15 th Meeting of the Austrian Neuroscience Association 24 th - 26 th September 2017 IST Austria

Transcription

1 15 th Meeting of the Austrian Neuroscience Association 24 th - 26 th September 2017 IST Austria

2 Dear neuroscientists in Austria: Welcome to IST Austria! It is a great pleasure and honor for IST to host the bi-annual meeting of the Austrian Neuroscience Association (ANA), particularly because neuroscience is a strong focus of our scientific activities. Looking through the program, I find it exciting to see abstracts on both basic neuroscience and brain diseases. As you know, until 10 years ago the main building of IST Austria harbored patients with various neurological and psychiatric diseases. It is interesting to see how basic neuroscience research is starting to impact our strategies for the treatment of these diseases. The location of IST Austria in the center of the Vienna Woods can provide an ideal environment for productive scientific discussions, the development of collaborative ideas, and a focus on exciting recent results. I am confident that this and future meetings at IST Austria will promote the interactions across universities and research institutes, disciplines, and countries, which is one of our main goals at IST Austria. I wish you a highly productive and successful meeting. Thomas A. Henzinger, President of IST Austria Dear colleagues, as the organizers of the 15 th meeting of the Austrian Neuroscience Association (ANA), we would like to welcome you to IST Austria. We have tried to put together an exciting and diversified program. It has always been a hallmark of ANA meetings to cover a broad range of topics, from molecular to systemic, and from basic to applied neurosciences. ANA meetings thus differ from specialized conferences, but they also differ conceptually from large interdisciplinary meetings like the FENS Forum or SfN. Since we have few parallel sessions, you will be able to hear of topics you might otherwise miss. Still, such topics could eventually impact on your own research, and even if not, you may simply enjoy it by mere curiosity. Already before the meeting has even started, we can make two conclusions. First, the ANA meeting has matured from a symposium style into an international scientific congress, with a steeply increasing number of registrations and abstract submissions. Second, an impressive amount of cutting edge neuroscience, now shown by your presentations, is performed in Austria. We also have a remarkable number of senior scientists registered with and without their own contributions, and you may thus expect valuable feedback at both your oral and poster presentations. Thus, the "Neuroscience of the future" has arrived, and Austria plays a leading role in the expansion of this important area of research within Europe. We thank you for participating in these exciting efforts. We also thank the Land Niederösterreich and IST Austria for support. We wish you a productive and highly successful meeting. It now all depends on you! Peter Jonas & Sigismund Huck

3 Sunday September 24, Registration, Mounting of Posters Opening Plenary lecture: Deconstructing fear Andreas Luethi (FMI, Basel, Switzerland) Chair: Francesco Ferraguti (Medical University Innsbruck, Austria) Minisymposium: Neural architectures for the basic mind Chair: Wulf Haubensak (IMP, Vienna, Austria) The neural circuitry of instinct control Cornelius Gross (EMBL Monterodondo, Italy) Dissecting CRH-related circuits that modulate emotional behaviors and stress vulnerability Jan Deussing (MPI Psychiatry, Munich, Germany) MicroRNAs in learned safety Daniela D. Pollak (MedUni, Vienna, Austria) Learning to fear with dopamine Wulf Haubensak (IMP, Vienna, Austria) Oral Session 1: Structural and functional plasticity Chair: Sébastien Couillard-Després (PMU Salzburg, Austria) O1 Physiological maturation and network integration of non-proliferative neuronal precursors in the adult piriform cortex Bruno Benedetti (Spinal Cord Injury and Tissue Regeneration Center Salzburg & Inst Experimental Neuroregeneration, PMU Salzburg, Austria)

4 O2 Functional integration of transplanted embryonic neurons in the adult visual cortex Susanne Falkner (MPI of Neurobiology, Martinsried, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Germany; Present Address: University of Basel, Biocenter, Basel, Switzerland) O3 An increase of the readily releasable pool accounts for post-tetanic potentiation at the hippocampal mossy fiber bouton CA3 pyramidal neuron synapse David Vandael (IST Austria Klosterneuburg, Austria) O4 3 -UTR dependent trafficking of Rgs4 mrna in response to synaptic activity in living hippocampal neurons Karl E. Bauer (Biomedical Center, Ludwig- Maximilians-University, Munich, Germany) O5 A cooperative mechanism involving Ca 2+ - permeable AMPA receptors and retrograde activation of GABA B receptors in interpeduncular nucleus plasticity Peter Koppensteiner (Department of Psychiatry, NYU Neuroscience Institute, NYU Langone Medical Center, New York, USA) Poster Flash I Chair: Johannes Berger (MedUni Vienna, Austria) Posters 1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 76, 79, 82, Poster I & Coffee

5 Plenary lecture: From evolution to computation Gilles Laurent (MPI Brain Research, Frankfurt, Germany) Chair: Kristin Tessmar-Raible (MFPL, Vienna, Austria) Otto-Loewi-Award Ceremony Chair: Ludwig Aigner (PMU, Salzburg, Austria) Dinner Monday September 25, Registration Plenary Lecture: All optical interrogation of neural circuits Michael Häusser (UC London, UK) Chair: David A. Keays (IMP, Vienna, Austria) Minisymposium: Neuronal networks to keep you informed Chair: Thomas Klausberger (CBR, MedUni Vienna, Austria) Delayed hippocampus development in a rodent model of extreme longevity Erik Keimpema (CBR, MedUni Vienna, Austria) A system of fast oscillations coordinates hippocampal information processing Bálint Lasztóczi (CBR, MedUni Vienna, Austria) The synaptic microcircuit of pattern completion in the hippocampal CA3 network Jose Guzmán (IMBA, Vienna, Austria)

6 Oral Session 2: Ion channels in health & disease Chair: Gerald Obermair (Division of Physiology, Medical University Innsbruck, Austria) O6 The presynaptic calcium channel subunit α2δ-2 regulates axonal wiring and postsynaptic GABAAreceptor abundance Stefanie Geisler (Division of Physiology, Medical University Innsbruck, Austria) O7 Calcium signals from either L-type calcium channels or ryanodine receptors critically regulate AChR pre-patterning during neuromuscular junction formation Mehmet M. Kaplan (Department of Physiology and Medical Physics, Medical University Innsbruck, Austria) O8 Closed-loop gene therapy for intractable focal epilepsy Andreas Lieb (Department for Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK) O9 The link between mitochondria and epileptiform activity Matej Hotka (Department of Neurophysiology and Neuropharmacology, Center of Physiology and Pharmacology, MedUni Vienna, Austria) Coffee Break Poster Flash II Chair: Daniela Pollak (MedUni Vienna, Austria) Posters 2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32, 35, 38, 41, 44, 47, 50, 53, 56, 59, 62, 65, 68, 71, 74, 77, 80, Poster II & buffet

7 Plenary Lecture: What does brain imaging reveal on infants cognition? Ghislaine Dehaene Lambertz (Inserm U992, Gif sur Yvette/Paris, France) Chair: Rupert Lanzenberger (Department of Psychiatry and Psychotherapy, MedUni Vienna, Austria) Poster Flash III Chair: Petra Scholze (MedUni Vienna, Austria) Posters 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 63, 66, 69, 72, 75, 78, 81, Minisymposium: Calcium channels Chair: Bernhard Flucher (Physiology & Medical Physics, Medical University Innsbruck, Austria) Trafficking of T-type channels in health and disease Norbert Weiss (Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic) The CRAC channel machinery Christoph Romanin (Institute of Biophysics, JKU Linz, Austria) Curtailing calcium currents in CaV1.1 calcium channels Bernhard Flucher (Physiology & Medical Physics, Medical University Innsbruck, Austria) Oral Session 3: Neuronal circuits Chair: Thomas Hummel (Department of Neurobiology, Faculty of Life Science, University of Vienna, Austria) O10 A global brain state underlies C. elegans sleep behavior Manuel Zimmer (IMP, Vienna, Austria) O11 Functional dissociation of motion vision circuits in drosophila Georg Ammer (MPI of Neurobiology, Martinsried, Germany)

8 O12 Puzzling out nociceptive neural circuitries in the rat spinal cord using voltage-sensitive dye imaging Teresa Haider (Department of Neurophysiology, CBR, MedUni Vienna, Austria) O13 Neuron-type-specific activity in orbitofrontal cortex during a post-decision confidence task (Michael Lagler CBR, Div. Cognitive Neurobiology, MedUni Vienna, Austria) Poster III & Coffee ANA General Assembly & FENS Agenda Plenary Lecture: Stem cell dynamics in the adult Brain Fiona Doetsch (Univ. Basel, Switzerland) Chair: Sandra Siegert (IST Austria, Klosterneuburg, Austria) Conference Dinner

9 Tuesday September 26, Plenary Lecture: Light on an ancestral sensory interface linking cerebrospinal fluid to motor circuits in vertebrates Claire Wyart (ICM Hôpital Pitié Salpêtrière, Paris, France) Chair: Vanja Nagy (Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria) Minisymposium: Computational and theoretical neuroscience Chair: Gašper Tkačik (IST Austria, Klosterneuburg, Austria) Optimal coding strategies for populations of sensory neurons Julijana Gjorgjieva (MPI Brain Research, Frankfurt, Germany) Bayesian computations in neural circuits Mate Lengyel (University of Cambridge, UK) Synaptic designs for efficient coding: an example from the auditory pathway Mantas Gabrielaitis (MPI for Dynamics and Self Organization, Göttingen, Germany) Oral Session 4: Amygdala Signaling Chair: Tibor Harkany (Division of Molecular Neurosciences, CBR, MedUni Vienna, Austria) O14 Central amygdala circuitry underlies the benzodiazepine anxiolytic effect Johannes Griessner (IMP, Vienna, Austria) O15 Disinhibitory amygdala microcircuits for aversive learning Enrica Paradiso (Department of Pharmacology, Medical University Innsbruck, Austria)

10 O16 Role of the dopamine system in the deficient fear extinction of S1 mice Simone B. Sartori (Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria) O17 Probing the association between serotonin-1a autoreceptor and amygdala reactivity in healthy volunteers Georg S. Kranz (Department of Psychiatry and Psychotherapy, MedUni Vienna, Austria) Coffee Break Podium Discussion: Open Access (OA) Publishing Chair: Sigismund Huck (CBR, MedUni Vienna, Austria) Open Access Publishing: What are we talking about? Falk Reckling (FWF) UK Policy on OA Paul Bolam (Co-Editor in Chief, EJN, Univ. Oxford, UK) Austrian Transition to OA (AT2OA) Patrick Danowski (IST Austria, Klosterneuburg, Austria) OA unintended consequences and perverted incentives Michael Freissmuth (Editorial Board JBC, MedUni Vienna, Austria) Awards Satellite Event: Scientific Writing: Paul Bolam (Co- Editor in Chief, EJN, Univ. Oxford, UK)

11 POSTER PI Poster Session: Sunday, September 24, PII Poster Session: Monday, September 25, PIII Poster Session: Monday, September 25, Poster Session: Development, Disease & Regeneration PI.1 Astrocytes generated from induced pluripotent human stem cells derived from psychiatric patients Susanne Zach 1, Bastian Hengerer 1 ( 1 Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany) PII.2 Effects of general anesthesia on microglia Alessandro Venturino 1, Rouven Schulz 1, Gloria Colombo 1 and Sandra Siegert 1 ( 1 Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria) PIII.3 Quantitative analysis of microglial morphology and cell interaction during postnatal development Gloria Colombo, Rouven Schulz, Sandra Siegert (IST Austria, Klosterneuburg, Austria) PI.4 Microglial alterations in a mouse model of innate anxiety and depression Sinead Rooney 1, Anupam Sah 1, Susanne A. Wolf 3, Simone B. Sartori 1, Christoph Schwarzer 2, Helmut Kettenmann 3, Nicolas Singewald 1 * ( 1 Department of Pharmacology and Toxicology, Institute for Pharmacy and CMBI, University of Innsbruck, A-6020 Innsbruck, Austria; 2 Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Straße 1a, A-6020 Innsbruck, Austria; 3 Department of Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125, Berlin, Germany) PII.5 Doublecortin positive brain infiltrating CD8+ T-Cells and microglia in transgenic AD mouse models and human brains: a potential role in shaping plaque pathology? Unger M.S. 1,2, Marschallinger J.1, 2,3, Johnson M.4, Klein B. 1,2, Khundakar

12 A.A. 4, Heneka M.T. 5, Couillard-Despres S. 2,6, Masliah E.7, Attems J. 4, Aigner L. 1,2 ( 1 Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; 2 Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria; 3 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, USA; 4 Institute of Neuroscience, Ageing Research Laboratories, Newcastle upon Tyne, UK; 5 University Hospital Bonn, Clinic and Polyclinic for Neurology, Clinical Neuroscience, Bonn, Germany; 6 Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria; 7 Department of Neuroscience, School of Medicine, University of California San Diego, USA) PIII.6 Micro-Environmental Influence on the Integrity of human in vitro Blood-Brain Barrier models during Ischemia Anna Gerhartl 1, Nadja Pracser 1, Antje Appelt-Menzel 2, Marco Metzger 2, Winfried Neuhaus 1 ( 1 AIT - Austrian Institute of Technology GmbH, Competence Center Health and Bioresources, Competence Unit Molecular Diagnostics, Vienna, Austria; 2 Department of Tissue Engineering and Regenerative Medicine, University Hospital Würzburg, Germany) PI.7 Nutritional influence on behavior of A53T alpha-synuclein Parkinsons s Disease mice Magdalena Temmel 1, Vera Niederkofler 1, Heinrich Römer 2, Roland Rabl 1, Birgit Hutter- Paier 1 ( 1 QPS Austria GmbH, Grambach, Austria; 2 Karl-Franzens University of Graz, Institute of Zoology, Austria) PII.8 The subcellular location of the Aβ-degrading peptidase Insulin Degrading Enzyme is determined by conditional transport processes Markus Kunze, Johannes Berger (Center for Brain Research, Department for Pathobiology of the Nervous System, Medical University of Vienna) PIII.9 HACE1 deficiency leads to structural and functional neurodevelopmental defects in humans and mice Ewelina

13 Lenartowicz 2, Ronja Hollstein 3,Tsung-Pin Pai 1, Michel K. Herde 4, Paul Möseneder 1, Anoop Kavirayani 1, Georg-Christoph Korenke 11, Ivona Kozieradzki 1, Roberto Nitsch 1,6, Ana Cicvaric 5, Francisco J. Monje Quiroga 5, Matthew A. Deardorff 7, Emma C. Bedoukian 7, Yun Li 8, Gökhan Yigit 8, E. Ferda Percin 12, Bernd Wollnik 8, Christian Henneberger 4,9,11, Frank J. Kaiser 3, Vanja Nagy 1,2*, and Josef M. Penninger 1 1 Institute of Molecular Biotechnology, 1030 Vienna, Austria; 2 Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria; 3 Section for Functional Genetics at the Institute of Human Genetics, University of Lübeck, Lübeck, Germany; 4 Institute of Cellular Neurosciences, University of Bonn Medical School, Bonn, Germany; 5 Department of Neuro-physiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria; 6 AstraZeneca R&D, Mölnadal, Sweden; 7 Division of Genetics and the Roberts Individualized Medical Genetics Center, Children's Hospital of Philadelphia, PA, USA; Departments of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; 8 Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany; 9 Institute of Neurology, University College London, WC1N 3BG London, United Kingdom; 10 German Center for Neurogedegenerative Diseases (DZNE), Bonn, Germany; 11 Zentrum für Kinder- und Jugendmedizin, Neuropädiatrie, Klinikum Oldenburg, Oldenburg, Germany; 12 Department of Medical Genetics, Faculty of Medicine, Gazi University, Ankara, Turkey PI.10 Information system for support in the diagnosis of Alzheimer's disease Jure Fabjan 1, 2, Luka Toni 3, Nejc Nadižar 1, Miha Moškon 4, Milica Gregorič Kramberger 2, Uršula Prosenc Zmrzljak 1, Damjana Rozman 1, Zvezdan Pirtošek 2, 3 ( 1 Centre for Functional Genomic and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia; 2 Neurological clinic, UMC, Ljubljana, Slovenia; 3 Chair of Neurology, Faculty of Medicine,

14 University of Ljubljana, Slovenia; 4 Faculty of Computer and Information Science, University of Ljubljana, Slovenia) PII.11 Overcoming Plasmalogen Deficiency in Peroxisomal Disorders Fabian Dorninger 1, Christoph Wiesinger 1, Gerhard Zeitler 1, Hans R. Waterham 2, Sonja Forss-Petter 1, Johannes Berger 1 ( 1 Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; 2 Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, The Netherlands) PIII.12 Mononuclear phagocytes are skewed towards a proinflammatory phenotype in X-linked adrenoleuko-dystrophy Bettina Zierfuss 1, Isabelle Weinhofer 1, Simon Hametner 2, Hannes Stockinger 3, Wolfgang Köhler 4, Romana Höftberger 5, Sonja Forss- Petter 1, Hans Lassmann 2, Johannes Berger 1 ( 1 Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; 2 Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Austria; 3 Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria; 4 Department of Neurology and Neurological Intensive Care, Fachkrankenhaus Hubertusburg, Germany; 5 Institute of Neurology, Medical University of Vienna, Austria PI.13 Neuroprotective Activity of Mesenchymal Stromal Cells and their Secreted Vesicles in a Spinal Cord Contusion Rat Model Pasquale Romanelli 1,6, Lara Bieler 1,6, Cornelia Scharler 2,6, Karin Pachler 3,6, Christina Kreutzer 1,6, Pia Zaunmair 1,6, Ludwig Aigner 4,6, Francisco J. Rivera 4,6, Eva Rohde 3,5,6, Bruno Benedetti 1,6, Mario Gimona 3,6, Dirk Strunk 2,6, Sebastien Couillard- Despres 1,6 ( 1 Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria; 2 Institute of Experimental and Clinical Cell Therapy, Paracelsus Medical University, Salzburg, Austria; 3 GMP Laboratory, Paracelsus Medical

15 University, Salzburg, Austria; 4 Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria; 5 University Department of Blood Serology and Transfusion Medicine, SALK, Salzburg, Austria; 6 Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Austria; Contact: pasquale.romanelli@pmu.ac.at) PII.14 A non-surgical technique for minimally-invasive complete spinal cord lesion in minipigs Elena Esra Foditsch 1,4, Karin Roider 1,4, Gratian Miclaus 2, Irina Patras 3, Ioan Hutu 3, Günter Janetschek 1, Ludwig Aigner 4, Reinhold Zimmermann 1 ( 1 Department of Urology, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria; 2 Neurorad SLR, Timisoara, Romania; 3 University of Agronomy and Veterinarian Medicine, Timisoara, Romania; 4 Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria) PIII.15 ENDF1- a prenylated hops-derived flavonoid- as treatment to restore peripheral nerve function after sciatic nerve crush (SNC) Lara Bieler 1,2, Lisa Jakob1,2, Michael Vogl 1,2, Corinna Urmann 3, Michael Kirchinger 3, Julia Tevini 4, Herbert Riepl 3, Thomas Felder 4, Ludwig Aigner 2,5 and Sébastien Couillard- Després 1,2 ( 1 Institute of Experimental Neuroregeneration, Paracelsus Medical University, Salzburg, Austria; 2 Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University Salzburg, Salzburg, Austria; 3 Organic and Analytical Chemistry, Weihenstephan-Triesdorf University of Applied Sciences, Straubing, Germany; 4 Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria; 5 Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria) PI.16 Retinal frequency-dependent responses are delayed in a mouse model of multiple system atrophy Hartwig Seitter 1,

16 Nadia Stefanova 2, Alexandra Koschak 1 ( 1 University of Innsbruck, Institute of Pharmacy, Department of Pharmacology and Toxicology, Innsbruck, Austria; 2 Innsbruck Medical University, Division of Neurobiology, Department of Neurology, Innsbruck, Austria) PII.17 Does the Pathology of Multiple System Atrophy manifest in the Neuroretina? Kathrin Kaehler 1, Hartwig Seitter 1, Adolf Sandbichler 2, Nadia Stefanova 3 and Alexandra Koschak 1 ( 1 University of Innsbruck, Institute of Pharmacy, Department of Pharmacology and Toxicology, Center for Chemistry and Biomedicine, Innsbruck, Austria; 2 University of Innsbruck, Institute of Zoology, Innsbruck, Austria; 3 Innsbruck Medical University, Division of Neurobiology, Department of Neurology, Innsbruck, Austria) PIII.18 Screening of antiproliferative properties of methyl gallate derivates in C6 glioma brain tumour cells Alexander Fraueneder 1 Abdul M. Gbaj 2, Verena Kainz 1, Anton Hermann 1, Salah M. Bensaber 2, Nasren H Moagel 2 and Thomas M. Weiger 1 ( 1 University of Salzburg, Department of Cell Biology and Physiology, Division of Cellular and Molecular Neurobiology; 2 Tripoli University, Faculty of Pharmacy, Department of Medicinal Chemistry, Tripoli, Libya) PI.19 No evidence for caudate D2 receptor alterations in Tourette syndrome: evidence from a meta-analysis of PET studies with the radioligand [ 11 C]raclopride Silberbauer L 1, Gryglewski G 1, Hienert M 1, Kasper S 1, Lanzenberger R 1 (Department of Psychiatry and Psychotherapy, Medical University of Vienna) PII.20 Brown fat activity in depression Spyros Sideromenos 1, Timo Partonen 2 and Daniela D. Pollak 1 ( 1 Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Austria 2 National Institute for Health and Welfare (THL), Department of Health, Helsinki, Finland)

17 PIII.21 Flotillin-1 interacts with the serotonin transporter and determines susceptibility to depression-like behavior Sonali N. Reisinger 1, Eryan Kong 1, 2, Barbara Molz 1, Ana Cicvaric 1, Thomas Steinkellner 3, Jae-Won Yang 3, Maureen Cabatic 1, Spyros Sideromenos 1, Thomas Humberg 1, Francisco J. Monje 1, Harald H. Sitte 3, Benjamin J. Nichols 4 and Daniela D. Pollak 1 ( 1 Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria; 2 Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, China; 3 Department of Pharmacology, Center for Physiology and Pharmacology Medical University of Vienna, Vienna Austria; 6 MRC Laboratory of Molecular Biology, Cambridge, UK) PI.22 Depression in acute intermittent porphyria pathogenic principles and neurobiological mechanisms Stefanie Berger 1, Miranda Stattmann 1, Ana Cicvaric 1, Francisco Monje 1, Gerda Ricken 2, Johannes Hainfellner 2, Margot Ernst 3, Petra Scholze 3, Susanne Greber-Platzer 4, Makiko Yasuda 5, Robert Desnick 5, Daniela Pollak 1 ( 1 Department of Neurophysiology and - pharmacology, Center of Physiology and Pharmacology; 2 Institute of Neurology; 3 Department of Pathobiology of the Nervous System, Center for Brain Research; 4 Department of Pediatrics and Adolescent Medicine; 1-4 Medical University Vienna; 5 Icahn School of Medicine at Mount Sinai, New York, New York, USA) PII.23 The effects of gestational immune activation on the maternal brain Alice Zambon 1, Marianne Ronovsky 1, Angelika Berger 2 and Daniela D. Pollak 1* ( 1 Department of Neurophysiology and Neuropharmacology, 2 Department of Pediatrics and Adolescent medicine, Medical University of Vienna, Austria) PIII.24 Balance matters: maternal dietary polyunsaturated fatty acid intake modulates fetal brain development through altered endocannabinoid availability and signaling

18 Valentina Cinquina 1, Daniela Calvigioni 1,2, Matthias Farlik 3, Christoph Bock 3, Edit Szodorai 1 Vincenzo Di Marzo 4, Catherine H. Botting 5, Zoltán Máté 6, Gábor Szabó 6 and Tibor Harkany 1,2 ( 1 Department of Molecular Neurosciences, Medical University of Vienna, Vienna, Austria, 2 Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 3 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 4 Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Naples, Italy, 5 School of Chemistry, University of St. Andrews, St Andrews, United Kingdom and 6Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary) Poster Session: Synaptic Mechanisms & Ion Channels PI.25 Mephedrone and its metabolites reveal chiral selectivity towards monoamine transporters Felix P. Mayer 1, Laurin Wimmer 2, Dino Lüthi 3, Dora Pittrich 1, Nadine Burchardt 1, Diethart Schmid 4, Simon Bulling 1, Marko D. Mihovilovic 2, Matthias E. Liechti 3, Harald. H. Sitte 1 ( 1 Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria; 2 Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria; 3 Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland. 4 Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Physiology, Vienna Austria)

19 PII.26 How to rescue dopamine transporter variants associated with dopamine transporter deficiency syndrome in Drosophila melanogaster? H.M. Mazhar Asjad ( Institute of Pharmacology, Medical University of Vienna, A-1090 Vienna, Austria) PIII.27 Synaptotagmin 7 promotes sustained high-frequency transmission and vesicle replenishment at a central inhibitory synapse Chong Chen 1 and Peter Jonas 1 ( 1 IST Austria (Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria) PI.28 Flash and Freeze: Combining high-pressure freezing and optogenetics to evaluate synaptic transmission at hippocampal mossy fiber synapses Olena Kim*, Carolina Borges-Merjane*, Walter A. Kaufmann, Daniel Gütl, Peter Jonas (Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg) *co-authors with equal contribution PII.29 Synaptic excitation of PV-expressing interneurons on inhibition in the dentate gyrus of the hippocampus Claudia Espinoza, Segundo J. Guzmán, and Peter Jonas (Institute of Science and Technology (IST) Austria, Am Campus 1, 3400 Klosterneuburg, Austria) PIII.30 Excitatory connections between CA2 pyramidal cells Kazuki Okamoto 1 and Yuji Ikegaya 1 ( 1 Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan) PI.31 2-linoleoylglycerol is an ancestral endocannabinoid at CB1 cannabinoid receptors and potentially functions as regulator of neurite outgrowth Johannes Beiersdorf 1, Giuseppe Tortoriello 2, Gareth Williams 3, Gary A. Cameron 4, Heather B. Bradshaw 5, Ken Mackie 5, Michael Williams6, Vincenzo Di Marzo7, Leanne LU3, Patrick Doherty 3, Thomas Hummel 8, Tibor Harkany 1 ( 1 Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna,

20 Austria; 2 Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden; 3 Wolfson Centre for Age-related Diseases, King's College London, London, United Kingdom; 4 Schools of Applied Medicine and Dentistry University of Aberdeen, Aberdeen, United Kingdom; 5 Department of Psychological and Brain Sciences, Gill Center for Biomolecular Science Indiana, Bloomington, USA; 6 Department of Neuroscience Uppsala University, Uppsala, Sweden; 7 Endocannabinoid Research Group Istituto di Chimica Biomoleculare, Naples, Italy; 8 Department for Neurobiology, University of Vienna, Vienna, Austria) PII.32 Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake Andrea Chicca 1,a, Simon Nicolussi 1,a, Ruben Bartholomäus 2, Martina Blunder 3,4, Alejandro Aparisi Rey 5, Vanessa Petrucci 1, Ines del Carmen Reynoso- Moreno 6, Juan Manuel Viveros-Paredes 6, Marianela Dalghi Gens 1, Beat Lutz 5, Helgi B. Schiöth 3, Michael Soeberdt 7, Christoph Abels 7, Roch-Philippe Charles 1, Karl-Heinz Altmann 2 and Jürg Gertsch 1 (1 University of Bern, Switzerland; 2 ETH Zurich, Switzerland; 3 Uppsala University, Sweden; 4 UFRN, Natal Brazil; 5 Johannes Gutenberg University Mainz, Germany; 6 University of Guadalajara, Mexico; 7 Dr. August Wolff GmbH & Co. KG Arzneimittel, Germany) a authors contributed equally PIII.33 Alpha subunits in GABAA receptors are dispensable for GABA and diazepam Xenia Simeone 1, Nisa Wongsamitkul 2, Maria Maldifassi 2, Roland Baur 2, Margot Ernst 1, Erwin Sigel 2 ( 1 Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna; 2 Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland) PI.34 The GABAA receptor binding site of α5-subunit selective Benzodiazepines Markus Müllegger 1, Andreas Smetka 1, James M. Cook 2, Margot Ernst 1 and Petra Scholze 1 ( 1 Center for Brain Research, Medical University of Vienna, Austria; 2 Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, USA)

21 PII.35 Identification of Amino acids in the GABAA receptor α5- subunit, which contribute to α5-subunit selective Benzodiazepine Binding Andreas Smetka 1, James M. Cook 2, Margot Ernst 1 and Petra Scholze 1 ( 1 Center for Brain Research, Medical University of Vienna, Austria; 2 Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, USA) PIII.36 Synthesis of novel ring structures as GABAA receptor ligands 2 Maria Teresa Iorio, 1 Sabah Rehman, 1 Konstantina Bampali, 1 Petra Scholze, 1 Friederike Steudle, 1 Margot Ernst, 2 Marko Mihovilovic ( 1 Center for Brain Research, Medical University of Vienna; Institute of Applied Synthetic 2 Chemistry, TU Wien, Getreidemarkt 9/163, 1060 Vienna, Austria) PI.37 Structural analysis of novel GABAA receptor binding sites for the characterization of subtype selective ligands Konstantina Bampali 1, David C. B. Siebert 2, Maria Teresa Iorio 2, Martin Berger 3, Yong Chen 3, Zarina Hogekamp 1, Luca Silva 1, Marko D. Mihovilovic 2, Nuno Maulide 3, Matthäus Willeit 4 and Margot Ernst 1 ( 1 Department of Molecular Neurosciences, Medical University of Vienna; 2 Institute of Applied Synthetic Chemistry, Vienna University of Technology; 3 Institute of Organic Chemistry, University of Vienna; 4 Department of Psychiatry and Psychotherapy, Medical University of Vienna) PII.38 IgG4 Autoantibodies against Muscle-Specific Kinase undergo Fab-Arm Exchange in Myasthenia Gravis Patients Inga Koneczny, DPhil 1, Jo A. Stevens, PhD 1, Anna de Rosa 2, Saif Huda, MD PhD 3, Maartje G. Huijbers, PhD 4, Abhishek Saxena, PhD 1, Michelangelo Maestri, MD 2, Konstantinos Lazaridis, MD 5, Paraskevi Zisimopoulou 5, Socrates Tzartos, MD, PhD 5, Jan Verschuuren, MD, PhD 4, Silvère M van der Maarel, PhD 4, Philip van Damme, MD 5,6, Angela Vincent, FRCPath, FRS, PhD 3, Marc H de Baets, MD, PhD 1, Peter C Molenaar, PhD 1, Roberta Ricciardi, MD 2, Pilar Martinez-Martinez, PhD 1#, Mario Losen, PhD 1# ( 1 Department of Psychiatry and Neuropsychology, School for Mental Health and

22 Neuroscience, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands; 2 Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Paradisa 2, Pisa, Italy; 3 Neurology Department, Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; 4 Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands; 5 Department of Neurobiology, Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue , Ampelokipi, Athens, Greece; 5 Neurology Department, University Hospital, Herestraat 49, 3000 Leuven, Belgium; 6 KU Leuven - University of Leuven, Department of Neurosciences, VIB - Vesalius Research Center, Experimental Neurology - Laboratory of Neurobiology, Leuven, Belgium) PIII.39 Characterizing endocytosis of muscle specific kinase via ph-sensitive fluorescent proteins Maria Graeber 1, Laura Geid 1,2, Ruth Herbst 1 ( 1 Center for Pathophysiology, Infectiology & Immunology, Institute of Immunology, Medical University of Vienna; 2 Center for Brain research, Medical University of Vienna) PI.40 Characterizing agrin-dependent muscle specific kinase endocytosis Laura Geid 1,2, Jasmin Hatami 1, Maria Graeber 1, Ruth Herbst 1 ( 1 Institute of Immunology, Medical University of Vienna; 2 Center for Brain research, Medical University of Vienna) PII.41 Nicotinic Acetylcholine Receptors (nachr) control the release of norepinephrine in the mouse spinal cord Petra Scholze 1, Florian Grössl 1,2 and Sigismund Huck 1 ( 1 Center for Brain Research, Medical University of Vienna, Austria; 2 present address: Research Institute of Molecular Pathology (IMP), Vienna Biocenter)

23 PIII.42 On the effects of phosphodiesterase 5 inhibitors on sympathetic neurotransmitter release Florian Zirpel 1, Helmut H. Drobny 1 and Stefan Boehm 1 ( 1 Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria) PI.43 Kv7 and TRPV1 channels: neuronal targets for the analgesic action of paracetamol Sutirtha Ray 1, Isabella Salzer 1 and Stefan Boehm 1 ( 1 Department of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Austria) PII.44 Light-driven impairment of Cav1.4 mutant mouse retinas shown with Multielectrode Array recordings Zanetti L., Seitter H., Koschak A. (University of Innsbruck, Institute of Pharmacy, Pharmacology and Toxicology, Innsbruck, Austria) PIII.45 Morphological modulations of bipolar cells in congenital stationary night blindness type 2 mouse models Kilicarslan I 1, Seitter H 1, Strettoi E 2 and Koschak A 1 ( 1 Department of Pharmacology and Toxicology, University of Innsbruck, Innsbruck, Austria; 2Neuroscience Institute, Italian National Research Council (CNR), Pisa, Italy) PI.46 Distinct roles of auxiliary α2δ subunits of voltage-gated calcium channels in excitatory/inhibitory neurotransmission and network activity Arthur Bikbaev a,b,1, Anna Ciuraszkiewicz a,b,1, Jennifer Heck a, Romy Freund a, Jessica Mitlöhner c, Gerald J. Obermair d, Valentina Di Biase e and Martin Heine a,b,2 ( a RG Molecular Physiology, Leibniz Institute for Neurobiology, Magdeburg, Germany; b Center for Behavioral Brain Sciences, Magdeburg, Germany; c RG Brain Extracellular Matrix, Leibniz Institute for Neurobiology, Magdeburg, Germany; d Division of Physiology, Department of Physiology and Medical Physics, Medical University, Innsbruck, Austria; e Institute of

24 Biophysics, Medical University; Graz, Austria; 1 Equal contribution; 2 Corresponding author) PII.47 Mechanisms of modulating dendritic spine morphology by CaV1.3 L-type calcium channels Ruslan Stanika 1, Jörg Striessnig 2, Marta Campiglio 1 and Gerald J. Obermair 1 ( 1 Division of Physiology, Medical University Innsbruck, 6020 Innsbruck, Austria; 2 Department of Pharmacology and Toxicology, University of Innsbruck, 6020 Innsbruck, Austria) PIII.48 Sodium acetate and acetic acid modulate BK channels resting membrane potential of GH3 rat pituitary tumor cells Anna Moßhammer 1, Aisylu S. Gaifullina 2, Guzel F. Sitdikova 2, Anton Hermann 1 and Thomas M. Weiger 1 ( 1 University of Salzburg, Department of Cell Biology and Physiology, Division of Cellular and Molecular Neurobiology, Austria; 2 Department of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia) PI.49 High variation of kynurenic acid levels in dropping samples of birds Carina Kronsteiner 1,2, Mirosław Więcek 3, Theo Blaickner4, Berthold Kepplinger1 and Halina Baran 1,5* ( 1 Karl Landsteiner Research Institute Mauer, Austria; 2 Faculty for Biology, University of Würzburg, Germany; 3 Friends of Nature Society IWA, Pustynia, Poland; 4 Horses and Golden Eagles for Performance, Film and Publicity, Hinterstoder, Austria; 5 Neurophysiology, Dep. of Biomedical Sciences, Veterinary Medical University Vienna, Austria) PII.50 Tryptophan metabolism in bats Carina Kronsteiner 1,2, Małgorzata Misielak 3, Berthold Kepplinger 1 and Halina Baran 1,4* ( 1 Karl Landsteiner Research Institute Mauer, Austria; 2 Faculty for Biology, University of Würzburg, Germany; 3 Friends of Nature Society IWA, Pustynia, Poland; 4 Neurophysiology, Dep. of Biomedical Sciences, Veterinary Medical University Vienna, Austria)

25 PIII.51 Kynurenic acid and kynurenine aminotransferase activity in ganglia and liver of Helix pomatia Carina Kronsteiner 1,2, Berthold Kepplinger 1 and Halina Baran 1,3* ( 1 Karl Landsteiner Research Institute Mauer, Austria; 2Faculty for Biology, University of Würzburg, Germany; 3 Neurophysiology, Dep. of Biomedical Sciences, Veterinary Medical University Vienna, Austria) Poster Session: Neuropeptides PI.52 A novel organizing principle of the hypothalamus reveals molecularly segregated periventricular dopamine neurons Romanov R.A. 1,2, Zeisel A. 4, Tomer R. 5, Deisseroth K. 5, Hökfelt T. 3, Bock C. 6, Linnarsson S. 4, Horvath T.L. 7, Harkany T. 1,3 (Center for Brain Research, Medical University of Vienna; 2 Immanuel Kant Baltic Federal University, Kaliningrad, Russia; 3 Department of Neuroscience, and 4 Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; 5 Department of Bioengineering & CNC Program, Stanford University, Stanford, CA 94305, USA; 6 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; 7 Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA) PII.53 Functional neuroanatomy of prodynorphin Iwona Kmiec 1, Mario Mietzsch 2, Luca Zangrandi 1, Lill Anderson 3, Thomas Rülicke 3, Regine Heilbronn 2, Christoph Schwarzer 1 ( 1 Department of Pharmacology, Medical University of Innsbruck, Austria, 2 Institute of Virology, Campus Benjamin Franklin, Charité Medical School, Berlin, Germany, 3 Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria) PIII.54 Detection of the regulatory peptide galanin in biological samples Andreas Koller 1, Susanne M. Brunner 1, Felix Locker 1, Julia

26 M. Stockinger 1, Isabella Rauch 1, Peter Strasser 2, Stefan Leis 2, Florian Ernst 2, Alexandra Kaser-Eichberger 3, Falk Schrödl 3, Dariya Kalcheva 4, Emmanuel Klaus 4 and Barbara Kofler 1 ( 1 Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics; 2 Department of Neurology; 3 Department of Ophthalmology and Optometry; 4 Department of Surgery; Paracelsus Medical University, Salzburg, Austria) PI.55 The role of the galanin system in psoriasis-like skin inflammation Felix Locker 1, Silvia Vidali 1, Barbara S. Holub 1,2, Julia Stockinger 1, Andreas Koller 1, Susanne M. Brunner 1, David Schwarzenbacher 1, Roland Lang 2 and Barbara Kofler 1 ( 1 Laura Bassi Centre of Expertise THERAPEP, Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria; 2 Department of Dermatology, University of Salzburg, Austria) PII.56 Lack of Galanin receptor 3 but not receptor 2 influences DSS-induced colitis in mice Susanne M. Brunner 1, Florian Reichmann 2, Esther Fröhlich 2, Aitak Farzi 2, Peter Holzer 2, Barbara Kofler 1 ( 1 Laura Bassi Centre of Expertise THERAPEP, Research Program for Receptor Biochemistry and Tumor Metabolism, Paracelsus Medical University, Salzburg Austria; 2 Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria) Poster Session: Neuronal Circuits PIII.57 Closing the loop: Integration of sensory and motor information in C. elegans chemotaxis Julia Riedl 1, Manuel Zimmer 1 ( 1 Research Institute of Molecular Pathology IMP, Campus-Vienna-Biocenter 1, 1030 Vienna, Austria)

27 PI.58 Mechanisms Underlying Coordinated Neuronal Population Dynamics in C. elegans Kerem Uzel 1, Manuel Zimmer 1 ( 1 The Research Institute of Molecular Pathology (IMP), Vienna, Austria) PII.59 Interactions between brain-wide dynamics and central pattern generators drive behavior in C. elegans Harris Kaplan 1, Oriana Salazar Thula 1, and Manuel Zimmer 1 ( 1 The Research Institute of Molecular Pathology (IMP), Vienna, Austria) PIII.60 Memory of recent oxygen experience switches pheromone valence in Caenorhabditis elegans Lorenz A. Fenk 1,2 and Mario de Bono 1 ( 1 MRC Laboratory of Molecular Biology, Division of Cell Biology, Cambridge, United Kingdom; 2 present address: Max Planck Institute for Brain Research, Department of Neural Systems and Coding, Frankfurt/Main, Germany) PI.61 Split-Brain in a fly: Developmental mechanism underlying bilateral nervous system organization Rashmit Kaur, Sebastian Hoger, Thomas Hummel (Department for Neurobiology, Vienna University, Vienna, Austria) PII.62 Structural plasticity in the Drosophila olfactory system Sebastian Erath, Ashwaq Batawi, Mirjam Knoll and Thomas Hummel (Department of Neurobiology, Faculty of Life Science, University of Vienna, 1090 Vienna, Austria) PIII.63 Tomographic and Transcriptomic Analysis of Hair Cells with Iron-Rich Organelles from the Rock Pigeon Columba livia Simon Nimpf, Mattias Lauwers, Thomas Burkard and David A. Keays (Research Institute of Molecular Pathology, Vienna, Austria. Campus-Vienna-Biocenter 1, 1030, Vienna) PI.64 Molecular Characterisation of Pigeon Cryptochromes Tobias Hochstoeger 1, David Keays 1 ( 1 Research Institute of Molecular Pathology, Vienna) PII.65 Magnetically-induced neuronal activation in the pigeon Columba livia Nordmann, G. C., Nimpf, S., Malkemper, E.,

28 Landler, L., Papadaki, A., Ushakova, L., Wenninger-Weinzierl, A., Hochstoeger, T., and Keays, D. A. (Research Institute of Molecular Pathology, Vienna, Austria) PIII.66 The mouse: a new old model system in magnetoreception? Lukas Landler 1, E. Pascal Malkemper 1, Gregory Nordman 1, Simon Nimpf 1, Lyubov Ushakova 1, Artemis Papadaki-Anastasopoulou 1 and David A. Keays 1 ( 1 Research Institute of Molecular Pathology, Vienna-Biocenter Vienna, Austria) PI.67 A deep brain photoreceptor-dependent mechanism involved in behaviour adjustment Bruno M. Fontinha 1,2, Miguel Gallach 3,4, Florian Reithofer 1,2, Alison Barker 5, Max Hofbauer 1,2,6, Ruth M. Fischer 1, Stephanie Bannister 1,2, Arndt von Haeseler 1,2,3,4, Herwig Baier 5 and Kristin Tessmar-Raible 1,2,7 ( 1 Max F. Perutz Laboratories, University of Vienna and Medical University of Vienna, Austria; 2 Research Platform Rhythms of Life, Vienna, Austria: 3 Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna and Medical University of Vienna; 4 Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna, Austria; 5 Max Planck Institute of Neurobiology, Martinsried, Germany; 6 Loopbio GmbH, Kritzendorf, Austria; 7 FENS-Kavli network of Excellence) PII.68 Circadian sleep regulation in Cav1.4 mutant mouse models Eimansberger R. 1*, Richter A. 1*, Fritz E.M. 1, Kreuzer M. 2, Seitter H. 1, Koschak A. 1, Fenzl T. 3# ( 1 Institute for Pharmacology and Toxicology, Leopold Franzens University, Innsbruck, Austria; 2 Department of Anesthesiology, Emory University, Atlanta, USA; 3 Institute for Pharmacology, Medical University Innsbruck, Austria) * Both authors contributed equally; # Corresponding author PIII.69 Task-specific changes in brain glucose metabolism and connectivity assessed with simultaneous PET/MR imaging Lucas Rischka 1, Andreas Hahn 1, Lukas Nics 2, Gregor Gryglewski 1, Sebastian Ganger 1, Helen Sigurdardottir 1, Leo Silberbauer 1,

29 Thomas Vanicek 1, Alexander Kautzky 1, Wolfgang Wadsak 2,4, Markus Mitterhauser 2,3, Markus Hartenbach 2, Marcus Hacker 2, Siegfried Kasper 1, Rupert Lanzenberger 1 ( 1 Department of Psychiatry and Psychotherapy, Medical University of Vienna; 2 Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna; 3 Ludwig Boltzmann Institute Applied Diagnostics, Vienna; 4 Center for Biomarker Research in Medicine (CBmed), Graz) PI.70 Correlation of occupancy by Selective Serotonin Reuptake Inhibitors with dynamic connectivity, a pharmacological PET/MR study Gryglewski G 1, Silberbauer L 1, Pichler V 2, Berroterán-Infante N 2, Rischka L 1, Kautzky A 1,Nics L 2, Klöbl M 1, Vanicek T 1, James GM 1, Hienert M 1, Hartenbach M 2, Hahn A 1, Mitterhauser M 2,3, Wadsak W 2,4, Hacker M 2, Kasper S 1, Lanzenberger R 1 ( 1 Department of Psychiatry and Psychotherapy, Medical University of Vienna; 2 Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna; 3 Ludwig Boltzmann Institute Applied Diagnostics, Vienna; 4 Center for Biomarker Research in Medicine (CBmed), Graz) PII.71 Different activity modes of dentate gyrus granule cells in awake, behaving mice during running Xiaomin Zhang, Alois Schlögl, and Peter Jonas (Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria) PIII.72 Visual word recognition relies on a sensory prediction error signal Benjamin Gagl 1,2, Jona Sassenhagen 1, Sophia Haan 1, Fabio Richlan 3 and Christian J. Fiebach 1,2 ( 1 Department of Psychology, Goethe University Frankfurt, Theodor-W.-Adorno-Platz 6, Frankfurt/Main, Germany; 2 Center for Individual Development and Adaptive Education of Children at Risk (IDeA), Frankfurt am Main, Germany; 3 Centre for Cognitive Neuroscience, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria)

30 PI.73 The activity of orbitofrontal neurons shows synchronisation with breathing rhythm Áron Kőszeghy 1, Bálint Lasztóczi 1 and Thomas Klausberger 1 ( 1 Medical University of Vienna, Center for Brain Research, Divison of Cognitive Neurobiology, Vienna, Austria) PII.74 Differential Involvement of Prefrontal Delay-Tuned Neurons to Cognitive Flexibility A. Tugrul Oezdemir 1, Michael Lagler 1, Sabria Lagoun 1, Romana Hauer 1, Bálint Lasztóczi 1 and Thomas Klausberger 1 ( 1 Division of Cognitive Neurobiology, Center for Brain Research, Medical University of Vienna) PIII.75 Negative feedback scaling guides optimal choice adaptations in the medial prefrontal cortex Johannes Passecker 1, Nace Mikus 1, Hugo Malagon-Vina 1, Philip Anner 1,2, Georg Dorffner 2, and Thomas Klausberger 1 ( 1 Center for Brain Research, Medical University Vienna, Vienna, Austria; 2 Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria) PI.76 Histological identification of multiple in vivo recorded prefrontal neurons in freely moving rats Philip Anner, Johannes Passecker, Thomas Klausberger, Georg Dorffner ( 1 Department of Neurophysiology, Center for Brain Research, Medical University of Vienna) PII.77 A path to the aversiveness of pain: Electrophysiological characterization of amygdala-projecting parabrachial neurons receiving spinal input Hannah L. Teuchmann 1, Roni Hogri 1, Bernhard Heinke 1, Jürgen Sandkühler 1 ( 1 Department of Neurophysiology, Center for Brain Research, Medical University of Vienna)

31 PIII.78 Neuronal responses of ventral hippocampal neurons during anxiogenic stimulus Hugo Malagon-Vina 1, Stephane Ciocchi 1,2 and Thomas Klausberger 1 ( 1 Center for Brain Research, Medical University Vienna, Vienna, Austria; 2 Department of Physiology, University of Bern, 3012 Bern, Switzerland) PI.79 Periaqueductal gray/dorsal raphe dopamine neurons gate associative learning of fear Florian Grössl 1, Thomas Munsch 2#, Susanne Meis 2#, Johannes Griessner 1,3, Pinelopi Pliota 1, Dominic Kargl 1, Sylvia Badurek 4, Klaus Kraitsy 4, Arash Rassoulpour 5, Volkmar Lessmann 2 and Wulf Haubensak 1* ( 1 Research Institute of Molecular Pathology (IMP), Vienna Biocenter; 2 Institute of Physiology (Medical Faculty), and Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke University, Magdeburg, Germany; 3 Medical University of Vienna, 1090 Vienna, Austria; 4 Preclinical Phenotyping Facility, Vienna Biocenter Core Facilities (VBCF), Vienna Biocenter (VBC),1030 Vienna, Austria; 5 Brains On-Line LLC, San Francisco, USA) PII.80 Modulation of visual information in the thalamus by a novel axo-axonal synapse Santiago B. Rompani 1, Alex Attinger 1, Adrian Wanner 1, Chiara N. Roth 1, Josephine Juettner 1, and Botond Roska 1 ( 1 Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland)

32 Poster Session: Techniques PIII.81 Bioimpedance spectroscopy for quality assurance microelectronic neurochips I. Schmied, P. Schuller, A. Kocis, L. Varain, Heinz Wanzenboeck 1 and P. Scholze 2 ( 1 Institute for Solid State Electronics, TU Wien Floragasse 7/1 E362, A-1040 Vienna; 2 Center for Brain Research Medical University Vienna, A Vienna) PI.82 Motor functions and Metabolism Klaus Kraitsy 1, Anna Jelem 1 and Sylvia Badurek 1 ( 1 preclinical phenotyping facility (pcpheno); Vienna Biocenter Core Facilities GmbH (VBCF)) PII.83 Comparing Rivals: Learning and Memory vs. Anxiety and Depression Anna Jelem 1, Klaus Kraitsy 1 and Sylvia Badurek 1 ( 1 preclinical phenotyping facility (pcpheno), Vienna Biocenter Core Facilities GmbH (VBCF)) PIII.84 Light sheet microscopy of cleared and fluorescently labeled whole adult fruit fly Drosophila melanogaster Marko Pende 1,2, Martina Wanis 1,3, Rashmit Kaur 3, Saiedeh Saghafi 1,2, Christian Hahn 1,2, Klaus Becker 1,2, Thomas Hummel 3 and Hans- Ulrich Dodt 1,2 ( 1 FKE, Vienna University of Technology, Vienna Austria; 2 Center for Brain Research, Medical University of Vienna, Vienna Austria; 3 Department of Neurobiology, University of Vienna, Vienna Austria) PI.85 Breaking the diffraction limit of light sheets allows fast isotropic imaging of whole mouse brains by ultramicroscopy Hans-Ulrich Dodt 1,2, Saiedeh Saghafi 1, Klaus Becker 1,2, Christian Hahn 1,2, Marko Pende 1,2, Inna Sabdyusheva- Litschauer 1,2 ( 1 Department of Bioelectronics, FKE, TU Vienna, 2 Section of Bioelectronics, Center of Brain Research, Medical University Vienna)

33 General Information Conference site: Raiffeisen Lecture Hall, Institute of Science and Technology Austria (IST Austria) Am Campus 1, A 3400 Klosterneuburg, Austria The campus of IST Austria is located in Maria Gugging, near Klosterneuburg, about 18 km outside of the center of Vienna. Oral sessions Please note that you will have time for a 10 minute presentation, followed by a 5 minute discussion. Chairs of the sessions are requested to strictly stick to the schedule. Please put your PowerPoint slides on a USB stick and hand it over for copying the file to the person in charge at our registration desk at least 1 hour before your session starts. Poster sessions Poster Flashes take place in the main lecture hall. You have one minute and ONE PowerPoint slide to highlight your research. Posters will be mounted at the beginning and remain in place until the end of the meeting. Poster attendance is required according to the grouping PI, PII, or PIII and the indicated time. Poster dimensions are A0 portrait format (width: 84 cm, height: 119 cm). How to reach us - from Vienna Take the subway U4 until its end station (Heiligenstadt). See the Vienna subway map for connections with U4. Sunday From Heiligenstadt, take either the ANA Meeting shuttle bus (free of charge) or the public bus 239. Make sure that the 239 goes to its final destination (Lourdesgrotte) and not just to Klosterneuburg. Both buses depart directly from outside the subway station (12. Februar-Platz). The ANA Meeting shuttle bus departs (just once!!) at and has a stop in Klosterneuburg, Niedermarkt (in front of hotel "Schrannenhof"). The bus 239 runs about every half hour and has several stops in Klosterneuburg (check schedule). Each trip on the public bus takes about 35 minutes and costs 3.90 Euro. You can purchase tickets on the bus. The ANA Meeting shuttle bus departs Sunday night at from IST Austria to U4 station Heiligenstadt, with a stop in Klosterneuburg/Niedermarkt.

34 Monday and Tuesday On working days, the public bus 239 may be very crowded. We thus recommend using the ANA Meeting shuttle bus, which departs (just once!!) in the morning at from the subway station Heiligenstadt, with a stop in Klosterneuburg, Niedermarkt. The ANA Meeting shuttle bus will depart from IST Austria on Monday at 22.15, and on Tuesday at How to reach us - from Klosterneuburg The ANA Meeting shuttle bus will stop once at Klosterneuburg, Niedermarkt. The bus 239 has several stops in Klosterneuburg. Ride with a colleague Many participants live in Vienna and will be happy to give you a ride. The website will only work if those colleagues insert their names FIRST and use the online form for setting up your contact. If as a customer you take advantage of the ride with a colleague option, please make sure that you are at the respective meeting point a few minutes ahead of the time agreed upon in the online form. Taxi If you miss all these opportunities, you may have to take a taxi. A ride from Vienna will cost about 30 (depending on where you start). These two taxi companies are located in Klosterneuburg: Taxi Danzinger ( , ) Taxi Glueck ( , )

35 Accommodation Hotel Schrannenhof**** Enchanting building of the 15 th century, located in the city center, offering the comfort of a modern 4-stars house Klosterneuburg, Niedermarkt info@schrannenhof.at Hotel Restaurant Anker*** Family-run hotel with an ambient atmosphere, located in the city center of Klosterneuburg 3400 Klosterneuburg, Niedermarkt info@hotel-anker.at Frühstückspension Alte Mühle*** Charming atmosphere, friendly service, a rich breakfast buffet and a nice garden guarantee a pleasant stay Klosterneuburg, Mühlengasse info@hotel-altemuehle.at Bürgerhaus Salmeyer 15 th century private town house with big garden located in the city centre of Klosterneuburg. All apartments are equipped with kitchenette, bathroom Klosterneuburg, Stadtplatz info@buergerhaus-salmeyer.at

36 Accommodation in the Viennese woods Hotel Marienhof*** Hotel Marienhof is situated in the Viennese woods. It is perfect for people who want to stay away from the city. Includes swimming pool and gym room. The hotel will provide transfers to IST Austria (10 minutes) Unterkirchbach Registration fees The conference fee includes participation in the program, the program and abstract booklet (pdf), lunch, coffee breaks, and dinners (but not accommodation). Registered participants will receive a link for downloading the booklet pdf at least two weeks before the meeting. Registration from June 16 to August 31, 2017 ANA regular members: 150,- ANA student members: 100,-* Non-members: 210,- Student non-members: 120,-* On-site registration (cash only please; the only option after August 31, 2017) ANA regular members: 180,- ANA student members: 120,-* Non-members: 240,- Student non-members: 140,-* Scientific Writing Course at IST Austria Registration includes a simple lunch. Registration after June 23, 2017 and on-site: Students & non-students: 20,- *Reduced registration fees are applicable to students upon confirmation of student status by their supervisors at the registration desk

37 About IST Austria The Institute of Science and Technology Austria (IST Austria) is an international, multidisciplinary research institution dedicated to basic research in the natural, computer and mathematical sciences. The Institute is located in the city of Klosterneuburg, 18 km from the center of Vienna. As a PhD granting institution, the graduate school at IST Austria educates doctoral students from diverse and international backgrounds with the aim of cultivating world-class research scientists. IST Austria was established jointly by the federal government of Austria and the provincial government of Lower Austria and inaugurated in Currently, more than 570 employees from over 50 countries work at IST Austria. At present, the faculty of the institute consists of 46 professors. Following the implementation of the ambitious development plan, about 90 research groups will be working at IST Austria in a highly modern environment by To foster a creative and interdisciplinary scientific atmosphere, separating organizational structures, such as departments, are avoided at IST Austria. The scientists are organized into independent research groups, each headed by a Professor or a tenure-track Assistant Professor. The decision to promote an Assistant Professor to Professor with a permanent contract is based entirely on an evaluation of the scientific achievements of the Assistant Professor by international experts. Research excellence and promise are the exclusive hiring criteria for all scientists at IST Austria - from doctoral students to professors. The Institute chooses which fields of science to enter based solely on the availability of outstanding individuals. It will pursue a direction of research only if it can compete with the best in the world. Contact Information: Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Am Campus 1. Phone:

38 General Information Conference site: Raiffeisen Lecture Hall, Institute of Science and Technology Austria (IST Austria) Am Campus 1, A 3400 Klosterneuburg, Austria The campus of IST Austria is located in Maria Gugging, near Klosterneuburg, about 18 km outside of the center of Vienna. Oral sessions Please note that you will have time for a 10 minute presentation, followed by a 5 minute discussion. Chairs of the sessions are requested to strictly stick to the schedule. Please put your PowerPoint slides on a USB stick and hand it over for copying the file to the person in charge at our registration desk at least 1 hour before your session starts. Poster sessions Poster Flashes take place in the main lecture hall. You have one minute and ONE PowerPoint slide to highlight your research. Posters will be mounted at the beginning and remain in place until the end of the meeting. Poster attendance is required according to the grouping PI, PII, or PIII and the indicated time. Poster dimensions are A0 portrait format (width: 84 cm, height: 119 cm). How to reach us - from Vienna Take the subway U4 until its end station (Heiligenstadt). See the Vienna subway map for connections with U4. Sunday From Heiligenstadt, take either the ANA Meeting shuttle bus (free of charge) or the public bus 239. Make sure that the 239 goes to its final destination (Lourdesgrotte) and not just to Klosterneuburg. Both buses depart directly from outside the subway station (12. Februar-Platz). The ANA Meeting shuttle bus departs (just once!!) at and has a stop in Klosterneuburg, Niedermarkt (in front of hotel "Schrannenhof"). The bus 239 runs about every half hour and has several stops in Klosterneuburg (check schedule). Each trip on the public bus takes about 35 minutes and costs 3.90 Euro. You can purchase tickets on the bus. The ANA Meeting shuttle bus departs Sunday night at from IST Austria to U4 station Heiligenstadt, with a stop in Klosterneuburg/Niedermarkt.

39 Monday and Tuesday On working days, the public bus 239 may be very crowded. We thus recommend using the ANA Meeting shuttle bus, which departs (just once!!) in the morning at from the subway station Heiligenstadt, with a stop in Klosterneuburg, Niedermarkt. The ANA Meeting shuttle bus will depart from IST Austria on Monday at 22.15, and on Tuesday at How to reach us - from Klosterneuburg The ANA Meeting shuttle bus will stop once at Klosterneuburg, Niedermarkt. The bus 239 has several stops in Klosterneuburg. Ride with a colleague Many participants live in Vienna and will be happy to give you a ride. The website will only work if those colleagues insert their names FIRST and use the online form for setting up your contact. If as a customer you take advantage of the ride with a colleague option, please make sure that you are at the respective meeting point a few minutes ahead of the time agreed upon in the online form. Taxi If you miss all these opportunities, you may have to take a taxi. A ride from Vienna will cost about 30 (depending on where you start). These two taxi companies are located in Klosterneuburg: Taxi Danzinger ( , ) Taxi Glueck ( , )

40 Accommodation Hotel Schrannenhof**** Enchanting building of the 15 th century, located in the city center, offering the comfort of a modern 4-stars house Klosterneuburg, Niedermarkt info@schrannenhof.at Hotel Restaurant Anker*** Family-run hotel with an ambient atmosphere, located in the city center of Klosterneuburg 3400 Klosterneuburg, Niedermarkt info@hotel-anker.at Frühstückspension Alte Mühle*** Charming atmosphere, friendly service, a rich breakfast buffet and a nice garden guarantee a pleasant stay Klosterneuburg, Mühlengasse info@hotel-altemuehle.at Bürgerhaus Salmeyer 15 th century private town house with big garden located in the city centre of Klosterneuburg. All apartments are equipped with kitchenette, bathroom Klosterneuburg, Stadtplatz info@buergerhaus-salmeyer.at

41 Accommodation in the Viennese woods Hotel Marienhof*** Hotel Marienhof is situated in the Viennese woods. It is perfect for people who want to stay away from the city. Includes swimming pool and gym room. The hotel will provide transfers to IST Austria (10 minutes) Unterkirchbach Registration fees The conference fee includes participation in the program, the program and abstract booklet (pdf), lunch, coffee breaks, and dinners (but not accommodation). Registered participants will receive a link for downloading the booklet pdf at least two weeks before the meeting. Registration from June 16 to August 31, 2017 ANA regular members: 150,- ANA student members: 100,-* Non-members: 210,- Student non-members: 120,-* On-site registration (cash only please; the only option after August 31, 2017) ANA regular members: 180,- ANA student members: 120,-* Non-members: 240,- Student non-members: 140,-* Scientific Writing Course at IST Austria Registration includes a simple lunch. Registration after June 23, 2017 and on-site: Students & non-students: 20,- *Reduced registration fees are applicable to students upon confirmation of student status by their supervisors at the registration desk

42 About IST Austria The Institute of Science and Technology Austria (IST Austria) is an international, multidisciplinary research institution dedicated to basic research in the natural, computer and mathematical sciences. The Institute is located in the city of Klosterneuburg, 18 km from the center of Vienna. As a PhD granting institution, the graduate school at IST Austria educates doctoral students from diverse and international backgrounds with the aim of cultivating world-class research scientists. IST Austria was established jointly by the federal government of Austria and the provincial government of Lower Austria and inaugurated in Currently, more than 570 employees from over 50 countries work at IST Austria. At present, the faculty of the institute consists of 46 professors. Following the implementation of the ambitious development plan, about 90 research groups will be working at IST Austria in a highly modern environment by To foster a creative and interdisciplinary scientific atmosphere, separating organizational structures, such as departments, are avoided at IST Austria. The scientists are organized into independent research groups, each headed by a Professor or a tenure-track Assistant Professor. The decision to promote an Assistant Professor to Professor with a permanent contract is based entirely on an evaluation of the scientific achievements of the Assistant Professor by international experts. Research excellence and promise are the exclusive hiring criteria for all scientists at IST Austria - from doctoral students to professors. The Institute chooses which fields of science to enter based solely on the availability of outstanding individuals. It will pursue a direction of research only if it can compete with the best in the world. Contact Information: Institute of Science and Technology Austria (IST Austria), 3400 Klosterneuburg, Am Campus 1. Phone:

43 The conference will take place at the at IST Austria, Raiffeisen Lecture Hall (RLH, Building 02) Registration

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