Metabolic syndrome management: trendy ways to innovate in health prevention

Metabolic syndrome management: trendy ways to innovate in health prevention 25/09/2014

2

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Higher risk of type 2 diabetes and cardiovascular diseases Strong need for prevention at early age by a better management of food intake (quality) and satiety (quantity) 3

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Omega 3 Plant sterols Red yeast rice Probiotics Satiety inducers and appetite reducers: Konjac Fat burners Fat binders Prebiotic fibers Glucose binders Glycemic response management Anti-hypertension molecules Anti-inflammatory molecules + Services E-nutrition 4

Omega 3 Functional food and beverages Plant sterols Functional food and beverages Dietary supplements Dietary supplements EU allegation: «Help maintain constant blood cholesterol levels» EU allegation: «Help reduce blood cholesterol levels» 5

Authorized EFSA claim in Europe: «Monacolin K from red yeast rice contributes to maintain a normal blood cholesterol level» 6

Efficiency of Limicol proven by a first clinical study (2008) and confirmed by 2 other ones Effect of Limicol supplementation on total cholesterol level - 13% (2010) - 12% (2011) Ingredients Red yeast rice Artichoke extract Garlic extract Vitamin B2, B3 and E Sugar cane polycosanols Proanthocyanidins Effect of Limicol supplementation on blood LDL-cholesterol levels 2013: Limicol received a positive opinion from the EFSA for a health claim 1st in the EU 7

Combination probiotics + red yeast rice INGREDIENT Combination of 3 strains of Lactic Acid Bacteria Efficiency on blood cholesterol levels supported by a clinical study 8

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Omega 3 Plant sterols Red yeast rice Probiotics Satiety inducers and appetite reducers: Konjac Fat burners Fat binders Prebiotic fibers Glucose binders Glycemic response management Anti-hypertension molecules Anti-inflammatory molecules + Services E-nutrition 9

Glucomannan fibers = the only ingredient which benefits from an authorized health claim in Europe Ingredients Dietary supplements Functional food Stragen Pharma InQPharm 10

Cactus extract Patented ingredient in USA 2 clinical studies Potatoe extract Active ingredient: proteinase PI2 inhibitor Mecanism of action: enhances the liberation of cholecystokinine, which triggers satiety 12 clinical studies 11

islim Active (Biover) Appetite Reducer (BMI start) XLS Medical (Omega Pharma) Active ingredient: Lipoxitral (prickly pear extract), fibers Mecanism: Binds fat and dietary fats Clinically proven Active ingredient: Redusure (Konjac) Mecanism: fibers swell into the stomach, forming a viscous gel, promoting the feeling of satiety Active ingredient: Litramine : dehydrated cactus leaves Mecanism: Litramine forms a complex fiberfat in the stomach, and captured fats are naturally eliminated 12

Agrum and guarana extract Active ingredient: citrus polyphenols Mecanism: lipolysis enhancer 2 clinical studies Brown seaweed extract, pomegranate Active ingredient: fucoxanthin, punicic acid Mecanism: Decreases differenciation of fat cells, Increases energy expenditure, Reduces white adipose tissue Decreases expression of adipogenic genes 13

Le Chatelier E, et al; Nature 2013 Individuals with a low bacterial richness [ ] are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals Gut microbiota development Prebiotic fibers 14

Non digestible fiber passes through the colon where it is fermented: Stimulation of beneficial bacteria Other health benefits: Satiety inducer Lowering glycemic response Low calorie properties Soluble fiber derived from corn Modulation of the intestinal flora composition Support of beneficial bacteria Other health benefits: Sugar and fat reduction Modulation of glycemic response Satiety inducer Two ingredients providing a complete management of metabolic syndrom, prebiotic effect included 15

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Omega 3 Plant sterols Red yeast rice Probiotics Satiety inducers and appetite reducers: Konjac Fat burners Fat binders Prebiotic fibers Glucose binders Glycemic response management Anti-hypertension molecules Anti-inflammatory molecules + Services E-nutrition 16

Brown seaweeds extract Active ingredient: Polyphenols Mecanism: exert an inhibitory activity on enzymes implicated in sugar digestion Clinical studies Converts food from high to low glycemic index Strawberry and cranberry extracts Active ingredient: polyphenols Mecanism: improves insulin sensibility, prevents insulin secretion Clinical study Could represent an alternative approach to prevention of type 2 diabetes 17

Apple extract Active ingredient: Phloridzin Mecanism: inhibits sugar absoprtion through the intestine wall Ash fruit extract Active ingredients: Nuzhenide et GI3 Mecanism: enhances sugar absorption by the liver and muscular cells Increases the sugar use 18

Reduces postprandial glycemia Product: MealShape Cinnamon extract (Launch: 2013) National winner of the French new innovative company creation award Overall glycemia management Moderated insulin secretion Type 2 diabetes prevention Weight management Cholesterol control Longer satiety feeling Oxydative stress reduction Cardiovascular diseases prevention GLOBAL METABOLIC SYNDROME PREVENTION 19

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Omega 3 Plant sterols Red yeast rice Probiotics Satiety inducers and appetite reducers: Konjac Fat burners Fat binders Prebiotic fibers Glucose binders Glycemic response management Anti-hypertension molecules Anti-inflammatory molecules + Services E-nutrition 20

Hypertension is a developed market in the ingredients world but inflammation remains under-exploited Pomegranate extract Active ingredient: Polyphenols Health benefits: Anti-hypertensive Decreases inflammatory markers Decreases oxydative markers Clinical studies Blueberry extract Active ingredient: anthocyanins Health benefits: Lowers vascular inflammatory response Lowers blood cholesterol levels (LDL) Clinical studies 21

Dyslipidemia Excessive waist circumference Dysglycemia Hypertension and vascular inflammation Omega 3 Plant sterols Red yeast rice Probiotics Satiety inducers and appetite reducers: Konjac Fat burners Fat binders Prebiotic fibers Glucose binders Glycemic response management Anti-hypertension molecules Anti-inflammatory molecules + Services E-nutrition 22

Serious games Mobile apps Connected devices Online coachings 23

The app that helps diabetic patients count carbohydrates! Determination of glucose intake Customizable food base Monthly database to check blood sugar levels and glycemic events 24

1. Choose profile: Type 1 diabete Type 2 diabete Non diabetic 2. Choose meal: Breakfast Lunch/Diner Snack 3. Choose ingredients 4. Nutritional evaluation of the meal: Quantity of proteins/lipids/carbs ingested Total calories intake Associated nutritional advice 25

Kids initiation to nutrition Virtual community Mini-reportages More than 40 games Home activities Recipes adapted to children Articles about nutrition and physical activity 26

1. Collection of information: Total duration of the meal Average number of bites per minute Time interval between 2 bites 2. Synchronization of data 3. Results Statistics of meals Comparison between objectives and results Improvement of users eating behaviors 27

How to manage blood cholesterol levels? Diet program Practical tools: meal planner Weekly analysis and check-up Forum for discussions between patients Supported by a famous nutritionnist 28

PREVENTION TREATMENT E-support Mobile App Mobile App Serious game + + Stablor (Dietary supplement) Products Bariamed (FSMP) First brand dedicated to bariatric patients 29

4 major axes to innovate: action on the 4 risk factors of metabolic syndrome Metabolic syndrome represents a growing market worldwide Functional foods Dietary supplements Innovative ingredients E-nutrition on the rise for nutritional education and metabolic syndrome prevention Better compliance Better efficacy 30

Follow us on @Nutrikeo