Institute of Cellular Medicine, Newcastle University (United Kingdom)

Transcription

1 Curriculum vitae PERSONAL INFORMATION Ruben Thanacoody WORK EXPERIENCE 2009 Present Consultant in Acute Medicine with an interest in Clinical Toxicology, Royal Victoria Infirmary, Newcastle-upon-Tyne and Honorary Senior Clinical Lecturer, Institute of Cellular Medicine, Newcastle University (United Kingdom) Consultant in Acute Medicine and Toxicology Royal Infirmary Edinburgh, Edinburgh (United Kingdom) Locum Consultant in Acute Medicine and Toxicology Royal Infirmary Edinburgh, Edinburgh (United Kingdom) Research Fellow, Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), (United Kingdom) Consultant in Acute Medicine and Toxicology, Royal Infirmary Edinburgh, Edinburgh (United Kingdom) Locum Consultant in Acute Medicine and Toxicology, Royal Infirmary Edinburgh (United Kingdom) Newcastle-upon-Tyne Hospitals NHS Trust Research Fellow, Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), (United Kingdom) EDUCATION AND TRAINING 1995 Bachelor of Medicine and Bachelor of Surgery Newcastle University (United Kingdom) 2005 Doctor of Medicine (MD) Newcastle University (United Kingdom) 2005 Certificate of Completion of Specialist Training (CCST) in General Internal Medicine and Clinical Pharmacology Newcastle University (United Kingdom) 1998 Membership of Royal College of Physicians MRCP (UK) Newcastle University (United Kingdom) ADDITIONAL INFORMATION Expertise Clinical Toxicology Acetylcysteine regimens for paracetamol overdose 8/1/18 European Union, Page 1 / 8

2 Publications Peer reviewed articles and reviews Rehman B, Wind K, Wood DM, Thanacoody R, Bailey GP, Nash S, Archer JRH, Eddleston M, Thompson JP, Vale JA, Thomas SHL, Dargan PI. Taking stock: UK national antidote availability increasing, but further improvements are required. Eur J Hosp Pharmacy 2016; 23: Thanacoody HKR, Gilfillan C, Bradberry SM, Davies J, Jackson G, Vale JA, Thompson JP, Eddleston M, Thomas SHL. Management of poisoning with ethylene glycol and methanol in the UK: a prospective study conducted by the National Poisons Information Service (NPIS). Clin Toxicol 2016; 54: Thanacoody HKR. Quinine and chloroquine. Medicine 2016; 44: Thanacoody HKR. Serotonin syndrome. Medicine 2016; 44: Thanacoody R, Caravati EM, Troutman WG, Höjer J, Benson BE, Hoppu K, Erdman A, Bedry R, Mégarbane B. Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Clin Toxicol 2015; 53: Kamour A, George N, Gwynette D, Cooper G, Lupton D, Eddleston M, Thompson JP, Vale JA, Thanacoody HK, Hill SL, Thomas SH. Increasing frequency of severe clinical toxicity after use of 2,4- dinitrophenol in the UK: a report from the National Poisons Information Service. Emerg Med J 2015; 32: Kamour A, James D, Lupton DJ, Cooper G, Eddleston M, Vale JA, Thompson JP, Thanacoody HK, Hill SL, Thomas SH. Patterns of presentation and clinical features of toxicity after reported use of ([2- aminopropyl]-2,3-dihydrobenzofurans), the benzofuran compounds. A report from the UK National Poisons Information Service. Clin Toxicol 2014; 52: Kamour A, James D, Spears R, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale AJ, Thanacoody HK, Hill SL, Thomas SH. Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom. A report from the UK National Poisons Information Service. Clin Toxicol 2014; 52: Thompson J, Watson I, Thanacoody H, Morley S, Thomas S, Eddleston M, Vale J, Bateman D, Krishna C. Guidelines for laboratory analyses for poisoned patients in the United Kingdom. Ann Clin Biochem 2014; 51: Bateman DN, Dear JW, Thanacoody HKR, Thomas SHL, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vligenthaart ADB, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomized controlled trial. Lancet 2014; 383(9918): Antoine DJ, Dear JW, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 2013; 58(2): Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN. Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol 2013;14: 20. Thanacoody HKR, Aldridge G, Laing W, Nash S, Dargan PI, Vale JA, Bateman DN, Thompson JP, Thomas SHL. National Audit of Antidote Stocking in Acute Hospitals in the United Kingdom. EMJ 2013; 30: Benson BE, Hoppu K, Troutman WG, Bedry R, Erdman A, Höjer J, Mégarbane B, Thanacoody R, Caravati EM. Position paper update: gastric lavage for gastrointestinal decontamination. Clin Toxicol 2013; 51: Höjer J, Troutman WG, Hoppu K, Erdman A, Benson BE, Mégarbane B, Thanacoody R, Bedry R, Caravati EM. Position paper update: ipecac syrup for gastrointestinal decontamination. Clin Toxicol 2013; 51: Thanacoody HKR. Serotonin syndrome. Medicine 2012; 40: Pettie J, Dow M, Sandilands EA, Thanacoody HKR, Bateman DN. An integrated care pathway improves the management of paracetamol poisoning. EMJ 2012; 29(6): Thanacoody HKR. Thioridazine: The Good and the Bad. Recent Patents in Anti-Infective Drug Discovery. 2011; 6(2):92-8. Thanacoody RH. Extracorporeal elimination in acute valproic acid poisoning. Clin Toxicol 2009; 47: Thanacoody HKR, Jay J, Sherval J. The association between drug-related deaths and prior contact 8/1/18 European Union, Page 2 / 8

3 with hospital-based services. SMJ 2009; 54:7-10 Thanacoody HKR, Waring WS. Toxins affecting the cardiovascular system. Clin Med 2008; 8(1):92-95 Thanacoody HKR, Good AM, Waring WS, Bateman DN. A survey of cases of paracetamol overdose in the UK referred to NPIS consultants. Emerg Med J 2008; 25(3): Thanacoody HKR. Chronic valproic acid intoxication: reversal by naloxone. Emerg Med J 2007; 24(9): Thanacoody HKR. Thioridazine: Resurrection as an antimicrobial agent? Br J Clin Pharmacol 2007; 64(5): Thanacoody HKR, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Factors affecting drug concentrations and QT interval during thioridazine therapy. Clin Pharmacol Ther 2007; 85: Salih I, Thanacoody HKR, McKay G, Thomas SHL. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses. Clin Pharmacol Ther 2007; 85: Thanacoody HKR. Gamma-hydroxybutyrate. Medicine 2007; 35(11): 619 Thanacoody HKR. Serotonin syndrome. Medicine 2007; 35(10): Thanacoody HKR. Serotonin syndrome. Adv Drug React Bull 2007; 243: Thanacoody HKR, Thomas SHL. Tricyclic Antidepressant poisoning: Cardiovascular Toxicity. Toxicological Reviews 2005; 24(3): Bradberry SM, Thanacoody HKR, Watt BE, Thomas SHL, Vale JA. Management of the Cardiovascular Complications of Tricylic Antidepressant Poisoning. Role of Sodium Bicarbonate. Toxicological Reviews 2005; 24(3): Thanacoody HKR, Thomas SHL. Antidepressant poisoning. Clin Med 2003; 3: Editorials and letters Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M. Treatment of paracetamol overdose- author s reply. Lancet 2014; 383:1383. Sandilands E, Thanacoody HK. Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine. Emerg Med J Thanacoody HKR. Chronic valproic acid intoxication: reversal by naloxone. BMJ Case Rep 2009; 2009: bcr Bateman DN, Thanacoody HK, Waring WS. Digitalis intoxication induced by paroxetine coadministration. Lancet 2006; 368(9551): Monographs, reports and guidelines Opiate overdose. Monograph for BMJ Best Evidence/Point of Care (June 2010, revised October 2011). Thanacoody R, Waring WS, Good AM, Bateman DN, Lynch-Farmery R, O Moore E. Burden of disease -Poisoning. Report commissioned by the Health Protection Agency Sept published online: Book chapters Walker RS, Whittlesea C. Clinical Pharmacy & Therapeutics, 5th Edition, Churchill Livingstone, Drug Interactions Chapter 4, pages Oxford Desk Reference Toxicology eds Bateman DN Jefferson RD, Thomas DHL, Thompson JP, Vale JA Oxford University Press 2014 Library of Congress ISBN Pharmacovigilance, pages Drug and alcohol withdrawal pages Serotonin syndrome pages Malignant hyperpyrexia pages Methotrexate and other chemotherapeutic agents pages Vitamins pages Cyanide pages Published abstracts Thanacoody HKR, Nijhout HF, Reed MC, Thomas SHL. Mathematical modelling of the effect of a high 8/1/18 European Union, Page 3 / 8

4 dose acetylcysteine regimen based on the SNAP regimen on hepatic glutathione regeneration and hepatocyte death. Clin Toxicol 2016; 54(4): 494. Thanacoody HKR, Thomas SHL. Pharmacokinetic modelling of a high dose acetylcysteine regimen based on the SNAP trial. Clin Toxicol 2016; 54(4): 423. Elamin MEMO, Dunn M, Thomas SHL, Thanacoody HKR. Massive accidental caffeine overdose treated with continuous veno-venous haemofiltration (CVVHDF). Clin Toxicol 2016; 54(4): 494 Hill SL, Hawkins L, Jackson G, Eddleston M, Thompson JP, Vale JA, Thanacoody HKR, Thomas SHL. Toxicity of 2,4 dinitrophenol: impact of public health measures discouraging use on episodes of toxicity referred to the UK National Poisons Information Service. Clin Toxicol 2016; 54(4): Kamour A, James D, Lupton DJ, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas, SHL. Patterns of presentation and clinical toxicity after reported intravenous use of mephedrone in the United Kingdom. A report from the UK National Poisons Information Service Clin Toxicol 2014: 52(4); Kamour A, James D, Lupton DJ, Cooper G, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas, SHL. Toxicity after reported use of benzofury compounds ([2-aminopropyl]-2,3- dihydrobenzofurans) compared with mephedrone: A report from the UK National Poisons Information Service. Clin Toxicol 2014; 52(4): Kamour A, James D, Spears R, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas, SHL. Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom: A report from the UK National Poisons Information Service. Clin Toxicol 2014; 52(4): Kamour A, Gwynette G, George N, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas, SHL. Severe toxicity after use of 2,4-dinitrophenol reported to the UK National Poisons Information Service. Clin Toxicol 2014; 52(4): Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Clin Toxicol 2013; 51: 255 Thanacoody HKR. Clinical Toxicology of Ayurvedic Medicines. Clin Toxicol 2013; 51: Elamin M, Thanacoody R. Paracetamol-induced hepatotoxicity despite paracetamol concentrations below treatment threshold. Clin Toxicol 2013; 51: 269. Brown J, Thanacoody R. Paracetamol-induced hepatotoxicity at therapeutic doses. Clin Toxicol 2013; 51: 269. Lam H, Hayhurst C, Holmes P, Thanacoody HKR, Thomas SHL. Subcutaneous self-injection of tetrodotoxin and ouabain. Clin Toxicol 2013; 51: 283 Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. J Hepatol 2013; 58: S211-S211 Thanacoody HKR, Weatherall I, Davies J, Thomas SHL. Treatment of severe toxic alcohol and glycol poisoning in the UK. Clin Toxicol 2012; 50: 581 Thanacoody HKR, Weatherall I, Davies J, Thomas SHL. Toxic Alcohol and glycol poisoning in the UKa 12 month prospective follow-up study. Clin Toxicol 2012; 50: 641. Bradley S, George N, Thanacoody HKR. Heavy Metal Exposures Reported to the UK NPIS Clin Toxicol 2012; 50: 308 Thanacoody HKR, Aldridge G, Laing W, Nash S, Dargan PI, Vale JA, Bateman DN, Thompson JP, Thomas SHL. Antidote Stocking in Acute Hospitals in the United Kingdom. Clin Toxicol 2012; 50:300. Weatherall I, Thanacoody HKR, Davies J, Cooper G, Thomas SHL. Characteristics of Toxic Alcohol and Glycol Poisoning in the UK. Abstract. EAPCCT XXXI International Congress, Dubrovnik, Croatia May 2011.Clin Toxicol. 2011; 49: 236. Amaral L, Abbate E, Boeree R, Gillespie S, Thanacoody R, Udwadia Z, van Ingen J, van Soolingen D, Viveiros M. In vitro, ex vivo and in vivo studies indicate that the neuroleptic thioridazine cures multidrug-resistant tuberculosis. 21st European Congress of Clinical Microbiology and Infectious Diseases and the 27th International Congress of Chemotherapy, Milan 7 10 May Pettie JM, Dow MA, Thanacoody HKR, Sandilands EA, Bateman DN. Integrated care pathway for the management of the paracetamol poisoned patient. Care pathway Association Conference 25th May /1/18 European Union, Page 4 / 8

5 Pettie JM, Dow MA, Thanacoody HKR, Sandilands EA, Bateman DN. Integrated care pathway for the management of the paracetamol poisoned patient. Abstract. EAPCCT XXX International Congress, Bordeaux, May Clin Toxicol 2010; 48: Thanacoody HKR. Clinical Toxicology of Ayurvedic Medicines. Abstract. EAPCCT XXVIII International Congress, Seville, May Clin Toxicol 2008; Bateman DN, Thanacoody R. Genetic Aspects of Poisoning. Abstract. EAPCCT XXVI International Congress, Prague, Czech Republic April Clin Toxicol 2006; 44: Thanacoody HKR, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Effects of CYP2D6 genotype on QTc interval in recipients of thioridazine. Br J Clin Pharmacol 2006; 61(5):621. Abstract.Oral communication at the BPS Winter meeting, December 2005, London. Salih I, Thanacoody HKR, McKay G, Thomas SHL. Effect of single-dose thioridazine and mesoridazine on the QTc interval in healthy adult volunteers. Br J Clin Pharmacol 2006; 61(5):631 Abstract. Oral communication at the BPS Winter meeting, December 2005, London. Thanacoody HKR, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Genetic factors influencing steadystate plasma concentrations of thioridazine and its metabolites. Br J Clin Pharmacol 2006; 61(5): Abstract. Poster presentation at the BPS Winter meeting, December 2005, London. Salih I, Thanacoody HKR, McKay G,Thomas SHL. Effect of single-dose chlorpromazine on the QTc interval in healthy adult volunteers. Br J Clin Pharmacol 2006; 61(5):631 Abstract. Poster presentation at the BPS Winter meeting, December 2005, London. Thanacoody HKR, Thomas T, Purcell N, Graham K, Thomas SHL. Spontaneous reporting of fatal adverse drug reactions in the north-east of England. Br J Clin Pharmacol 2005; 59(5):649. Abstract. Poster presentation at the BPS Winter meeting, December 2004, Newcastle-upon-Tyne. Thanacoody HKR, Daly AK, Thomas SHL. Influence of CYP2D6 and CYP2C19 genotypes on the QTc intervals of psychiatric patients taking thioridazine. Br J Clin Pharmacol 2003; 55:445. Abstract. Poster presentation at the BPS winter meeting, January 2003, Brighton. Thanacoody HKR, Daly AK, Thomas SHL. Influence of CYP2D6 genotype on the QTc interval and plasma concentration of thioridazine and its metabolites of psychiatric patients taking chronic therapy. Clin Pharmacol Ther 2003; 73:77. Abstract. Poster presentation at the ASCPT meeting, April 2003, Washington DC, USA. Projects Consultant input to the Assessment Suite out-of-hours rota 1:16 Consultant input to General Medicine Short Stay Ward 2 months/year Head of Unit, Clinical Governance Lead, Clinical Lead and Educational Lead Educational Supervisor to 2 Foundation trainees and 1 Teaching Fellow Clinical Supervision of Foundation trainees/cmt/st (6-8/year) TOXICOLOGY ACTIVITIES Management of poisoned patients admitted to the Royal Victoria Infirmary, Newcastle-upon-Tyne 1:3. Provision of telephone advice for the National Poisons Information Service, during office hours ( ) for the Newcastle unit and participation in the national consultant rota for out-of-hours cover for UK and Ireland. Ad-hoc additional toxicology cover e.g G8 summit Gleneagles 2005, London Olympics Writing new entries, updating old entries and editing of entries written by other units for inclusion on TOXBASE, the on-line poisons information database used in the UK. Monthly review of Current Awareness in Toxicology to identify literature which may have an impact on TOXBASE content Provision of updates on TOXBASE for health care professionals in emergency situations e.g following London bombings and Hemel Hampstead explosions. Contribution to quarterly CPD meetings for NPIS consultants and other staff Management of hypotension and arrhythmias in tricyclic poisoning Jan 2006 Paracetamol calls referred to consultants- 1 year s experience June 2006 Valproic acid toxicity: Controversies in management April 2007 Antidote guidance: BAEM/NPIS October 2007 Gamma-hydroxybutyric acid February 2008 SNAP- a new approach to paracetamol poisoning November /1/18 European Union, Page 5 / 8

6 Ecstasy- case report and management October 2009 Scorpion Stings- November 2010 Antidote audit November 2011 Toxic Alcohol study- November 2013 Whole Bowel Irrigation update November 2014 Acetylcysteine treatment for paracetamol overdose: what does the future really hold?- November 2015 Valproate overdose: what is the role of L-carnitine? November 2016 Contribution to WikiTox, a web-based Clinical Toxicology Teaching Resource Project ( set up following a workshop held in Edinburgh in July 2006 under the auspices of WHO to develop and deliver a curriculum in clinical toxicology. Participation in a joint NPIS/College of Emergency Medicine working group to produce national guidance for antidote stocking in acute hospitals in the UK. National audit conducted and completed Jan Guidelines updated and reissued in Participation in a joint NPIS/ACB working group to produce national guidance for laboratory assays used for poisoned patients in acute hospitals in the UK. Contributing to reports for the NPIS and HPA Thanacoody R, Waring WS, Good AM, Bateman DN, Lynch-Farmery R, O Moore E. Burden of disease -Poisoning. Report commissioned by the Health Protection Agency Sept Medical Briefing note on TOXBASE front page following explosion in Hemel Hampstead Dec Memberships Fellow Royal College of Physicians Fellow Royal College of Physicians of Edinburgh Member European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) Other Relevant Information Invited Lectures at International Conferences/Congresses Keynote lecture at NACCT International Congress, Boston, September Valproate overdose: what is the role of L-carnitine. Keynote lecture at EAPCCT XXXVI International Congress, Madrid, May Valproate overdose: what is the role of L-carnitine. Keynote lecture, NACCT International Congress, Atlanta, October Implications for acetylcysteine dosing regimen following results of the UK SNAP trial. Keynote lecture at EAPCCT XXXIII International Congress, Copenhagen, May Clinical Toxicology of Ayurvedic Medicines. Keynote lecture at EAPCCT XXXI International Congress, Dubrovnik, Croatia, May 2011.The pharmacology of drug delivery. Invited lecture at ESF EMRC Exploratory Workshop: Multidisciplinary consortium for the development of effective, but non-toxic drugs against MDRTB and XDR-TB. Lisbon (Portugal), 30 November 4 December Clinical Trials using thioridazine for XDR-TB. Keynote lecture at EAPCCT XXX International Congress, Bordeaux, May What is the evidence for Added benefit from Hemoperfusion? Con Keynote lecture at EAPCCT XXVIII International Congress, Seville, May Clinical Toxicology of Ayurvedic Medicines. ASCOT clinical trial (sub-investigator) Sever PS, Dahlof B, Poulter NR et al. for ASCOT investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial- Lipid Lowering Arm (ASCOT- LLA): a multicentre randomised controlled trial. Lancet 2003; 361: Dahlof B, Sever PS, Poulter NR et al. for ASCOT investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo- Scandinavian Cardiac Outcomes Trial- Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366: REFEREES 8/1/18 European Union, Page 6 / 8

7 1. Professor S H L Thomas Director of NPIS (Newcastle) and Consultant Physician Professor of Clinical Pharmacology Wolfson Unit Newcastle-upon-Tyne NE2 4HH 2. Professor Sir Michael Rawlins Chairman MHRA Emeritus Professor of Clinical Pharmacology Newcastle University michael.rawlins@mhra.gsi.gov.uk 3. Professor D N Bateman Emeritus Professor of Clinical Toxicology University of Edinburgh drnickbateman@gmail.com Current: Early Clinical Trial Group, Trust R&D Faculty of Medical Sciences Ethics Committee, Newcastle University EAPCCT Gut Decontamination Position Statement Panel Member of MHRA PEAG (Pharmacovigilance Expert Advisory Group) Dec 11- Peer reviewer for NIHR HTA programme Peer reviewer for international journals e.g BMJ, British & European Journal of Clinical Pharmacology, Clinical Toxicology, International Journal of Pharmacy Practice, Pediatrics International. Past Member of MHRA ISAC (Independent Scientific and Advisory Committee) Nov 07- Nov 14 RCP representative for RCPath Toxicology SAC College of Emergency Medicine (CEM) Antidote Guideline Group Association of Clinical Biochemists. Lab Assay Working Group NHS Lothian Drug-Related Deaths Review Group Nov 05-Mar 09 Review of deaths related to drug misuse in the Lothian region to identify patterns which may lead to implementation of preventative public health measures Lothian Joint Formulary Committee Member May 06-Dec 08 Evaluation of requests by clinicians for inclusion of new drugs in the Lothian Formulary Evaluation of guidance issued by NICE and SMC Update of Lothian Formulary Yellow Card Centre Scotland Evaluation of spontaneous adverse drug reaction reports TEACHING Involvement in teaching of clinical pharmacology and clinical toxicology to undergraduates and postgraduates Current: Strand Lead Clinical Pharmacology, Therapeutics and Prescribing (CPTP) MBBS Newcastle University and Course Director CPTP4 Educational Lead Clinical Pharmacology & Therapeutics MRCP (UK) Part 1 Exam Board, Federation of the Royal Colleges of Physicians, Nov 15- Module Leader Experimental Medicine & Therapeutics, MRes Translational Medicine and Therapeutics, Newcastle University Sept 10- Module Leader Clinical Drug Development, MSc Clinical and Health Sciences, Newcastle University 8/1/18 European Union, Page 7 / 8

8 2015- Lecturer BSc Pharmacology, Diploma in Clinical Research and MRes Toxicology courses Internal Examiner, MD Newcastle University Educational Supervisor to 1 Foundation Year 1 trainees and 1 ST in GIM/Clinical pharmacology Clinical Supervision of Foundation trainees/cmt/st Past MRCP (UK) Specialty Question Group Therapeutics, Federation of the Royal Colleges of Physicians, Jan External examiner, Certificate/Diploma/Masters in Clinical Toxicology, Cardiff University Member of Safe Prescribing Group, Education Centre, RVI Module Leader Diploma in Therapeutics, University of Newcastle, IMPACT Course, RCPS Glasgow, Clinical Lead for teaching of Acute Medicine module in Year 5 undergraduate curriculum University of Edinburgh July 06-March 09 Development of an e-learning module in management of poisoning for nurses and junior medical staff. Clinical pharmacology (vertical theme) teaching- lectures and seminars for year 3 and 5 medical students, University of Edinburgh Current Issues in Poisoning, TOXTALKS course Current Issues in Therapeutics Course, Lister Institute, Nurse Prescribing Course, Queen Margaret s University College Adult Medical Emergencies Course, Lister Institute, 2006 SPQ Course for Critical Care nurses 2006 Diploma in Therapeutics, University of Newcastle-upon-Tyne, MRCP Part I Course, Clinical Pharmacology, Postgraduate Institute, Newcastle-upon-Tyne Outreach educational activities organised by the National Poisons Information Service (Newcastle) on the management of overdose patients. Teaching on regional study days organised by the National Poisons Information Service (Newcastle) and for new A&E SHOs in district general hospitals on the management of overdose patients, Organisation of clinical examinations for final year medical students and close-marking sessions for medical examinations, University of Newcastle-upon-Tyne, /1/18 European Union, Page 8 / 8