CheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer
|
|
- Valentine O’Connor’
- 5 years ago
- Views:
Transcription
1 CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn L, Creeln B, Bbu S, Leighl NB, Couture F, Chndler J, Goss G, Keogh G, Gron EB, Blnkstein KB, Dniel DB, Mohmed M, Li A, Anur N, Jotte R
2 Bckground Nivolumb is the stndrd of cre for previously treted NSCLC, demonstrting long-term survivl benefit, with 5-yer OS rte of 6% The mjority of nivolumb dt re bsed on tretment until PD or uncceptble toxicity Dt from phse I CheckMte 3 suggest tht ~2 yers of nivolumb monotherpy re sufficient for long-term clinicl benefit in ptients with previously treted NSCLC CheckMte 3 implemented stopping rule for nivolumb t 96 weeks 75% of ptients live >5 yers remined tretment- nd progression-free 25% of ptients live >5 yers stopped nivolumb erlier thn 96 weeks due to AEs Optiml durtion of tretment with PD-/PD-L inhibitors remins n importnt question CheckMte 53 is the first rndomized study to evlute tretment durtion with PD-/PD-L inhibitor Not mutully exclusive. Brhmer J, et l. Presented t: AACR Annul Meeting 27; April -5, 27; Wshington, DC. Abstrct 8356.
3 Study Design Key eligibility criteri: Advnced/ metsttic NSCLC prior systemic therpy ECOG PS -2 Treted CNS metstses llowed Nivolumb 3 mg/kg IV Q2W Continuous nivolumb R c Tretment for yer b Nivolumb Stop nivolumb retretment llowed t PD Explortory endpoints d : Sfety/efficcy e with continuous vs -yer tretment, efficcy, other (eg, biomrkers, PK) At dtbse lock (My 5, 27), minimum/medin follow-up time post-rndomiztion ws./4.9 months Conventionl systemic therpies, excluding immuno-oncology therpies. b Tretment until PD, uncceptble toxicity, or withdrwl of consent; tretment beyond investigtor-ssessed PD permitted. c All ptients on tretment t yer were rndomized regrdless of response sttus. d Primry endpoint ws incidence of high-grde select tretment-relted AEs.,2 e Responses were investigtor-ssessed every 8 weeks ± 5 dys from week 9. Hussein M, et l. Presented t: IASLC 6th World Conference on Lung Cncer; September 6-9, 25: Denver, Colordo. Abstrct ORAL Wterhouse D, et l. J Clin Oncol. 26;34(suppl): Abstrct 359.
4 Ptient Flow nd Anlysis Popultions Efficcy nlyses Continuous nivolumb 76 hd response or SD t rndomiztion c 22 ptients on 245 ptients treted tretment t yer R b Stop nivolumb 87 hd response or SD t rndomiztion d Min US cohort 25 ptients discontinued prior to yer due to progression, deth, study withdrwl, toxicity, or other resons. b All 22 ptients continuing on tretment t yer were rndomized regrdless of response sttus. 57 of these 22 ptients hd PD nd were rndomized s llowed per protocol; sfety nlyses were bsed on ll 22 ptients, 7 in the continuous rm nd 3 in the stop rm. c 8 ptients discontinued tretment due to ptient request or withdrwl of consent. d 2 ptients discontinued tretment due to ptient request or withdrwl of consent
5 Bseline Ptient Chrcteristics (Efficcy Anlyses) Continuous tretment (n = 76) -yer tretment b (n = 87) Medin ge, yers (rnge) 7 yers, % 67 (5 92) 4 67 (49 86) 4 Femle, % 5 45 ECOG PS, c % Current or former/never smoker, % 96/4 97/3 Squmous histology, % PD-L sttus, d % Quntifible <% e % e 5% e Prior lines of therpy, f % CR or PR prior to rndomiztion, g % Ptients who did not hve PD t rndomiztion. b With optionl retretment llowed t PD. c Not reported: Continuous, n =. yer, n = 2. d Using Dko PD-L IHC 28-8 phrmdx ssy. e Percentge of ptients with quntifible PD-L expression. f Not reported: Continuous, n = ; -yer, n = 3. g CRs: Continuous, n = 8; -yer, n = 2
6 PFS From Rndomiztion 8 Medin, Months (95% CI) PFS Rte, % 6-Month -Yer Continuous tx NR (NR) yer tx b.3 (6.4, 5.2) 69 4 HR:.42 (95% CI:.25,.7) PFS, % Time Post-Rndomiztion, Months Number t risk Continuous tx yer tx Ptients who did not hve PD t rndomiztion. minimum/medin follow-up time post-rndomiztion,./4.9 months. b With optionl retretment llowed t PD NR = not reched; tx = tretment
7 PFS From Rndomiztion by Response Sttus CR/PR SD Continuous tx -yer tx b,c Medin, Months (95% CI) NR (NR).6 (4.8, NA) Continuous tx Medin, Months (95% CI) NR (5.6, NA) -yer tx b 9.6 (4.5, 2.6) 8 HR:.45 (95% CI:.24,.85) 8 HR:.44 (95% CI:.7,.9) PFS, % 6 4 PFS, % Number t risk Time Post-Rndomiztion, Months Continuous tx yer tx Time Post-Rndomiztion, Months Number t risk Continuous tx -yer tx Best overll response prior to rndomiztion; minimum/medin follow-up time post-rndomiztion,./4.9 months. b With optionl retretment llowed t PD. c Two ptients who stopped tretment hd CR prior to rndomiztion; both ptients lost CR (6 nd 3 months fter stopping tretment) with progression due to new lesions. NA = not vilble
8 PFS From Rndomiztion by Subgroup Overll (.25,.7) <7 yers 7 yers n (.3,.6).66 (.32,.37) ECOG PS - b (.25,.73) Mle Femle (.8,.74).56 (.25,.25) Former/current smoker c (.25,.72) Squmous histology Non-squmous histology Second-line tretment Third-line tretment Fourth-/lter-line tretment/unknown <% PD-L expression % PD-L expression 5% PD-L expression PD-L not quntifible/not reported (.8,.93).46 (.23,.92).34 (.4,.82).65 (.27,.56).35 (.3,.95).35 (.,.7).36 (.5,.86).5 (.3,.76).5 (.23,.2) HR (95% CI) 2 Fvors continuous tx Fvors stopping tx HR =.43 (95% CI:.25,.76) when djusted for gender, histology, best overll response, nd PD-L sttus using multivrite nlysis Ptients who did not hve PD t rndomiztion; minimum/medin follow-up time post-rndomiztion,./4.9 months. b HR not clculted for ptients with ECOG PS 2 due to smll smple size (n = 8); 3 ptients hd unreported ECOG PS. c HR not clculted for never-smokers/ptients with unknown smoking sttus due to smll smple size (n = 6)
9 OS From Rndomiztion 8 OS (%) Medin, Months (95% CI) OS Rte, % 6-Month -Yer Continuous tx NR (NR) yer tx b 23.2 (23.2, NA) 95 8 HR:.63 (95% CI:.33,.2) Number t risk Continuous tx 76 -yer tx Time Post-Rndomiztion, Months Ptients who did not hve PD t rndomiztion; minimum/medin follow-up time post-rndomiztion,./4.9 months. b With optionl retretment llowed t PD
10 Retretment in -Yer Tretment Arm Efficcy nlyses Continuous nivolumb c 76 hd response or SD t rndomiztion 245 ptients treted 22 ptients on tretment t yer R b Stop nivolumb d 87 hd response or SD t rndomiztion 43 (49%) hd PD fter stopping nivolumb 34 (79%) were retreted with nivolumb Dt t time of nlysis (dtbse lock My 5, 27) Min US cohort; 25 ptients discontinued prior to yer due to progression, deth, study withdrwl, toxicity, or other resons. b All 22 ptients continuing on tretment t yer were rndomized regrdless of response sttus; 57 of these 22 ptients hd PD nd were rndomized s llowed per protocol; sfety nlyses were bsed on ll 22 ptients, 7 in the continuous rm nd 3 in the stop rm. c 8 ptients discontinued tretment due to ptient request or withdrwl of consent. d 2 ptients discontinued tretment due to ptient request or withdrwl of consent
11 Initition nd Durtion of Retretment Ptient Time Since Rndomiztion, Months Off nivolumb tretment Nivolumb retretment Dt t time of nlysis (dtbse lock My 5, 27) Medin time between progression nd retretment:.6 months (rnge,.-4.9) Medin durtion of retretment: 3.8 months (rnge,.-7.5) Ptients who hd not died nd were not continuing retretment were in follow-up nd live s of dtbse lock PD Retretment ongoing Ptient died
12 Tumor Burden Chnge of Trget Lesions in Retreted Ptients Tumor burden chnge in trget lesions following retretment,b Type of PD n (%) Trget lesions only 2 (35) Nontrget lesions only (3) New lesions only 4 (4) Trget lesions nd new lesions 4 (2) Nontrget lesions nd new lesions (3) Trget lesions, nontrget lesions, nd new lesions 2 (6) Chnge in Trget Lesion Size From Rndomiztion, % Strt of retretment % chnge truncted to % Dys Since Rndomiztion Ptients with PD in trget lesions only. b n = : ptient without further ssessment fter retretment strt ws excluded
13 Subsequent Therpies Ptients, % Subsequent Therpy Continuous tretment (n = 76) -yer tretment b (n = 87) Any 2 37 Rdiotherpy 8 Surgery 7 6 Systemic therpy 3 29 Type of systemic therpy Post-study nivolumb Pclitxel Docetxel Crbopltin Gemcitbine Rmucirumb Erlotinib Investigtionl ntineoplstic Pembrolizumb Pemetrexed Other Investigtionl immunotherpy Other investigtionl gent c Ptients who did not hve PD t rndomiztion. b With optionl retretment llowed t PD. c Etoposide, irinotecn, nd vinorelbine (n = ech)
14 Summry of Sfety Post-Rndomiztion Continuous tretment (n = 7) -yer tretment b (n = 3) Any grde, % Grde 3-4, % Any grde, % Grde 3-4, % Tretment-relted AEs Tretment-relted SAEs Select tretment-relted AEs Tretment-relted AEs leding to discontinution Few new-onset events occurred fter yer No tretment-relted deths were reported mong rndomized ptients No new sfety signls were observed All rndomized ptients. b AEs in this group include those during retretment
15 Summry CheckMte 53 is the first rndomized study to evlute durtion of therpy with PD-/PD-L inhibitor Among ptients still on nivolumb t yer, PFS ws significntly improved for those treted continuously vs stopping: PFS HR =.42 (95% CI:.25,.7) OS HR =.63 (95% CI:.33,.2), showing trend fvoring continuous nivolumb; follow-up for OS is ongoing The frequency of tretment-relted AEs ws numericlly higher with continuous vs -yer tretment, but overll, few new-onset events occurred fter yer
Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis
Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell
More informationIntroduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5
Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Abstrct 553 André T,
More informationSYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT
Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of
More informationEfficacy of Sonidegib in Patients With Metastatic BCC (mbcc)
AAD 216 eposter 3368 Efficcy of Sonidegib in Ptients With Metsttic BCC (mbcc) Colin Morton, 1 Michel Migden, 2 Tingting Yi, 3 Mnish Mone, 3 Dlil Sellmi, 3 Reinhrd Dummer 4 1 Stirling Community Hospitl,
More informationClinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number
EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess
More informationIMpower133: Primary PFS, OS, and safety in a Ph1/3 study of 1L atezolizumab + carboplatin + etoposide in extensive-stage SCLC
IMpower133: Primry PFS, OS, nd sfety in Ph1/3 study of 1L tezolizumb + crbopltin + etoposide in extensive-stge SCLC S. V. Liu, 1 A. S. Mnsfield, 2 A. Szczesn, 3 L. Hvel, 4 M. Krzkowski, 5 M. J. Hochmir,
More informationCheckMate-142 Study Design
Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Thierry André, 1 Sr
More informationReference Slide Deck. Abstract 553 Abstract 554 Abstract 560
Clinicl Spotlight Immunotherpy Advnces for Colorectl Crcinom in 2018: Newly Relesed Dt From the Gstrointestinl Cncers Symposium in Sn Frncisco Reference Slide Deck Abstrct 553 Abstrct 554 Abstrct 560 Mismtch
More informationThe RUTHERFORD-2 trial in heterozygous FH: Results and implications
The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of
More informationSafety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA
Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,
More informationA review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital
MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground
More informationUniversity of Texas Health Science Center, San Antonio, San Antonio, Texas, USA
Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University
More informationSponsor / Company: Sanofi Drug substance(s): AVE0005 (aflibercept)
These results re supplied for informtionl purposes only. Prescribing decisions should be mde bsed on the pproved pckge insert in the country of prescription. Sponsor / Compny: Snofi Drug substnce(s): AVE0005
More informationClinical Evidence for Second- and Third-Line Treatment Options in Advanced Non-Small Cell Lung Cancer
Clinicl Evidence for Second- nd Third-Line Tretment Options in Advnced Non-Smll Cell Lung Cncer Filippo de Mrinis, Frncesco Grossi b Thorcic Oncology Unit I, Deprtment of Lung Diseses, Sn Cmillo nd Forlnini
More informationPresented at the 75 th Annual Meeting of the American Academy of Dermatology, Orlando, FL, March 3-7, 2017 METHODS INTRODUCTION OBJECTIVE
Seven-Yer Interim Results from the ESPRIT 10-Yer Postmrketing Surveillnce Registry of Adlimumb for Moderte to Severe Psorisis Frncisco Kerdel, 1 Aln Menter, 2 Jshin J. Wu, 3 Mreike Bereswill, 4 Dilek Arikn,
More informationAbstract. Background. Aim. Patients and Methods. Patients. Study Design
Impct of the Use of Drugs nd Substitution Tretments on the Antivirl Tretment of Chronic Heptitis C: Anlysis of Complince, Virologicl Response nd Qulity of Life (CHEOBS). Melin, 1 J.-. Lng, D. Ouzn, 3 M.
More informationOriginal Article. Breast Care 2016;11: DOI: /
Originl Article Brest Cre 2016;11:323 327 DOI: 10.1159/000452079 Published online: October 24, 2016 Neodjuvnt Chemotherpy with Docetxel, Crbopltin nd Weekly Trstuzumb Is Active in HER2-Positive Erly Brest
More informationThe incidence of melanoma, the most serious
Efectiveness nd sfety of ipilimumb therpy in dvnced melnom: evidence from clinicl prctice sites in the US Kim A Mrgolin, MD, Ahmd Trhini, MD, PhD, b Sumti Ro, PhD, c Monic Ktyl, JD, MPH, d I-Fen Chng,
More informationOne of the most important biological mechanisms of
Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,
More informationCommunity. Profile Powell County. Public Health and Safety Division
Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationCommunity. Profile Big Horn County. Public Health and Safety Division
Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationPrognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic
Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of
More informationY. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3
Greter remission rtes in ptients with erly versus long-stnding disese in biologic-nive rheumtoid rthritis ptients treted with btcept: post hoc nlysis of rndomised clinicl tril dt Y. Yzici 1, D. Moniz Reed
More informationCommunity. Profile Anaconda- Deer Lodge County. Public Health and Safety Division
Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12
More informationCommunity. Profile Yellowstone County. Public Health and Safety Division
Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Lewis & Clark County. Public Health and Safety Division
Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Missoula County. Public Health and Safety Division
Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationGemmis Injection 38 mg/ml
Gemmis Injection 8 mg/ml Gemcitbine (Gemcitbine HCl) is nucleoside nlogue tht exhibits nti-tumor ctivity. The empiricl formul for Gemcitbine HCl is C 9H 11F 2N O.HCl. It hs moleculr weight of 299.66. Gemcitbine
More informationMetformin and breast cancer stage at diagnosis: a population-based study
ORIGINAL ARTICLE METFORMIN AND BREAST CANCER STAGE AT DIAGNOSIS, Leg et l. Metformin nd brest cncer stge t dignosis: popultion-bsed study I.C. Leg md msc,* K. Fung msc,* P.C. Austin phd, nd L.L. Lipscombe
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationMulticenter Randomized Phase 2 Clinical Trial of a Recombinant Human Endostatin Adenovirus in Patients with Advanced Head and Neck Carcinoma
The Americn Society of Gene & Cell Therpy originl rticle Multicenter Rndomized Phse Clinicl Tril of Recombinnt Humn Endosttin Adenovirus in Ptients with Advnced Hed nd Neck Crcinom Wen Ye, Rnyi Liu, Chngchun
More informationManagement of Relapsed/Refractory Follicular Lymphoma
April 2018 Volume 16, Issue 4, Supplement 10 Mngement of Relpsed/Refrctory Folliculr Lymphom n How I Tret Relpsed/Refrctory Folliculr Lymphom: An Expert Perspective n Highlights from: The 2017 Americn
More informationStart ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4
F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND
More informationClinicalTrials.gov Identifier: NCT
Efficcy of Drtumumb, Lenlidomide, nd Dexmethsone Versus Lenlidomide nd Dexmethsone in Relpsed or Refrctory Multiple Myelom Ptients With to 3 Prior Lines of Therpy: Updted Anlysis of POLLUX Sd Z. Usmni,
More informationClinical Study. Oncology 2006;71:32 39 DOI: /
Oncology Clinicl Study Oncology 2006;71:32 39 DOI: 10.1159/000100447 Received: My 29, 2006 Accepted fter revision: December 9, 2006 Published online: Mrch 5, 2007 Efficcy of Consolidtion High-Dose Chemotherpy
More informationAge related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer
MOLECULAR AND CLINICAL ONCOLOGY 9: 329-334, 2018 Age relted differences in prognosis nd prognostic fctors mong ptients with epithelil ovrin cncer KENJI YOSHIKAWA, TAKESHI FUKUDA, RYO UEMURA, HIROAKI MATSUBARA,
More informationSee 17 for PATIENT COUNSELING INFORMATION. Revised: 02/2011 FULL PRESCRIBING INFORMATION: CONTENTS*
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use GEMZAR sfely nd effectively. See full prescribing informtion for GEMZAR. GEMZAR (gemcitbine for injection)
More informationImmunotherapy in the clinic. Lung Cancer. Marga Majem 20 octubre 2017
Immunotherapy in the clinic. Lung Cancer Marga Majem 20 octubre 2017 mmajem@santpau.cat Immunotherapy in the clinic. Lung Cancer Agenda Where we come from? Immunotherapy in Second line Immunotherapy in
More informationSafety of Ocrelizumab in Multiple Sclerosis: Updated Analysis in Patients With Relapsing and Primary Progressive Multiple Sclerosis
Sfety of Ocrelizumb in Multiple Sclerosis: Updted Anlysis in Ptients With Relpsing nd Primry Progressive Multiple Sclerosis SL Huser, L Kppos, X Montlbn, H Koendgen, C Chognot, C Li, C Mrcillt, A Prdhn,
More informationA PHASE IIA STUDY OF TISOTUMAB VEDOTIN (HUMAX -TF-ADC) IN PATIENTS WITH RELAPSED, RECURRENT AND/OR METASTATIC CERVICAL CANCER
A PHASE IIA STUDY OF TISOTUMAB VEDOTIN (HUMAX -TF-ADC) IN PATIENTS WITH RELAPSED, RECURRENT AND/OR METASTATIC CERVICAL CANCER Vergote I, Concin N, Den E, Lssen U, Drew Y, Mchiels JP, Nielsen D, Arkenu
More informationCommunity. Profile Carter County. Public Health and Safety Division
Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationLung cancer is the most common cause of cancer deaths in
Originl Article A Phse I/II Study of Bortezomib in Combintion with Pclitxel, Crbopltin, nd Concurrent Thorcic Rdition Therpy for Non Smll-Cell Lung Cncer North Centrl Cncer Tretment Group (NCCTG)-N0321
More informationImpact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors
Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms
More informationkey words: bortezomib, multiple myeloma, retrospective analysis, treatment outcomes, subcutaneous, intravenous
reserch report Effect of Route of Bortezomib Administrtion on Tretment Outcomes in Previously Untreted Ptients with Multiple Myelom: A Retrospective Anlysis from US Community Oncology Prctices Robert M
More informationPrime Enrollees Consumer Watch NHC Patuxent River FY 2016 Defense Health Cost Assessment & Program Evaluation
Prime Enrollees Consumer Wtch NHC Ptuxent River 16 Defense Helth Cost Assessment & Progrm Evlution NHC Ptuxent River: Smple size-1,457 Response rte-1.2% Source: Helth Cre Survey of DoD Beneficiries Inside
More informationCheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer
CheckMate 12: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer Abstract 31 Hellmann MD, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE,
More informationEsophageal carcinoma is the eighth most common cancer
ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescribing informtion for ALIMTA. ALIMTA (pemetrexed for injection),
More informationFertility in Norwegian testicular cancer patients
DOI: 0.054/ bjoc.999.0989, vilble online t http://www.idelibrry.com on Fertility in Norwegin testiculr cncer ptients SD Fosså nd Ø Krvdl 2 The Norwegin Rdium Hospitl, Montebello, N-030 Oslo, Norwy; 2 The
More informationXII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV
XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies
More informationResults. Table 1: Demographic and Baseline Characteristics, Open-Label Safety Population Prior Double-Blind OC/APAP ER (n=77)
Open-Lbel Extension of Rndomized, Double-Blind, Plcebo-Controlled, Phse 3 Study of the Sfety nd Anlgesic Efficcy of MNK-795 Oxycodone/Acetminophen Extended-Relese (OC/APAP ER) Tblets in n Acute Pin Model
More informationPNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :
PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged
More informationImmune Checkpoint Inhibitors for Lung Cancer William N. William Jr.
Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Diretor de Onco-Hematologia Hospital BP, A Beneficência Portuguesa Non-Small Cell Lung Cancer PD-1/PD-L1 Inhibitors in second-line therapy
More informationIncreased Relative Mortality in Women With Severe Oxygen-Dependent COPD
CHEST Originl Reserch Incresed Reltive Mortlity in Women With Severe Oxygen-Dependent COPD Mgnus Ekström, MD ; Krl A. Frnklin, MD, PhD ; nd Kerstin E. Ström, MD, PhD COPD Bckground: Although the incidence
More informationMEDALIST Trial Background and Rationale
The MEDALIST Tril: Results of Phse 3, Rndomized, Double-Blind, Plcebo-Controlled Study of to Tret Ptients With Very Low-, Low-, or Intermedite-Risk Myelodysplstic Syndromes (MDS) Associted Anemi With Ring
More informationChilblains (pernio, perniosis) are cold-induced, painful or itching
Nifedipine vs Plcebo for Tretment of Chronic Chilblins: A Rndomized Controlled Tril Ibo H. Souwer, MD 1 Jcobus H. J. Bor, BSc (Mth) 2 Pul Smits, MD, PhD 3 Antoine L. M. Lgro-Jnssen, MD, PhD 1 1 Deprtment
More informationSymptom Management and Supportive Care
This mteril is protected y U.S. Copyright lw. Unuthorized reproduction is prohiited. For reprints contct: Reprints@AlphMedPress.com Symptom Mngement nd Supportive Cre Erly Intervention with Epoetin Alf
More informationImpact of Pharmacist Intervention on Diabetes Patients in an Ambulatory Setting
Impct of Phrmcist Intervention on Dibetes Ptients in n Ambultory Setting Julie Stding, PhrmD, CDE, Jmie Herrmnn, PhrmD, Ryn Wlters, MS, Chris Destche, PhrmD, nd Aln Chock, PhrmD Dibetes is the seventh-leding
More informationManaging treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer
MEDICAL ONCOLOGY Mnging tretment-relted dverse events ssocited with egfr tyrosine kinse inhibitors in dvnced non-smll-cell lung cncer V. Hirsh md* ABSTRACT Non-smll-cell lung cncer (nsclc) hs the highest
More informationManaging treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer
MEDICAL ONCOLOGY Mnging tretment-relted dverse events ssocited with egfr tyrosine kinse inhibitors in dvnced non-smll-cell lung cncer V. Hirsh md* ABSTRACT Non-smll-cell lung cncer (nsclc) hs the highest
More informationLung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas
Originl Article EGFR Muttion nd Brin Metstsis in Pulmonry Adenocrcinoms Dong-Yeop Shin, MD,* Im Il N, MD,* Cheol Hyeon Kim, MD, PhD, Sunhoo Prk, MD, PhD, HeeJong Bek, MD, PhD, nd Sung Hyun Yng, MD, PhD*
More informationThe Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. doi: /ajg.2012.
A 12-Week, Rndomized, Controlled Tril with 4-Week Rndomized Withdrwl Period to Evlute the Efficcy nd Sfety of Linclotide in Irritble Bowel Syndrome with Constiption The Hrvrd community hs mde this rticle
More informationTR Spitzer 1, CJ Friedman 2, W Bushnell 2, SR Frankel 3, J Raschko 4. Summary:
(2000) 26, 203 210 2000 Mcmilln Publishers Ltd All rights reserved 0268 3369/00 $15.00 www.nture.com/bmt Double-blind, rndomized, prllel-group study on the efficcy nd sfety of orl grnisetron nd orl ondnsetron
More informationRisk of Colorectal Cancer by Subsite in a Swedish Prostate Cancer Cohort
Specil Report Risk of Colorectl Cncer by Subsite in Swedish Prostte Cncer Cohort Yunxi Lu, MD, PhD, Rickrd Ljung, MD, PhD, Ann Mrtling, MD, PhD, nd Mts Lindbld, MD, PhD Bckground: The reltionship between
More informationSummary. Effect evaluation of the Rehabilitation of Drug-Addicted Offenders Act (SOV)
Summry Effect evlution of the Rehbilittion of Drug-Addicted Offenders Act (SOV) The Rehbilittion of Drug-Addicted Offenders Act (SOV) ws lunched on April first 2001. This lw permitted the compulsory plcement
More informationMOLECULAR AND CLINICAL ONCOLOGY 5: , 2016
MOLECULAR AND CLINICAL ONCOLOGY 5: 429-436, 2016 Improvement of survivl with postmstectomy rdiotherpy in ptients with 1-3 positive xillry lymph nodes: A systemtic review nd met-nlysis of the current literture
More informationMaintenance paradigm in non-squamous NSCLC
Maintenance paradigm in non-squamous NSCLC L. Paz-Ares Hospital Universitario Virgen del Rocío Sevilla Agenda Theoretical basis The data The comparisons Agenda Theoretical basis The data The comparisons
More informationPatient Survival After Surgical Treatment of Rectal Cancer
Originl Article Ptient Survivl After Surgicl Tretment of Rectl Cncer Impct of Surgeon nd Hospitl Chrcteristics Dvid A. Etzioni, MD, MSHS 1,2 ; Toni M. Young-Fdok, MD, MS 1 ; Robert R. Cim, MD, MA 2,3 ;
More informationRevised: 6/2018 History of severe hypersensitivity reaction to pemetrexed. (4)
HIGHLIGHTS OF PRESCRIBING INFORMATION ------------------------ WARNINGS AND PRECAUTIONS ----------------------- These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively.
More informationSeasonal influenza vaccination programme country profile: Ireland
Sesonl influenz vccintion progrmme country profile: Irelnd 2012 13 Seson Bckground informtion Influenz immunistion policy nd generl fcts bout Irelnd Volume indices of GDP per cpit in 2011 nd 2013 (EU-
More informationWSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;
FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension
More informationPD L1 expression is associated with advanced non small cell lung cancer
ONCOLOGY LETTERS 12: 921-927, 2016 PD L1 expression is ssocited with dvnced non smll cell lung cncer ZHIQUAN CHEN 1 3, JIANDONG MEI 3 5, LUNXU LIU 4,5, GUOCHEN WANG 2, ZUOSHENG LI 2, JINGPU HOU 2, QIUYANG
More informationOlanzapine for the prophylaxis and rescue of chemotherapyinduced nausea and vomiting (CINV): a retrospective study
Originl Article Olnzpine for the prophylxis nd rescue of chemotherpyinduced nuse nd vomiting (CINV): retrospective study Leonrd Chiu, Nichols Chiu, Ronld Chow, Liying Zhng, Mrk Psetk, Jordn Stinson, Brenne
More informationPatients with cancer are at an increased
Risk of Cncer-Associted Thrombosis nd Bleeding in Veterns With Mlignncy Who Are Receiving Direct Orl Anticogulnts Mtthew Stnkowicz, PhrmD; Megn Bnszynski, PhrmD, BCOP; nd Russell Crwford, BPhrm, BCOP The
More informationPatient Monitoring Checklist
Ptient Monitoring Checklist Ptient nme Dte This checklist is intended for nurses or other helthcre professionls (HCPs) to use prior to dosing ech ptient nd t ny follow-up visits or clls with the ptient
More informationAddendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)
Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments
More informationSensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients
ORIGINAL ARTICLE Sensor-controlled sclp cooling to prevent chemotherpy-induced lopeci in femle cncer ptients M.K. Fehr md,* J. Welter mph,* W. Sell md,* R. Jung,* nd R. Felberbum md ABSTRACT Bckground
More informationFor Adults With Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)
For Adults With Previously Treted Advnced Non-Smll Cell Lung Cncer (NSCLC) individuls depicted re models used for illustrtive purposes only. It cn be overwhelming to lern tht your previously treted dvnced
More informationIn the treatment of cardiovascular disease (CVD), national
n report n Beyond LDL Cholesterol: The Role of Elevted Triglycerides nd Low HDL Cholesterol in Residul CVD Risk Remining After Sttin Therpy Peter Algon Jr, MD, FACC In the tretment of crdiovsculr disese
More informationCorrelations Between Cytogenetic and Molecular Monitoring Among Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase
Originl Articles Correltions Between Cytogenetic nd Moleculr Monitoring Among Ptients With Newly Dignosed Chronic Myeloid Leukemi in Chronic Phse Post Hoc Anlyses of the Rtionle nd Insight for Gleevec
More informationAntiviral Therapy 2014; 19: (doi: /IMP2721)
Antivirl Therpy 2014; 19:191 200 (doi: 10.3851/IMP2721) Originl rticle Chnge in vitmin D levels nd risk of severe vitmin D deficiency over 48 weeks mong HIV 1 infected, tretment-nive dults receiving rilpivirine
More informationMetabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction
Metbolic Syndrome nd Helth-relted Qulity of Life in Obese Individuls Seeking Weight Reduction Adm Gilden Tsi 1, Thoms A. Wdden 1, Dvid B. Srwer 1, Robert I. Berkowitz 1, Leslie G. Womble 1, Louise A. Hesson
More informationNivolumab: esperienze italiane nel carcinoma polmonare avanzato
NSCLC avanzato: quali novità nel 2018? Negrar, 30 Ottobre 2018 Nivolumab: esperienze italiane nel carcinoma polmonare avanzato Francesco Grossi UOC Oncologia Medica Fondazione IRCCS Ca Granda Ospedale
More informationPROVEN ANTICOCCIDIAL IN NEW FORMULATION
PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules
More informationClinical Study. Oncology 2010;79: DOI: /
Oncology Clinicl Study DOI: 10.59/000320625 Received: June 24, 2010 Accepted: July 27, 2010 Published online: Mrch 1, 20 Prospective Multicenter Rndomized Phse III Study of Weekly versus Stndrd Docetxel
More informationAdverse Events Grading Card
Adverse Events Grding Crd Common Terminology Criteri for Adverse Events* In clinicl studies, 2 of the most common dverse events reported with ALAVEN were peripherl neuropthy nd neutropeni. 1 With this
More informationA retrospective study on combination therapy with ifosfamide, adriamycin and cisplatin for progressive or recurrent uterine sarcoma
MOLECULAR AND CLINICAL ONCOLOGY 2: 591-595, 2014 A retrospective study on combintion therpy with ifosfmide, drimycin nd cispltin for progressive or recurrent uterine srcom WATARU YAMAGAMI, NOBUYUKI SUSUMU,
More informationEGFR inhibitors in NSCLC
Suresh S. Ramalingam, MD Associate Professor Director of Medical Oncology Emory University i Winship Cancer Institute EGFR inhibitors in NSCLC Role in 2nd/3 rd line setting Role in first-line and maintenance
More informationMaintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute
Maintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute e.smit@nki.nl Evolution of front line therapy in NSCLC unselected pts
More informationEmerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data
Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic
More informationAsian Journal of Andrology (2017) 19,
(2017) 19, 20 25 2017 AJA, SIMM & SJTU. All rights reserved 1008-682X www.sindro.com; www.jndrology.com Prostte Cncer Open Access ORIGINAL ARTICLE Refining the Americn Urologicl Assocition nd Americn Society
More informationTargeted Agents as Maintenance Therapy. Karen Kelly, MD Professor of Medicine UC Davis Cancer Center
Targeted Agents as Maintenance Therapy Karen Kelly, MD Professor of Medicine UC Davis Cancer Center Disclosures Genentech Advisory Board Maintenance Therapy Defined Treatment Non-Progressing Patients Drug
More informationOpioid Use and Survival at the End of Life: A Survey of a Hospice Population
532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,
More informationR Martino 1, P Romero 1, M Subirá 1, M Bellido 1, A Altés 1, A Sureda 1, S Brunet 1, I Badell 2, J Cubells 2 and J Sierra 1
Bone Mrrow Trnsplnttion, (1999) 24, 283 287 1999 Stockton Press All rights reserved 0268 3369/99 $12.00 http://www.stockton-press.co.uk/bmt Comprison of the clssic Glucksberg criteri nd the IBMTR Severity
More informationSee 17 for PATIENT COUNSELING INFORMATION. Revised: 09/2017 FULL PRESCRIBING INFORMATION: CONTENTS*
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use Gemzr sfely nd effectively. See full prescriing informtion for Gemzr. GEMZAR (gemcitine for injection),
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved. Revised: 01/2019
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescribing informtion for ALIMTA. ALIMTA (pemetrexed for injection),
More informationMetastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian
Metastatic NSCLC: Expanding Role of Immunotherapy Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Disclosures: No relevant disclosures Please note that some of the studies reported in
More informationNonpharmacologic Interventions for Treatment-Resistant Depression in Adults Executive Summary
Comprtive Effectiveness Review Numer 33 Effective Helth Cre Progrm Nonphrmcologic Interventions for Tretment-Resistnt Depression in Adults Executive Summry Bckground Mjor depressive disorder (MDD) is common
More information