Heart & Stroke Foundation Research Report

Transcription

1 Heart & Stroke Foundation Research Report

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3 Heart & Stroke Foundation Research Report Mission The Heart & Stroke Foundation s mission is to prevent disease, save lives and promote recovery. A volunteer-based health charity, we strive to tangibly improve the health of every Canadian family, every day. Healthy lives free of heart disease and stroke. Together we will make it happen. Every seven minutes in Canada, someone dies from heart disease or stroke. Heart disease and stroke are two of the three leading causes of death in Canada; more than 62,000 strokes, an estimated 70,000 heart attacks, and up to 40,000 cardiac arrests occur every year. Since its inception in 1952, the Foundation has invested more than $1.45 billion into vital heart & stroke research, making it the largest contributor in Canada after the federal government. Over the past 60 years, thanks to the work of the Foundation and our partners, the death rate from heart disease and stroke in Canada has declined by more than 75 per cent. This decline has resulted in 1.6 million people living with their effects today. i

4 Heart & Stroke Foundation Research Report Table of contents Acknowledgements Purpose and Scope Summary Tables Research Funding Overview Scientific Review Process Research Enterprise Components Investments across Health Research Themes Research Funding by Program Directed Research Fund National Personnel Awards Grant-in-Aid Province Specific Research Initiatives Research Chairs and Professorships Provincial Personnel Awards Other Provincial Initiatives Tables Table 1. Summary Foundation-wide and Province Specific Research Funding (2015-)... 2 Table 2. Detailed Foundation-wide and Province Specific Research Funding (2015-)... 3 Table 3. Number of National Personnel Awards and Investment of Funds (2015-)... 9 Table 4. National Personnel Awards by Health Research Theme (2015-) Table 5. Number of Grants-in-Aid and Investment of Funds (2015-)...11 Table 6. Research Chairs and Professorships (2015-) Table 7. H&S Provincial Personnel Awards Funded (2015-) Table 8. Other Provincial Research Initiatives (2015-) Figures Figure 1. H&S Research Funding by Program (2015-)... 5 Figure 2. H&S Research Funding Trends by Program (2011-)... 6 Figure 3. H&S Research Funding by Health Research Theme (2015-)... 6 Figure 4. H&S Research Funding Trends by Health Research Theme (2011-)...7 Figure 5. Directed Research Fund Leveraged Funding (2011-)... 8 Figure 6. Directed Research Fund Funding by Health Research Theme (2015-)... 8 Figure 7. Directed Research Fund Funding Trends by Health Research Theme (2011-)... 8 Figure 8. National Personnel Awards Funding by Health Research Theme (2015-) Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2011-) Figure 10. Grant-in-Aid Funding by Health Research Theme (2015-)...11 Figure 11. Grant-in-Aid Funding Trends by Health Research Theme (2011-)...11 Figure 12. Number of Grant-in-Aid Applications Submitted by Province(s)/Territory(ies) (2011-) Figure 13. Number of Grant-in-Aid Applications Funded by Province/Territory (2011-) ii

5 Heart & Stroke Foundation Research Report Appendix A: Directed Research Fund New Initiative...20 Population-Level Nutrition Intervention...20 Emerging Research Leaders Initiative (ERLI) Canadian Resuscitation Outcomes Consortium (CanROC) Continuing Initiatives Operating Grant: Population Health Intervention Research Coalitions Linking Action and Science for Prevention 2 (CLASP2) Canadian Alliance for Healthy Hearts and Minds (CAHHM) Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN)...27 HSFC/CIHR Chair in Hypertension Prevention and Control Operating Grant: Programmatic Grants in Health and Health Equity Resuscitation Outcomes Consortium (ROC) Renewal Appendix B: National Personnel Awards Doctoral Research Awards Focus on Stroke Doctoral Research Awards Research Fellowships Focus on Stroke Research Fellowships Research Scholarships New Investigators...37 Distinguished Clinician Scientist Industry-Supported Research Fellowship Awards Appendix C: Grants-in-Aid...41 British Columbia/Yukon Alberta/Northwest Territories/Nunavut Saskatchewan... NA Manitoba Ontario Quebec Nova Scotia Newfoundland and Labrador Appendix D: Research Chairs and Professorships Appendix E: Provincial Personnel Awards Alberta/Northwest Territories/Nunavut British Columbia/ Yukon Ontario Newfoundland and Labrador Appendix F: Other Provincial Initiatives...75 British Columbia/Yukon Alberta/Northwest Territories/Nunavut Manitoba...77 Quebec Nova Scotia Appendix G: Research Committee Members Appendix H: Definition of Health Research Themes iii

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7 Heart & Stroke Foundation Research Report Acknowledgements Each year, individuals across Canada join together to further the Heart & Stroke Foundation (H&S) mission of eliminating heart disease and stroke. Canadians from coast to coast to coast donate valuable resources, including their time, money, and expertise, to improve the health and quality of life of all Canadians. The following groups deserve special thanks: Donors. Providing funds to support heart and stroke research is the first step in a process which culminates in scientific breakthroughs that touch all our lives. The donors and volunteers in every community across Canada that have supported the Foundation s fundraising efforts have made lasting investments in the future health and well being of Canadians. Council on Mission: Priorities, Advice, Science and Strategy (CoMPASS). The Foundation s primary mechanism for informing Mission directions. Comprised of a cadre of thoughtfully selected, dedicated Canadian experts and H&S Mission champions, the CoMPASS mandate is to provide considered and strategic advice on Mission priorities. The members of this committee are identified in Appendix G (page 79). Scientific Review Committees. The scientific and lay reviewers expertise and commitment enable H&S to fund the highest standard of scientific excellence. Exemplary leadership to over 150 volunteer reviewers has been provided by the Scientific Review Committee s Chair and Vice Chair, Drs Rob Beanlands and Glen Tibbits, respectively. The Chairs of H&S vital peer review committees across the Foundation are identified in Appendix G (page 79). 1. Purpose and Scope The purpose of this report is two-fold: 1. To illustrate the Heart & Stroke Foundation s overall research investments made in across all research funding programs and initiatives. 2. To serve as a reference tool for volunteers and staff across the Heart & Stroke Foundation, the research community, other research funding agencies, and academic institutions. This report covers the period from July 1, 2015 to June 30,. It is a snapshot of expenditures in research during that period. The report presents financial and statistical data for new grants and awards made in 2015-, as well as continued funding of previously reported multi-year grants and awards. Heart and Stroke Researchers. Each one of H&S researchers, through extraordinary work, contributes to advancements in the understanding of cardio- and cerebrovascular disease. The knowledge gained from their efforts leads to earlier diagnoses, better treatments and new insights into prevention. Their ongoing commitment to the advancement of knowledge helps H&S move closer to achieving its mission. Partners. A number of organizations collaborated with H&S in 2015-, enabling the Foundation to leverage funding and resources for heart and stroke research. 1

8 Heart & Stroke Foundation Research Report Summary Tables Table 1. Summary Foundation-wide and Province Specific Research Funding (2015-) Province(s)/ Territory(ies) Foundation-wide Research Initiatives Province-specific Research Initiatives Total Grant-in-Aid National Personnel Awards Directed Research Fund Personnel Awards Chairs Other # $ # $ # $ # $ # # $ # $ 20 1,704, , , ,114,620 British Columbia/ Yukon Alberta/Northwest 26 2,047, , , ,449,855 Territories/Nunavut Saskatchewan Manitoba 8 703, , , ,512 Ontario ,694, ,735, ,429,179 Quebec 28 2,405, , ,543,281 New Brunswick Nova Scotia 4 355, , ,283 Prince Edward Island Newfoundland and 1 91, , ,163 Labrador All ** ,000,196* 24 2,200, ,000, ,200,311 TOTAL 210 $18,002, $2,000, $2,200, $2,986, $2,828, $28,018,204 *Includes award stipends and applicable travel and/or allowances. **Denotes competitions/initiatives eligible nationally. H&S contributions to the Canadian Partnership for Stroke Recovery For the most part, Research Chair and Professorship awards are funded by endowments and are partnered with academic / health research institutions. The amounts, therefore, are not shown in the financial charts/summary information provided with this report. 2

9 Heart & Stroke Foundation Research Report Table 2. Detailed Foundation-wide and Province Specific Research Funding (2015-) Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Grant-in-Aid 20 1,704,828 Research Chairs*: Chair in Cardiology Research 1 - Chair in Cardiovascular Prevention Research 1 - Professorship in Clinical Stroke Research 1 - Professorship in Women's Cardiovascular Health 1 - Personnel Awards: Robert Hayden Research Fellowship 1 45,833 Other Provincial Initiatives: H&S-UBC Cardiology Research Partnership: ,959 Cardiology Academic Practice Plan 2,114,620 Alberta/ Grant-in-Aid 26 2,047,855 Northwest Territories/ Nunavut Research Chairs*: Chair in Cardiovascular Research 2 - Chair in Stroke Research 1 - Professorship in Cardiovascular Research 1 - Professorship in Stroke Research 3 - Professorship in Neonatal Resuscitation 1 - Personnel Awards: New Investigators 3 180,000 Other Provincial Initiatives: Seed Grants 5 222,000 2,449,855 Saskatchewan Grant-in-Aid - - Research Chairs*: Chair in Clinical Stroke Research 1-0 Manitoba Grant-in-Aid 8 703,512 Research Chairs*: Chair in Primary Prevention 1 - Personnel Awards: Sanofi Aventis/HSFM Award in Cardiology 1 10,000 Master's Student Award 1 1,000 Dr. Dexter Harvey Award 1 5,000 Other Provincial Initiatives: Primary Prevention Challenge Grant 2 80, ,512 3

10 Heart & Stroke Foundation Research Report Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) Ontario Grant-in-Aid ,694,179 Research Chairs*: Chair in Population Health Research 1 - Chair in Cardiac Nursing 1 - Chair in Cardiovascular Research 5 - Chair in Aboriginal and Rural Health 1 - Personnel Awards: Career Investigator 14 1,079,000 Clinician Scientist 6 450,000 Mid-Career Investigator 14 1,120,000 Summer Student Scholarship 16 86,000 Other Provincial Initiatives: Bridge Grant - - Evelyn McGloin Top-up Award ,429,179 Quebec Grant-in-Aid 28 2,405,538 Other Provincial Initiatives: Awards for Excellence in Research 5 95,000 Training Bursaries 1 42,743 2,543,281 New Brunswick Grant-in-Aid Nova Scotia Grant-in-Aid 4 355,283 Research Chairs*: Chair in Cardiology Research 1 - Other Provincial Initiatives: BrightRed Graduate Research Award 5 25, ,283 Prince Edward Island Grant-in-Aid Newfoundland and Grant-in-Aid 1 91,663 Labrador Graduate Scholarship 1 1,500 Grant NeuroFIT Program 1 3,500 Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship 1 1,500 Undergraduate Nursing Award in Stroke 1 1,500 Undergraduate Nursing Award in Cardiovascular Health 1 1, ,163 SUBTOTAL ,817,893 21,817,893 Directed Research Fund 24 2,200,115 2,200,115 National Personnel Awards 54 2,000,196 2,000,196 H&S Canadian Partnership for Stroke Recovery - 2,000,000 2,000,000 TOTAL 405 $28,018,204 28,018,204 * For the most part, Research Chair and Professorship awards are funded by endowments and are partnered with academic / health research institutions. Includes award stipends and applicable travel and/or allowances. H&S contributions to the Canadian Partnership for Stroke Recovery. 4

11 Heart & Stroke Foundation Research Report Research Funding Overview 3.1 Scientific Review Process Scientific peer review is the cornerstone of the Foundation s research enterprise. All research funded by H&S, at a national or provincial level, undergoes peer review and must meet criteria for scientific rigor. The purpose of peer review is to ensure excellence in research funded by H&S. Peer review is carried out by committees of experts (peer review committees) that encompasses all four themes of health research (basic biomedical, clinical, health services/systems, and social, cultural, environmental and population health). The Foundation s peer review is overseen by the Scientific Review Committee (SRC), an advisory committee. For recurring competitions, standing peer review committees are formed, and committee members are recruited for a term of service (typically three years) in order to ensure consistency and continuity in the review process. Standing committee membership may be supplemented by additional members as required, based on the applications received and expertise needed for their review. For ad hoc competitions, committees are formed to review applications for that particular competition and then disbanded. A typical SRC peer review committee consists of a Chair, Deputy Chair, scientific peer reviewers, H&S staff secretariat and other specialized roles, such as lay reviewers or knowledge users, depending on the funding opportunity. Committee members are selected for their high levels of expertise related to the mandate of the review committee and their experience in evaluating and reviewing research funding applications. In addition, membership balances expertise, and ensure that each committee has the capacity to review applications submitted in English or French. Peer review meetings are held in English, but internal and external reviewers are assigned with linguistic abilities in mind. Standard Steps in Peer Review Process: External reviewers supplement the expertise of the panels and provide written comments on the application submitted. The Foundation relies on the support and commitment of many researchers across Canada and internationally to ensure this process is effective. 3. Peer review meetings are held in December through to March where the applications are discussed. The Chair or Deputy Chair writes an SRC report which summarizes the discussion and the application is rated. 4. Based on the ratings/rankings as well as available funds, the Foundation determines which Grants and Awards will be funded. In 2015-, over 150 of Canada s top cardio- and cerebrovascular scientists participated on the SRC. 3.2 Research Enterprise Components The H&S research enterprise contains four key parts presented in Figure 1. The Grant-in-Aid program (research project operating grants); the National Personnel Awards program (salary awards at doctoral, post doctoral, and new investigator levels); the Directed Research Fund initiatives (strategic research initiatives primarily in partnership with other funding agencies); and provincial research initiatives (personnel awards, program grants, and other programs). Figure 1. H&S Research Funding by Program (2015-) Grant-in-Aid $18,002,858 64% Provincial Research Initiatives $5,815,035 21% Directed Research Fund $2,200,115 8% National Personnel Awards $2,000,196 7% 1. Applications submitted to the Heart & Stroke Foundation are administratively reviewed and sorted into their appropriate committee. 2. An allocation meeting to distribute applications is held. The Chair and Deputy Chair of the committee select two internal reviewers (and any required external reviewers) for each application. Internal reviewers are members of the Scientific Review Committee who meet face to face whereas external reviewers are members of the scientific community across Canada and internationally selected for their particular expertise. 5

12 Heart & Stroke Foundation Research Report Figure 2. H&S Research Funding Trends by Program (2011-) Numbers represent $ Millions Directed Research Fund National Personnel Awards Investments across Health Research Themes Research supported by H&S spans the four health research themes: basic biomedical, clinical, health services/systems, and social, cultural, environmental and population health (defined in Appendix H). Figures 3 and 4 show the relative H&S investments across health Clinical research themes. Further in the report, funding by health research 24% theme in each of the Foundation- wide programs is presented. Currently, we do not have data on provincial initiatives by theme. Figure 3. H&S Research Funding by Health Research Theme (2015-) Basic Biomedical 65% S Clinical 24% H S E P 8% Grant-in-Aid Health Services/ Systems 3% Basic Biomedical 65% Social, Cultural, Environmental and Population Health 8% Provincial Research Initiatives Includes Directed Research Fund, National Personnel Awards (stipends only), and Grant-in-Aid funding. Total Does not include Chair and Professorship values. Includes Heart & Stroke Foundation Canadian Partnership for Stroke Recovery value. 6

13 Heart & Stroke Foundation Research Report Figure 4. H&S Research Funding Trends by Health Research Theme (2011-) Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Social, Cultural, Environmental and Population Health Includes Directed Research Fund, National Personnel Awards (stipends only), and Grant-in-Aid funding Research Funding by Program This section provides summary information for each of the four main components of the H&S research enterprise: Foundation-wide research programs: 1. Directed Research Fund 2. National Personnel Awards 3. Grant-in-Aid 4. Province-specific research initiatives: i. Provincial Research Chairs and Professorships ii. Provincial Personnel Awards iii. Other Provincial Research Initiatives 4.1 Directed Research Fund The Directed Research Fund (DRF) supports research in areas of strategic priority to the Foundation, typically through a Request for Applications process, and in partnership with other agencies and organizations. New initiative appearing in this year s report: 1) Population-Level Nutrition Interventions: The purpose of this initiative is to focus on generating evidence about the impact of nutrition on population-level policy and/or program interventions. Ultimately, funded projects should contribute to primary prevention of heart disease and stroke within and/or applicable to Canadian contexts and populations. The intent is to generate evidence for decision-makers who require relevant research to inform policies and programs. 2) Emerging Research Leaders Initiative (ERLI): ERLI is an establishment grant program for researchers at the transition stage from post doctoral fellow to early professional career stage in the areas of cardiovascular, cerebrovascular, and/ or respiratory health research. This initiative aims to support successful early career launch of new investigators. Through this initiative, partners will provide establishment grant funds that will create a set of conditions conducive to the successful career launch of emerging research leaders in the cardiovascular, cerebrovascular, and/or respiratory health research domains. 7

14 Heart & Stroke Foundation Research Report Services/ s 3% 3) Canadian Resuscitation Outcomes Consortium (CanROC): The overall goal is 3.7 to improve the outcomes of out-of-hospital cardiac arrest (OHCA) 4.7 and trauma patients, both adult and paediatric. The plan is to create a Canadian version of ROC (CanROC) that is more national in breadth and that can stand 3.3 alone to perform intervention studies in OHCA and major trauma, as well as 2.6to also collaborate with US-ROC and other international partners. The 8.0goal is to advance the capacity, competitiveness, and impact of resuscitation clinical research conducted in Canada The majority of the projects listed in Appendix A represent the continuation of previously reported research investments. A total 11.4 of 10 initiatives, representing 24 individual grants and awards, are detailed in Appendix A. The total value of the Foundation s investment in these strategic projects for is over $2.2 million. In addition to the Foundation s investment, partner funds have further extended the DRF research portfolio, leveraging donors dollars. As outlined in Figure 5, Foundation funding is leveraged by a ratio of five to one. Over a 5 year period, the Foundation has taken steps Clinical 41% to more fully align the DRF s investments with the strategic mission priorities of the Foundation. Figure 5. Directed Research Fund Leveraged Funding (2011-) ural, ntal and Health 53% Numbers represent Basic $ Millions Biomedical 3% HSFC Partner(s) Figure 6. Directed Research Fund Funding by Health Research Theme (2015-) Health Services/ Systems 3% Social, Cultural, Environmental and Population Health 53% Clinical 41% Figure 7. Directed Research Fund Funding Trends by Health Research Theme (2011-) Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Basic Biomedical 3% Social, Cultur and Populati Ba Bi 57 eng Social, Cultural, Environmental and Population Health One of the objectives of the DRF is to support multidisciplinary research in the areas of health services/systems and social, cultural, environmental and population health. Figures 6 and 7 illustrate significant progress in achieving this objective while remaining responsive across health research themes Total fig 7 eng

15 Heart & Stroke Foundation Research Report National Personnel Awards National Personnel Awards build Canada s cardio- and cerebrovascular research capacity by providing salary support to investigators at early scientific career stages. Heart & Stroke did not launch a new competition for National Personnel Awards. However, existing awards continued being funded in These programs included Distinguished Clinician Scientist, New Investigator, Research Scholarship, Research Fellowship and Doctoral Research Award. Focus on Stroke Initiative The emphasis of this award is on building capacity in the later themes/pillars of stroke research (i.e., clinical, health services/policy, and/ or social, cultural, environmental and population health) and supporting research training of health professionals (e.g. nurses, occupational therapists, pharmacists, physiotherapists, speech therapists). This initiative is offered through Doctoral Research Awards, Research Fellowships, and Research Scholarships. National Personnel Awards Programs in Distinguished Clinician Scientist A salary award to support clinical new investigators who wish to establish their own independent research laboratory. This award is given to the highest ranked eligible clinician in the New Investigator competition ($75,000 stipend + $25,000 research allowance per year for five years, including fringe benefits). New Investigator A salary award to support new investigators who wish to establish their own independent research laboratory ($60,000 per year for five years, including fringe benefits). Research Scholarship A salary award intended for individuals with a Masters and/or PhD and with credential(s) in a regulated accredited health discipline. The applicant must hold a faculty appointment and have less than 5 years research experience. ($45,000 + $5,000 research allowance, per year for two years). In 2015-, there were 54 continuing awards. This included two awards supported in part by industry. The total H&S investment in National Personnel Awards in was over $2 million (Table 3). A list of award recipients can be found in Appendix B. Table 3. Number of National Personnel Awards and Investment of Funds (2015-) Program Recipients (#) Funds Invested ($) Distinguished Clinician Scientist 3 200,000 New Investigator ,000 Research Scholarship 1 45,000 Research Fellowship ,728 Doctoral Research Award ,375 Research Allowance - 75,000 Travel Allowance - 22,093 TOTAL 54 $2,000,196 Research Fellowship A training award for applicants who have completed a doctorate level professional degree, MD or PhD ($40,000 or $50,000 + $1,500 travel allowance per year for up to two or three years, depending upon eligibility). Doctoral Research Award A training award for graduate students, enrolled in a PhD program, who are undertaking full-time research training ($21,000 + $1,000 travel allowance per year for up to three years). Additional salary support was offered through the Focus on Stroke initiative. 9

16 Heart & Stroke Foundation Research Report Table 4. National Personnel Awards by Health Research Theme (2015-) Type of Award Basic Biomedical Clinical Health Services/ Systems Social, Cultural, Environmental and Population Health Total (#) ($) (#) ($) (#) ($) (#) ($) (#) ($) Distinguished Clinician , , , , ,000 Scientist New Investigator , , , , ,000 Research Scholarship , , ,000 Research Fellowship , , , , ,728 Doctoral Research Awards , , ,375 TOTAL 31.9 $1,080, $653, $140, $28, $1,903,103 Includes award stipends only. Figure 8. National Personnel Awards Funding by Health Research Theme (2015-) Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2011-) ronmental th 2% Social, Cultural, Environmental and Population Health 2% Health Services/ Systems 7% Health Services/ Systems 7% Clinical 34% Numbers represent $ Millions Basic Biomedical Basic Clinical Biomedical 34% 57% Includes award stipends only Clinical Alta./N al Health Services/Systems Social, Cultural, Environmental and Population Health eng Includes award stipends Total only Canadians st

17 Heart & Stroke Foundation Research Report edical 4.3 Grant-in-Aid Grants-in-Aid form the largest category of research expenditure for the Heart & Stroke Foundation. The Grant-in-Aid program supports the direct operating costs of conducting research, including laboratory supplies, technicians, and some equipment. In 2015-, 210 Grants-in-Aid (new and continuing) were funded, representing an investment of over $18 million (Table 5). A list of grant recipients can be found in Appendix C. Clinical Table 5. Number 20% of Grants-in-Aid and Investment of Funds (2015-) Health Services/ Province(s)/Territory(ies) Systems Recipients 3% (#) Funds Invested ($) British Columbia/Yukon 20 1,704,828 Alberta/Northwest Territories/Nunavut Social, Cultural, Environmental and Population Health 264% 2,047,855 Saskatchewan - - Manitoba 8 703,512 Ontario ,694,179 Quebec 28 2,405,538 New Brunswick - - Nova Scotia 4 355,283 Prince-Edward-Island - - Newfoundland and Labrador 1 91,663 TOTAL 210 $18,002,858 Figure 10. Grant-in-Aid Funding by Health Research Theme (2015-) Figure 11. Grant-in-Aid Funding Trends by Health Research Theme (2011-) Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Social, Cultural, Environmental and Population Health Clinical 20% Health Services/ Systems 3% Total The number of applications submitted and funded in the Grant-in-Aid 29.8 program varies widely across provinces (Figures 12 and 13). The 26.3 overall success rate for the Grant-in-Aid 21.7 competition in was approximately 15% Social, Cultural, Environmental and Population Health 4% Basic Biomedical 73% 11

18 12 Heart & Stroke Foundation Research Report Figure 12. Number of Grant-in-Aid Applications Submitted by Province/Territory (2011-) Figure 13. Number of Grant-in-Aid Applications Funded by Province/Territory (2011-) N.L. P.E.I. N.S. N.B. Que. Ont. Man. Sask. Alta./N.W.T./Nunavut B.C./Yukon Numbers represent $ Millions P.E.I. N.S. N.B. Que. Ont. Man. Sask. Alta./N.W.T./Nunavut B.C./Yukon Numbers represent $ Millions N.L. P.E.I. N.S. N.B. Que. Ont. Man. Sask. Alta./N.W.T./Nunavut B.C./Yukon

19 Heart & Stroke Foundation Research Report Province Specific Research Initiatives In addition to the Grant-in-Aid program, many of the provincial offices administer Research Chairs and Professorships; provincial Personnel Awards; and other research initiatives Research Chairs and Professorships Research Chair and Professorships funding provides salary, research and infrastructure support to enable a leading researcher to develop a particular research focus at a Canadian university. In a total of 23 Chairs and Professorships were supported by H&S in the areas of aboriginal and rural health, cardiology, cardiac nursing, stroke, neonatal resuscitation, population health and primary prevention. The recipients of these Chairs and Professorships can be found in Appendix D. Table 6. Research Chairs and Professorships (2015-) Province(s)/Territory(ies) Program Awards (#) Total (#) British Columbia/Yukon Chair in Cardiology Research 1 Chair in Cardiovascular Prevention Research 1 Professorship in Clinical Stroke Research 1 Professorship in Women's Cardiovascular Health 1 4 Alberta/Northwest Territories/Nunavut Chair in Cardiology Research 2 Chair in Stroke Research 1 Professorship in Cardiology Research 1 Professorship in Stroke Research 3 Professorship in Neonatal Resuscitation 1 8 Saskatchewan Chair in Clinical Stroke Research 1 1 Manitoba Chair in Primary Prevention 1 1 Ontario Chair in Population Health Research 1 Chair in Cardiac Nursing 1 Chair in Cardiovascular Research 5 Chair in Aboriginal and Rural Health 1 8 Quebec New Brunswick Nova Scotia Chair in Cardiology Research 1 1 Prince Edward Island Newfoundland and Labrador TOTAL For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions. 13

20 Heart & Stroke Foundation Research Report Provincial Personnel Awards In 2015-, the provincial offices funded a total of 62 Personnel Awards, building capacity by supporting cardio- and cerebrovascular researchers throughout their careers, from high school students working in research settings to established senior scientists (Table 7). The recipients of these awards can be found in Appendix E. Table 7. H&S Provincial Personnel Awards Funded (2015-) Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Robert Hayden Research Fellowship 1 45,833 45,833 Alberta/Northwest Territories/Nunavut New Investigator 3 180, ,000 Saskatchewan Manitoba Sanofi Aventis/HSFM Award in Cardiology 1 10,000 Master's Student Award 1 1,000 Dr. Dexter Harvey Award 1 5,000 16,000 Ontario Career Investigator 14 1,079,000 Clinician Scientist 6 450,000 Mid-Career Investigator 14 1,120,000 Summer Student Scholarship 16 86,000 2,735,000 Quebec New Brunswick Nova Scotia Prince Edward Island Newfoundland and Labrador Graduate Scholarship 1 1,500 Grant - NeuroFIT Program 1 3,500 Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship 1 1,500 Undergraduate Nursing Award in Stroke 1 1,500 Undergraduate Nursing Award in Cardiovascular Health 1 1,500 9,500 TOTAL 62 $2,986,333 $2,986,333 14

21 Heart & Stroke Foundation Research Report Description of Provincial Personnel Awards Heart & Stroke Foundation, British Columbia/Yukon (HSF,BCY) Robert Hayden Research Fellowship The Robert Hayden Research Fellowship was established to promote cardiovascular outcomes research that utilizes the rich clinical data in to improve cardiovascular care in British Columbia. The award will provide a stipend and travel allowance to support a post-doctoral fellow using data in their research project. The successful candidate will be provided with a workspace at ICVHealth in Vancouver and work collaboratively with epidemiologists, biostatisticians and knowledge translation experts. Heart & Stroke Foundation, Alberta/Northwest Territories/Nunavut (HSF,A) New Investigator The New Investigator Awards aim to provide outstanding Alberta investigators in their early career with the opportunity to establish research programs and build teams through provision of a contribution to their group research efforts, laboratories or salary. The intent is to foster research excellence and support retention of outstanding talents in Alberta. This initiative provides salary support to excellent Alberta applicants whose innovative research plans have demonstrated strong potential to deliver impact on the H&S mission. The applicants are expected to demonstrate that their overall research program and plan have a cardio or cerebrovascular focus. Heart & Stroke Foundation, Manitoba (HSF,M) Sanofi / Heart and Stroke Foundation of Manitoba Award in Cardiology This $10,000 award is given to stimulate and support excellence in research and scholarly activity in the discipline of Cardiology at the Manitoba. The award funds a clinical cardiology resident, preferably in their third year, who demonstrates academic excellence within the clinical residency program, possesses humanistic qualities with respect to patient care, collegiality and interpersonal dealings with medical and paramedical staff, has clinical competence in the field, and is expected to pursue further academic training beyond core cardiology. ICS (Institute of Cardiovascular Sciences) Master s Student Award This award was established by HSF,M to encourage the training of young investigators in cardiovascular sciences in Manitoba and to recognize the achievements of a student at the Master s level. The award total is $1,000. Dr. Dexter Harvey Award This $5,000 award encourages and supports training for outstanding Master s or PhD students enrolled in a Manitoba university program whose research focuses on primary prevention risk factor reduction in the areas of physical inactivity, excess weight and tobacco smoking. The annual award was named after retired H&S board member, Dr. Dexter Harvey, whose dedication to improving the public health and well-being of Manitobans has been demonstrated through his 30-year commitment as a senior volunteer with the Foundation. Heart & Stroke Foundation, Ontario (HSF,O) Career Investigator Stipend support for up to five years for investigators of national/international stature. Clinician Scientist Phase 1 Stipend support for up to four years, to provide clinician-scientists who are within 4 years of their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Clinician Scientist Phase 2 Stipend support for up to three years, to provide clinician-scientists within no fewer than 4, and no more than 8 years since their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Mid-Career Investigator Stipend support for up to four years, to provide investigators within no fewer than 8, and no more than 18 years since their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Summer Student Scholarship: Medical Student Award Stipend support for up to four months for medical students to conduct cardioor cerebrovascular research with mentorship from established investigators. Heart & Stroke Foundation, Newfoundland and Labrador (HSF,NL) Graduate Scholarship This scholarship, valued at $1,000 per annum, is awarded to a full-time graduate level student in the Faculty of Medicine, who is pursuing a research program related to cardiovascular disease. Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship This scholarship, valued at $1,500 per annum, was established through a generous contribution by the Griffiths family, in memory of their father, Keith Griffiths, a stroke survivor and dedicated volunteer, and in partnership with the Heart & Stroke Foundation. The scholarship is awarded to a full-time graduate level student in the Faculty of Medicine, who is pursuing a research program in stroke or neurological issues related to stroke. 15

22 Heart & Stroke Foundation Research Report Undergraduate Nursing Award in Stroke This scholarship, valued at $1,500 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in patient health related to stroke care, have actively volunteered with the Heart & Stroke Foundation and also have met the minimum academic requirements for an award Other Provincial Initiatives In 2015-, the provincial offices funded a wide variety of other research initiatives. Table 8 provides details of these initiatives and a list of recipients can be found in Appendix F. Undergraduate Nursing Award in Cardiovascular Health This scholarship, valued at $1,500 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in cardiovascular health, have actively volunteered with the Heart & Stroke Foundation and also have met the minimum academic requirements for an award. Grant NeuroFIT Program Neurofit is a community-based exercise re-integration initiative for people with major neurological physical and cognitive impairments due to stroke, Multiple Sclerosis, Parkinson s Disease, traumatic brain injury and hereditary neurological diseases. It is the only program of it s kind in Newfoundland and Labrador. Table 8. Other Provincial Research Initiatives (2015-) Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon H&S-UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) ,000 Knowledge to Action Grants 3 98,959 Bridge Grant 1 65, ,959 Alberta/Northwest Territories/Nunavut Seed Grants 5 222, ,000 Saskatchewan Manitoba Primary Prevention Challenge Grant 2 80,000 80,000 Ontario Bridge Grant Quebec Awards for Excellence in Research 5 95,000 Training Bursaries 1 42, ,743 New Brunswick Nova Scotia BrightRed Graduate Research Award 5 25,000 25,000 Prince Edward Island Newfoundland and Labrador Heart & Stroke Foundation Canadian Partnership for Stroke Recovery - 2,000,000 2,000,000 TOTAL 32 $2,828,701 $2,828,701 H&S contributions to the Canadian Partnership for Stroke Recovery. 16

23 Heart & Stroke Foundation Research Report Description of Other Provincial Research Initiatives Heart & Stroke Foundation, British Columbia/Yukon (HSF,BCY) HSF- UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) As part of its mandate to support innovative research and its application to improve the health of Canadians, Heart & Stroke Foundation, BC & Yukon, has partnered with the British Columbia s Division of Cardiology to support research by early career cardiologists. By providing grant support that will protect the research time of awardees, the academic practice plan will cultivate academic capacity, supporting increased clinical research and education. This will in turn strengthen the recruitment and retention of outstanding early career physicians in British Columbia. Knowledge to Action Grants HSF Knowledge to Action (KTA) Grants provide support for the practical application of knowledge generated by research operating grants. Their focus is on promoting collaboration between researchers and practitioners (i.e. knowledge users) in the clinic or in the community or policy arena to facilitate the implementation of research findings to improve clinical practice, patient outcomes and/or health in the community at a local or population level. KTA Grants are delivered in two ways: a) Knowledge to Action Grants I Support for knowledge translation and dissemination through meetings and conferences that bring together researchers and practitioners. Funding will also contribute to support the development of interdisciplinary teams, collaborations, and networks involving researchers and practitioners. KTA I Grants focus mainly but not exclusively on identified emerging areas of strength in cardio- and cerebrovascular research in BC: Physical activity/nutrition/obesity, cardiac and stroke rehabilitation and treatment, and social and clinical factors in cardio- and cerebrovascular disease. The implementation setting may be the clinic, a school, community, workplace, or another environment in which an intervention holds the potential to improve cardio- and cerebrovascular health. Bridge Grant The Bridge Grant was part of a special initiative offered by the BC & Yukon Provincial Office of the Heart & Stroke Foundation in the funding year. This was a short-term grant used to support eligible direct research expenses as per the H&S guidelines. Bridge funding was offered to a BC-based Grant-in-Aid (GIA) applicant whose funding proposal was ranked highly based on percentile standing in their Scientific Review Committee, but did not meet the national GIA funding cut-off. Heart & Stroke Foundation, Alberta (HSF,A) Seed Grant Seed Grants provide funding support to New Investigators to conduct research which will lay the groundwork for a new and competitive peer-reviewed application. The intent is to enhance Alberta success in national and provincial granting competitions. This initiative provides opportunity for investigators to develop high-impact novel ideas and encourages innovative research with the potential for significant impact on cardio and/or cerebrovascular health. Heart & Stroke Foundation, Manitoba (HSF,M) Primary Prevention Challenge Grant As part of its commitment to primary prevention research, the Heart & Stroke Foundation, Manitoba allocated funds towards the Primary Prevention Challenge Grant program to support innovate and unique projects that have direct policy and/or practice relevance and application to reducing risk factors at a population level in Manitoba. The program builds on the findings of Making the Case for Primary Prevention: An Economic Analysis of Risk Factors in Manitoba, which clearly demonstrated the need to reduce the prevalence of risk factors for chronic disease which will reduce health care costs and improve population health. b) Knowledge to Action Grants II Support for individuals or teams to put evidence generated through operating grants (from any source) in cardio- and/or cerebrovascular health into practice in clinical or community settings in British Columbia and Yukon. This may include pilot projects or implementation of systemic changes. KTA II Grants provide support for an integrated process in which researchers collaborate with practitioners in the relevant setting to design and shape the implementation of the intervention and report on its outcomes and the potential for wider uptake or application. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 17

24 Heart & Stroke Foundation Research Report Heart & Stroke Foundation, Quebec (HSF,Q) Awards for Excellence in Research A number of Awards for Excellence in Research are awarded each year by HSF,Q mostly in partnership with individual and corporate donors. These awards are in partnership with the Grant-in-Aid program to support Quebec researchers. The awards range from $5,000 to $50,000. Training Bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de la recherche du Québec en santé (FRQS) and the Heart & Stroke Foundation, Québec (HSF,Q). The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart & Stroke Foundation, Québec (HSF,Q). Heart & Stroke Foundation, Nova Scotia (HSF,NS) BrightRed Student Research Award The BrightRed Student Research Awards Program recognizes excellent emerging cardiovascular and cerebrovascular researchers in Nova Scotia at differing stages of career development, by providing financial support to students and trainees enrolled in research-based Masters, Doctorate, or Postdoctorate programs at academic institutions in Nova Scotia. 18

25 Appendix A Directed Research Fund Photo: Dr. Sylvia Santosa (Concordia ) was a recipient of a Emerging Research Leaders Initiative grant.

26 Heart & Stroke Foundation Research Report New Initiatives Population-Level Nutrition Interventions Partner(s): H&S. Total Initiative Funding: $779,346 Total H&S Funding: $779,346 Description: The purpose of this initiative is to focus on generating evidence about the impact on nutrition of population-level policy and/or program interventions. Ultimately, funded projects should contribute to primary prevention of heart disease and stroke within and/or applicable to Canadian contexts and populations. The intent is to generate evidence for decision-makers who require relevant research to inform policies and programs. Population-Level Nutrition Interventions Principal Investigator(s) L Abbé, Mary R. Naylor, Patti-Jean Vatanparast, Hassanali Research Institution Toronto Victoria Saskatchewan Project Co-Investigator(s) Term $ Total $ H&S (All Partners) Total $ Total $ Theme(s) H&S (All Partners) ,971 72, , ,640 IV ,700 99, , ,630 IV FoodSwitch: testing the effectiveness of a food information app to promote the selection Ontario: Lou, Wen-Yi Wendy W; Quebec: Dubé, Laurette of healthier foods. Eat, play, live: a British Columbia: population intervention Mâsse, Louise C.; to promote Alberta: Olstad, Dana; nutrition guideline Nova Scotia: Kirk, implementation in Sara; Langille, recreation facilities Jessie-Lee; across three Canadian Ontario: Hanning, provinces. Rhona The impact of Saskatchewan: Health-Start-Depart- Engler-Stringer, Sante intervention Rachel; Froehlich on improving dietary Chow, Amanda; intake of 3-5 year-old Humbert, Margaret children attending Louise; Muhajarine, childcare centers in Nazeem; Osgood, Saskatchewan and Nathaniel D.; Szafron, New Brunswick. Michael; Quebec: Bélanger, Mathieu ,400 94, , ,076 III, IV 20

27 Heart & Stroke Foundation Research Report Emerging Research Leaders Initiative (ERLI) Partner(s): Canadian Respiratory Research Network; Canadian Stroke Prevention Intervention Network; Canadian Vascular Network; AllerGen NCE; Brain Canada Foundation; New Brunswick Health Research Foundation; Pfizer Canada Inc.; Canadian Cardiovascular Society; Canadian Institutes of Health Research; H&S. Total Initiative Funding: $1,195,038 Total H&S Funding: $373,934 Description: ERLI is an establishment grant program for researchers at the transition stage from post doctoral fellow to early professional career stage in the areas of cardiovascular, cerebrovascular, and/or respiratory health research. This initiative aims to support successful early career launch of new investigators. Through this initiative, partners will provide establishment grant funds that will create a set of conditions conducive to the successful career launch of emerging research leaders in the cardiovascular, cerebrovascular, and/or respiratory health research domains. Emerging Research Leaders Initiative (ERLI) Principal Investigator(s) Arcand, JoAnne L. Brunham, Liam R. de Azeredo Coutinho, Thais Kramer, Caroline Sandhu, Roopinder Santosa, Sylvia Research Institution of Ontario Institute of Technology of British Columbia Ottawa Heart Institute Mount Sinai Hospital Alberta Concordia Project Mentor(s) Term $ Total $ Total $ H&S (All Partners) H&S Evaluation of web-based dietary screening tools in the management of cardiovascular risk factors. Genomic markers of cerebral small vessel ischemia. Investigating the pathogenesis and clinical applications of arterial health in cardiovascular diseases. Longitudinal course of metabolic health across the full spectrum of body weight. Improving stroke prevention in atrial fibrillation through pharmacist prescribing: PIAAF Rx Study. Acute and chronic effects of obesity on cardiovascular disease risk factors. Total $ Theme(s) (All Partners) Floras, John S.; , ,762 II,III,IV L Abbé, Mary R. Khan, Nadia A ,710 49,420 74, ,260 I,II Beanlands, Rob S.B , ,927 II Retnakaran, Ravi R.; ,000 50, , ,804 I,II Zinman, Bernard McAlister, Finlay A , ,000 II,III Bacon, Simon L.; ,000 50, , ,000 I,II Morais, José A. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 21

28 Heart & Stroke Foundation Research Report Principal Investigator(s) West, Christopher Wilton, Stephen Research Institution of British Columbia Calgary Project Mentor(s) Term $ Total $ Total $ Total $ Theme(s) H&S (All Partners) H&S (All Partners) Habitual physical activity, exercise and cardiovascular function in spinal cord injury. An individualized shared decision-making intervention for atrial fibrillation stroke prevention. Sheel, Andrew W , ,282 I,II Ghali, William A.; , ,003 II,III Sheldon, Robert S. 22

29 Heart & Stroke Foundation Research Report Canadian Resuscitation Outcomes Consortium (CanROC) Partner(s): The CIHR Institute of Circulatory and Respiratory Health and H&S. Total Initiative Funding: $3,000,000 Total H&S Funding: $1,500,000 Description: The overall goal is to improve the outcomes of out-of-hospital cardiac arrest (OHCA) and trauma patients, both adult and paediatric. The plan is to create a Canadian version of ROC (CanROC) that is more national in breadth and that can stand alone to perform intervention studies in OHCA and major trauma, as well as to also collaborate with US-ROC and other international partners. The goal is to advance the capacity, competitiveness, and impact of resuscitation clinical research conducted in Canada. Canadian Resuscitation Outcomes Consortium (CanROC) Principal Investigator(s) Christenson, James M Morrison, Laurie J. Stiell, Ian G. Research Institution of British Columbia St. Michael s Hospital Ottawa Hospital-Civic Campus Project Co-Investigator(s) Term $ Total $ H&S (All Partners) CanROC - Canadian British Columbia: Resuscitation Ramanathan, Outcomes Consortium: Krishnan Toward a National Resuscitation Clinical Research Network. CanROC - Canadian Ontario: Nascimento, Resuscitation Barto; Scales, Outcomes Consortium: Damon; Hutchinson, Toward a National Jamie; Dainty, Katie; Resuscitation Clinical Parker, Melissa; Research Network. Dorian, Paul; Verbeek, Rick; Rizoli, Sandro; Cheskes, Sheldon; Brooks, Steve; Lin, Steve CanROC - Canadian Ontario: Vaillancourt, Resuscitation Christian; Wells, Outcomes Consortium: George; Osmond, Toward a National Martin Resuscitation Clinical Research Network. Total $ Total $ Theme(s) H&S (All Partners) , , , ,000 IV ,000-1,500,000 IV , , , ,000 IV 2020 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 23

30 Heart & Stroke Foundation Research Report Continuing Initiatives Operating Grant: Population Health Intervention Research Partner(s): The CIHR Institute of Population and Public Health and H&S. Total Initiative Funding: $400,000 Total H&S Funding: $400,000 Description: The purpose of this funding opportunity is to support the prompt initiation of population health intervention research on rapidly unfolding programs, policies and resource distribution approaches that have been initiated by others (e.g., policy makers) and have the potential to impact health and health equity at the population level. Operating Grant: Population Health Intervention Research Principal Investigator(s) Clavier, Carole Kirk, Sara Research Institution Université de Québec à Montreal Dalhousie Project Co-Investigator(s) Term $ Total $ Total $ Total $ Theme(s) H&S (All Partners) H&S (All Partners) Comparing healthy Ontario: Poland, public policies: Active Blake; Savan, Beth; transportation policies Quebec: Bilodeau, in Montreal and Toronto. Angèle; Divay, Gerard Health eating in Alberta: Olstad, recreation and sport Dana; Raine, Kim D.; settings. British Columbia: Naylor, Patti-Jean; Nova Scotia: McIsaac (Langille), Jessie-Lee; Rehman, Laurene; Shearer, Cindy L , , , ,000 IV , , , ,000 IV 24

31 Heart & Stroke Foundation Research Report Coalitions Linking Action and Science for Prevention 2 (CLASP2) Partner(s): Canadian Partnership Against Cancer and H&S. Total Initiative Funding: $4,697,268 Total H&S Funding: $1,200,000 Description: The CLASP2 initiative is a priority initiative of CPAC. CLASP2 brings together research, practice and policy specialists working across provinces and territories to form multidisciplinary coalitions working to improve the health of Canadians by preventing cancer and chronic disease. Coalitions Linking Action and Science for Prevention 2 (CLASP2) Principal Investigator(s) Collins, Mary Oh, Paul Research Institution BC Healthy Living Alliance Toronto Rehabilitation Institute Project Co-Investigator(s) Term $ Total $ H&S (All Partners) Total $ Total $ Theme(s) H&S (All Partners) Working on Wellness in Strategic Populations (WOW). N/A , , ,000 2,297,270 III,IV Activity, Smoking N/A , , ,000 2,399,998 III,IV Cessation, Healthy Eating and Alcohol Intervention & Motivation Program (ACCELERATION). Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 25

32 Heart & Stroke Foundation Research Report Canadian Alliance for Healthy Hearts and Minds (CAHHM) Partner(s): Canadian Partnership Against Cancer; H&S. Total Initiative Funding: $15,998,465 Total H&S Funding: $1,999,852 Description: CAHHM is a pan-canadian, multi-ethnic cohort (South Asian, Asian and African descent) study which will enroll predominantly healthy men and women between the ages of 35 to 69 years. CAHHM primarily aims to increase our understanding of the impact of the individual, socio-economic and other environmental factors leading to cardiac and vascular disease. The H&S provides support to the overall initiative, and specifically includes an aboriginal component that would otherwise not be included. Canadian Alliance for Healthy Hearts and Minds (CAHHM) Principal Investigator(s) Anand, Sonia S.; Friedrich, Matthias; Tu, Jack Research Institution McMaster Project Co-Investigator(s) Term $ H&S Total $ (All Partners) Total $ H&S Total $ (All Partners) Theme(s) The Canadian Alliance Alberta: Anderson, ,000 4,511,149 1,999,852 15,998,465 II, IV for Healthy Hearts Todd; Smith, Eric and Minds. British Columbia: McManus, Bruce Nova Scotia: Blanchard, Christopher Ontario: Jenkins, David; Moody, Alan; Roberts, Bob Quebec: Despres, Jean-Pierre; Tsoukas, Chris 26

33 Heart & Stroke Foundation Research Report Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN) Partner(s): The CIHR Institute of Circulatory and Respiratory Health and the Institute of Aging; H&S. Total Initiative Funding: $18,520,000 Total H&S Funding: $1,000,000 Description: The ultimate goal of an Emerging Network will be to generate new knowledge and bridge gaps between research and outcomes by contributing to one or more of the following: identifying key knowledge gaps, promoting national and international collaborations among scientists from all themes to address those gaps in a coherent fashion by sharing ideas, tools, methods, and scarce resources, accelerating translation of biomedical discoveries into clinical applications and best practices as well as; to the marketplace; developing, validating, and implementing an intervention that changes a significant aspect of practice; and evaluating outcomes to demonstrate impact. The Canadian Stroke Prevention Intervention Network (C-SPIN) stems from the necessity to develop relevant and integrated stroke-prevention strategies to reduce embolic strokes across Canada and address the specific challenges of our population. Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN) Principal Investigator(s) Healey, Jeff S.; Sheldon, Robert S. Research Institution McMaster Project Co-Investigator(s) Term $ H&S Total $ (All Partners) Total $ H&S Total $ (All Partners) Theme(s) Canadian Atrial Alberta: Wilton, ,000 4,125,000 1,000,000 18,520,000 II Fibrillation Stroke Stephen; Sandhu, 2019 Prevention Intervention Roopinder; Quinn, Network (CAF-SPIN) Francis Russell; McRae, Andrew; Hill, Michael D; Exner, Derek V British Columbia: Krahn, Andrew D.; Andrade, Jason G.; Tang, Anthony S.L. Nova Scotia: Parkash, Ratika Ontario: Whitlock, Richard P; Verma, Atul; Tobe, Sheldon W.; Thabane, Lehana; Sharma, Mukul; Redfearn, Damian Paul P; Nieuwlaat, Robby; Morillo, Carlos A; Meshkat, Nazanin; Ivers, Noah; Hart, Robert; Ha, Andrew C.T.; Graham, Ian D.; Goeree, Ron; Gladstone, David J.; Dolovich, Lisa R; Connolly, Stuart J; Atzema, Clare L.; Dorian, Paul; Birnie, David H Quebec: Talajic, Mario; Philippon, François; Khairy, Paul; Huynh, Thao T; Essebag, Vidal Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 27

34 Heart & Stroke Foundation Research Report HSFC/CIHR Chair in Hypertension Prevention and Control Partner(s): CIHR Institute of Circulatory and Respiratory Health; H&S. Total Initiative Funding: $750,000 Total H&S Funding: $375,000 Description: The goal of this strategic initiative is to support a Chair in the area of hypertension research who will focus on improving awareness, prevention and control of hypertension; identifying gaps in knowledge transfer and exchange / knowledge translation from evidence to practice for hypertension prevention and control; and developing and evaluating new policies, programs and interventions aimed at reducing the burden and/or impact of hypertension. HSFC/CIHR Chair in Hypertension Prevention and Control Principal Investigator(s) Campbell, Norm RC Research Institution Calgary Project Co-Investigator(s) Term $ H&S Total $ (All Partners) Total $ H&S Total $ (All Partners) Theme(s) Prevention and control N/A , , , ,000 II,III,IV of hypertension in Canada. 28

35 Heart & Stroke Foundation Research Report Operating Grant: Programmatic Grants in Health and Health Equity Partner(s): CIHR Institute of Population and Public Health; Institute of Circulatory and Respiratory Health, Gender and Health; Institute of Neurosciences, Mental Health and Addiction and Institute of Nutrition, Metabolism and Diabetes; The New Brunswick Health Research Foundation and the Ministry of Health and Long-term Care; H&S. Total Initiative Funding: $4,000,000 Total H&S Funding: $100,000 Description: The specific objectives of this funding opportunity are to support programmatic research that contributes new knowledge to improve health and health equity at a population level; support interdisciplinary collaborations that involve researchers and knowledge-users in public health and other sectors in Canada and if appropriate, also with other countries; and faciliate effective knowledge translation approaches that enhance the integration and use of new and existing knowledge to inform decision-making in public health and other sectors. Operating Grant: Programmatic Grants in Health and Health Equity Principal Investigator(s) Martens, Patricia; Katz, Alan; Chateau, Dan; Nickel, Nathan; Burland, Elaine Research Institution Manitoba Project Co-Investigator(s) Term $ H&S Total $ (All Partners) Total $ H&S Total $ (All Partners) Theme(s) PATHS Equity for Manitoba: Bolton, , ,000 4,000,000 III,IV Children: A program James; Chartier, of research into what Mariette; Doupe, works to reduce the Malcolm; Finlayson, gap for Manitoba s Greg; Fransoo, children. Randy; Katz, Laurence; Lix, Lisa; McGavock, Jon; Metge, Colleen; Raymond, Colette; Roos, Les; Roos, Noralou; Santos, Rob; Smith, Mark USA: Jutte, Doug Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 29

36 Heart & Stroke Foundation Research Report Resuscitation Outcomes Consortium (ROC) Renewal 2009 Partner(s): US National Institutes of Health National Heart, Lung and Blood Institute; CIHR Institute of Circulatory and Respiratory Health; H&S. Total Initiative Funding: $7,667,600 Total H&S Funding: $3,000,000 Description: ROC is the first large-scale effort to conduct clinical trials in sudden cardiac arrest and severe traumatic injury focusing on interventions by Emergency Medical Services teams in the field, when there is optimal potential for patient benefit. The goal is to improve survival rates from sudden cardiac arrest and severe traumatic injury. The renewal of the Consortium, through a competitive process, ensures continued support for the ten regional Clinical Centres and one Data and Coordinating Centre in the U.S. and Canada. This is much needed infrastructure for the rapid translation of research advances into improved resuscitation outcomes. H&S co-funds the two Canadian sites listed below. Resuscitation Outcomes Consortium (ROC) Renewal 2009 Principal Investigator(s) Morrison, Laurie J.; Dorian, Paul; Slutsky, Arthur Stiell, Ian G. Research Institution St. Michael s Hospital Ottawa Hospital Research Institute Project Co-Investigator(s) Term $ Total $ Total $ Total $ Theme(s) H&S (All Partners) H&S (All Partners) Toronto regional Ontario: Black, resuscitation research Sandra E.; Davis, out of hospital network. David; Hutchison, James S.; Lavery, James; Redelmeier, Donald A.; Rotstein, Ori D.; Sibbald, William. ROC Ottawa Ontario: Herbert, OPALS/BC. Paul C.; Osmond, Martin H.; Vaillancourt, Christian; Wells, George A. British Columbia: Abu-Laban, Riyad B.; Christenson, James A.; Macnab, Andrew J.; Russell, James A.; Simons, Richard K.; Sun, Charles Y , ,027 1,500,000 3,509,800 I,II,III , ,027 1,500,000 4,157,800 II,III,IV 30

37 Appendix B National Personnel Awards Photo: Dr. Robert Rose (Dalhousie ) was funded in through his National New Investigator Award, which was awarded in.

38 Heart & Stroke Foundation Research Report Doctoral Research Awards Awardee Supervisor(s) Research Institution Adnan, Areeba Turner, York Gary R. Smith, Kurt J. Ainslie, Philip of British Columbia Sun, Yao Zehr, E. Paul Victoria Focus on Stroke Doctoral Research Awards Awardee Supervisor(s) Research Institution Barss, Zehr, E. Paul Trevor S. Victoria Eftekhar, Parvin Brooks, Dina; Mochizuki, George Corbett, Dale R. Toronto Ottawa Project Keywords Term $ Total $ Total $ Total $ Theme(s) H&S* (All Partners)* H&S* (All Partners)* Project Keywords Term $* Total $* Theme(s) A brain-based approach to Aging, goal management ,000 73,500 II enhancing executive control training, multi-modal mild in multi-modal mild cognitive cognitive impairment, impairment. rehabilitation, cerebrovascular health. Cerebrovascular functioning Cerebral blood flow, ,500 24,500 I,II following acute and chronic prostaglandins, aging. administration of selective versus non selective non-steroidal anti-inflammatory treatment. Improving efficiency and Rehabilitation, strength ,000 63,000 I,II efficacy of unilateral strength training, interlimb, training after stroke. cross-education, spasticity ,500 10,500 36,750 43,750 I,II ,000 21,000 53,000 63,000 II Gomez- Smith, Mariana Can strength Post-stroke training the less rehabilitation, affected arm resistance training, improve the more neuromuscular affected arm? plasticity, cross-education, electro-myography. Examining the Stroke, upper effectiveness limb function, of combined botulinum toxin, rehabilitation rehabilitation. and botulinum toxin injection on functional improvement of the upper limb after stroke. Impact of cafeteria Stroke, metabolic diet induced syndrome, inflammation on cerebrovasculature, brain vasculature and stroke outcome. MRI, two-photon microscopy ,500 3,500 63,000 63,000 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. * Amount shown represents stipend value only. 32

39 Heart & Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Klarner, Zehr, E. Paul Taryn Victoria Kwan, Donna Malik, Aqsa Mullick, Aditi A. Rosenbaum, R. Shayna MacVicar, Brian Levin, Mindy; Fung, Joyce York of British Columbia McGill Project Keywords Term $ Total $ Total $ Total $ Theme(s) H&S* (All Partners)* H&S* (All Partners)* Can arm and leg cycling training improve walking ability after stroke? Walking, training intervention, neuromuscular adaptation, motor recovery, spasticity. Searching for Frontal stroke, impaired and episodic preserved futureoriented future thought, cognitive decision-making, processes in focal neuroeconomics. frontal stroke survivors. Mitochondrial Spreading modulation of depression, glutamate release oxidative stress, and cell death glutamate release, during spreading presynaptic depression. NMDARs, mitochondrial dysfunction. Mechanisms of Motor recovery, motor recovery stroke, reaching, and arm use in obstacle people with stroke. avoidance, cognition ,500 3,500 42,500 52,500 I,II,III ,500 3,500 29,750 42,000 I,II ,500 26,250 42,000 I ,000 21,000 53,000 63,000 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 33

40 Heart & Stroke Foundation Research Report Research Fellowships Awardee Supervisor(s) Research Institution Brazeau, Dasgupta, McGill Anne-Sophie Kaberi Das, Samir Van Petegem, Filip British Columbia Edwards, Jodi D. Black, Sunnybrook Sandra E. Research Institute Eny, Karen M. Paterson, Hospital for Andrew D. Sick Children Freeman, Grinstein, Hospital for Spencer A. Sergio Sick Children Hamza, Dyck, Jason Shereen M. R.B. Alberta Hayward, Kathryn Boyd, Lara A. British Columbia Klaiman, Jordan M. Regnier, Michael Washington Lalu, Manoj Stewart, Ottawa Hospital Mathew Duncan Research Institute Ludke, Ana Li, Ren-Ke Health Network Project Keywords Term $* Total $* Theme(s) Does shared-diabetes risk imply shared screening and shared health behaviour change? Prediabetes, insulin resistance, cardiovascular risk factors, physical activity, eating behaviours. Sodium channel beta subunits: Sodium channel, structure and function in native membrane protein, and diseased states. X-ray crystallography, cardiovascular disease, disease mutation. Relationship between Post-stroke dementia, amyloid burden and cognitive covert small vessel disease, impairment in periventricular transient ischemic attack, white matter disease. beta amyloid, amyloid PET imaging. Diet, genetics, and Nutrition, genetics, cardiovascular disease risk cardiovascular disease, CVD factors in subject with risk factors, genome-wide Type 1 Diabetes. association study. The role of Class B scavenger Atherosclerosis, receptors in the innate inflammation, macrophages, immune response controlling scavenger receptors. atherosclerosis. Role of fatty acid translocase Obesity, cardiac dysfunction, CD36 in cardiac dysfunction in vivo, FAT/CD36, associated with obesity. lipotoxicity. Characterisation of the Stroke, upper limb, structural and functional neuroimaging, severe, dose. capacity to recovery after severe stroke. Investigation of 2-deoxy-ATP Dilated cardiomyopathy, as a treatment for dilated 2-deoxy-ATP (datp), muscle cardiomyopathy. biomechanics, myofilament targeted therapy. Therapeutic effects and Sepsis induced cardiac mechanisms of mesenchymal dysfunction, mesenchymal stromal cell conditioned stromal cells, exosomes. medium in sepsis. Role of interleukin-10 in uterine Angiogenesis, stem cell differentiation myocardial ischemia, cell and preservation of cardiac transplantation, cytokines, function after myocardial cell culture. infarction , ,000 II,III,IV ,667 80,000 I ,000 80,000 I,II,IV , ,708 I,II ,000 80,000 I ,000 80,000 I ,852 46,852 I,II ,000 80,000 I , ,000 I , ,000 I * Amount shown represents stipend value only. 34

41 Heart & Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Marnane, Michael Hsiung, Ging-Yuek British Columbia Robin; Mackenzie, Ian R. A. McNeill, Brian Suuronen, Erik Ottawa Heart Institute Menzies, Keir J. Auwerx, Johan Ecole polytechnique Fédérale de Lausanne (EPFL) Munce, Sarah E. P. Bayley, Mark T. Toronto Rehabilitation Institute Pezeshki, Adel Chelikani, Prasanth Calgary Shah, Amin Davidge, Sandra T. Alberta Subramanian, Feldman, Université de Sandeep Anatol; Montréal Barthélemy, Dorothy Sun, Bo Chen, S.R. Wayne Calgary Tian, Xixi Backx, Peter H.; Toronto Dorian, Paul Yang, Kai MacVicar, Brian British Columbia Zarruk Serrano, David, Samuel McGill Juan Guillermo Project Keywords Term $* Total $* Theme(s) Pathologic study of the role of cerebrovascular disease in Mixed, vascular, Alzheimers, dementia, pathology. mixed Alzheimer dementia. Enhancing cell therapy Progenitor cells, cell therapy, using a protein modified revascularization, collagen collagen matrix. matrix. The role of the corepressor Metabolic homeostasis, protein SMRT/NCoR2 in mitochondria, corepressors, metabolic homeostasis. transcriptional control, high fat diet. Quality improvement strategies Systematic review, in post-stroke care. meta-analysis, stroke, quality improvement, quality of life. Bariatric surgeries for obesity: Bariatric surgery, obesity, mechanisms of action on cardiovascular function, cardiovascular function and metabolism. metabolism. Mechanism and sustainability Intrauterine growth of resveratrol to improve restriction, western diet, cardiovascular and metabolic oxidative stress, resveratrol, function. cardiovascular function. Reaching after stroke: role Arm-trunk coordination, of arm-trunk coordination stroke, transcranial magnetic and anticipatory postural stimulation, upper limb, adjustments. anticipatory postural adjustments. Mechanism and treatment of Cardiac alternans, ryanodine receptor-associated ventricular fibrillation, cardiac alternans. sarcoplasmic reticulum, intracellular calcium release, ryanodine receptors. Understanding the mechanism Atrial fibrillation, alternans, of atrial fibrillation. exercise, hypertension, TNF-alpha. The activation of pannexin by Pannexin, cell swelling, cell swelling. edema. Role of TNF-alpha and Neuroinflammation, IFn-gamma in macrophage macrophage polarization, polarization after transient neuroprotection, transient brain ischemia. ischemic stroke ,000 80,000 II ,000 80,000 I ,333 80,000 I ,667 66,667 III ,000 80,000 I ,000 80,000 I ,000 80,000 I,II ,000 80,000 I ,000 80,000 I ,000 80,000 I ,000 80,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 35

42 Heart & Stroke Foundation Research Report Focus on Stroke Research Fellowships Awardee Supervisor(s) Research Institution DePaul, McIlroy, McMaster Vincent G. William Lakhani, Bimal Boyd, Lara A. of British Columbia Phillips, Aaron A. Ainslie, Philip of British Columbia Okanagan Project Keywords Term $ Total $ Total $ Total $ Theme(s) H&S* (All Partners)* H&S* (All Partners)* The need for speed: training rapid compensatory Stroke, balance, gait, physiotherapy, reactive control. balance reactions after stroke. Structural Stroke, and functional rehabilitation, correlates of imaging, myelin, neuroplastic motor learning. change associated with stroke. Cerebrovascular Orthostatic control in high level hypotension, spinal cord injury stroke, spinal cord during orthostatic injury, cerebral challenge. blood flow. Research Scholarships Awardee Mentor(s) Research Institution Schmoelzer, Cheung, Royal Georg M. Po-Yin Alexandra Hospital ,167 4, , ,167 II ,333 13,333 53,400 80,000 I,II ,667 6,667 57,000 80,000 I,II Project Keywords Term $* Total $* Theme(s) Sustained inflations during chest Neonatal resuscitation, chest ,000 90,000 I,II compression to improve survival compression, sustained during resuscitation of asphyxiated inflation, newborn infants, newborns. asphyxia. These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. * Amount shown represents stipend value only. 36

43 Heart & Stroke Foundation Research Report New Investigators Auger-Messier, Mannix Université de Sherbrooke Préservation de la contractilité et de la structure des cardiomyocytes dans l insuffisance cardiaque. Insuffisance cardiaque, contractilité, sarcomere, dual-specificity phosphatases (DUSP), ArfGAP with dual PH domains (ADAPs). Carrier, Marc Ottawa Hospital Screening for occult cancer in Venous thromboembolism, Research Institute patients with unprovoked venous unprovoked thrombosis, deep thromboembolism. vein thrombosis, pulmonary, randomized controlled trial. Claydon, Victoria E. Simon Fraser Cerebrovascular control following Blood pressure, cerebral spinal cord injury. autoregulation, spinal cord injury, autonomic dysreflexia, orthostatic hypotension. Dowlatshahi, Dariush Ottawa Hospital Predicting intracerebral hemorrhage Intracerebral hemorrhage, Research Institute expansion using the dynamic stroke, CT-angiography, CT-angiography spot sign. hematoma expansion, critical care. Girouard, Hélène Université de Mechanisms underlying Neurovascular coupling, Montréal neurovascular coupling dysfuncton angiotensin, astrocytes, in hypertension. calcium, parenchymal arteries. Lagace, Thomas A. Ottawa Regulation of circulating low-density Low-density lipoprotein Heart Institute lipoprotein cholesterol levels. receptor, PCSK9, cholesterol, protein-protein interaction, epidermal growth factor-like domain. Larrivée, Bruno Université de Targeting BMP signaling for the Angiogenesis, vascular biology, Montréal treatment of cardiovascular cell signalling, blood vessel complications of diabetes. morphogenesis, diabetes. Rose, Robert A. Dalhousie Natriuretic peptides regulate Natriuretic peptide, sinoatrial sinoatrial node function node, electrophysiology, and arrhythmogenesis in arrhythmias, ion channels. heart disease. Schweizer, Tom A. St. Michael s Cognitive, functional and Aneurysm, subarachnoid Hospital neuroimaging profiles of aneurysmal hemmorhage, cognitive subarachnoid hemmorhage. function, functional outcome, neuroimaging. Simpson, Jeremy A. Myocardial production of Cardiac, cytokines, hemoglobin, Guelph erythropoietin and hemoglobin heart failure, erythropoietin, variants. rodent. Stickland, Carotid chemoreception and Sympathetic nerve activity, Michael K. of Alberta sympathetic nervous activity vascular regulation, in chronic obstructive pulmonary chemosensitivity, exercise, disease. lung disease. Awardee Research Institution Project Keywords Term $* Total $* Theme(s) Atzema, Clare L. Institute for Clinical Evaluative Sciences Atrial fibrillation in the emergency room: The AFTER study. Atrial fibrillation, emergency department, health services, clinical decision rule, arrhythmia , ,000 II,III,IV , ,000 I , ,000 II,III,IV , ,000 I,II , ,000 I,II , ,000 I , ,000 I , ,000 I , ,000 I , ,000 I,II , ,000 I , ,000 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 37

44 Heart & Stroke Foundation Research Report Awardee Research Institution Project Keywords Term $* Total $* Theme(s) Swartz, Richard H. Sunnybrook Health DOC: screening depression, OSA, Stroke prevention, vascular , ,000 II,III,IV Sciences Centre and cognition to identify high-risk stroke clinic patients. risk factors, vascular cognition, cognitive impairment, post-stroke depression, obstructive sleep apnea Zheng, Xiufen Lawson Health Research Institute The role of toll-like receptors in intima thickening of vein graft in coronary artery bypass grafting. Toll like receptor, toll like receptor 4, coronary artery bypass grafting (CABG), intima thickening, sirna , ,000 I Distinguished Clinician Scientist Awardee Research Project Keywords Term $ Total $ (All Total $ Total $ Theme(s) Institution H&S* Partners)* H&S* (All Partners)* McMurtry, Michael Sean Alberta Vascular metabolism and angiogenesis. Endothelium, metabolism, arteriogenesis, angiogenesis peripheral arterial disease ,000 75, , ,000 I Saposnik, Gustavo St. Michael s Hospital Efficacy of Virtual Reality Exercises using Wii gaming technology in STroke Rehabilitation: A multicentre randomized clinical trial (EVREST multicentre). Stroke, clinical trial, outcomes research, virtual reality, rehabilitation ,000 75, , ,000 I,II,III Wijeysundera, Harindra C. Sunnybrook Research Institute Evaluating therapeutic decision-making, outcomes and resource utilization in chronic stable angina: an interprovincial population-based study. Agina, quality of life, health care costs, variation in care, administrative database ,000 75, , ,000 II,III,IV * Amount shown represents stipend value only. 38

45 Heart & Stroke Foundation Research Report Industry-Supported Research Fellowship Awards The H&S wishes to thank Pfizer for their generous contributions to support the H&S Research Program. Industry-Supported Research Fellowship Awards Awardee Supervisor(s) Research Institution Kwiatkowska, Day, Robert Université de Anna Sherbrooke Maxson, Grinstein, Hospital for Michelle Sergio Sick Children Project Keywords Term $ Total $ Total $ Total $ Theme(s) H&S* (All Partners)* H&S* (All Partners)* Development of peptide-based PCSK9 inhibitors for the treatment of hypercholesterolemia. Hypercholesterolemia, PCSK9 inhibitors, protein-protein interactions, anexxin A2, H/ DX-MS ,667 40,000 40,000 80,000 I The role of SCARB1, ,000 20,000 60, ,000 I,II scavenger cholesterol receptor SCARB1 transport, HDL, in the transport of edocytosis, cholesterol and cardiovascular in cardiovascular health. health. * Amount shown represents stipend value only. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 39

46 Heart & Stroke Foundation Research Report

47 Appendix C Grants-in-aid Photo: Dr. Terry Hébert (McGill ) was funded in through his Grant-in-Aid awarded in.

48 Heart & Stroke Foundation Research Report British Columbia/Yukon Principal Investigator and Co-Investigator(s) Andrade, Jason G.; Tang, Anthony S.L.; Wells, George Bernatchez, Pascal N; Seidman, Michael; Van Breeman, Casey Brown, Craig E.; Nashmi, Raad Choy, Jonathan C.; Unrau, Peter Claydon, Thomas W. Claydon, Victoria E.; Sanatani, Shubhayan; Kwon, Brian Clee, Susanne M. Eng, Janice J.; Mortenson, Ben; Yao, Jennifer Fedida, David Hoodless, Pamela A. Karsan, Aly Research Institution Project Keywords Term $ Cumulative Theme(s) $ to British Columbia Double short vs standard exposure duration during cryoballoon pulmonary vein isolation: the DOSE study. Atrial fibrillation, catheter ablation, cryoablation. St. Paul s Hospital Aberrant endothelial Nitric oxide, atherosclerosis, mechano-sensing is a cause mechano-sensing, shear stress, of early atherosclerosis and a caveolae. pharmacological target. A role for alpha-4 nicotinic Stroke recovery, nicotinic of Victoria acetylcholine receptors in regulating receptors, GABA, cortical stroke recovery. plasticity, imaging. Simon Fraser Regulation of graft arteriosclerosis Transplantation, graft by IL-6. arteriosclerosis, T cell, IL-6, cell death. Simon Fraser Molecular mechanisms of gating Electrophysiology, cardiac and drug binding in herg cardiac excitation, Ion channels, voltage potassium channels. clamp fluorimetry (VCF), lanthanide-based resonance energy transfer (LRET). Simon Fraser Cardiovascular autonomic control in Cardiovascular autonomic acute spinal cord injury. control, spectral analysis, arrhythmia, spinal cord injury, blood pressure. Identification of novel genes affecting Obesity, positional cloning, British Columbia body weight mouse genetics, food intake, metabolism. Use of a robotic exoskeleton Rehabilitation, stroke, assistive British Columbia to promote walking recovery technology. after stroke. Identification and characterization of Heart, potassium channels, British Columbia molecular interactions between the repolarization, unnatural amino subunits of the cardiac repolarizing acid, mutagenesis. current, IKs, studied using unnatural amino acid mutagenesis and mass spectrometry. British Columbia Regulatory networks in heart Embryogenesis, atrioventricular Cancer Agency valve formation. canal, valve development, genomics. British Columbia Mechanisms of vascular Transcription factors, meis1, Cancer Agency development. hemogenic endothelium, vascular endothelium, gene-targeted mouse , ,911 II ,645 88,645 I , ,757 I ,666 84,666 I ,800 91,800 I ,211 96,823 I,II , ,536 I ,127 72,127 II,III , ,981 I , ,966 I , ,000 I 42

49 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Krahn, Andrew D.; Sanatani, Shubhayan; Birnie, David; Hamilton, Robert; Dube, Marie-Pierre; Arbour, Laura; Talajic, Mario; Gollob, Michael; Chauhan, Vijay; Gardner, Martin; Gow, Robert; Healey, Jeff; Simpson, Christopher; Lettre, Guillaume; Gerull, Brenda; Klein, George; Chakrabarti, Santabhanu Krahn, Andrew D.; Gardner, Martin; Hamilton, Robert; Gerull, Brenda; Talajic, Mario; Arbour, Laura; Healey, Jeff; Sanatani, Shubhayan; Spears, Danna; Laksman, Zachary; Bennett, Matthew; Klein, George Liu-Ambrose, Teresa; Best, John; Davis, Jennifer; Field, Thalia; Goldsmith, Charlie; Hsiung, Ging Yuek (Robin); Madden, Kenneth; Tam, Roger Madden, Kenneth M.; Meneilly, Graydon McKay, Heather A.; Macdonald, Heather; Naylor, Patti-Jean; Paez, Antonio; Winters, Meghan; Sims-Gould, Joanie; Nettlefold, Lindsay; Voss, Christine Murphy, Timothy H. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to British Columbia CASPER: Canadian genetic heart rhythm network. National long QT syndrome registry British Columbia and BioBank. Reshaping the path of vascular British Columbia cognitive impairment with resistance training. Acarbose and older adults with British Columbia postprandial hypotension. Active streets, active people -junior: British Columbia an integrated community partnership to enhance physical activity and active transport to school in children and youth. Using light to probe and modify British Columbia neuronal excitability and blood flow of the evolving ischemic penumbra. Arrhythmia, electrophysiology, cardiology, genetics, sudden death. Long QT syndrome, genetics, arrythmia. Exercise training, white matter lesions, executive functions, rehabilitation, small vessel disease. Postprandial hypotension, geriatric medicine, syncope, alpha-glucosidase inhibitor, falls in older adults. Built environment, physical activity, children health, youth health, active transport. Stroke, penumbra, imaging, 2-photon, optogenetics , ,580 I,II , ,582 II ,905 99,905 II , ,915 I,II , ,371 II,IV , ,642 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 43

50 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Pryzdial, Edward L.G. Sanatani, Shubhayan; Kannakeril, Prince; Krahn, Andrew; Lehman, Anna; Wilde, Arthur Zehr, E. Paul BC Children s Hospital Understanding the risk of sudden death in families: cascade screening in CPVT. CPVT, sudden cardiac death, inherited arrhythmias, cardiac channelopathies, family screening. Tapping into interlimb neuronal Neurophysiology, stroke Victoria linkages to enhance locomotor ability recovery, walking, translational after stroke. research. Alberta/Northwest Territories/Nunavut Principal Investigator and Co-Investigator(s) Ahmed, Sofia B; Exner, Derek; Hemmelgarn, Brenda Barber, Philip A; Demchuk, Andrew; Frayne, Richard; Goyal, Mayank; Lee, Ting-Yim; Menon, Bijoy; Tuor, Ursula Beaulieu, Christian; Butcher, Kenneth; Emery, Derek Braam, Geert Branko; Cupples, William A Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Calgary Vitamin D supplementation and cardiac autonomic tone in hemodialysis patients: a blinded, randomized placebo-controlled trial. Cardiac autonomic tone, vitamin D, hemodialysis, kidney, sudden cardiac death. Recanalization following Stroke, reperfusion injury, Calgary Endovascular treatment and imaging thrombectomy, MRI. of PErfusion, Regional infarction and atrophy to Understand Stroke Evolution (REPERFUSE). Advances in high field MRI Magnetic resonance imaging, Alberta of stroke. stroke, transient ischemic attack, diffusion weighted imaging, perfusion weighted imaging. Renal venous pressure, renal Renal venous pressure, Alberta function and experimental renal hemodynamics, heart failure. glomerular filtration, experimental heart failure. Research Institution Project Keywords Term $ Cumulative $ to Theme(s) Canadian Auxiliary cofactors in fibrinolysis. Fibrinolysis, thrombosis, factor , ,975 I,II Blood Services X, tissue plasminogen activator, hemostasis ,303 92,303 I,II,III,IV , ,619 I,II ,080 61,160 II , ,570 I,II , ,173 II , ,834 I 44

51 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Butcher, Ken; Hill, Michael; Jeerakathil, Thomas; Wilman, Alan; Gladstone, David; Saposnik, Gustavo; Lanthier, Sylvain; Demchuk, Andrew; Shuaib, Ashfaq; Coutts, Shelagh; Dowlatshahi, Dariush; Asdaghi, Negar; Casaubon, Leanne; Jurasz, Paul; Aviv, Richard; Buck, Brian; Beaulieu, Christian; Qureshi, Adnan Clanachan, Alexander S; Zaugg, Michael Dukelow, Sean; Scott, Stephen; Hill, Michael; Demchuk, Andrew Ezekowitz, Justin A.; Armstrong, Paul; Kaul, Padma; Welsh, Robert Febbraio, Maria Fedak, Paul Kassiri, Zamaneh Kassiri, Zamaneh Kubes, Paul Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Alberta The intracerebral hemorrhage acutely decreasing arterial pressure trial II. Novel therapy against Alberta ischemia-reperfusion injury in the infarct-remodeled heart. A randomized controlled trial of early Calgary robotic rehabilitation of the upper limb following stroke. PROACT-4. Alberta Periodontal disease mechanisms in Alberta atherosclerosis. Epicardial infarct repair: defining Calgary mechanisms to optimize therapy. Paradoxical role of matrix Alberta metaloproteinase-2 in aortic aneurysm. Role of TNF-alpha Converting Alberta Enzyme (TACE) in heart disease. Role of platelets in sterile and Calgary infectious perturbations. Stroke, intracerebral hemorrhage, hypertension, ischemia, MRI. Cardiac ischemia-reperfusion, cardioprotection, fat emulsions, energy substrate metabolism. Stroke, rehabilitation, robotics, neuroscience. Acute coronary syndrome, ambulance, troponin. CD36, Toll like receptors, atherosclerosis, periodontal disease. Tissue engineering, extracellular matrix, cardiac remodeling. Aortic aneurysm, vascular extracellular matrix, smooth mucle cell, TGFbeta pathway. Heart disease, myocardial infarction, pressure overload, TNF-alpha-converting enzyme (TACE), cardiac remodeling. Inflammation, neutrophils, platelets, vasculature, endothelium , ,500 I,II , ,244 I , ,654 II , ,736 II , ,596 I,II ,639 96,639 I , ,684 I , ,884 I ,982 74,982 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 45

52 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) McAlister, Finlay A.; James, Matthew; McMurtry, Sean Michael; Sandhu, Roopinder; Tonelli, Marcello; Wiebe, Natasha Michelakis, Evangelos D. O Brien, Edward R.M. Plane, Frances Poulin, Marc; Anderson, Todd; Hanly, Patrick Proctor, Spencer D. Schmoelzer, Georg M. Schulz, Richard Seubert, John M. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Alberta Exploring the interplay between renal function and outcomes in non-valvular atrial fibrillation. Clinical epidemiology, atrial fibrillation, health outcome research, stroke, risk prediction. A chamber-specific mitochondriaangiogenesis Angiogenesis, right ventricle, Alberta axis underlies right heart failure, pulmonary ventricular failure in pulmonary hypertension, metabolism. hypertension. Heat shock protein 27: extracellular Atherosclerosis, macrophage, Calgary release and signaling. inflammation, heat shock protein. Endothelial potassium channels as Endothelial dysfunction, Alberta targets for novel vascular drugs. diabetes, potassium channel, nitric oxide. Role of intermittent hypoxia in Obstructive sleep apnea, Calgary the pathogenesis of obstructive intermittent hypoxia, sleep apnea. cerebrovascular regulation, stroke, endothelial dysfunction. Mechanisms that promote remnant Human atherosclerosis, Alberta lipoprotein retention in arterial tissue remnant cholesterol, arterial during atherogenesis and insulin retention, apolipoprotein B, resistance. proteoglycans. Royal Alexandra Novel resuscitation techniques Neonatal resuscitation, Hospital to improve the recovery of cardio-pulmonary resuscitation, asphyxiated newborns. cerebral hemodynamics, hemodynamics. Matrix metalloproteinase-2 at the Matrix metalloproteinase, Alberta myocardial endoplasmic reticulum/ mitochondria-associated mitochondrial interface in cardiac membrane, ischemia/ ischemia/reperfusion injury. reperfusion injury, protease substrates/targets. Role of eicosanoids in regulating Mitochondria, aging, Alberta mitochondrial quality in the epoxyeicosatrienoic acid, aged heart. ischemia-reperfusion injury, autophagy ,038 65,038 II,III , ,391 I , ,401 I,II , ,061 I , ,916 I,II,III,IV , ,460 I,II ,436 77,436 I ,375 81,375 I , ,039 I 46

53 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Smith, Eric E.; Lear, Scott; Yusuf, Salim; Teo, Koon; Poirier, Paul; O Donnell, Martin; Dagenais, Gilles; Pare, Guillaume; Islam, Shofiqul; Hart, Robert; Benavente, Oscar; Stotts, Grant Stickland, Michael K.; Haykowsky, Mark; Ezekowitz, Justin; McMurtry, Michael; Edgell, Heather Sykes, Brian D.; Hwang, Peter; West, Frederick West, Lori J.; Dijke, Ilona Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Relationship between covert brain Calgary ischemia and cognitive and physical decline in middle-aged Canadians. Mechanisms and functional Alberta significance of enhanced carotid chemosensitivity in health and heart failure. Development of calcium sensitizers Alberta that target troponin. ABO-incompatible heart Alberta transplantation: pathways to tolerance. Stroke, silent stroke, cognitive impairment, vascular dementia, leukoaraiosis. Heart failure, carotid chemosensitivity, sympathetic nerve activity, ultrasound. Heart failure, calcium sensitizers, drug development, ischemic heart disease, protein structure. ABO blood group, heart transplantation, tolerance, B cell, neonate , ,982 II,IV , ,600 I,II , ,000 I ,500 84,500 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 47

54 Heart & Stroke Foundation Research Report Manitoba Principal Investigator and Co-Investigator(s) Dakshinamurti, Shyamala Dixon, Ian M C; Czubryt, Micheal; Wigle, Jeffery Garland, Allan; Sanmartin, Claudia; Forget, Evelyn; Fransoo, Randall; Iwashyna, Theodore; Scales, Damon; Wunsch, Hannah Hatch, Grant M. Kirshenbaum, Lorrie A. McGavock, Jonathan; Dolinsky, Vernon W.; Wicklow, Brandy; Sellers, Elizabeth; Dean, Heather; Dart, Allison Ravandi, Amir Stetefeld, Jörg Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Manitoba Effect of neonatal hypoxia on pulmonary artery and right ventricle adenylyl cyclase. Ski and scleraxis form a negative Manitoba feedback loop in regulation of cardiac myofibroblast function. Changes in work and earnings after Manitoba heart attack and stroke. Regulation of cardiolipin Manitoba biosynthesis in the heart. Mechanisms of P53 mediated cell Manitoba death in the heart. Developmental origins of diabetic Manitoba cardiomyopathy. St. Boniface G.H. Role of oxidized phospholipids Research Centre in myocardial ischemia and reperfusion injury. Rhodocetin- A snake venom lectin Manitoba with dual platelet surface receptor binding profiles. Neonatal hypoxia, adenylyl cyclase, G alpha s, pulmonary hypertension, PPHN. Heart failure, myocardial infarction, cardiac fibrosis, gene expression, myofibroblasts. Myocardial infarction, stroke, income, employment status, outcomes research. Heart failure, phospholipid, gene therapy, cardiolipin, pulmonary hypertension. P53, apoptisis, heart failure, ventricular myocytes, cell culture. Developmental origins, diabetic cardiomyopathy, lipotoxicity, AMPK, exercise. Lipidomics, oxidized lipids, oxidative stress, reperfusion injury, apoptosis. Snake venom lectin rhodocetin, a2b1 integrin and GPIb surface receptor, platelet activation and aggregation, structural biology and integrated approach, structure-based drug design , ,686 I , ,765 I ,000 99,000 III,IV , ,434 I , ,150 I , ,680 I,II , ,382 I , ,000 I 48

55 Heart & Stroke Foundation Research Report Ontario Principal Investigator and Co-Investigator(s) Adeli, Khosrow Advani, Andrew; Connelly, Kim Alter, David A.; Redelmeier, Donald; Stukel, Therese; Oh, Paul; Marzolini, Susan; Bartel, Lee; Faulkner, Guy; Goodman, Jack; Trainor, Laurel; Grahn, Jessica Research Institution Project Keywords Term $ Cumulative $ to Theme(s) Hospital for Mechanisms of hepatic steatosis Lipoproteins, glucagon like ,000 93,000 I Sick Children and VLDL overproduction in insulin peptide, liver, brain, gut. resistance: role of the gut-brain-liver axis. St. Michael s HDAC6 in cardiorenal disease. Cardiorenal disease, diastolic , ,747 I Hospital dysfunction, chronic kidney disease, histone, acetylation. Institute for Clinical The efficacy of personalized Physical activity, adherence, ,954 99,954 II,IV Evaluative Sciences audio-playlists with rhythmic auditory music, cardiac rehabilitation, stimulation on exercise adherence in rhythmic auditory stimulation. cardiac rehabilitation. Andrew, R. David Queen s Higher brain susceptibility Neurophysiology, , ,566 I,II and lower brain resiliency to ischemic injury. neurons, ischemia, stroke, neuroprotection. Austin, Richard C. St. Joseph s Contribution of cell surface GRP78 to Cell surface GRP78, , ,962 I Hospital the development and progression of atherothrombosis. tissue factor, thrombin generation, atherosclerosis, thromboembolic disease. Austin, Richard C. St. Joseph s Molecular and cellular basis of Atherosclerosis, vascular ,950 91,950 I Hospital endoplasmic reticulum (ER) stress and its role in atherothrombotic disease. function, reactive nitrogen species, endoplasmic reticulum stress, endothelial cells and macrophages. Bai, Donglin Connexin43 and connexin40 Cardiac arrhythmias, gap , ,273 I,II Western Ontario mutants and cardiac arrhythmias. junction, connexin, atrial fibrillation, patch clamp. Beanlands, Rob Ottawa Atherosclerotic plaque imaging Atherosclerosis, PET/ , ,390 I,II,III S.B.; Spence, John; DaSilva, Jean; Ruddy, Terrence; de Kemp, Robert; Prato, Frank; Cocker, Myra; Lum, Cheemun; Stotts, Grant; Hammond, Robert Heart Institute using NaF and FDG imaging: validation and evaluation of disease progression. A Canadian atherosclerosis imaging network (CAIN)-II histopathology validation study. CT imaging, sodium fluoride, calcification, fluorodeoxyglucose. Béïque, Synaptic mechanisms in post-stroke Stroke, post-stroke depression, ,360 91,360 I Jean-Claude Ottawa depression. electrophysiology, synapses, optogenetics. Bendeck, Michelle P. Toronto N-cadherin and strategies to inhibit smooth muscle cell migration. Smooth muscle cell, cadherin, migration, polarity, therapeutic ,375 95,375 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 49

56 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Birnie, David H; Essebag, Vidal; Nery, Pablo; Healey, Jeff; Verma, Atul; Ayala Paredes, Felix; Coutu, Benoit; Sapp, John; Philippon, Francois; Coyle, Doug; Eikelboom, John; Wells, George Bolz, Steffen-Sebastian Chakrabarti, Subrata Chauhan, Vijay S., Krahn, Andrew; Sapp, John; Healey, Jeff; Gollob, Michael; Yee, Raymond; Wintersperger, Bernd Chauhan, Vijay S.; Krishnan, Sridhar Chen, Hsiao-Huei; Stewart, Alexandre Coles, John G.; Maynes, Jason Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Ottawa Heart Institute BRUISE CONTROL-2: A randomized controlled trial to compare Continued versus Interrupted Dabigatran at the time of device surgery, in patients at high risk of stroke. anti-coagulation, peri-operative, arrhythmia device, novel anti-coagulants, stroke. Correcting CFTR dysfunction: a new Resistance arteries, cystic Toronto therapeutic strategy for normalizing fibrosis transmembrane microvascular reactivity in heart regulator (CFTR), failure. vascular smooth muscle, sphingosine-1-phosphate, tumour necrosis factor. Vasoactive and cardioactive factors Diabetes, endothelial Western Ontario in diabetic heart disease. mesenchymal transition, microrna, cardiac fibrosis. Electrocardiographic evaluation of Cardiomyopathy, sudden death, Health Network ventricular arrhythmia vulnerability in electrocardiography, magnetic hypertrophic cardiomyopathy. resonance imaging. Characterizing focal electrical Atrial fibrillation, electrogram Health Network sources and substrate in human analysis, scar, catheter ablation, atrial fibrillation. humans. Ottawa Hospital Modulation of innate immunity Innate immunity, stroke, Research Institute to reduce stroke injury and improve apotosis, translational regulation, recovery. knockout mice. Hospital for Rescue of disrupted Gene therapy, integrin linked Sick Children mechanotransduction as a new kinase, dilated cardiomyopathy, therapeutic strategy in human mouse models, SERCA2A. dilated cardiomyopathy , ,500 II,III , ,298 I , ,220 I ,030 96,030 I,II , ,440 I,II , ,359 I , ,714 I Connelly, Kim A. St Michael s Hospital Identifying the role of silent information regulator (Sirt1) in ventricular remodeling using genetic ablation and pharmacological strategies. Heart failure, non histone lysine acetylation, smad, growth factors, silent information regulator ,955 84,955 I Copeland, John W. Ottawa Shear stress induced activation of cytoskeletal signaling pathways. Shear stress, endothelium, cytoskeleton, signal transduction, gene regulation , ,356 I Cregan, Sean P. Western Ontario Role of ATF4 and P53 family transcription factors in the regulation of neuronal cell death. Apoptosis, neuron, P53, ATF4, ischemia ,400 85,400 I 50

57 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Crowther, Mark A.; Blostein, Mark; Ginsberg, Jeffrey; Kahn, Susan; Schulman, Sam; Carrier, Marc; Wu, Cynthia Cummins, Carolyn Cunningham, Charles H.; Connelly, Kim; Wright, Graham Danckert, James A.; Ferber, Susanne; Black, Sandra; Roy, Eric Davis, Darryl R. Dawson, John F.; Van Raay, Terence Douketis, James D.D.; Shivakumar, Sudeep; Syed, Summer; Schulman, Sam; Solymoss, Susan; Bell, Benjamin; Lee, Anges; Spencer, Frederick; Carrier, Marc; Kassis, Jeannine; Gross, Peter; Blostein, Mark; MacKay, Elizabeth Dowlatshahi, Dariush; Chakraborty, Santanu; Momoli, Franco; Stotts, Grant; Aviv, Richard; Hogan, Matthew; Demchuk, Andrew Drangova, Maria; Gillies, Elizabeth; Pickering, Geoff Drucker, Daniel J. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to McMaster Rivaroxaban for the secondary prevention of thromboembolism in patients with the antiphospholipid antibody syndrome. EPCs in atherosclerosis: role Toronto of intracellular cholesterol and LXR signaling. Sunnybrook Health Metabolic imaging of the Sciences Centre hypertrophic heart. Working memory in spatial neglect: Waterloo developing a novel theory and rehabilitation program. Ottawa Strategies to reverse the effect Heart Institute of hyperglycemia on cardiac stem cells. Hypertrophic cardiomyopathy: Actin Guelph variants in the actomyosin interface. McMaster Perioperative new oral anticoagulant study. Ottawa Hospital Predicting intracerebral hemorrhage Research Institute expansion using the dynamic CT-angiography spot sign. Dual energy micro-ct for 3D Western Ontario angiography and cardiovascular histology. Samuel Lunenfeld Cardiovascular biology of dipeptidyl Research Institute peptidase-4 Stroke, myocardial infarction, venous thromboembolism, cohort study, rivaroxaban. Endothelial progenitor cell, liver x receptor, cholesterol, atherosclerosis, LDLR. Heart failure, hypertrophy, metabolism, imaging, hyperpolarized MRI. Spatial neglect, spatial working memory, rehabilitation. Cardiac stem cells, heart failure, diabetes. Hypertrophic cardiomyopathy, actomyosin interactions, baculovirus expression system, zebrafish model of disease, molecular causes of disease. New oral anticoagulants, perioperative, laboratory testing. Cerebral hemorrhage, stroke, diagnosis, critical care. Micro-CT, atherosclerosis, dual energy, myocardial infarction. Diabetes, gut peptides, cardiomyocytes , ,336 II , ,337 I , ,500 I,II , ,167 I,II , ,288 I ,300 73,300 I , ,448 II , ,286 I,II , ,550 I , ,160 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 51

58 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Eikelboom, John W.A.; Connolly, Stuart; Bosch, Jackie; Moayyedi, Paul; Pogue, Janice; O Donnell, Martin Epelman, Slava Feldman, Ross D., Gros, Robert Finestone, Hillel M; Sveistrup, Heidi; Bilodeau, Martin; Levac, Danielle; Fergusson, Dean Flynn, Lauren; Amsden, Brian; Hess, David Giacca, Adria Goldfield, Gary S.; Barrowman, Nick; Walker, Mark; Doucet, Eric; Tremblay, Mark; Adamo, Kristi; Fried, Peter Graham, Simon J; Saposnik, Gustavo; Boe, Shaun; Staines, Richard William; Schweizer, Tom; Black, Sandra Gramolini, Anthony O. Grant, David; Levy, Gary; Ross, Heather Gros, Robert Research Institution Project Keywords Term $ Cumulative Theme(s) $ to McMaster INTERBLEED-Pilot: a study of risk factors for GI bleeding and of cardiovascular outcomes after GI bleeding. Bleeding, myocardial infarction, stroke, death. Precise functional characterization Viral, myocarditis, macrophage, Health Network of macrophage and dendritic cell dendritic cell, IRF8. subsets during viral myocarditis. Estrogen regulation of vascular Estrogen, vascular biology, Western Ontario remodelling: role of GPER. aldosterone. Elisabeth Does virtual reality exercise improve Stroke, rehabilitation, virtual Bruyère Hospital sitting balance ability and function reality, balance, exercise. after stroke? Co-delivery of adipose-derived Tissue engineering and Western Ontario stem cells and SDF-1/HGF-1 in regenerative medicine, ligand grafted, in situ setting gels for peripheral vascular disease, the treatment of peripheral arterial cell and drug delivery vehicles, disease. therapeutic angiogenesis, adipose-derived stem cells. Resveratrol and nitric oxide delivery Restenosis, resveratrol, nitric Toronto as strategies to bypass vascular oxide, insulin resistance. insulin resistance. Children s Hospital Effects of prenatal exposure Childhood obesity, smoking, of Eastern Ontario to cigarettes on adiposity and pregnancy, metabolism. metabolism in young children. Sunnybrook Health FMRI neurofeedback applied to Functional MRI, stroke recovery, Sciences Centre motor imagery in stroke. neurofeedback, motor imagery, physical rehabilitation. Phospholamban mutations, Excitation contraction coupling, Toronto sarcoplasmic reticulum calcium calcium, cardiomyocyte. defects and cardiomyopathy. Toronto General Fgl2/FGL2 and heart Transplantation, tolerance, Hospital allotransplantation. macrophage, T regulatory cells, receptors. The protective role of the cholinergic Genetically modified mice, Western Ontario system in the heart. cholinergic tone, cardiac dysfunction, hemodynamic measurements, ECG telemetry ,625 74,625 II ,821 99,821 I ,582 94,582 I , ,499 II,III ,500 89,500 I , ,538 I,II , ,397 IV , ,214 I , ,289 I,II , ,287 I,II , ,181 I 52

59 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Haas, Tara L.; Ellis, Christopher; Birot, Olivier Hamilton, Jill K.; Comelli, Elena; Hanley, Anthony; Parkinson, John; Retnakaran, Ravi; Zinman, Bernhard Hegele, Robert A. Hess, David A.; Postovit, Lynne-Marie Heximer, Scott P. Huff, Murray W. Ikura, Mitsuhiko Janssen, Ian M.; McIsaac, Michael Johri, Amer M.; Heyland, Daren; Spence, John Kassner, Andrea; Narang, Indra; deveber, Gabrielle; Shroff, Manohar; Janzen, Laura Keeley, Fred W.; Parkinson, John Khan, Zia A. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to York Angiogenic regulators in peripheral Angiogenesis, microcirculation, limb ischemia. oxygen transport, ischemic muscle, shear stress. Hospital for Cardiometabolic risk, obesity and Sick Children the microbiome: development over the first two years of life in children exposed to gestational diabetes in utero. Robarts Genomics and phenomics Research Institute of hypertriglyceridemia and cardiometabolic syndrome. Robarts Progenitor cell regulation of the Research Institute vascular regenerative niche. Defining novel mechanisms in the Toronto pathogenesis of bradyarrhythmias and sick sinus node syndrome. Regulation of dyslipidemia and Western Ontario insulin resistance by flavonoids: Relationship to atherosclerosis. Structural basis for STIM and Health Network Orai function in the heart and vasculature. Cardiometabolic risk, obesity, intestinal microbiota, gestational diabetes, child. Lipoproteins, triglycerides, metabolic syndrome,human genetic variation,atherosclerosis. Umbilical cord blood progenitor cells, aldehyde dehydrogenase activity, angiogenesis, peripheral vascular disease, ischemia. SAN function, RGS proteins, parasympathetic signaling, autorhythmicity, autophagy. Dyslipidemia, flavonoids, insulin signalling, mouse model of insulin resistance, atherosclerosis. Calcium signaling, signal transduction, structural biology, ion channel, protein structure. Queen s Effect of carnitine supplementation on progression of carotid plaque in the metabolic syndrome (ECoM Study). Atherosclerosis, metabolic syndrome, three-dimensional carotid ultrasound, plaque, obesity. Hospital for MRI assessment of cerebral Sick Children vascular injury in obese children with obstructive sleep apnea. Hospital for Effects of sequence polymorphisms Sick Children in human tropoelastin on the assembly and mechanical properties of the elastic matrix. Implications for susceptibility to later onset vascular disease. Regulation of vascular stem cell Western Ontario differentiation and plasticity. Obstructive sleep apnea, vascular, neuroimaging, MRI, stroke. Sequence polymorphism, tropoelastin, elastic matrix, mutation, vascular disease. Vascular stem cells, vasculogenesis, blood vessels, stem cell plasticity, cell differentiation ,144 87,144 I,II , ,182 I,II,IV ,804 93,804 I,II,III,IV , ,417 I ,976 74,976 I , ,584 I , ,950 I Queen s The active play study. Physical activity, cardiovascular , ,330 IV risk factors, children, determinants of health , ,119 I,II,III,IV ,958 85,958 II , ,086 I ,800 77,800 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 53

60 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Ko, Dennis T; Jackevicius, Cynthia A.; Stukel, Therese; Tu, Jack; Austin, Peter Koschinsky, Marlys L.; Boffa, Michael Kuebler, Wolfgang M. Kutryk, Michael JB Lagace, Thomas A. Le Gal, Grégoire; Anderson, David; Tan, Melanie; Huisman, Menno; Kahn, Susan; Kovacs, Michael; Ramsay, Timothy; Rodger, Marc; Wells, Philip Le Gal, Grégoire; Kahn, Susan; Shivakumar, Sudeep; Anderson, David; Wells, Philip; Ramsay, Timothy; de Witt, Kerstin; Rodger, Marc; Righini, Marc; Kearon, Clive Lee, Douglas S.; Stukel, Therese; Ko, Dennis; Ross, Heather; Austin, Peter; Tu, Jack; Newton, Gary; Farkouh, Michael Lewis, Gary Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Institute for Clinical Evaluative Sciences Comparative effectiveness of cardiac drugs post-myocardial infarction. Role of oxidized phospholipids in the Windsor pathogenicity of lipoprotein(a). St. Michael s The mast cell - B cell axis in lung Hospital vascular remodelling and pulmonary hypertension. St. Michael s Surface modification of implantable Hospital materials for novel therapeutic applications. Ottawa Regulation of the PCSK9 binding Heart Institute interaction with LDL receptor. Ottawa Hospital Clinical predictors for venous Research Institute thromboembolism in patients with a history of thrombosis. Ottawa Hospital Age-adjusted D-dimer cutoff levels Research Institute to rule out deep vein thrombosis. (The ADJUST-DVT Study). Toronto General Early phase interventions for acute Research Institute ischemic heart failure. Toronto General CNS-mediated effects of insulin Research Institute and GLP-1 on intestinal and hepatic lipoprotein particle production in humans. Acute myocardial infarction, comparative effectiveness evaluation, anti-platelet therapy, lipid lowering medication, generic medication. Lipoprotein(a), apolipoprotein(a), atherosclerosis, oxidized phospholipids. Pulmonary hypertension, vascular remodelling, mast cells, B cells, endothelial cells. Antibody immobilization, regional drug delivery, vascular prostheses, material functionalization. Low-density lipoprotein receptor, PCSK9, low-density lipoprotein cholesterol, protein-protein interaction, plasma clearance. Deep vein thrombosis, pulmonary embolism, anticoagulants, recurrence, clinical decision rule. Deep vein thrombosis, diagnostic strategy, D-dimer, age. Heart failure, coronary heart disease, outcomes, health services research, quality of care. Lipoprotein, insulin, GLP-1, intestine, brain , ,980 II,III ,374 22,057 I , ,674 I ,639 75,639 I ,420 84,420 I,II , ,658 II ,604 88,604 II , ,275 II,III,IV ,856 88,856 I,II 54

61 Heart & Stroke Foundation Research Report Research Institution Project Keywords Term $ Cumulative Theme(s) $ to A new growth factor, CNPY2, Health Network to induce angiogenesis after cardiac Iischemia. Feasibility of a conductive polymer Health Network biomaterial to resynchronize the infarcted heart. Toronto PISCES-Pilot: Protection against General Hospital Incidences of Cardiovascular Events Study with Daily Fish Oil Supplementation in Dialysis Patients - Pilot Study in Satellite Dialysis. Children s Hospital LIFE and health for young children of Eastern Ontario with congenital heart defects (Learning, Inclusion, Friends and Emotional and physical Health). St. Michael s TNF-alpha signaling in subarachnoid Hospital hemorrhage. Role of CLOCK in heart disease. Guelph Sunnybrook Health Examination of the novel angiopoietin Sciences Centre peptide mimetic vasculotide as a treatment for atherosclerosis and ischemia. London Health Mechanisms of microvascular Sciences Centre endothelial cell apoptosis in sepsis. Engineered human vascular tissues Western Ontario as platforms for preclinical testing. McMaster Contribution of the lipid sensor GPR120 loss-of-function coding variant R270H to energy intake, obesity and type 2 diabetes in humans. Ischemic cardiomyopathy, angiogenesis, gene therapy, growth factor, cardiac function. Myocardial infarction, cardiac conduction, conductive biomaterial, tissue engineering, cardiac function. Satellite dialysis, omega-3, cardiovascular events, hemodialysis. Physical activity, motor skill, paediatric, congenital heart disease, accelerometry. Subarachnoid hemorrhage, vasospasm, TNFalpha, microvessels, sphingosine kinase 1. Cardiovascular disease, myocardial infarction, circadian rhythms, physiology, molecular biology, immune. Tie2, artherosclerosis, ischemia, limb disease, myocardial infarction. Sepsis, endothelium, apoptosis, neutrophil, human. Engineered vascular tissues, pre-clinical model, elastin, vascular smooth muscle phenotype, notch signaling. Lipid sensor, obesity, type 2 diabetes, genetics, ethnic diversity ,362 88,362 I , ,528 I ,129 99,129 II Principal Investigator and Co-Investigator(s) Li, Ren-Ke Li, Ren-Ke; Weisel, Richard D. Lok, Charmaine E; Farkouh, Michael; Tomlinson, George; Moist, Louise Longmuir, Patricia E.; Barrowman, Nicholas; Timmons, Brian; Tremblay, Mark; Dillenburg, Rejane; Adamo, Kristi; Lee, Suzie Macdonald, Robert; Bolz, Steffen- Sebastian; Ai, Jinglu Martino, Tami A. McGlade, Jane Mehta, Sanjay; Gill, Sean Mequanint, Kibret Meyre, David; Mente, Andrew; Anand, Sonia; Gerstein, Hertzel , ,244 II , ,848 I ,441 96,441 I,II , ,860 I , ,752 I ,458 82,458 I , ,652 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 55

62 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Mielniczuk, Lisa M.; Wells, George A.; Beanlands, Rob S.B.; DaSilva, Jean; de Kemp, Robert A; Davies, Ross; Haddad, Haissam; Dick, Alexander; Stewart, Duncan Min, Wei-Ping; Zheng, Xiufen Monnier, Philippe P. Morra, Dante J.; Tu, Karen; Thorpe, Kevin; Saposnik, Gustavo; Dorian, Paul; Jaakkimainen, Liisa; Gladstone, David; Meshkat, Nazanin; Ivers, Noah; Butt, Debra; Bhatia, Sacha; Leblanc, Kori; Valentinis, Alissia Nemer, Mona Nemer, Mona Ni, Heyu Pare, Guillaume; O Donnell, Martin; Sharma, Mike; Hart, Robert; Shoamanesh, Ashkan; Yusuf, Salim Park, David S. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Ottawa Heart Institute Right ventricular substrate metabolism as a predictor of right heart failure in patients with pulmonary arterial hypertension (RV-MET study). The role of mtor and Western Ontario TLR signaling networks on alloimmune modulation in heart transplantation. Toronto Modulation of the RGMa/Neogenin Western Hospital pathway promotes cell survival and regeneration after stroke. Improving stroke prevention for Health Network patients with atrial fibrillation in primary care. Mechanisms of TBX5 action in Ottawa the heart. Transcription networks in Ottawa cardiac hypertrophy. St. Michael s Apolipoprotein A-IV and platelet Hospital function: Novel links with thrombosis, inflammation, and atherosclerosis. McMaster Genetic determinants of early stroke A population study from INTERSTROKE. Mechanisms of delayed death of Ottawa in stroke. Heart failure, pulmonary hypertension, cardiac metabolism, PET imaging. Heart transplantation, mtor, TLR, RNA interfrence, tolerance. Neuronal survival, axonal regeneration, stroke, membrane proteins. Knowledge translation, atrial fibrillation, cluster random trial, stroke, guideline adherence. Holt-oram syndrome, transcription regulation, heart development, animal models of disease, TBX proteins. Cardiac hypertrophy, heart failure, gene regulation, transcription factors, vasoactive hormones. Apolipoprotein A-IV, platelets and integrins, thrombosis and hemostasis, atherosclerosis, inflammation. Stroke, genetics, next-generation sequencing. Stroke, neuronal death, cell cycle, in vivo, ischemia , ,950 I,II , ,574 I , ,993 I , ,261 II,III , ,542 I , ,998 I ,899 81,899 I ,400 62,400 I,II ,802 75,802 I 56

63 Heart & Stroke Foundation Research Report Parkinson, John; Keeley, Fred Hospital for Sick Children Towards a systems level understanding of the elastic fibre and its role in cardiovascular disease. Elastic fibres, systems biology, thoracic aortic aneurysm and dissection, next generation sequencing, sequence polymorphisms. Pausova, Zdenka; Hospital for Visceral fat and hypertension: Lipidomics profiling, visceral Bennett, Steffany; Sick Children sex-specific lipidomic biomarkers fat, hypertension, sex, Gaudet, Daniel; across generations. adolescence-adulthood. Abrahamowicz, Michal Rand, Margaret L. Hospital for The procoagulant surface of Platelets, thrombosis, Sick Children activated platelets: Development and procoagulant activity, persistence in vitro and in vivo. phosphatidylserine. Reid, Robert D.; Ecologically Optimizing Exercise Physical activity, cardiac Grace, Sherry L.; Pipe, Ottawa Maintenance in Men and Women rehabilitation, maintenance/ Andrew; Kingsbury, Heart Institute Post-Cardiac Rehabilitation: adherence, coronary Kori; Chessex, A Randomized Controlled Trial of artery disease. Caroline; Manuel, Efficacy with Economics (ECO-PCR) Douglas; Blanchard, Chris; Mark, Amy; Mullen, Keri-Anne; Harris, Jennifer; Krahn, Murray Reid, Robert D.; Randomized trial of nordic walking Heart failure, cardiac Wells, George; Ottawa vs. standard cardiac rehabilitation in rehabilitation, functional Mielniczuk, Lisa; Heart Institute patients with heart failure. capacity, quality of life, Chan, Kwan-Leung; nordic walking. Pipe, Andrew; Mark, Amy; Tulloch, Heather; Harris, Jennifer; Keast, Marja-Leena Roy, Eric A.; Neuropsychological profiles Movement neuroscience, Black, Sandra E.; Waterloo and neuroanatomic correlates apraxia, neuropsychology, motor Park, Norman; of limb apraxia. control, cognitive deficits. Staines, Richard; Hebert, Deborah; Schweizer, Tom; Graham, Simon Principal Investigator Research Institution Project Keywords Term $ Cumulative Theme(s) and Co-Investigator(s) $ to Park, David S. Ottawa The role of Pink1 in stroke. Stroke, neuronal death, , ,457 I,II mitochondria, AKT, oxidative stress. Parker, Thomas G. St. Michael s Hospital S100A1 and A6 proteins in pulmonary vascular pathophysiology: intracellular, extracellular, and cell-lineage specific mechanisms of action. S100 proteins, pulmonary hypertension, cell signalling , ,689 I , ,085 I,II,IV , ,693 I,IV , ,478 I , ,233 II,III,IV , ,919 II,III , ,175 I,II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 57

64 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Saposnik, Gustavo; Bayley, Mark T.; Mamdami, Muhammed; McIlroy, William; Teasell, Robert; Thorpe, Kevin; Laupacis, Andrea; Dukelow, Sean Scholey, James W. Scott, Ian Sharpe, Simon J; Pomès, Régis; Keeley, Fred Sheffield, William P. Simmons, Craig; Yau, Terrence M. Slack, Ruth S. Sorisky, Alexander Stanford, William L. Steinman, David A. Stiell, Ian G.; Wells, George; Birnie, David; Perry, Jeffrey; Brison, Robert; Borgundvaag, Bjug Research Institution Project Keywords Term $ Cumulative Theme(s) $ to St Michael s Efficacy of Virtual Reality Exercises Hospital using Wii gaming technology in STroke Rehabilitation: A multicentre randomized clinical trial (EVREST multicentre) Adiponectin signaling pathways and Toronto diabetic kidney injury. Hospital for Live analysis of CCM mechanism Sick Children and progression in a zebrafish CCM3 model. Hospital for Linking structural and functional Sick Children consequences of sequence polymorphisms in human tropoelastin with susceptibility to late-onset vascular diseases. McMaster Targeting factor XIa for improved antithrombotic therapy. The roles of C-type natriuretic of Toronto peptide in aortic valve disease. Regulation of Opa1 to maintain of Ottawa mitochondrial energy metabolism and survival after stroke. Ottawa Hospital Adipose progenitor cell responses to Research Institute nutrient stress and macrophages. Ottawa Hospital The role of aberrant Lamin A splice Research Institute isoforms in vascular smooth muscle aging and disease. Hemodynamics of cerebral of Toronto aneurysms: back to basics. Ottawa Hospital A randomized, controlled Research Institute comparison of electrical versus pharmacological cardioversion for emergency department patients with recent-onset atrial fibrillation and flutter (RAFF). Stroke rehabilitation, virtual reality, motor function, ischemic stroke, clinical trial. Adiponectin, diabetes, angiotensin, camp, NADPH oxidase. Intracranial hemorrhage, cerebral cavernous malformation, vascular integrity, stroke, zebrafish. Vascular diseases, elastin structure and function, structural biology, arterial elasticity, genetic risk factors for disease. Coagulation, thrombosis, coagulation factor XI, protease nexin 2, aptamers. C-type natriuretic peptide, calcific aortic valve disease, fibrosis,hemodynamics, bicuspid aortic valve , ,710 II,III , ,600 I , ,000 I ,279 91,279 I ,210 60,210 I ,120 96,120 I Stroke, cell death, mitochondria , ,410 I Obesity, adipose progenitor, , ,810 I,II macrophage, high glucose, inflammation. Atherosclerosis, vascular , ,810 I smooth muscle cells, aging, induced pluripotent stem cells, lamin A. Cerebral aneurysm, , ,699 I,II hemodynamics, rupture risk, hemodynamics, turbulence. Atrial fibrillation, atrial flutter, , ,354 II,III cardioversion, randomized trial, emergency department. 58

65 Heart & Stroke Foundation Research Report Sun, Hong-Shuo Toronto Cellular and molecular mechanisms of stroke in diabetes and its potential therapeutic treatments. Stroke, diabetes, animal models, ion channels, treatment. Sweeney, Gary York Metabolic effects of adiponectin on Adiponectin, cardiac the heart: mechanisms and functional metabolism, cardiomyopathy, consequences. obesity, diabetes. Sweeney, Gary York Regulation of cardiac structure and Lipocalin-2, inflammation, function by lipocalin-2. cardiac remodeling, metabolism, autophagy. Teasell, Robert W.; Viana, Ricardo; Speechley, Mark Lawson Health Research Institute A temporal analysis of stroke rehabilitation evidence. Stroke, rehabilitation, evidencebased, randomized controlled trial, intervention. Thiruganasambandamoorthy, Ottawa Hospital Risk stratification of adult emergency Syncope, arrhythmia, death, Venkatesh; Research Institute department syncope patients to risk-stratification, emergency Stiell, Ian; Wells, predict short-term serious adverse department. George; Calder, Lisa; events after discharge (RiSEDS Taljaard, Monica; study) phase II. Sivilotti, Marco; Graham, Ian; Sheldon, Robert; Krahn, Andrew Timmons, Brian W.; McMaster Cardiovascular Health in children Physical activity, fitness, risk MacDonald, Maureen; with a chronic inflammatory factors, inflammatory disease, Cellucci, Tania; condition: role of Physical activity, vascular function. Thabane, Lehana fitness, and inflammation: The CHAMPION Study Tremblay, Mark S.; Children s Hospital Active transportation, independent Active transportation, physical Larouche, Richard; of Eastern Ontario mobility, and physical activity among activity, independent mobility, Faulkner, Guy; school children: a multi-site study. social-ecological model, Trudeau, Francois moderators. Trigatti, Bernardo L. McMaster Molecular mechanisms by which Atherosclerosis, cytokine, interleukin-15 contributes to the receptor, genetics, lipoprotein. development of atherosclerosis. Trigatti, Bernardo L. McMaster Role of the multisubunit adaptor HDL, PDZK1, atherosclerosis, protein, PDZK1, in leukocytes in regression, macrophage. atherosclerosis development and HDL induced plaque regression. Tuana, Balwant S. The role of E2F6 in dilated Heart failure, dilated heart, Ottawa cardiomyopathy. hypertrophy, transcription, remodeling. Principal Investigator Research Institution Project Keywords Term $ Cumulative Theme(s) and Co-Investigator(s) $ to Storey, Kenneth B. Carleton Suspended animation: hypometabolic hearts in a model of primate torpor. Primate hibernation, regulation of hypometabolism, signal transduction & metabolic regulation, anti-apoptosis, epigenetic & microrna control of gene expression , ,300 I , ,950 I , ,320 I , ,206 I ,625 26,625 II,III,IV ,263 81,263 II,III , ,229 I,II ,063 40,063 IV , ,527 I ,036 84,036 I , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 59

66 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Tulloch, Heather E.; Collins, Barbara; McHugh, Tara; LeMay, Michel; Duchesne, Lloyd; Quinlan, Bonnie; Awad Shimoon, Nesrine; Wells, George Udell, Jacob A; Redelmeier, Donald A; Laskin, Carl; Dayan, Natalie Vasconcelos, Sara S. Nunes Verma, Subodh Verma, Subodh; Anderson, Todd J. Weitz, Jeffrey I. Wells, James W. Wen, Shi Wu; Walker, Mark; Sprague, Ann; Gaudet, Laura; Graves, Erin; Leader, Arthur; Taljaard, Monica Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Ottawa Neurocognitive outcomes after Heart Institute out-of-hospital cardiac arrest. Women s Investigation of Notable College Hospital Failed Endeavours at Reproductive Treatment and Ischemic Long-term Events (INFERTILE) Study. Arterio-venous specification during Health Network adult neovascularization. St. Michael s Elucidating the role of BRCA1 as Hospital a target to improve endothelial function, promote angiogenesis and attenuate atherosclerosis. St. Michael s The role of autophagy in Hospital cardiovascular disease: a bench to bedside translational approach. McMaster Impact of gamma -fibrinogen on clot formation and clot lysis at sites of plaque rupture. Nature of the signalling complex Toronto between cardiac muscarinic receptors and G proteins. Ottawa Hospital Congenital heart disease in infants Research Institute born to mothers conceived by assisted reproductive technology: a record linkage study with Ontario registries. Cardiac arrest, neurocognitive, quality of life, psychosocial outcome, heart attack. Fertility therapy, risk factors, cardiovascular disease, women s health, pregnancy. Neovascularization, vessel maturation, artery and vein specification, endothelium, diabetes. BRCA1, endothelial function, atherosclerosis, tissue specific knockout mouse. Integrative cardiovascular medicine, knockout mice, translational science, endothelial function, atherosclerosis. Coagulation, fibrinolysis, thrombolysis, plasminogen activators. G protein-coupled receptors, transmembrane signalling, oligomers and co-operativity, drug-receptor interactions, protein-protein interactions. Congenital heart disease, assisted reproductive technology, ovulation stimulation, obesity, epidemiology ,090 52,090 II,IV ,759 71,759 II,III,IV , ,850 I , ,143 I , ,410 I,II , ,511 I , ,277 I ,416 82,416 II,III,IV 60

67 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Wijeysundera, Duminda N.; Cuthbertson, Brian; Thorpe, Kevin; Beattie, W. Scott; Mazer, C. David; Granton, John; Mamdani, Muhammad; Oh, Paul; Brull, Richard; Wijeysundera, Harindra; McCartney, Colin Wu, Lingyun (Lily); Wang, Rui Yan, Andrew T.; Wald, Ron; Wright, Graham; Goldstein, Marc; Yuen, Darren; Kirpalani, Anish; Lebovic, Gerald; Kiaii, Mercedeh; Leipsic, Jonathan; Leong-Poi, Howard; Connelly, Kim Zandstra, Peter W. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to St. Michael s Hospital The METS study: an international multicentre prospective cohort study of cardiopulmonary exercise testing for improving preoperative risk stratification for major non-cardiac surgery. Preoperative risk stratification, cardiopulmonary exercise testing, functional capacity, perioperative cardiac complications, prognostic studies. Lakehead Regulation of aldolase B expression Methyglyoxal, fructose, and scavenging methylglyoxal in aldolase B, ChREBP, FoxO1/3a. vascular smooth muscle cells. St. Michael s Impact of in-centre nocturnal End-stage renal disease, Hospital hemodialysis on cardiac remodeling dialysis, left ventricular mass in end-stage renal disease: and function, cardiac magnetic A long-term follow-up study. resonance imaging, biomarkers. Accelerating the development of Myocardial infarction, human Toronto regenerative biologics for myocardial pluripotent stem cell derived infarction using functional human cardiomyocytes, engineered microtissues. cardiac micro-tissue model, cardiomyocyte survival and proliferation screening, targeted protein delivery , ,000 II,III , ,038 I , ,641 I,II,III , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 61

68 Heart & Stroke Foundation Research Report Quebec Principal Investigator and Co-Investigator(s) Afilalo, Jonathan; Graham, Michelle; Stevens, Louis-Mathieu; Joseph, Lawrence Allen, Bruce Anand-Srivastava, Madhu B. Beaudoin, Jonathan; Pibarot, Philippe; Mathieu, Patrick; Arsenault, Marie; Couet, Jacques Blostein, Mark D. Boivin, Benoit Bonnet, Sébastien; Couture, Christian; Provencher, Steve Bossé, Yohan; Pibarot, Philippe; Mathieu, Patrick Bousette, Nicolas Cerruti, Marta G.; Murshed, Monzur; Mantovani, Diego Couet, Jacques; Laplante, Mathieu; Arsenault, Marie D Avanzo, Nazzareno Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Sir Mortimer B. Davis Jewish General Hospital Optimal revascularization strategy in patients undergoing aortic valve replacement. Aortic valve replacement, coronary artery bypass, revascularization, outcomes, coronary artery disease. Institut de MAP Kinase-Activated Protein Protein kinase, p38 MAP kinase, cardiologie Kinases (MKs) mediate distinct hypertrophy, fibrosis, signal de Montréal detrimental effects of p38 MAP transduction. kinase activation in heart. Université de Natriuretic peptide receptors Natriuretic peptide receptors A Montréal in cardiovascular physiology and C, knockout mice, and pathology. G proteins, hypertension, cell proliferation. Institut Role and mechanisms of mitral Mitral regurgitation, cardiac universitaire de leaflet remodeling in functional mitral imaging, animal models, heart cardiologie et regurgitation. failure, valvular heart disease. de pneumologie de Québec Lady Davis Institute Role of gas6 and inflammation in Venous thrombosis, for Medical the pathophysiology of venous inflammation, gas6. Research thromboembolism. Institut de Understanding PTP1B regulation of Cardiac hypertrophy, signalling, cardiologie microrna-mediated gene silencing transgenic, protein phosphatase, de Montréal in cardiac hypertrophy. gene silencing. Institut Role for DNA damage signalling in Pulmonary arterial hypertension, universitaire de pulmonary arterial hypertension. integrative studies, gene therapy, cardiologie et animal model. de pneumologie de Québec Institut Multidimensional genomic Calcific aortic valve stenosis, universitaire de profiling to elucidate the molecular genomics, epigenetics, cardiologie et mechanisms underpinning calcific microrna, gene expression. de pneumologie de aortic valve stenosis. Québec Montreal The protective role of perilipin-2 in Diabetes, lipotoxicity, ER stress, Heart Institute diabetic cardiomyopathy lipids, apoptosis. McGill A multidisciplinary approach to Vascular calcification, unravel the mystery of vascular elastin, matrix Gla protein, calcification. spectroscopic analysis, molecular biology techniques. Institut Modulating mtor activity in aortics Heart valve disease, heart universitaire de stenosis. hypertophy, mtor, aortic cardiologie et stenosis, pressure overload. de pneumologie de Québec Université de Lipid regulation of purified eukaryotic Lipid regulation of ion channels, Montréal potassium channels. electrophysiology, bochemistry, ion channel, arrhythmias ,448 98,448 II , ,931 I ,624 92,624 I ,066 78,066 I , ,523 I ,159 89,159 I , ,977 I,II ,823 99,823 I,II , ,816 I , ,056 I ,777 89,777 I , ,375 I 62

69 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Hébert, Terence; Tanny, Jason Jacques, Danielle Kriz, Jasna; Sato, Sachiko Levin, Mindy; Feldman, Anatol Marette, André; Mathieu, Patrick; Sweeney, Gary Mathieu, Patrick; Pibarot, Philippe; Marette, Andre; Paquin, Jean-Francois Mourad, Walid M. Nattel, Stanley Nattel, Stanley Parent, Lucie Rousseau, Guy Sébire, Guillaume Université de Sherbrooke Regulation of secretion of cardiac endocardial endothelial cells by neuropeptide Y. Endocardial endothelium, neuropeptide Y, left and right ventricles, endothelin-1, hypertrophy. Centre Hospitalier The role of galectin-3 in Immune response, microglia, Universitaire post-ischemic immune responses. stroke, galectins, therapy. de Québec Jewish Corticospinal contribution to Hypertonicity, modulatory Rehabilitation spasticity and disordered system, upper limb, stroke, TMS. Hospital motor control. Institut Cardioprotective action of PDX Diabetes, obesity, cardiac universitaire de in obese diabetic mice. dysfunction, aortic stenosis, cardiologie et omega 3 fatty acids. de pneumologie de Québec Institut de Inhibition of ectonucleotide Calcific aortic valve cardiologie pyrophosphatase / disease, aortic stenosis, de Québec phosphodiesterase-1 with a novel ectonucleotidase, quinazolin-derived compound in pharmacological treatment, order to prevent the progression of animal model. aortic stenosis. Centre hospitalier Role of CD154 and its receptors CD154, receptors, integrins, de l université in atherothrombosis. atherosclerosis, inflammation. de Montréal Montreal Factors altering the interaction Cardiac arrhythmias, atrial Heart Institute between antiarrhythmic drugs fibrillation, remodeling, nuclear and cardiac tissue: role of nuclear function, cell calcium. receptors and remodeling. Montreal Molecular control of cardiac Remodeling, proarrhythmia, Heart Institute repolarization and the substrate for sudden death, ion channels, lethal ventricular arrhythmias. cell calcium. Institut de Unraveling the complex Arrhythmias, ion channel, cardiologie interactions between the auxiliary genetic diseases, calcium de Montréal Cavalpha2delta subunit and the cycling, structure. cardiac L-type calcium channel. Hôpital du The importance of resolvins in the Resolvin, omega-3, myocardial Sacré-Coeur cardioprotective effect of omega-3 infarction, inflammation, de Montréal fatty acids. protection. Université de Rôle de la réponse inflammatoire Accident vasculaire Sherbrooke maternofoetale dans la cerebral, cytokines, physiopathologie des accidents inflammation gestationnelle, vasculaires cérébraux (AVC) vasculoprotection, périnatals. neuroprotection. Research Institution Project Keywords Term $ Cumulative $ to Theme(s) McGill The role of the RNA polymerase Cardiac hypertrophy, heart ,000 98,000 I II elongation complex in cardiac failure, transcription elongation, hypertrophy and heart disease. RNA polymerase, G protein signalling , ,697 I , ,606 I , ,794 I,II ,964 92,964 I , ,850 I , ,194 I , ,579 I ,965 77,965 I ,824 83,824 I , ,179 I , ,198 I,II,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 63

70 Heart & Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Shrier, Alvin; Glass, Leon M.; Essebag, Vidal Thanassoulis, George; Tsimikas, Sotirios Thorin, Eric; Lesage, Frederic Vohl, Marie-Claude; Tchernof, Andre; Perusse, Louis Nova Scotia Principal Investigator and Co-Investigator(s) Pasumarthi, Kishore Babu S. Pavlov, Evgeny Robertson, George S. Waisman, David M. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Dalhousie Molecular and functional characterization of cardiac progenitor cells. Cardiac progenitor cells, cell proliferation and differentiation, cell transplantation, donor cell and drug interactions, cardiomyogenic pathways. Dalhousie Molecular basis of the pathological Mitochondria, inorganic mitochondrial membrane transport: polyphosphate, roles of inorganic polyphosphate and polyhydroxybutyrate, polyhydroxybutyrate. permeability transition pore, calcium. Dalhousie Mitochondrial calcium uptake and Neuroprotection, mitochondria, targeted therapeutics. calcium, CREB, synergism. Dalhousie Defining the physiological function S100A10, plasminogen, stroke, of S100A10 with the S100A10 fibrinolysis, plasmin. knockout mouse. Newfoundland and Labrador Principal Investigator and Co-Investigator(s) Woods, Michael; McGowan, Ross Research Institution Project Keywords Term $ Cumulative $ to Theme(s) McGill Transition to tachycardia. Arrhythmia, dynamics, ,851 58,851 I,II heterogeneities, fluorescent imaging, tissue culture. Research Institute The lipoprotein(a), Valve disease, lipoproteins, ,314 80,314 I,II of the McGill oxidized phospholipid and phospholipids, molecular and Unversity Health lipoprotein-associated genetic epidemiology. Centre phospholipase A2 pathway in aortic valve calcification. Institut de Pulse pressure-dependent Cerebral arteries, cerebral ,771 87,771 I Cardiologie regulation of cerebrovascular circulation, brain imaging, aging, de Montreal endothelial function through age pulse pressure. and cardiovascular diseases. Université Laval A study of genetic and epigenetic Metabolic syndrome, obesity, , ,000 I,IV factors influencing obesity-related genetics, epigenetics, adipose metabolic complications. tissue ,850 91,850 I , ,261 I ,610 89,610 I , ,472 I Research Institution Project Keywords Term $ Cumulative $ to Theme(s) Memorial Identification of novel genes causing Intracranial aneurysms, ,663 91,663 I,II of Newfoundland intracranial aneurysms. gene discovery, next generation sequencing, zebrafish model organism. 64

71 Appendix D Research Chairs and Professorships Photo: Dr. Sonia Anand (McMaster ) is the Heart & Stroke Foundation / Micheal G. DeGroote Chair in Population Health Research.

72 Heart & Stroke Foundation Research Report Research Chairs and Professorships Research Chairs Title Type Province(s)/Territory(ies) Krahn, Andrew British Columbia Lear, Scott St. Paul s Hospital/ Simon Fraser Becher, Harald Alberta Demchuk, Andrew Calgary Duff, Henry Calgary Kelly, Michael Saskatchewan Katz, Alan Manitoba Anand, Sonia McMaster Goodman, Shaun Toronto McGillion, Michael McMaster Mital, Seema Hospital for Sick Children Pickering, Geoffrey Western Ontario Tobe, Sheldon Northern Ontario School of Medicine Weitz, Jeffrey McMaster Yusuf, Salim McMaster Cox, Jafna Dalhousie The Sauder Family / Heart and Stroke Foundation Chair in Cardiology Cardiology British Columbia/Yukon Pfizer / Heart and Stroke Foundation Cardiovascular Prevention British Columbia/Yukon Chair in Cardiovascular Prevention Research Research Heart and Stroke Foundation Cardiovascular Alberta/Northwest Chair in Cardiovascular Research Territories/Nunavut Heart and Stroke Foundation Stroke Alberta/Northwest Chair in Stroke Research Territories/Nunavut Heart and Stroke Foundation Cardiovascular Alberta/Northwest Chair in Cardiovascular Research Territories/Nunavut Saskatchewan Clinical Stroke Research Chair Clinical Stroke Saskatchewan Manitoba Research Chair in Primary Prevention Primary Prevention Manitoba Heart and Stroke Foundation / Michael G. Population Health Ontario DeGroote Chair in Population Health Research Heart and Stroke Foundation Polo for Heart Chair Cardiology Ontario Heart and Stroke Foundation / Michael G. DeGroote Chair in Cardiovascular Nursing Cardiac Nursing Ontario Heart and Stroke Foundation / Robert M. Freedom Cardiology Ontario Chair in Cardiovascular Science Heart and Stroke Foundation / Barnett-Ivey Cardiology Ontario Chair at the Robarts Research Institute Heart and Stroke Foundation / NOSM Chair in Aboriginal and Rural Health Aboriginal and Rural Health Ontario Heart and Stroke Foundation / J. Fraser Mustard Cardiology Ontario Chair in Cardiovascular Research Heart and Stroke Foundation / Marion W. Burke Cardiology Ontario Chair in Cardiovascular Disease Heart and Stroke Foundation Chair Endowed Cardiology Nova Scotia Chair in Cardiovascular Outcomes Research 66

73 Heart & Stroke Foundation Research Report Professorships Title Type Province(s)/Territory(ies) Humphries, Karin British Columbia UBC / Heart and Stroke Foundation Professorship in Women's Cardiovascular Health Women's Cardiovascular Health British Columbia/Yukon Teal, Philip British Columbia The Sauder Family/ Heart and Stroke Foundation Professorship in Clinical Stroke Research Clinical Stroke British Columbia/Yukon Bijoy K., Menon Calgary The Heart and Stroke Foundation / of Calgary Professorship in Brain Imaging Stroke Alberta/Northwest Territories/Nunavut Butcher, Ken Alberta Heart and Stroke Foundation Professorship in Stroke Research Stroke Alberta/Northwest Territories/Nunavut Chen, Wayne Calgary Heart and Stroke Foundation / Libin Cardiovascular Institute Professorship in Cardiovascular Research Cardiology Alberta/Northwest Territories/Nunavut Georg, Schmolzer Alberta The Heart and Stroke Foundation / Alberta Professorship in Neonatal Resuscitation Neonatal Resuscitation Alberta/Northwest Territories/Nunavut Hill, Michael Calgary Heart and Stroke Foundation / Hotchkiss Brain Institute Professorship in Stroke Research Stroke Alberta/Northwest Territories/Nunavut Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from other sources. 67

74 Heart & Stroke Foundation Research Report

75 Appendix E Provincial Personnel Awards Photo: Dr. Moira Kapral (Toronto General Hospital) was funded in through her Ontario Career Investigator Award, awarded in Photo credit to Jacklyn Atlas.

76 Heart & Stroke Foundation Research Report Alberta/Northwest Territories/Nunavut New Investigator Awards Awardee Research Institution Project Term $ Total $ Gordon, Grant Calgary Parallel control of the micro-vasculature by astrocytes and neurons. Ussher, John Alberta The role of pyruvate dehydrogenase in FoxO1/3- driven diabetic cardiomyopathy. White, James Calgary MRI allocation of pacing targets in cardiac resynchronization therapy (MAPIT-CRT) , ,000 60, ,000 60, ,000 British Columbia/Yukon Robert Hayden Research Fellowship Awardee Research Institution Project Term $ Total $ Kearns, Mark J. British Columbia Sternal closure technique in patients at high-risk of developing sternal wound complications: a study of cardiac surgery patients in British Columbia , ,000 Ontario Career Investigator Awards Awardee Research Institution Project Term $ Total $ Austin, Peter C. Institute for Clinical Evaluative Sciences Statistical methods for cardiovascular research Beanlands, Rob S. B. Ottawa Metabolism, energetics and neurohormonal signaling and Heart Institute their response to therapy in dysfunctional myocardium. Bolz, Steffen-Sebastian Toronto Translating molecular mechanisms governing microvascular behaviour - a bench to bedside strategy. Crowther, Mark A. St. Joseph's Hospital Improving the quality of anticoagulant care for patients with cardiovascular disease. Devereaux, Philip J. McMaster Major vascular complications after noncardiac surgery Drangova, Maria Robarts Research Institute Cardiac imaging for therapy guidance and pre-clinical research studies. Ferguson, Molecular regulation of G protein-coupled receptor signal Stephen S.G. Western Ontario transduction, desensitization and resensitization. Husain, Mansoor Toronto General Hospital Molecular studies of cardiac and vascular disease Kapral, Moira K. Toronto General Hospital Evaluation of stroke care in Canada Nanthakumar, Toronto General Hospital Human ventricular fibrillation, refibrillation, and Kumaraswamy cardiac arrest: mechanisms & modulation. 83, ,000 41, ,500 83, ,000 83, ,000 83, ,000 83, ,000 41, ,500 83, ,000 83, ,000 83, ,000 70

77 Heart & Stroke Foundation Research Report Awardee Research Institution Project Term $ Total $ 83, ,000 83, ,000 83, ,000 83, ,000 Clinician Scientist Awardee Research Institution Project Term $ Total $ Park, David S. Ottawa Pathways which regulate neuronal death Rodger, Marc A. The Ottawa Hospital Venous thrombosis and thrombophilia Sweeney, Gary York Cardiac remodelling by adipokines: mechanisms and pathophysiological significance in heart failure. Yang, Burton B. Sunnybrook Health The roles of MicroRNAs in Regulating Cell Activities and Science Centre Angiogenesis. Epelman, Slava Health Network Distinct mononuclear phagocyte subsets mediate cardiac tissue injury and repair Johri, Amer Queen's Carotid artery plaque quantification to assess progression of atherosclerosis. Ko, Dennis T. Institute for Clinical Improve the quality and outcomes of care of patients with Evaluative Sciences cardiovascular diseases. Le Gal, Gregoire The Ottawa Hospital Improving the diagnostic management of venous Research Institute thromboembolism. Mielniczuk, Lisa M. Ottawa Cardiopulmonary energetics and metabolism in right Heart Institute heart failure and pulmonary hypertension. Tang, Ada McMaster Exercise and cardiovascular health after stroke , ,000 70, ,000 80, ,000 80, ,000 80, ,000 70, ,000 71

78 Heart & Stroke Foundation Research Report Mid-Career Investigator Awardee Research Institution Project Term $ Total $ Alter, David A. Institute for Clinical Evaluative Sciences Characterizing the adherence phenotypes of populations with cardiovascular disease: Applications for health services research and interventions Birnie, David H. Ottawa Comprehensive program of patient orientated research in Heart Institute cardiac arrhythmia. Booth, Gillian L. St. Michael's Hospital Population-based strategies for reducing the burden of cardiovascular disease due to diabetes. Chauhan, Vijay Health Network Electrical sources and substrate in human atrial fibrillation Chen, Hsiao-Huei Ottawa Hospital A systems approach to stroke recovery Research Institute Eikelboom, John McMaster Mechanisms and treatment of antithrombotic drug failure Fowler, Robert A. Sunnybrook Health Improving end-of-life care for Canadians with heart disease Science Centre and stroke. Gollob, Michael H. Health Network Novel molecular targets and mechanisms of human atrial fibrillation. Healey, Jeff S. Hamilton Health Sciences Detection and treatment of sub-clinical atrial fibrillation to prevent stroke. Lok, Charmaine E. Toronto General Hospital A program of cardiovascular health improvement in chronic and endstage kidney disease. Retnakaran, Ravi R. Mount Sinai Hospital The early natural history and pathophysiology of cardiometabolic disease in mother and child. St. Lawrence, Keith S. Developing non-invasive optical techniques to detect cerebral Western Ontario ischemia in critical-care patients. Steinman, David A. Toronto Hemodynamic and geometric risk factors: Turning theory into practice. Wu, Lingyun Laurentian Methylgloxal metabolism and vascular remodelling , ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 Summer Student Scholarship Awardee Award Name Supervisor Research Institution $ Aziza, Eitan Dr. Jack V. Tu Scholarship* Mashari, Azad Toronto 2,500 Burrows, Claire HSF-TD scholarship** Atoui, Rony Northern Ontario School of Medicine 12,000 Chung, Amy Hannah Pherril Scholarship Sun, Louise Ottawa 5,000 Hui, Sonya Evelyn McGloin Scholarship Ouzounian, Maral McMaster 5,000 McConnery, Jason HSF Summer Ross, Heather Toronto 5,000 Medical Scholarship Metias, Maged HSF Summer Meineri, Massimiliano Toronto 5,000 Medical Scholarship Olivier, Christopher HSF-TD scholarship** Tobe, Sheldon Northern Ontario School of Medicine 12,000 Raju, Sneha Dr. Jack V. Tu Scholarship* Rao, Vivek Toronto 2,500 Roy, Meagan A. HSF-TD scholarship** Tobe, Sheldon Northern Ontario School of Medicine 12,000 Swenson, Luke HSF Summer Medical Scholarship Loufty, Mona Toronto 5,000 72

79 Heart & Stroke Foundation Research Report Awardee Award Name Supervisor Research Institution $ Fung, Elizabeth Irwin Bernick Scholarship* Williams, Suzan Toronto 2,500 Williams, Curtis Irwin Bernick Scholarship* Jiminez-Juan, Laura Toronto 2,500 Muise, Stephanie Maunder Scholarship Petrella, Rob Western 5,000 Krett, Jonathan Miriam Neveren Scholarship Cook, D.J. Queen's 5,000 Levit, Alexander Qi, Yuan *Shared Award R. John and Agnes M. Adams Scholarship* R. John and Agnes M. Adams Scholarship* Whitehead, Shawn Western 2,500 John-Baptiste, Ava Western 2,500 **The HSF-TD Scholarship supports a four month research project with funding of $12,000. Newfoundland and Labrador Award Research Institution $ Graduate Scholarship Grant - NeuroFIT Program Keith Griffiths Memorial Scholarship Undergraduate Nursing Award in Cardiovascular Health Undergraduate Nursing Award in Stroke Memorial of Newfoundland Memorial of Newfoundland Memorial of Newfoundland Memorial of Newfoundland Memorial of Newfoundland 1,500 3,500 1,500 1,500 1,500 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 73

80 Heart & Stroke Foundation Research Report

81 Appendix F Other Provincial Initiatives Photo: Dr. Todd Duhamel ( Manitoba) was a recipient of the HSF, Manitoba Primary Prevention Challenge Grant. Photo credit to Kim Babij (FKRM Communication Officer, Manitoba).

82 Heart & Stroke Foundation Research Report Alberta/Northwest Territories/Nunavut Seed Grants Seed Grants provide funding support to New Investigators to conduct research which will lay the groundwork for a new and competitive peer-reviewed application. The intent is to enhance Alberta success in national and provincial granting competitions. This initiative provides opportunity for investigators to develop high-impact novel ideas and encourages innovative research with the potential for significant impact on cardio and/or cerebrovascular health. Principal Investigator Research Institution Project $ Bainey, Kevin Alberta Vascular scanning in family members of patients with premature vascular 45,000 disease: (VAS-SCAN) Pilot Study. Cheng, Adam Calgary Optimizing integration of CPR feedback technology with CPR coaching for 45,000 cardiac arrest. Ezekowitz, Justin Alberta HiLo-HF Trial. 45,000 Kirton, Adam Calgary Mind control for severe hemiparesis in children: brain-computer interface development in perinatal stroke. VanDiepen, Sean Alberta Identifying hospitalized heart failure patients who require a critical care admission. 45,000 42,000 British Columbia/Yukon H&S-UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) As part of its mandate to support innovative research and its application to improve the health of Canadians, Heart & Stroke Foundation, BC & Yukon, has partnered with the British Columbia s Division of Cardiology to support research by early career cardiologists. Grant: $200,000 Principal Investigator Davis, Margot Deyell, Marc Grewal, Jasmine Ong, Kevin Ramanathan, Krishnan Saw, Jacqueline Sedlak, Tara Taylor, Carolyn Tsang, Michael Wood, David Research Institution Vancouver General Hospital St. Paul's Hospital St. Paul's Hospital St. Paul's Hospital St. Paul's Hospital Vancouver General Hospital Vancouver General Hospital St. Paul's Hospital Vancouver General Hospital Vancouver General Hospital 76

83 Heart & Stroke Foundation Research Report Knowledge to Action Grant Principal Investigator and Co-Investigator(s) Brunham, Liam; Anis, Aslam; Pimstone, Simon Harris, Kevin; Voss, Christine Miller, Kimberly; Abel, James; Aikman Ramsay, Pamela; Humphries, Karin; Ramanathan, Krishnan Bridge Grant Principal Investigator Research Institution $ and Co-Investigator(s) Francis, Gordon St. Paul's Hospital 65,000 Manitoba Research Institution Project Term $ St. Paul's Hospital SAVE-BC: Study to avoid vascular events in British Columbia ,000 BC Children's Hospital Provincial use of physical activity trackers for children with ,159 congenital heart disease. Simon Fraser Informing coronary revascularization decisions in diabetic patients: ,800 Moving knowledge to action. Primary Prevention Challenge Grant Principal Research Institution Project Term $ Total $ Investigator Duhamel, Todd Manitoba Developing the ENCOURAGE app to support physical activity ,000 80,000 promotion in diverse workplaces. Madden, Shoni Green Action Centre Completing the picture: mapping how children fit into the transportation landscape ,000 80,000 77

84 Heart & Stroke Foundation Research Report Quebec Heart & Stroke Foundation of Quebec Awards for Excellence in Research Awards for excellence highlighting the outstanding contribution of researchers. Principal Investigator Award Name Research Institution Project $ Boivin, Benoît Jacques de Champlain Montreal Heart Institute Understanding PTP1B regulation of microrna-mediated 10,000 Foundation Award gene silencing in cardiac hypertrophy. Bossé, Yohan Harvey Zalcman Award Institut universitaire de Multidimensional genomic profiling to elucidate the 5,000 cardiologie et pneumologie de Québec molecular mechanisms underpinning calcific aortic valve stenosis. Parent, Lucie Groupe Jean-Coutu Montreal Heart Institute Unraveling the complex interactions between auxiliary 50,000 (PJC) Inc. Award Cavalpha2-delta subunit and the cardiac L-type calcium channel. Shrier, Alvin John J. Day Award McGill Transition to Tachycardia. 10,000 Thorin, Eric RBC Royal Bank Award Montreal Heart Institute Pulse pressure-dependent regulation of cerebrovascular endothelial function through age and cardiovascular diseases. 20,000 Training bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de recherche du Québec en santé (FRQS) and the Heart & Stroke Foundation, Quebec (HSF,Q). The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart & Stroke Foundation, Quebec. Principal $ Investigator Huguet, Jade 6,600 Sweet, Shane 36,143 Nova Scotia BrightRed Graduate Research Award Grant: $5,000 Awardee Supervisor(s) Research Institution Project Burkovskiy, Yan Lehmann, Christian Dalhousie Cannabinoid 2 receptor inhibition in CNS Injury-Induced Immunodeficiency Syndrome (CIDS). Fraser, Elizabeth McLeod, Peter Acadia Successful discontinuation of opiod replacement therapy: the experience of Nova Scotians dependent on prescription opiods. Hernandez, Kimberley Kirk, Sara Dalhousie Examining teacher attitudes and experiences to address food literacy in the classroom. Houser, Natalie Stone, Michelle; Dalhousie Canadian assessment of physical literacy. Kolen, Angie Wong, Chloe Legare, Jean-Francois Dalhousie Implications of a novel TGF-β trap in Ang-II mediated myocardial fibrosis. 78

85 Appendix G Research Committee Members Photo: Dr. Jonathan McGavock was a member of Scientific Review Committee Leadership team in

86 Heart & Stroke Foundation Research Report Council on Mission: Priorities, Advice, Science and Strategy (CoMPASS) Kim Raine, PhD, Co-Chair Alberta Mary Lewis, Co-Chair Heart & Stroke Foundation Penny Ballem, MD, MSc City of Vancouver Rob Beanlands, MD Ottawa Heart Institute Sandra E. Black, O.Ont., MD Sunnybrook Research Institute Adalsteinn D. Brown, PhD Toronto Roy Cameron, PhD Homewood Health Centre James Christenson, MD Vancouver General Hospital Mary Collins BC Healthy Living Alliance Jafna Cox, MD Queen Elizabeth II Health Sciences Centre Jonathon Fowles, PhD Acadia David Hammond, PhD Waterloo Moira Kapral, MD Health Network Andrew Krahn, MD Vancouver General Hospital Michael McGillion, PhD McMaster Gary Newton, MD Mount Sinai Hospital Philippe Pibarot, DVM, PhD Université Laval J. Geoffrey Pickering, MD, PhD Robarts Research Institute Andrew Pipe, CM, MD, LLD, DSc Ottawa Heart Institute Cathy Praamsma Health Canada Jeffrey Reading, PhD Dalla Lana School of Public Health Institute for Indigenous Health Mike Sharma, MD, MSc McMaster Eldon R. Smith, O.C., MD Calgary Eric Smith, MD Calgary John C. Spence, PhD Alberta Glen Tibbits, PhD Simon Fraser Jack V. Tu, MD, PhD Institute for Clinical Evaluative Sciences Christian Vaillancourt, MD Ottawa Hospital Research Institute Thomas Warshawski, MD British Columbia Glenda Yeates Former Deputy Minister, Health Canada Mary L Abbé, PhD Toronto Kelly Lendsay, Aboriginal Human Resource Council Peter Liu, MD Ottawa Heart Institute 80

87 Heart & Stroke Foundation Research Report Scientific Review Committee Leadership Rob Beanlands, MD, Chair Ottawa Heart Institute Glen F. Tibbits, PhD, Vice Chair Simon Fraser Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research A Andrew Krahn, MD, Chair Vancouver General Hospital Ratika Parkash, MD, Deputy Chair Queen Elizabeth II Health Sciences Centre Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research B Jeff Healey, MD, Chair McMaster Shelagh Coutts, MD, Deputy Chair Foothills Medical Centre Integrative studies: genetic manipulations / imaging / bioengineering Éric Larose, DVM, MD, Chair Hôpital Laval Howard M. Leong-Poi, MD, Deputy Chair St. Michael s Hospital Basic science stroke / neurophysiology / neuroregulation James Eubanks, PhD, Chair Toronto Western Hospital Roger Thompson PhD, Deputy Chair Calgary Molecular, biochemical and cellular physiological approaches to cardiovascular health and disease, vascular disorders A Ian Dixon, PhD, Chair St. Boniface Hospital Research Centre Bernardo Trigatti, PhD, Deputy Chair McMaster Cardiac arrhythmias, cardiac mechanics, electrophysiological approaches to cardiovascular health and disease, ischemia related disorders B Terence Hébert, PhD, Chair McGill Scott Heximer, PhD, Deputy Chair Toronto Cardiovascular complications associated with obesity/diabetes, metabolism, and cardiac development/remodeling C Jason R.B. Dyck, PhD, Chair Alberta Ross Feldman, MD, Deputy Chair Memorial Newfoundland Molecular basis of cardiac and vascular function Stéphanie Lehoux, PhD, Chair McGill Jonathan Lytton, PhD, Deputy Chair Calgary Thrombosis / lipids and lipoproteins / fundamental nutrition research Grant Pierce, PhD, Chair St. Boniface Hospital Research Centre Marc Carrier, MD, Deputy Chair Ottawa Hospital, General Campus Health services and public health, health behaviour; health psychology Alexander Clark, PhD, Chair Alberta Jonathan McGavock, PhD, Deputy Chair Manitoba Senior Personnel Gary Newton, MD, Chair Mount Sinai Hospital Richard Frayne, PhD, Deputy Chair Calgary Emerging Research Leaders Initiative Peter Backx, DVM, PhD, Chair Toronto Martin Kolb, MD, PhD, Deputy Chair McMaster Canadian Alliance for Healthy Hearts and Minds Initiative Robert D. Reid, PhD, Chair Ottawa Heart Institute Budget Review Committee Eric Accili, PhD, Chair British Columbia Richard Frayne, PhD, Deputy Chair Calgary 81

88 Heart & Stroke Foundation Research Report Provincial Research Advisory Committee Chairs Heart & Stroke Foundation, Alberta, Northwest Territories and Nunavut Research and Medical Advisory Committee Gary Lopaschuk, PhD, Chair Alberta Heart & Stroke Foundation, Manitoba Research Advisory Committee Mark G. Torchia, MS, PhD, Chair Manitoba Heart & Stroke Foundation, Ontario Research Advisory Committee Mark Crowther, MD, MSc, FRCPC, Chair McMaster Comité scientifique de la Fondation des maladies du coeur du Québec Pedro D Orléans-Juste, PhD, Président Université de Sherbrooke Heart & Stroke Foundation, New Brunswick Medical Advisory Committee Marc Pelletier, MD, Chair New Brunswick Heart Centre Heart & Stroke Foundation, Nova Scotia Research Advisory Committee Stephen Phillips, MBBS, Chair Dalhousie 82

89 Appendix H Definition of Health Research Themes