With The NEW vccine ginst Swine Erysipels nd Porcine Prvovirus infection A powerful immunity you cn rely on
Swine Erysipels Erysipelothrix rhusiopthie cn e found on most pig frms: it cuses Swine Erysipels, worldwide disese tht hs n importnt economic impct.1 Swine Erysipels hs different clinicl presenttions nd is cple of ffecting ll stges of pig production.2 Joint infection Arthritis Chronic lmeness Acute deth Pyrexi 40-42ºC Aortions Decresed economic performnce Dimond-skin lesions Poor growth Decresed crcss vlue Reproductive losses Production losses E. rhusiopthie is zoonotic2 Gilt nd sow vccintion is essentil for controlling Swine Erysipels. Chrcteristic skin lesions in pig infected with E. rhusiopthie.
Porcine Prvovirus infection Porcine Prvovirus (PPV) hs spred worldwide nd is endemic in most swine herds. 3 An cute outrek of disese in non-vccinted herd cn cuse devstting reproductive losses: Infertility due to resorptions in erly gesttion stges. Smller litter sizes ssocited with emryo loss efore 35 dys of gesttion. Incresed numer of mummified foetuses. Incresed numer of stillirths. Increse in low irth weight piglets. Decresed frrowing rte. Consequences of PPV infection ccording to gesttion time (dpted from Diseses of Swine, 10th edition) Gesttion Dy 0 Dy 6 Dy 12 Dy 35 Dy 70 Dy 114 Emryo FOetus Foetl development Conception Htching Plcenttion Ossifiction egins Immunologicl competence Frrowing Result of PPV infection Conceptus protected Deth nd resorption of emryos Foetl deth nd mummifiction Immune response usully leds to survivl Mternl reproductive filure is the mjor nd only well-estlished clinicl sign of PPV infection. 3 A mix of norml pigs nd mummified foetuses tht died t different stges in the sme litter is strong indiction of PPV infection. 3
Highly-protective nd long-lsting immunity for the reeding herd. Exceptionl efficcy ginst Swine Erysipels thnks to two min components: A highly immunogenic ntigen. Its qulity could e relted to the presence of the cell surfce sp A protein of E. rhusiopthie: Responsile for inducing the production of highly protective ntiodies. 2 Considered to e the mjor immunizing ntigen of E. rhusiopthie. 2 Hiprmune G d, powerful djuvnt tht enhnces the durtion of immunity ginst E. rhusiopthie 4 : 6 months fter primry vccintion. Effectively protects sows nd gilts ginst Porcine Prvovirus nd lso their progenie ginst trnsplcentl infection. The immunity conferred y Eryseng Prvo covers the entire gesttion period 5,6 : Femles rech high PPV specific HI ntiody titres. Foetuses protected ginst PPV infection. Reduced reproductive losses: Infertility. % norml foetuses. Improved litter size: more totl piglets orn nd totl piglets orn live.
HIPRAMUNE G d is stte-of-the-rt queous djuvnt developed y HIPRA sed on GINSENG sponins with known immunologicl properties. Promotes ntigen prticultion incresing its vilility. 8 Activtes mixed cellulr nd humorl immune responses. 7 Stimultes the production nd mturtion of ntigen presenting cells (APCs) such s dendritic cells nd mcrophges. 7 Improves ntiody production. 7 enhnces nimls ntigen presenttion process: An increse in the numer of APCs nd the mount of ntigen on their surfce is one of the keys in the ility of djuvnts to increse the effectiveness of vccines. 9
protects gilts nd sows A study ws performed to compre the humorl immune responses elicited in nïve pigs ginst E. rhusiopthie y three different inctivted ivlent Porcine virus (PPV) nd E. rhusiopthie vccines. 10,11 Vccine A ws Eryseng Prvo. Vccine B ws commercilly ville vccine djuvnted with luminium hydroxide. Vccine C ws commercilly ville vccine djuvnted with dl-α-tocopherol cette. 1. Humorl immune response 10 IRPC Men ntiody levels ginst E. rhusiopthie Vccintion Revccintion Chllenge E. rhusiopthie: serotypes 1 nd 2 Results Dy 0 Dy 21 Dy 93 140 120 100 80, 60 40,c 20 c c c c 0-20 0 21 41 60 80 93 STUDY dy B Eryseng Prvo C Plceo,, c Different superscripts indicte sttisticlly significnt differences within the sme dy (Anov 1F; p<0.05). The humorl immune response ginst E. rhusiopthie in the group of nimls vccinted with is fster, higher nd lsts longer. is n lly in the durtion of An immunologicl study ws conducted to investigte the ction of Hiprmune G d on the length of seroconversion ginst E. rhusiopthie. 4 Gilts were vccinted twice intrmusculrly with 2 ml dose three weeks prt ginst E. rhusiopthie with one of the following formultions: luminium hydroxide (group A), Hiprmune G d (group B) nd PBS s negtive control (group C). Aluminium hydroxide Hiprmune G d * Vccines from groups A nd B contined the sme concentrtion of E. rhusiopthie ntigen with different djuvnts. PBS
ginst clinicl signs of Swine Erysipels 2. Body temperture fter chllenge 11 Averge ody temperture (ºC) post-chllenge 40.50 Temperture (ºC) 40.00 39.50 39.00 38.50 38.00 * * * * * * 93 94 95 96 97 98 99 100 mintins physiologicl tempertures fter infection. STUDY dy Eryseng Prvo B C Plceo * Sttisticlly significnt differences within the sme dy (Anov 1F; p<0.05). 3. Skin lesions fter chllenge 11 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% * Serotype 1 strin: ffected nimls (%) Serotype 2 strin: ffected nimls (%) * 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% B C Plceo B C Plceo Helthy Affected * Sttisticlly significnt differences with the plceo group (Anov 1F; p<0.05). Helthy Affected is effective in reducing typicl skin lesions produced fter the E. rhusiopthie infection. immunity ginst Erysipelothrix rhusiopthie Men ntiody levels ginst E. rhusiopthie IRPC 140 120 100 80 60 40 20 0-20 0 21 41 60 80 93 Study dy Group A Group B Group C * Sttisticlly significnt differences with the sme dy (Anov 1F; p<0.05). The humorl immune response ginst E. rhusiopthie in the group of nimls vccinted with vccine contining is fster nd longer.
with A NEW vccine for the reeding herd Highly-protective nd long-lsting immunity Reduction of Swine Erysipels clinicl signs Effective protection ginst Porcine Prvovirus infection Bsic vccintion. Sows nd gilts which hve not een previously vccinted 1 st dose 2 nd dose 6-8 weeks efore AI 3-4 weeks efore AI Artificil insemintion Revccintion. 1 st dose 2-3 weeks efore AI Artificil insemintion References: 1. Muirhed MR et l. 2013. Mnging pig helth, 2nd ed. 2. Opriessnig T et l. 2012. Diseses of swine, 10th ed: 750-759. 3. Truyen U et l. 2012. Diseses of swine, 10th ed: 447-455. 4. Cmprodon A et l. Hiprmune -Gd: An lly in the durtion of immunity ginst Erysipelothrix rhusiopthie. IPVS proceedings vol II 2014; P634: 614. 5. Cmprodon A et l. Durtion of the protective immunity ginst Porcine Prvocirus infection fter vccintion of sows using new ivlent Prvovirus nd Erysipels vccine. ESPHM proceedings 2014; P229; 251. 6. Cmprodon A et l. Efficcy ginst Porcine Prvovirus infection fter vccintion of gilts using Eryseng Prvo. IPVS proceedings vol II 2014; P636; 616. 7. Kng S, Min H. Ginseng, the Immunity Boost : The effects of Pnx ginseng on immune system. J Ginseng Res 2012; 36: 654-368. 8. Spickler AR, Roth JA. Adjuvnts in veterinry vccines: modes of ction nd dverse effects. J Vet Intern Med 2003; 17: 273-281. 9. Chse C. Swine immunology: Wht does it tke to mke the immune response tke? AASV 2012: 411-416. 10. Cmprodon A et l. Evlution of the Erysipelothrix rhusiopthie ntigenic component in ivlent Porcine Prvovirus nd E. rhusiopthie vccines y humorl immune responses in pigs. ESPHM proceedings 2014; P223: 248. 11. Cmprodon A et l. Evlution of n Erysipelothrix rhusiopthie experimentl infection in pigs vccinted with ivlent Porcine Prvovirus nd E. rhusiopthie vccines. ESPHM proceedings 2014; P222: 247. Suspension for injection for pigs. Composition: Ech dose of 2 ml contins: Active sustnces: Inctivted porcine prvovirus, strin NADL-2, RP > 1.15 *. Inctivted Erysipelothrix rhusiopthie, strin R32E11, ELISA > 3.34 IE50%**.* RP reltive potency (ELISA). **IE50% Inhiition ELISA 50%. Adjuvnts: Aluminium hydroxide, DEAE-Dextrn, Ginseng. Indictions: For the ctive immunistion of femle pigs for the protection of progeny ginst trnsplcentl infection cused y porcine prvovirus. For the ctive immunistion of mle nd femle pigs to reduce clinicl signs of swine erysipels cused y Erysipelothrix rhusiopthie, serotype 1 nd serotype 2. Onset of immunity: Porcine prvovirus: from the eginning of the gesttion period. E. rhusiopthie: three weeks fter completion of the sic vccintion scheme. Durtion of immunity: Porcine prvovirus: vccintion provides foetl protection for the durtion of gesttion. E. rhusiopthie: vccintion protects ginst swine erysipels until the time of the recommended revccintion (pproximtely six months fter the sic vccintion scheme). Administrtion route: Intrmusculr use. Dosge: Administer one dose of 2 ml y intrmusculr injection in the neck muscles ccording to the following schedule: Bsic vccintion: Pigs from 6 months of ge which hve not een previously vccinted with the product should e given two injections with n intervl of 3 4 weeks. The second injection should e dministered 3 4 weeks efore mting. Revccintion: A single injection should e given 2 3 weeks prior to ech susequent mting (pproximtely every 6 months). Side effects & Contrindictions: Very common dverse rections: Mild to moderte inflmmtion t the injection site tht typiclly resolves within four dys ut in some cses my persist for up to 12 dys post-vccintion. Common dverse rections: A trnsient increse in ody temperture within the first 6 hours fter vccintion, which spontneously resolves within 24 hours. Do not use in cses of hypersensitivity to the ctive sustnce, to the djuvnts or to ny of the excipients. Withdrwl period: Zero dys. Specil Precutions: None specil wrnings for ech trget species. Cn e used during pregnncy nd lcttion. Vccinte only helthy nimls. In cse of dverse rections following ccidentl self-injection, seek medicl dvice immeditely nd show the pckge leflet or the lel to the physicin. No informtion is ville on the sfety nd efficcy of this vccine when used with ny other veterinry medicinl product. A decision to use this vccine efore or fter ny other veterinry medicinl product therefore needs to e mde on cse y cse sis. Overdose: No dverse rections other thn those mentioned in section Side Effects & Contrindictions were oserved fter the dministrtion of 2-fold vccine dose. Do not mix with ny other veterinry medicinl product. Shelf life of the veterinry medicinl product s pckged for sle: 2 yers. Shelf life fter first opening the immedite pckging: use immeditely. Specil storge precutions: Store nd trnsport refrigerted (2-8 ºC). Do not freeze. Protect from light. Any unused veterinry medicinl product or wste mterils derived from such veterinry medicinl product should e disposed of in ccordnce with locl requirements. Keep out of the rech nd sight of children. Pckging: Vils of 10, 25 nd 50 doses. Mrketing Authoristion Holder: LABORATORIOS HIPRA, S.A. Avd. l Selv, 135. 17170 Amer (Giron) Spin. Tel. (972) 430660 Fx (972) 430661. Mrketing Authoriztion numer: EU/2/14/167/001-007. Under veterinry prescription. Use medicines responsily. Lortorios Hipr, S.A. Avd. l Selv, 135 17170 Amer (Giron) Spin Tel. (34) 972 43 06 60 Fx (34) 972 43 06 61 hipr@hipr.com www.hipr.com