter hyperintensities correlate with neuropsychiatric manifestations of Alzheimer s disease and frontotemporal lobar degeneration Annual Scientific Meeting Canadian Geriatric Society Philippe Desmarais,
More informationMaking dementia a European priority
Making dementia a European priority Glasgow 1 June 2015 Jean Georges, Executive Director Alzheimer Europe 36 associations in 31 countries 2 Paris Declaration Adopted by Annual General Meeting in Paris
More informationEvaluation and Treatment of Dementia
Evaluation and Treatment of Dementia Jeffrey M. Burns, MD Edward H. Hashinger Professor of Neurology Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science Unit Disclosures
More informationRecent publications using the NACC Database. Lilah Besser
Recent publications using the NACC Database Lilah Besser Data requests and publications Using NACC data Number of requests by year Type 2009 2010 2011 2012 2013 2014 2015 Data files* 55 85 217 174 204
More informationAlzheimer s Disease Neuroimaging Initiative
Alzheimer s Disease Neuroimaging Initiative Steering Committee Meeting April 18, 2016 Neuropathology Core John C. Morris, MD Nigel J. Cairns, PhD, FRCPath Erin Franklin, MS Table 1. Participants Autopsied
More informationDementia. Aetiology, pathophysiology and the role of neuropsychological testing. Dr Sheng Ling Low Geriatrician
Dementia Aetiology, pathophysiology and the role of neuropsychological testing Dr Sheng Ling Low Geriatrician Topics to cover Why is dementia important What is dementia Differentiate between dementia,
More informationOutline. Facts and figures Action plans Early / correct diagnosis Conclusions
Outline Facts and figures Action plans Early / correct diagnosis Conclusions Dementia: the greatest chalenge. Time to act now Philip Scheltens Professor of Neurology VU University Medical Center Amsterdam
More informationPiramal Imaging to Present New Research in PET Imaging at Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting
FOR IMMEDIATE RELEASE Media Contacts: Nicole Fletcher Piramal Imaging nicole.fletcher@piramal.com (857) 202-1122 Piramal Imaging to Present New Research in PET Imaging at Society of Nuclear Medicine and
More informationDo not copy or distribute without permission. S. Weintraub, CNADC, NUFSM, 2009
Sandra Weintraub, Ph.D. Clinical Core Director, Cognitive Neurology and Alzheimer s Disease Center Northwestern University Feinberg School of Medicine Chicago, Illinois Dementia: a condition caused by
More informationBioArctic announces detailed results of the BAN2401 Phase 2b study in early Alzheimer s disease presented at AAIC 2018
Press release BioArctic announces detailed results of the BAN2401 Phase 2b study in early Alzheimer s disease presented at AAIC 2018 Stockholm, Sweden, July 25, 2018 BioArctic AB (publ) (Nasdaq Stockholm:
More informationMRI Hippocampal Volume for Enrichment
MRI Hippocampal Volume for Enrichment Derek Hill 1,2 & Jerry Novak 3, Pat Cole 4, Diane Stephenson 5 1. IXICO plc 2. UCL, London, UK 3. Johnson and Johnson 4. Takeda 5. CAMD, Critical Path Institute 1
More informationCarol Manning, PhD, ABPP-CN Director, Memory Disorders Clinic University of Virginia
Carol Manning, PhD, ABPP-CN Director, Memory Disorders Clinic University of Virginia Case Study Mr. S. is a 74 year old man who has smoked for 20 years. He is overweight, has high cholesterol and high
More informationIl processo diagnostico dell Alzheimer dalla clinica al neuroimaging Giovanni B. Frisoni M.D.
Il processo diagnostico dell Alzheimer dalla clinica al neuroimaging Giovanni B. Frisoni M.D. Professor of Clinical Neurosciences, University of Geneva Médecin Responsable, Memory Clinic, Hôpitaux Universitaires
More informationAlzheimer s Disease - Dementia
- Dementia Neurocognitive disorder with dysfunction or loss of " Memory " Orientation " Attention " Language " Judgment " Reasoning Other characteristics that can manifest " Personality changes " Behavioral
More informationThey are updated regularly as new NICE guidance is published. To view the latest version of this NICE Pathway see:
diagnosis and assessment bring together everything NICE says on a topic in an interactive flowchart. are interactive and designed to be used online. They are updated regularly as new NICE guidance is published.
More informationComments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic Guidelines? The Debate Continues
Comments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic s? The Debate Continues Ever since new criteria came out for a research diagnosis of prodromal/preclinical
More informationWHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient
DEMENTIA WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient Progressive and disabling Not an inherent aspect of
More informationDEMENTIA ANDREA BERG, MD
DEMENTIA ANDREA BERG, MD What Is Dementia? Decline in memory, language, problem-solving and other cognitive skills that affects a persons ability to perform everyday activities Progressive and disabling
More informationAmsterdam Dementia Cohort: Performing Research to Optimize Care
Journal of Alzheimer s Disease 62 (2018) 1091 1111 DOI 10.3233/JAD-170850 IOS Press Review 1091 Amsterdam Dementia Cohort: Performing Research to Optimize Care Wiesje M. van der Flier a,b, and Philip Scheltens
More informationUDS version 3 Summary of major changes to UDS form packets
UDS version 3 Summary of major changes to UDS form packets from version 2 to VERSION 3 february 18 final Form A1: Subject demographics Updated question on principal referral source to add additional options
More information10 Facts We All Need to Know About Dementia (MNCD) in Old Age
10 Facts We All Need to Know About Dementia (MNCD) in Old Age DUNCAN ROBERTSON FRCP (LOND & EDIN) FRCPC MEDICAL ADVISOR TO ADVANCING DEMENTIA DIAGNOSIS AND MANAGEMENT IN ALBERTA AND PRIMARY HEALTH CARE
More information7/3/2013 ABNORMAL PSYCHOLOGY SEVENTH EDITION CHAPTER FOURTEEN CHAPTER OUTLINE. Dementia, Delirium, and Amnestic Disorders. Oltmanns and Emery
ABNORMAL PSYCHOLOGY SEVENTH EDITION Oltmanns and Emery PowerPoint Presentations Prepared by: Ashlea R. Smith, Ph.D. This multimedia and its contents are protected under copyright law. The following are
More informationEarly Onset Dementia From the background to the foreground
Early Onset Dementia From the background to the foreground Dr Jeremy Isaacs Consultant Neurologist St George s Hospital Excellence in specialist and community healthcare Themes of my talk The early onset
More informationRole of TDP-43 in Non-Alzheimer s and Alzheimer s Neurodegenerative Diseases
Role of TDP-43 in Non-Alzheimer s and Alzheimer s Neurodegenerative Diseases Keith A. Josephs, MD, MST, MSc Professor of Neurology 13th Annual Mild Cognitive Impairment (MCI) Symposium: Alzheimer and Non-Alzheimer
More informationBHIVA Best Practice Management Session
BHIVA Best Practice Management Session CNS (The brain) - I keep forgetting things DEMENTIA DIAGNOSIS, CLASSIFICATION AND INVESTIGATIONS Paul Holmes Consultant Neurologist Guy s and St Thomas Hospitals
More informationDiagnosing & Dealing with Dementia
Diagnosing & Dealing with Dementia Robert G. Arias, PhD. I have no financial disclosures or conflicts of interest to report. Robert G. Arias, PhD. 1 Today We Will Learn About: Diagnosing dementia Characteristics
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a postprint version which may differ from the publisher's version. For additional information about this
More informationDifferential Diagnosis
Differential Diagnosis 2 2.1 Introduction AD accounts for up to 75 % of all dementia cases. The differential diagnosis with other conditions is sometimes challenging since several disorders may produce
More informationClaims & Underwriting. You already told us that story! Maria C. Carrillo, Ph.D. Sr. Director, Medical & Scientific Relations Alzheimer s Association
Claims & Underwriting Alzheimer s & Cognitive Impairment: You already told us that story! Maria C. Carrillo, Ph.D. Sr. Director, Medical & Scientific Relations Alzheimer s Association 1 OVERVIEW Impact
More informationOLD AGE PSYCHIATRY. Dementia definition TYPES OF DEMENTIA. Other causes. Psychiatric disorders of the elderly. Dementia.
Psychiatric disorders of the elderly OLD AGE PSYCHIATRY Dementia Depression Delusional disorder/late onset schizophrenia Delirium Dementia definition LOCALISATION OF CEREBRAL FUNCTION Impairment of multiple
More informationRegulatory Challenges across Dementia Subtypes European View
Regulatory Challenges across Dementia Subtypes European View Population definition including Early disease at risk Endpoints in POC studies Endpoints in pivotal trials 1 Disclaimer No CoI The opinions
More informationreview of existing studies on ASL in dementia Marion Smits, MD PhD
review of existing studies on ASL in dementia Marion Smits, MD PhD Associate Professor of Neuroradiology Department of Radiology, Erasmus MC, Rotterdam (NL) Alzheimer Centre South-West Netherlands, Rotterdam
More informationWhat APS Workers Need to Know about Frontotemporal, Lewy Body and Vascular Dementias
What APS Workers Need to Know about Frontotemporal, Lewy Body and Vascular Dementias Presenter: Kim Bailey, MS Gerontology, Program & Education Specialist, Alzheimer s Orange County 1 1 Facts About Our
More informationFrontotemporal Dementia: Towards better diagnosis. Frontotemporal Dementia. John Hodges, NeuRA & University of New South Wales, Sydney.
I.1 I.2 II.1 II.2 II.3 II.4 II.5 II.6 III.1 III.2 III.3 III.4 III.5 III.6 III.7 III.8 III.9 III.10 III.11 III.12 IV.1 IV.2 IV.3 IV.4 IV.5 Frontotemporal Dementia: Towards better diagnosis Frontotemporal
More informationSECTION 1: as each other, or as me. THE BRAIN AND DEMENTIA. C. Boden *
I read all the available books by other [people with] Alzheimer s disease but they never had quite the same problems as each other, or as me. I t s not like other diseases, where there is a standard set
More informationAssessing Cognition. Andreana Haley, Ph.D. Department of Psychology University of Texas at Austin
Assessing Cognition Andreana Haley, Ph.D. Department of Psychology University of Texas at Austin Agenda Topic: Cognitive Aging Assessing Cognition Diagnosing Cognitive Impairment Dementia Diagnoses Symptoms
More informationNCFE Level 2 Certificate in The Principles of Dementia Care
The Principles of Dementia Care S A M P LE NCFE Level 2 Certificate in The Principles of Dementia Care Part A 1 These learning resources and assessment questions have been approved and endorsed by ncfe
More informationWhat is. frontotemporal. address? dementia?
What is frontotemporal address? dementia? Contents 03 What is frontotemporal dementia? 04 Symptoms 05 Diagnosis 06 Treatments Information in this booklet is for anyone who wants to know more about frontotemporal
More informationEuropean Prevention of Alzheimer s Dementia (EPAD)
European Prevention of Alzheimer s Dementia (EPAD) Ron Marcus, MD ISCTM Adaptive Design Workshop February 20, 2018 1 EPAD Goal The European Prevention of Alzheimer's Dementia (EPAD) project aims to develop
More informationDementia Awareness Handout
Dementia Awareness Handout This handout is designed to be used as a brief aid to remind you of the contents of your dementia awareness session. Definition of dementia The term dementia is used to describe
More informationLearning Outcomes. To have a clear understanding of the term dementia, and current facts and statistics relating to dementia.
Learning Outcomes To have a clear understanding of the term dementia, and current facts and statistics relating to dementia. To be familiar with some of the common types of dementia. To understand what
More informationThe current state of healthcare for Normal Aging, Mild Cognitive Impairment, & Alzheimer s Disease
The current state of healthcare for Normal Aging, g, Mild Cognitive Impairment, & Alzheimer s Disease William Rodman Shankle, MS MD FACP Director, Alzheimer s Program, Hoag Neurosciences Institute Neurologist,
More informationMOVEMENT DISORDERS AND DEMENTIA
MOVEMENT DISORDERS AND DEMENTIA FOCUS ON DEMENTIA WITH LEWY BODIES MADHAVI THOMAS MD NORTH TEXAS MOVEMENT DISORDERS INSTITUTE, INC DEMENTIA de men tia dəˈmen(t)sh(ē)ə/ nounmedicine noun: dementia a chronic
More informationRecognizing Dementia can be Tricky
Dementia Abstract Recognizing Dementia can be Tricky Dementia is characterized by multiple cognitive impairments that cause significant functional decline. Based on this brief definition, the initial expectation
More informationThe prevalence of YOD increases almost exponentially with age (as does the prevalence of late onset dementia).
Factsheet 1 Young Onset Dementia (YOD) Dementia is commonly seen as a health and social problem of older adults. Nevertheless dementia can occur earlier in life. Young onset dementia is defined by an onset
More informationDementia, Cognitive Aging Services and Support
Dementia, Cognitive Aging Services and Support Ronald C. Petersen, Ph.D., M.D. Professor of Neurology Mayo Clinic College of Medicine Rochester, MN NASUAD Washington September 2, 2015 Disclosures Pfizer,
More informationDementia Past, Present and Future
Dementia Past, Present and Future Morris Freedman MD, FRCPC Division of Neurology Baycrest and University of Toronto Rotman Research Institute, Baycrest CNSF 2015 Objectives By the end of this presentation,
More informationRound table: Moderator; Fereshteh Sedaghat, MD, PhD Brain Mapping in Dementias and Non-invasive Neurostimulation
Round table: Moderator; Fereshteh Sedaghat, MD, PhD Brain Mapping in Dementias and Non-invasive Neurostimulation 1. Reflection of Mild Cognitive Impairment (MCI) and Dementias by Molecular Imaging, PET
More informationResponse Ratio Female % Male % No Response(s) 1 <1 % Totals %
Constant Contact Survey Results Survey Name: Survey Questions for Researchers Status: Completed Filter: None Dec 03, 2008 1:30:39 PM What is your gender? Female 87 35.3 % Male 158 64.2 % No 1
More informationLatest Methods to Early Detection for Alzheimer's: Cognitive Assessments and Diagnostic Tools in Practice
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/alzheimers-disease-towards-earlier-detection/latest-methods-earlydetection-alzheimers-cognitive-assessments-and-diagnostic-tools-practice/8321/
More informationDementia: It s Not Always Alzheimer s
Dementia: It s Not Always Alzheimer s A Caregiver s Perspective Diane E. Vance, Ph.D. Mid-America Institute on Aging and Wellness 2017 My Background Caregiver for my husband who had Lewy Body Dementia
More informationRESEARCH AND PRACTICE IN ALZHEIMER S DISEASE VOL 10 EADC OVERVIEW B. VELLAS & E. REYNISH
EADC BRUNO VELLAS 14/01/05 10:14 Page 1 EADC OVERVIEW B. VELLAS & E. REYNISH (Toulouse, France, EU) Bruno Vellas: The European Alzheimer's Disease Consortium is a European funded network of centres of
More informationUpdate on functional brain imaging in Movement Disorders
Update on functional brain imaging in Movement Disorders Mario Masellis, MSc, MD, FRCPC, PhD Assistant Professor & Clinician-Scientist Sunnybrook Health Sciences Centre University of Toronto 53 rd CNSF
More informationAn integrated natural disease progression model of nine cognitive and biomarker endpoints in patients with Alzheimer s Disease
An integrated natural disease progression model of nine cognitive and biomarker endpoints in patients with Alzheimer s Disease Angelica Quartino 1* Dan Polhamus 2*, James Rogers 2, Jin Jin 1 212, Genentech
More informationCAREGIVER SUMMIT. The PD You Can't See: Dealing with Non-Motor Symptoms. Kaitlyn Roland, PhD. Sponsored by:
CAREGIVER SUMMIT The PD You Can't See: Dealing with Non-Motor Symptoms Kaitlyn Roland, PhD Sponsored by: Cognition VS Dementia Memory Executive Function Attention Bradyphrenia Visuospatial Language Hallucinations
More information8/24/18. Dementia. Risk of Dementia Following Traumatic Brain Injury: A Review of the Literature. Media Presence. Media Presence
Risk of Dementia Following Traumatic Brain Injury: A Review of the Literature Media Presence Carlos Marquez de la Plata, Ph.D. & Jeff Schaffert, M.S. Media Presence Dementia What is dementia? Dementia
More informationDementia is an overall term for a set of symptoms that is caused by disorders affecting the brain.
Vascular Dementia Vascular Dementia Other Dementias This information sheet provides an overview of a type of dementia known as vascular dementia. In this information sheet you will find: An overview of
More information