1 PHA 5451 Clinical Biochemistry 4 Semester Credit Hours Course Purpose: The course will provide a biochemical foundation for the understanding of drug action, drug absorption and drug metabolism. Examples of biochemical basis for different disease states will provide a framework in understanding cause of disease. Course Faculty and Office Hours Course Coordinator: Sihong Song Email: shsong@ufl.edu Phone: 352-273-7867 Co-Coordinator: Anthony Palmieri III Email: palmieri@cop.ufl.edu Office: P4-27, Health Science Center Office Hours Communication with Instructor can be done through the course discussion board, email or make an appointment (please allow at least 24 hours to response). See Appendix A for contact information of Teaching Assistants. Place and Time of Class Sessions Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday, except 8:30-9:20 AM on Sep 17, Oct 15 and Nov 19 (see appendix B) How This Course Relates to the Learning Outcomes You Will Achieve in the Pharm.D. Program: This course prepares the Pharm.D. student to accomplish the following abilities and the related Student Learning Outcomes (SLOs) upon graduation: 1. Provide Patient centered Care - Specifically: Design, implement, monitor, evaluate, and adjust pharmacy care plans that are patient specific; address health literacy, cultural diversity, and behavioral psychosocial issues; are evidence based and accomplished in collaboration with other health professionals. (Foundational) 2. Use pharmacy knowledge in the care of patients and resolution of practice problems. Course Objectives Upon completion of this course, the student will be able to: 1) Describe the structure, function and metabolic pathways for carbohydrates, amino acids and lipids.
2 2) Explain the alterations in lipid and carbohydrate metabolism that occur as a result of diabetes. 3) Explain the metabolism of lipoproteins, medical problems associated with abnormal lipoprotein levels and therapeutic agents used to treat lipid disorders. 4) Describe how enzyme activity is regulated through second messengers and hormones. 5) Describe the biochemistry of membranes including chemical composition and structure of biological membranes, as well as drug transporters. 6) Describe intercellular and intracellular signal transductions and explain the molecular mechanism of drug actions. 7) Describe the processes involved in replication, transcription and translation of genetic information. 8) Describe DNA recombination and discuss the impact it has on production of proteins as drugs. 9) Apply biochemistry concepts to solve clinical scenarios. 10) Clarify the information of biochemistry in eukaryotic cells, with an emphasis on those of human tissues. 11) To translate the biochemical event at cellular levels to physiological processes in human body. Pre-Requisite Knowledge and Skills Organic Chemistry (CHM 2210 and 2211, CHM 2215 and 2216, or their equivalents at other universities) or consent of instructor. Course Structure & Outline Course Structure. a) Learning activities are video lectures and students are required to come to campus for exams, b) Multiple self-directed learning activities are required (e.g., videos, readings and web-based learning); students must come to class for exams. Course Outline/Activities. See Appendix B. Textbooks Textbook of Biochemistry with Clinical Correlations T.M. Devlin Editor, Wiley-Liss, John Wiley & Sons, Inc. 7th Edition 2010 http://www.wiley.com/wileycda/wileytitle/productcd-0470601523.html Recycled 5th or 6th editions of the same textbook can also be used. Active Learning Requirements The lectures will follow the syllabus. There will be overlap between topics covered in Clinical Biochemistry and in Medicinal Chemistry. These should not be viewed as redundant but rather reinforcing the understanding of fundamental chemical principles regarding both Biochemistry and Drug Action. Students are encouraged to review those clinical correlations in the textbook for better understanding biochemical concepts related to disease or drug action.
3 Student Evaluation & Grading Evaluation Methods The average grade of 4 exams will be the final grade of the course for each student. If necessary, grades may be scaled at the end of the course based on the performance of the class. Grading Scale Based on UF grading system (http://www.registrar.ufl.edu/catalog/policies/regulationgrades.html) >90 A (4.0) >87, <90 A- (3.67) >83, <87 B+ (3.33) >80, <83 B (3.0) >77, <80 B- (2.67) >73, <77 C+ (2.33) >70, <73 C (2.0) >67, <70 C- (1.67) >63, <67 D+ (1.33) >60, <63 D (1.0) >57, <60 D- (0.67) <57 E (0) Class Attendance Policy Students in Gainesville campus are encouraged, but not required to attend classroom lectures. Quiz/Exam Policy Tests will be distributed at the beginning of class. There will be one seat separating each student. At the end of the two-hour period the exams will be taken up. Grades will be posted 7 to 10 days after the exams on the course web site. No calculators will be needed for any exams. Type of Examination Format(s) Fill in the blank, Matching, Short answer and Calculations. Multiple Choice, True or False. Make-up Quiz/Exam Policy Students are required to take all four exams. Missing exam will require documentation to have a make-up exam, such as a note from a physician. Policy on Old Quizzes and Assignments Students are encouraged to use questions and answers in the textbook to practice for the exams. Old exams may or may not be provided. General College of Pharmacy Course Policies The College of Pharmacy has a website that lists course policies that are common to all courses. This website covers the following:
4 1. University Grading Policies 2. Academic Integrity Policy 3. How to request learning accomodations 4. Faculty and course evaluations 5. Student expectations in class 6. Discussion board policy 7. Email communications 8. Religious holidays 9. Counseling & student health 10. How to access services for student success Please see the following URL for this information: http://www.cop.ufl.edu/wpcontent/uploads/dept/studaff/policies/general%20cop%20course%20policies.pdf Complaints Should you have any complaints with your experience in this course please visit: http://www.distancelearning.ufl.edu/student-complaints to submit a complaint. Appendix A: Directions for Contacting Faculty & Course Faculty List Directions for Contacting Course Faculty Communication with instructors can be done through the course discussion board, email or make an appointment. Approximately 70 to 80 students are assigned to each Teaching Assistant. Check the Groups key on the course web site to find out which TA you have been assigned to. The Teaching Assistants will hold office hours electronically for one hour per week using the group discussion board. The Teaching Assistant will select a time that accommodates the majority of their students and the Teaching Assistant s schedule. ] Course Coordinator Sihong Song, Associate Professor, shsong@ufl.edu Co-Coordinator: Anthony Palmieri III, Associate Scholar, palmieri@cop.ufl.edu Graduate Student Teaching Assistants Yasmeen Abouelhassan Group 1 y.abouelhassan@ufl.edu Barnett Alfant Group 2 alfant@ufl.edu Jason Deng Group 3 jdeng415@ufl.edu Aaron Garrison Group 4 atgarrison@ufl.edu
5 Appendix B. Schedule of Course Activities/Topics (Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday except 8:30-9:20 AM on Sep 17, Oct 15 and Nov 19) s Lecture Date Day Book Chapter Lecturer Specific Topics 8 7 6 5 4 3 2 1 1 8/21 w 1 Palmieri Introduction of the course. Water, ph, buffers 2 8/23 F 1 Palmieri Eukaryotic cellular structure and function 3 8/26 M 3 Palmieri Amino Acids-Chemical Properties 4 8/27 T 3 Palmieri Transition from amino acids to proteins 5 8/28 W 3 Palmieri Protein Structure 6 8/30 F 9 Palmieri Immunoglobulin 9/2 M Labor Day Holiday-NO CLASS!!! 7 9/3 T 9 Palmieri Serine Proteases, Protease Inhibitors 8 9/4 W 9 Palmieri Hemoglobin: Structure and Function 9 9/6 F 9 Palmieri Basal lamina protein complex 10 9/9 M 10 Palmieri Enzyme Classification and Reaction Kinetics 11 9/10 T 10 Palmieri Enzyme Kinetics and Enzyme Inhibition 12 9/11 W 10 Palmieri Regulation of Enzyme Activity 9/13 F Palmieri Review for Exam I (covers Ch. 1, 3, 9 &10) 13 9/16 M 11 Palmieri Cytochromes P450 14 9/17 T 11 Palmieri Nitric Oxide Synthases (8:30 AM) 15 9/18 W 12 Palmieri Biological Membranes I-composition 9/19 Th Palmieri Exam I (covers Ch. 1, 3, 9 &10; at 4:30-6:30PM) 16 9/20 F 12 Palmieri Biological Membranes II-structure 17 9/23 M 12 Palmieri Biological Membranes II-Function 18 9/24 T 14 Palmieri Biochemical Thermodynamics 19 9/25 W 14 Palmieri Tricarboxylic Acid Cycle 20 9/27 F 14 Palmieri Electron Transport Chain 21 9/30 M 14 Palmieri Mitochondrial Diseases 22 10/1 T 15 Palmieri Glycolysis 23 10/2 W 15 Palmieri Regulation of Glycolysis 24 10/4 F 15 Palmieri Glycogen Synthesis and Degradation 10/7 M Palmieri Review for Exam II (covers Ch. 11,12,14 &15) 25 10/8 T 16 Palmieri Pentose Phosphate Pathway 26 10/9 W 16 Palmieri Sugar Interconversions 27 10/11 F 17 Palmieri Lipid Metabolism I
6 s Lecture Date Day Book Chapter Lecturer Specific Topics 9 10 11 12 13 14 15 16 10/14 M Palmieri Exam II (covers Ch. 11,12, 14 &15; at 4:30-6:30 PM) 28 10/15 T 17 Palmieri Lipid Metabolism I (8:30AM) 29 10/16 W 18 Palmieri Lipid Metabolism II 30 10/18 F 18 Palmieri Lipid Metabolism II 31 10/21 M 19 Palmieri Amino Acid Metabolism: 32 10/22 T 19 Palmieri Amino Acid Metabolism: 33 10/23 W 19 Palmieri Amino Acid Metabolism: 34 10/25 F 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism 35 10/28 M 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism 10/29 T Palmieri Review for Exam III (covers Ch. 16,17,18,19 & 20) 36 10/30 W 2 Song DNA & RNA: Composition and Structure 37 11/1 F 2 Song DNA & RNA: Composition and Structure 11/4 M Palmieri Exam III (Ch. 16, 17, 18, 19 & 20; 4:30-6:30 PM) 38 11/5 T 4 Song DNA Replication 39 11/6 W 4 Song DNA Recombination and Repair 11/8 F Home Coming-NO CLASS!!! 11/11 M Veterans Day-No Class!!! 40 11/12 T 5 Song RNA: Transcription and RNA processing 41 11/13 W 5 Song RNA: Transcription and RNA processing 42 11/15 F 6 Song Protein synthesis-translation 43 11/18 M 6 Song Posttranslational modifications 44 11/19 T 13 Song Signal transduction-i (8:30AM) 45 11/20 W 13 Song Signal transduction-i 46 11/22 F 8 Song Regulation of gene expression in Bacteria 47 11/25 M 8 Song Regulation of gene expression in eukaryotes 48 11/26 T 7 Song Recombinant DNA and Biotechnology 49 11/27 W 7 Song Application of Biotechnology 11/29 F Thanksgiving Holidays-NO CLASS!!! 12/2 M Song Exam IV Review (Ch.. 2, 4, 5, 6, 13, 8 & 7) 12/3 T Song Exam IV (Ch. 2, 4, 5, 6, 13, 8 & 7; at 4:30-6:30 PM 12/4 W The End 12/6 F