FRONTIERS IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILIIT This copy is presented as a service to the medical profession by LEE FOUNDATION SINGAPORE
DEDICATION This book is dedicated to our wives and families for their support and encouragement.
FRONTIERS IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILITY EDITORS Charles SANg MA, MBB Chir(Camb), FRCOG, AM Senior Consultant and Head Dept of Obstetrics and Gynecology Singapore F M Maurine Tsakok MRCS LRCP, MBBS(Lond), MMed (O&G), FRCOG, PhD, AM Senior Consultant and Deputy Head Dept of Obstetrics and Gynecology Singapore Seang-Lin Tan MBBS, MRCOG(Lond), MMed (O&G), AM Obstetrician and Gynecologist Dept of Obstetrics and Gynecology 'B' Unit Kandang Kerbau Hospital Singapore Kong-HOD Chan MBBS, MRCOG(Lond), MMed (O&G) Obstetrician and Gynecologist Dept of Obstetrics and Gynecology Singapore KLUWER ACADEMIC PUBLISHERS DORDRECHT-BOSTON-LONDON
Distributors for the United States and Canada: KIuwer Academic Publishers, PO Box 358, Accord Station, Hingham, MA 02018~358, USA for all other countries: KIuwer Academic Publishers Group, Distribution Center, PO Box 322, 3300 AH Dordrecht, The Netherlands ISBN-13 :978-94-01 0-7684-5 DOl: I 0.1 007/978-94-009-2625-7 e-isbn-13 :978-94-009-2625-7 Copyright @ 1988 by KIuwer Academic Publishers Softcover reprint of the hardcover 1 st edition 1988 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers, KIuwer Academic Publishers BV, PO Box 17, 3300 AA Dordrecht, The Netherlands. Published in the United Kingdom by KIuwer Academic Publishers, PO Box 55, Lancaster, UK KIuwer Academic Publishers BV incorporates the publishing programmes of D. Reidel, Martinus Nijhoff, Dr W. Junk and MTP Press. IV
Contents List of Contributors Preface 1 Hypothalamic and Pituitary Disorders in Reproduction Roger J Pepperell 2 The Management of Unexplained Infertility Eric J Thomas and Ian D Cooke 3 Laser Surgery for Infertility: Past, Present and Future William R Keye 4 Luteal Phase Abnormalities: Diagnosis and Management David Archer 5 The Gonadotropin-Resistant Ovary Roger D Kempers 6 Laser Treatment in Female Reproductive Surgery James F Daniell VII ix 1 25 43 51 59 71 7 Management of Hyperandrogenisation in Women with Polycystic Ovarian Disease Maurine Tsakok 83 8 Transvaginal Sonographically Controlled Oocyte Recovery for IVF Wilfried Feichtinger 9 Prostaglandins and Fertility Regulation Marc Bygdeman Index 91 101 109 v
List of Contributors David F Archer, MD Director, Clinical Research Contraceptive Research & Development Program Dept of Obstetrics & Eastern Virginia Medical School 700 Olney Road Norfolk, Virginia 23507 USA Marc Bygdeman, MD Professor, Chairman Karolinska Hospital S-10401 Stockholm Sweden Kong-Hon Chan, MRCOG Obstetrician & Gynaecologist Singapore 0316 Ian D Cooke, FRCOG Professor University Department of Obstetrics & Jessop Hospital for Women Sheffield S3 7RE UK James F Daniell, MD, FACOG Women's Health Group 2222 State Street Nashville, Tennessee USA Wilfried Feichtinger, MD Facharzt fur Frauenheilkunde und Geburtshilfe Trauttmansdorffgasse 3A A-1130 Vienna Austria Roger D Kempers, MD, FACOG Professor Gynaccology Mayo Medical School & Mayo Clinic Rochester, Minnesota 55905 USA; Editor in Chief, Fertility & Sterility, President Elect, American Fertility Society William R Keye Jr, MD Associate Professor The University of Utah Room 2B200 50 North Medical Drive Salt Lake City, Utah 84132 USA VB
USf OF CONTRIBlTfORS Charles SANg, FRCOG Head, Consultant Obstetrician & Gynaecologist Singapore 0316 Roger J Pepperell, MD, BS, MGO, MD(Mon), FRACP, FRCOG, FRACOG Dept of Obstetrics & University of Melbourne Parkville, Victoria 3052 Australia Eric J Thomas, MBBS, MRCOG Consultant/Senior Lecturer Newcastle General Hospital Westgate Road Newcastle Upon Tyne NE4 6BE UK F H Maurine Tsakok, PhD, FRCOG Deputy Head, Consultant Obstetrician & Gynaecologist Singapore 0316 VIII
Preface This book presenting the latest thinking on Reproductive Endocrinology and Infertility is truly international as the authors hail from no less than four different continents (North America, Europe, Australia and Asia). The idea for this book was conceived during the XII World Congress On Fertility and Sterility where the unique confluence of our distinguished authors occurred in Singapore in October 1986. The authors were involved in the Pre And Post Congress Scientific Programmes which we organised. The overwhelming success of the Congress and the Pre And Post Congress Scientific Programmes prompted this book so that those unable to attend the meeting will still be able to benefit from the vast range of topics covered. This book will be a valuable addition to the knowledge in Reproductive Endocrinology and Infertility and will be useful reading for those wishing to pursue this subspecialty. The authors are indebted to Lee Foundation (Singapore) for help in the publication of this book. We would also like to thank Miss Jam Siew Fong and Miss Tang May Mey for their excellent secretarial assistance. Singapore, January 1988 Charles SANg F H Maurine Tsakok S LTan K H Chan ix