PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE July 12-15, 2012 Keystone, Colorado

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PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE Thursday, July 12, 2012 CONFERENCE SCHEDULE 10:00-12:30 PM Registration/View Exhibits/Snacks 12:30 12:40 PM Welcome and Introductory Remarks Satish K. Garg, MD, Robert Slover, MD and Jay Skyler, MD PLENARY ONE: What is Making Headlines for Diabetes Chair: Amanda Adler, MD, PhD 12:40 1:05 PM The Intersection of Healthcare Reform, Cost of Care, and Increasing Diabetes Prevalence Robert Ratner, MD 1:05 1:30 PM Dealing with Diabetes Prevention in the Setting of Rising Prevalence David Kendall, MD 1:30 1:50 PM NIH Perspective Judith Fradkin, MD 1:50 2:15 PM Devices in Diabetes Can We Achieve the Desired Goals? John Pickup, MD 2:15 2:40 PM Question & Answer and Panel Discussion Panelists: A. Adler, R. Ratner, D. Kendall, J. Fradkin, J. Pickup 2:40 3:00 PM Break PLENARY TWO: Regulatory Perspectives on Diabetes Drugs & Devices Chair: J. Skyler, MD 3:00 3:25 PM Regulatory Hurdles for Drug Approvals William Hiatt, MD 3:25 3:50 PM JDRF Perspective Richard Insel, MD 3:50 4:10 PM Pharma and Device Perspective Matthias Axel Schweitzer, MD 4:10 4:30 PM Device Perspective Terry Gregg, MD 4:30 4:55 PM Food & Drug Administration Perspectives Courtney Harper Lias, PhD 4:55 5:10 PM Question & Answer and Panel Discussion Panelists: J. Skyler, W. Hiatt, R. Insel, M. Schweitzer, T. Gregg, C. Harper Lias 7:30 9:00 PM Industry Sponsored Dinners 1

Friday, July 13, 2012 PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE 7:00 7:55 AM Continental Breakfast/View Exhibits 7:55 8:00 AM Welcome and Introductory Remarks Satish K. Garg, MD PLENARY THREE: Where Are Insulins Going? Chair: George Eisenbarth, MD 8:00 8:25 AM Are Insulin Analogs Worth Their Cost? Yes Irl Hirsch, MD 8:25 8:50 AM Are Insulin Analogs Worth Their Cost In Type 2 Diabetes? Amanda Adler, MD, PhD 8:50 9:15 AM Perspective on Biosimilar insulins: where are we? Didier Halimi, MD 9:15 9:40 AM We Actually Need Better Insulins Lutz Heinemann, PhD 9:40 10:05 AM Question & Answer and Panel Discussion Panelists: G. Eisenbarth, I. Hirsch, A. Adler, D. Halimi, L. Heinemann 10:05 10:20 AM Break/View Exhibits PLENARY FOUR: Insulin Resistance, Incretins & Diabetes Chair: John Pickup, MD 10:20 10:45 AM Insulin Resistance Should Fat Cell be the Treatment Target? Ronald Kahn, MD 10:45 11:10 AM Liver as the Source of Insulin Resistance Should This Be the Treatment Target? Gerald Shulman, MD, PhD 11:10 11:35 AM Changes in Incretin Levels After Bariatric Surgery Nestor De La Cruz-Munoz, MD 11:35 12:00 PM DPPIVs and GLPI analogs alone and/or Combinations with Basal Insulin Steve Edelman, MD 12:00 12:15 PM Question & Answer and Panel Discussion Panelists: J. Pickup, S. Garg, R. Kahn, G. Schulman, N. De La Cruz-Munoz, S. Edelman 12:15 1:15 PM Luncheon/View Exhibits 2

PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE 1:30 3:00 PM CONCURRENT SESSIONS Session 1 New Directions in Diabetes of Young Chair: A. Steck, MD 1:30 1:55 PM What are We Learning from the T1D Registry? G. Klingensmith, MD 1:55 2:20 PM Type 2 Diabetes in Children Philip Zeitler, MD 2:20 2:50 PM How will we Care for Everyone with T1D? Robert Slover, MD 2:50 3:00 PM Q & A/Panel Discussions Panelists: A. Steck, G. Klingensmith, P. Zeitler, R. Slover Session 2 New Therapeutic Options for Diabetes Treatment Chair: Aaron Michels, MD 1:30 1:55 PM SGLT2 inhibitors and Glucokinase Activators, SPARMS, DGATs, 11-OH-ß Robert Ratner, MD 1:55 2:20 PM Immune modulator in T1D Jay Skyler, MD 2:20 2:50 PM How Important is Glucose Variability for Diabetes? Irl Hirsch, MD 2:50 3:00 PM Q & A/Panel Discussions Panelists: A. Michels, R. Ratner, J. Skyler, I. Hirsch 3:00 3:30 PM Break 3:30 4:30 PM CONCURRENT SESSIONS Session 3 Meet the Peers - Pediatric 3:30 4:30 PM Providers Chair: R. Slover M. Rewers, R. Slover, G. Klingensmith, P. Chase, D. Maahs, P. Wadwa, P. Zeitler 3:30 4:30 PM Educators Chair: G. Koch C. Banion, C. Cain, S. Kassels, C. Mowry- Johnson, S. Hoops, G. Koch, S. Owen, K. Smith, G. Tellez, L. Tuthill, E. Fay-Itzkowitz, D. Shepard, G. Spiegel, D. Owen Session 4 Meet the Peers - Adult 3:30 4:30 PM Providers Chair: P. Gottlieb S. Garg, J. Skyler, P. Gottlieb, G. Eisenbarth, A. Michels, J. Pickup, S. Amiel, R. Ratner, W. Hiatt, D. Kendall, R. Bergenstal 3:30 4:30 PM Educators Chair: M. Voelmle M. Voelmle, C. Beatson, B. Lopez-Baca, S. Walker, L. Meyers 7:30 9:00 PM Industry Sponsored Dinner 3

Saturday, July 14, 2012 PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE 7:00 7:55 AM Continental Breakfast/View Exhibits 7:55 8:00 AM Opening Remarks Satish K. Garg, MD, PLENARY FIVE: Hypoglycemia and Diabetes Chair: David Kendall, MD 8:00 8:20 AM An Issue in Diabetes Reasons to Prevent? Stephanie Amiel, MD 8:20 8:40 AM Ways to Reduce Hypoglycemia in T1D Thomas Danne, MD 8:40 9:00 AM Ways to Reduce Hypoglycemia in T2D Amanda Adler, MD, PhD 9:00 9:20 AM Lesson learned from ACCORD regarding Hypoglycemia Richard Bergenstal, MD 9:20 9:40 AM Panel Discussion Panelists: D. Kendall, S. Amiel, T. Danne, A. Adler, R. Bergenstal 9:40 10:00 AM Break/View Exhibits PLENARY SIX: CGM and Close Loop Chair: Jay Skyler, MD 10:00 10:25 AM New CGM s Steve Edelman, MD 10:25 10:50 AM In-Clinic Close Loop Experience in the US Fran Kaufman, MD 10:50 11:15 PM Diabetes Management in the Young - European Perspective Thomas Danne, MD 11:15 11:40 PM Patch Pumps and Close Loop Experience in Europe John Pickup, MD 11:40 12:00 PM Q & A/Panel Discussions Panelists: J. Skyler, S. Edelman, F. Kaufman, T. Danne, J. Pickup 12:00 1:00 PM Luncheon/View Exhibits PLENARY SEVEN: Diabetes Complications Chair: Satish Garg, MD 1:00 1:25 PM CVD and Diabetes Jay Skyler, MD Printed 10/3/2011 11:20:10 AM 4

PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE 1:25 1:50 PM Microvascular Disease in Type 1 Diabetes David Kendall, MD 1:50 2:15 PM Ways to Reduce Diabetes Burden Marian Rewers, MD 2:15 2:30 PM Q & A/Panel Discussions Panelists: S. Garg, J. Skyler, D. Kendall, M. Rewers 2:30 3:10 PM Break 3:10 4:30 PM CONCURRENT SESSIONS Session 6 Nutrition in Diabetes Chair: R. Fiallo-Scharer, MD 3:10 3:30 PM Is Carbohydrate Counting Accurate Enough to Understand Insulin Rx? Gail Spiegel, RD, CDE 3:30 3:50 PM Is Carbohydrate Counting Really Needed? Richard Bergenstal, MD 3:50 4:10 PM Other Ways to Achieve Metabolic Control N. De La Cruz-Munoz, MD 4:10 4:30 PM Q & A/Panel Discussions Panelists: R. Fiallo-Scharer, G. Spiegel, R. Bergenstal, N. De La Cruz-Munoz Session 7 Hot Topics at the Pediatric Adult Border Chair: Rob Slover, MD 3:10 3:30 PM Transition of Care European Perspective Stephanie Amiel, MD 3:30 3:50 PM Glycemic Patterns in Pregnancy--What are the Metabolic Determinants of Fetal Growth? Linda Barbour, MD 3:50 4:10 PM The Issues Involved in Diabetes Care Transition Mary Voelme, NP, and Stephanie Kassels, NP 4:10 4:30 PM Q & A/Panel Discussions Panelists: R. Slover, S. Amiel, L. Barbour, M. Voelmle, S. Kassels Session 8 Complications in Type 1 Diabetes Chair: Georgeanna Klingensmith, MD 3:10 3:30 PM Renal Disease David Maahs, MD 3:30 3:50 PM Lipid Disorders R. Paul Wadwa, MD 3:50 4:10 PM Monogenic Diabetes(MODY) Andrea Steck, MD 4:10 4:30 PM Q & A/Panel Session Panelists: G. Klingensmith, D. Maahs, RP. Wadwa, A. Steck 7:30 9:00 PM Industry Sponsored Dinner Printed 10/3/2011 11:20:10 AM 5

Sunday, July 15, 2012 PRACTICAL WAYS TO ACHIEVE TARGETS IN DIABETES CARE 7:00 7:55 AM Continental Breakfast/View Exhibits 7:55 8:00 AM Opening Remarks Satish K. Garg, MD and Jay Skyler, MD PLENARY EIGHT: Self Blood Glucose Monitoring Chair: Peter Chase, MD 8:00 8:25 AM Role of SMBG and How to Combine SMBG and CGM in Clinical Practice Richard Bergenstal, MD 8:25 8:50 AM Strengths, Weaknesses and Performance Issues with SMBG Lutz Heinemann, PhD 8:50 9:15 AM Automated Clinical Decision Support Can Improve the Value and Utility of SMBG Helena Rodbard, MD 9:15 9:40 AM Results of the PRISMA Study Emanuele Bosi, MD 9:40 10:05 AM Panel Discussion Panelists: P. Chase, R. Bergenstal, L. Heinemann, H. Rodbard, E. Bosi 10:05 10:20 AM Break/View Exhibits PLENARY NINE: Beta-Cell Imaging & Targets for Prevention of Diabetes Chair: R. Slover, MD 10:20 10:45 AM Advances in Beta Cell Imaging Gary Cline, MD, PhD 10:45 11:10 AM New Targets for Prevention of Type 1 Diabetes George Eisenbarth, MD, PhD 11:10 11:35 AM Theranostic Agents for Diabetes Therapy Jeff Bulte, PhD 11:35 12:00 PM Panel Discussion Panelists: R. Slover, G. Cline, G. Eisenbarth, J. Bulte 12:00 PM Concluding Remarks & Departures Satish Garg, MD, Jay Skyler, MD & Robert Slover, MD Printed 10/3/2011 11:20:10 AM 6