PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules EFFICACIOUS Powerful nticoccidil efficcy nd productivity-enhncing effect in poultry, leding to improved profitility for poultry producers. Allows few oocysts to survive, helping to uild up nturl immunity. Significntly reduces the risk of secondry infection y pthogens nd minimizes weight loss nd poor feed conversion. Its specific ction mechnism reduces the hzrd of resistnce uild-up. SAFE Very well tolerted Does not dversely ffect feed nd wter intke Comptile with most other feed dditives (ntiiotics, vitmins, minerls) FREE-FLOWING Unique grnulted formultion Excellent mixility nd homogeneity Remins stle during pelletistion
Activity Coxidin is effective ginst the min coccidi species (including recent field isoltes): Eimeri tenell, E. cervulin, E. precox, E. mitis, E. runetti, E. mxim nd E. nectrix in chickens. E. denoides, E. melegrimitis nd E. gllopvonis in turkeys. It is most efficcious in the erly stges of the coccidi lifecycle. Coxidin llows few oocysts to survive nd helps the young nimls to uild up nturl immunity. Erly control of coccidi prevents dmge to the epithelil cells of the gut lining, thus reducing the risk of infections y pthogens, such s Clostridium perfringens. Efficcy trils Broilers Bttery-cge, floor-pen nd field trils were crried out in Frnce, Spin, Itly, nd Belgium. 1.83 1.82 1.82 Feed conversion rtio Floorpen tril roilers (IRTA Spin) RESULTS FROM CONTROLLED FLOOR-PEN TRIALS 6,000 roilers in Frnce, Belgium, nd Spin, Groups Coxidin 100 microgrnulte t 100 nd 125 ppm Other BSA monensin sodium feed dditive, 100 ppm Negtive control group. 1.81 1.8 1.79 1.78 1.77 1.76 1.75 1.773 1.783 1.778 Results were equivlent to, nd in some cses even etter thn the other BSA monensin sodium premix. The reson for this could e the etter nd more homogenous mixing of the new formultion in the roiler feeds. 2350 2300 2250 Totl weight gin (g) mles Floorpen tril roilers (INRA, Frnce) 1.74 50 49 48 47 Control Coxidin 100 Coxidin 125 Dily gin (g) Floorpen tril roilers (ILVO,Belgium) 48.5 48.3 Other BSA monesin 100 48.9 2200 46 2150 45 45.1 2100 2050 44 2000 Control Coxidin 100 Coxidin 125 Other BSA monesin 100 43 Control Coxidin 100 Coxidin 125 Other BSA monesin 100
Turkeys Turkeys: floor pen study in Evilis, Frnce ws conducted. The im of this study ws to ssess the efficcy of Coxidin in controlling coccidiosis under chllenge conditions in floor pens in turkeys. Results from the tril 1200 mle nd femles turkeys in 7 replictes per tretment were investigted There ws one non-treted infected control group (IUC), two Coxidin groups t dosges 60 nd 100 ppm nd nother EU (BSA) monensin t dosge 60 ppm At 22 dys of ge turkeys were inoculted with Eimeri melegrimits, Eimeri denoides, Eimeri gllopvonis nd Eimeri melegridis 9 0 8 0 7 0 6 0 5 0 4 0 3 0 2 0 10 0 Femle nimls: Zootechnicl results 7 dys post inocultion c IUC Coxidin 60 ppm Coxidin 100 ppm Another EU (BSA) monensin Dily gin (g) Dily feed (g) FCR 3 2. 5 2 1.5 1 0. 5 0 Femle nd mle nimls: Dily gin from dy 29 till dy 59 Another EU (BSA) monensin Coxidin 100 ppm Coxidin 60 60 ppm ppm IUC 8 5 85.5 86 86.5 887 7 87.5 8 8 88.5 89 Another EU (BSA) monensin Coxidin 100 ppm Lesions Eimeri denoides (mles nd femles) 7 dys post inocultion This tril demonstrted significnt improvements on dily gin nd FCR in the Monensin supplemented groups t 60 ppm Monensin compred to the infected untreted control group. No significnt differences were oserved etween Coxidin nd nother EU (BSA) monensin t concentrtion of 60 ppm. Coxidin 60 ppm IUC 0 0.5 1 1.5 2 2.5 3
Posology Coxidin 100 microgrnulte is mixed in the feed. For the est, most common results, it is recommended to mix in mesured quntity in stges. The recommended dose Trget species Minimum nd mximum content of monensin complete feedingstuff (ppm) Quntity of Coxidin 100 incorported in the feedingstuff (g/ton) Mximum ge Withdrwl period efore slughter Chickens for fttening 100-125 1000-1250 - 1 dy Chickens rered for lying 100-125 1000-1250 16 weeks 1 dy Turkeys 60-100 1000-1250 16 weeks 1 dy Formultion fetures Excellent stility nd mixing properties. The new, grnulted formultion hs mjor dvntge over other formultions tht still use the outdted nd inefficient technique of simple mixing, process, which my result in vrile concentrtions of ctive prticles in the feed. Coxidin ensures nimls will et feed contining correctly dosed ctive mteril - significnt dvntge. This formultion enles the correct dosge of the ctive ingredient to e mixed in the niml feed nd pplied to the ird, regrdless of the ge or weight. The grnultion technique lso helps to prevent grnules from segregting during production, trnsporttion nd storge. Coxidin s formultion covers the optiml prticle size distriution rnge of 200 µm 500 µm. Excellent flowility chrcteristics - minly chieved through its excellent prticle size distriution. GRANULATED FORMULA SIMPLE MIXING Coxidin 100 microgrnulte Another EU (BSA) monensin
Stility Coxidin 100 microgrnulte contining monensin sodium (feed dditive): 2 yers. Premixes contining Coxidin 100 microgrnulte: 6 months. Feedstuffs supplemented with Coxidin 100 microgrnulte: 3 months Coxidin 100 microgrnulte preserves its potency nd stility during pelletistion. Trget niml sfety Tolernce tests (GLP) in chickens Coxidin is well tolerted when fed t the recommended mximum dose rte of 125 ppm for 35 dys. At doule nd triple concentrtions (250 nd 375 ppm), moderte to mrke dose-relted decresed ody weight gin ws oserved, due to lower food intke. Tolernce tests (GLP) in turkeys Coxidin is well tolerted when fed for 84 dys t recommended mximum dose rte of 100 ppm. The dministrtion of doule nd triple concentrtions (200 nd 300 ppm) cused slight to moderte dose-relted lower ody weight gin, due to lower feed nd wter intke. Interctions Comptile with most feed dditives: ntiiotics, vitmins nd minerls. It is not comptile with timulin. Storge Store in the originl pckge in closed, dry nd well-ventilted re, t room temperture, protected from direct sunlight.
KEY ADVANTAGES Coxidin 100 microgrnulte YOUR PARTNER IN ROTATION PROGRAM Coxidin 100 microgrnulte hs proven nticoccidil nd productivityenhncing effects in poultry, leding to improved profitility for poultry producers. Its ctive ingredient, monensin sodium, is rod- spectrum coccidiostt with proven efficcy ginst the mjor coccidi species in chickens nd turkeys, while llowing nturl immunity to develop. The protective ction of Coxidin 100 microgrnulte reduces the risk of secondry infections, leding to reduced mediction costs. Coxidin 100 microgrnulte hs een shown to hve positive impct on feed conversion rte nd reduced feed costs. Coxidin 100 microgrnulte SUPERIOR PREMIX CHARCTARISTICS The unique wy in which it is formulted is significntly superior to similr products which use outdted simple mixing Coxidin 100 microgrnulte s formultion ensures tht the ctive ingredients re distriuted evenly throughout the feed, with no segregtion during trnsporttion, storge nd dispensing. Coxidin 100 microgrnulte hs een crefully formulted to enle the grnules to flow smoothly through mixing equipment without the genertion of excessive dust nd reducing the risk of crry-over. Coxidin 100 microgrnulte hs excellent stility properties. Its potency is preserved during processing (pelletistion) nd storge, oth s premix nd in compound feed. Coxidin 100 microgrnulte Sfety profile Coxidin 100 microgrnulte is comptile with most other feed dditives (ntiiotics, vitmins, nd minerls). It is well tolerted in roilers, chickens rered for lying nd turkeys nd hs no impct on feed intke Withdrwl period for met: 1 dy for roilers nd chickens rered for lying, 1 dy for turkeys Coxidin 100 microgrnulte is sfe for the environment nd is not resored y plnts fertilised with mnure from poultry treted with the compound. Huvephrm AD 3 Nikoly Hytov Str., 1113 Sofi, Bulgri P +359 2 862 5331 F +359 2 862 5334 sles@huvephrm.com www.huvephrm.com Huvephrm N.V. Uitreidingstrt 80 2600 Antwerp Belgium P +32 3 288 1849 F +32 3 289 7845 customerservice@huvephrm.com 2014 Huvephrm AD. All right reserved Cox.100.mG.Poult.0114.EN001