New Developments in Antirheumatic Therapy
|
|
- Dulcie Gray
- 5 years ago
- Views:
Transcription
1 New Developments in Antirheumatic Therapy
2 INFLAMMATION AND DRUG THERAPY SERIES VOLUME III New Developments in Antirheumatic Therapy Edited by KD Rainsford Department of Biomedical Sciences McMaster University Faculty of Health Sciences Hamilton, Ontario Canada GPVelo Institute of Pharmacology University of Verona... " KLUWER ACADEMIC PUBLISHERS KLUWER ACADEMIC PUBLISHERS DORDRECHT/BOSTON/LONDON
3 Distributors For the United States and Canada: Kluwer Academic Publishers, PO Box 358, Accord Station, Hingham, MA , For all other countries: Kluwer Academic Publishers Group, Distribution Center, PO Box 322, 3300 AH Dordrecht, The Netherlands British Library Cataloguing in Publication Data New developments in antirheumatic therapy. 1. Man. Joints. Arthritis & rheumatic diseases. Therapy I. Rainsford, K.D. (Kim D.), II. Velo, G.P. (Giampaolo) III. Series 616.7'206 ISBN -13: DOl: / Copyright e-isbn-13: by Kluwer Academic Publishers Softcover reprint of the hardcover 1st edition 1989 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers, Kluwer Academic Publishers BV, PO Box 17, 3300 AA Dordrecht, The Netherlands. Published in the United Kingdom by Kluwer Academic Publishers, PO Box 55, Lancaster,. Kluwer Academic Publishers BV incorporates the publishing programmes of D. Reidel, Martinus Nijhoft, Dr W. Junk and MTP Press. iv
4 Contents Preface vi List of Contributors vii Recent developments in antirheumatic therapy P Nash and BL Hazleman 2 Osteoarthritis: a metabolic disorder CWDenko 29 3 Concepts of mode of action and toxicity of anti-inflammatory drugs. A basis for safer and more selective therapy, and for future drug developments KD Rainsford 37 4 Animal models of arthritic disease: influence of novel, compared with classical, antirheumatic agents 1M Hunneyball, MEJ Billingham and KD Rainsford 93 5 Novel eicosanoid inhibitors LA Marshall and J Chang New steroidal anti-inflammatory drugs HJ Lee, AS Heiman and IB Taraporewala Oxyradicals, inflammation and drugs acting on oxyradical production DV Parke, AM Symons and AL Parke Gold(l) thiolates: slow-acting anti-arthritic drugs DR Haynes and MW Whitehouse Do platelet activating factor antagonists have a potential role in the therapy of rheumatoid arthritis? CP Page and AJ Coyle Interleukin 1: past, present, future MC Powanda and ED Moyer The T cell as a therapeutic target IG Otterness and ML Bliven Superoxide dismutase modifications for anti-inflammatory therapy FM Veronese, A Conforti and GP Velo 305 Index 315 v
5 Preface At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions. This is because we now recognise that although some advances have been made with the development of a large range of non-steroidal and steroidal drugs during the past two decades or so, we now recognise that many, if not all, of these have rather limited effects on many of the disease processes which underlie the manifestations of the various rheumatic states. Advances in molecular bi- 010gy in the past 5-10 years have enabled these tools to be applied extensively for developing further our understanding of the rheumatic disease processes. In some cases these molecular tools (e.g.,),-interferon, interleukin- 2, T-cell antibodies) have been directly employed as therapies themselves. While the outcome from trials with such agents in rheumatoid arthritis in particular has not been as would have been hoped, these results as with cyclosporin A and low-dose methotrexate in the therapy of rheumatoid arthritis have given us important indications for the approach employing what are generally described as "immunomodulators" to control this disease. But this may not be the same type of approach which is desirable for all types of rheumatic conditions. Indeed, even the way which the present range of drugs and other therapies are applied may not be the most effective and safe means of treating different types of arthritic conditions. Thus, it was considered that the time is appropriate to review what we understand about the current range of therapies; what basic developments are occurring in the search for the newer, more specific and more effective agents; and what progress has been made in the understanding of the disease processes which can give clues or leads for future therapeutic approaches. While it may be considered that the coverage of some areas may be limited because of the size limitations necessary for such a book, it should be pointed out that further consideration is being given in some newly emerging approaches in the fields of, for example, neuro-inflammation, the broader range of cytokines other than interleukin-l, and the non-articular rheumatic conditions in companion volumes which are currently in preparation. Special thanks are given to the valued efforts of the contributors, Dr Peter Clarke (Publishing Director, Kluwer Academic Publishers) and Mrs Veronica Rainsford-Koechli for her help in proof-reading the manuscripts. K D Rains/ord Hamilton, Ontario, Canada February 1989 vi
6 List of Contributors M.E.J. BILLINGHAM Lilly Research Centre Eli Lilly and Co. Windlesham, Surrey GU20 6PH M.L. BLIVEN Department of Immunology and Infectious Diseases Pfizer Central Research Groton, CT J. CHANG Immunopharmacology Subdivision Wyeth-Ayerst Research Inc. CN 8000 Princeton, NY A. CONFORTI Istituto di Farmacologia Universita di Verona Policlinico Borgo Roma Verona A.J. COYLE Department of Pharmacology King's College University of London Chelsea Campus, Manresa Road London SW3 C.W. DENKO Departments of Rheumatology and Medicine Case Western ReseNe University Cleveland, OH D.R. HAYNES Department of Pathology University of Adelaide GPO Box 498 South Australia 5001 Australia B.L. HAZLE MAN Rheumatology Research Unit Addenbrooke's Hospital Hills Road Cambridge CB2 2QQ A.S.HEIMAN Center for Anti-inflammatory Research College of Pharmacy Florida A&M University Tallahasee, FL I.M. HUNNEYBALL The Boots Company pic Nottingham NG2 3M H.J. LEE Center for Anti-inflammatory Research College of Pharmacy Florida A&M University Tallahasee, FL L.A. MARSHALL Immunopharmacology Subdivision Wyeth-Ayerst Research Inc. CN 8000 Princeton, NY E.D. MOYER KabiVitrum Inc 1311 Harbor Bay Parkway Alameda, CA94501 vii
7 NEW DEVELOPMENTS IN ANTIRHEUMATIC THERAPY P. NASH Rheumatology Research Unit Addenbrooke's Hospital Hills Road Cambridge CB2 2QQ I.G.OTTERNESS Department of Immunology and Infectious Diseases Pfizer Central Research Groton, CT C.P. PAGE Department of Pharmacology King's College University of London Chelsea Campus, Manresa Road London SW3 A.L. PARKE Department of Biochemistry University of Surrey Guildford GU2 5XH Surrey D.V. PARKE Department of Biochemistry University of Surrey Guildford Surrey GU2 5XH M.e. POWANDA Letterman Army Institute of Research Presidio San Francisco, CA K.D. RAINSFORD Department of Biomedical Sciences McMaster University Faculty of Health Sciences Hamilton, Ontario Canada L8N 3Z5 A.M. SYMONS Department of Biochemistry University of Surrey Guildford Surrey GU2 5XH I.B. TARAPOREWALA Center for Anti-inflammatory Research College of Pharmacy Florida A&M University Tallahasee, FL F.M. VERONESE Dipartimento di Scienze Farmaceutiche Centro di Chimica del Farmaco e dei Prodotti Biologicamente Attivi del CNR Universita di Pad ova Pad ova G.P. VELO Istituto di Farmacologia Universita di Verona Policlinico Borgo Roma Verona M.W. WHITEHOSE Department of Pathology University of Adelaide GPO Box 498 South Australia 5001 Australia viii
Copper and Zinc in Inflammatory and Degenerative Diseases
Copper and Zinc in Inflammatory and Degenerative Diseases Copper and Zinc in Inflammatory and Degenerative Diseases Edited by K.O. Rainsford Division of Biomedical Sciences, School of Science and Mathematics,
More informationTALKING POINTS IN DERMATOLOGY -III
TALKING POINTS IN DERMATOLOGY -III Other titles in the New Clinical Applications Series: Dermatology (Series Editor Dr J. L. Verbov) Dermatological Surgery Superficial Fungal Infections Talking Points
More informationLymphoproliferative Diseases
Lymphoproliferative Diseases IMMUNOLOGY AND MEDICINE SERIES Immunology of Endocrine Diseases Editor: A. M. McGregor Clinical Transplantation: Current Practice and Future Prospects Editor: G. R. D. Catto
More informationFRONTIERS IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILIIT
FRONTIERS IN REPRODUCTIVE ENDOCRINOLOGY AND INFERTILIIT This copy is presented as a service to the medical profession by LEE FOUNDATION SINGAPORE DEDICATION This book is dedicated to our wives and families
More informationLEGAL ASPECTS OF ANAESTHESIA
LEGAL ASPECTS OF ANAESTHESIA DEVELOPMENTS IN CRITICAL CARE MEDICINE AND ANESTHESIOLOGY Volume 21 For a list of the volumes in this series see final page of the volume. LEGAL ASPECTS OF ANAESTHESIA edited
More informationTHE ROLE OF LASER IN GASTROENTEROLOGY
THE ROLE OF LASER IN GASTROENTEROLOGY DEVELOPMENTS IN GASTROENTEROLOGY Volume 9 For a list of titles in this series see final page of the volume. THE ROLE OF LASER IN GASTROENTEROLOGY Analysis of Eight
More informationRANDOMISED CONTROLLED CLINICAL TRIALS, Second Edition
RANDOMISED CONTROLLED CLINICAL TRIALS, Second Edition RANDOMISED CONTROLLED CLINICAL TRIALS, Second Edition Christopher J Bulpitt Division of Geriatric Medicine Royal Postgraduate Medical School Hammersmith
More informationCOUNSELLING AND THERAPY. An Introductory Survey
COUNSELLING AND THERAPY An Introductory Survey COUNSELLING AND THERAPY An Introductory Survey Robert B. Burns Chairman, School of Education University of Bradford 1983.MTP PRESS LI.MITED ~. a member of
More informationAtlas of Rheumatoid Arthritis
Atlas of Rheumatoid Arthritis Atlas of Rheumatoid Arthritis Professor Paul Emery, Editor Published by Springer Healthcare Ltd, 236 Gray s Inn Road, London, WC1X 8HB, UK. www.springerhealthcare.com 2015
More informationCLINICAL PROBLEMS IN SEXUALLY TRANSMITTED DISEASES
CLINICAL PROBLEMS IN SEXUALLY TRANSMITTED DISEASES NEW PERSPECTIVES IN CLINICAL MICROBIOLOGY Brumfitt W, ed Hamilton-Miller JMT, assist. ed: New perspectives in clinical microbiology. 1978. ISBN 90-247-2074-5
More informationTo the memory of FRANCIS E. CAMPS
Drug Dependence To the memory of FRANCIS E. CAMPS Late Professor of Forensic Medicine, the London Hospital Medical College; Ex-President, Society for the Study of Addiction; First Chairman, Medical Council
More informationDEVELOPMENTS IN DAIRY CHEMISTRY-2. Lipids
DEVELOPMENTS IN DAIRY CHEMISTRY-2 Lipids CONTENTS OF VOLUME 1 Volume 1: Proteins 1. Chemistry of Milk Protein. HAROLD E. SWAISGOOD 2. Association of Caseins and Casein Micelle Structure. D. G. SCHMIDT
More informationCOPING WITH CANCER STRESS
COPING WITH CANCER STRESS COPING WITH CANCER STRESS edited by BASIL A. STOLL Honorary consultant physicion to oncology departments St. Thomos' Hospital and Royal Free Hospital London, U.K. Introduction
More informationDemographic Transition Theory
Demographic Transition Theory Demographic Transition Theory by John C. Caldwell The Australian National University, Canberra, Australia Contributing Co-Authors Bruce K. Caldwell Pat Caldwell Peter F. McDonald
More informationThyroid Ultrasound and Ultrasound-Guided FNABiopsy
Thyroid Ultrasound and Ultrasound-Guided FNABiopsy Thyroid Ultrasound and Ultrasound-Guided FNA Biopsy edited by H. Jack Baskin, M.D. Florida Thyroid and Endocrine Clinic Orlando, Florida, USA Springer-Science+Business
More informationAZAPROPAZONE. 20 years of clinical use
AZAPROPAZONE 20 years of clinical use AZAPROPAZONE 20 years of clinical use Edited by KD Rainsford Department of Biomedical Sciences McMaster University Faculty of Health Sciences Hamilton, Ontario Canada...
More informationCOMMON BILE DUCT EXPLORATION
COMMON BILE DUCT EXPLORATION DEVELOPMENTS IN SURGERY J.M. Greep, H.A.J. Lemmens, D.B. Roos, H.C. Urschel, eds., Pain in Shoulder and Arm: An Integrated View ISBN 90 247 2146 6 B. Niederle, Surgery of the
More informationPrevention of Skin Cancer
Prevention of Skin Cancer Cancer Prevention Cancer Causes Volume 3 Prevention of Skin Cancer Edited by David Hill, Ph.D. Centre for Behavioural Research in Cancer, The Cancer Council Victoria, Melbourne,
More informationAtlas of Male Reproductive Pathology
Atlas of Male Reproductive Pathology Current Histopathology Consultant Editor Professor G. Austin Gresham, TO, SeD, MO, FRC Path. Professor of Morbid Anatomy and Histology, University of Cambridge Volume
More informationINDUSTRIAL USES OF STARCH AND ITS DERIVATIVES
INDUSTRIAL USES OF STARCH AND ITS DERIVATIVES INDUSTRIAL USES OF STARCH AND ITS DERIVATIVES Edited by J. A. RADLEY M.Sc., C.Chem., F.S.D.C., F.R.I.C. APPLIED SCIENCE PUBLISHERS LTD LONDON APPLIED SCIENCE
More informationPRACTICAL ECHOCARDIOGRAPHY IN THE ADULT with Doppler and color-doppler flow imaging
PRACTICAL ECHOCARDIOGRAPHY IN THE ADULT with Doppler and color-doppler flow imaging PRACTICAL ECHOCARDIOGRAPHY IN THE ADULT with Doppler and color-doppler flow imaging by J.P.M. HAMER Thoraxcentre, Department
More informationSocial Psychology of Self-Referent Behavior
Social Psychology of Self-Referent Behavior Social Psychology of Self-Referent Behavior Howard B. Kaplan Baylor College of Medicine Houston, Teras Springer Science + Business Media, LLC Library of Congress
More informationOFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF HEADACHE
CLUSTER HEADACHE OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF HEADACHE CLUSTER HEADACHE EDITED BY NINAN 1. MATHEW, M.D. DIRECTOR, HOUSTON HEADACHE CLINIC AND DEPARTMENT OF NEUROLOGY
More informationShiva: the god oj destruction and of creativity symbolizes both the destructive power of schizophrenia and the creativity of many of its sufferers.
Shiva: the god oj destruction and of creativity symbolizes both the destructive power of schizophrenia and the creativity of many of its sufferers. The Biological Basis of Schizophrenia The Biological
More informationAdvances in Clinical Neuropsychology. Volume 3
Advances in Clinical Neuropsychology Volume 3 A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are
More informationTHE HEART IN DIABETES
THE HEART IN DIABETES Developments in Cardiovascular Medicine 173. C.A. Nienaber and U.Sechtem (eds.): Imaging and Intervention in Cardiology. 1996 ISBN 0-7923-3649-6 174. G. Assmann (ed.): HDL Deficiency
More informationPSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY. A Focus on MANAGEMENT
PSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY A Focus on MANAGEMENT PSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY A Focus on MANAGEMENT Edited by David K. Conn Bayerest Centre for
More informationTHE RELEVANCE OF SOCIAL SCIENCE FOR MEDICINE
THE RELEVANCE OF SOCIAL SCIENCE FOR MEDICINE CULTURE, ILLNESS, AND HEALING Studies in Comparative Cross-Cultural Research Editor-in-Chief: ARTHUR KLEINMAN University of Washington, Seattle, Washington,
More informationImmunological Aspects of Infectious Diseases
Immunological Aspects of Infectious Diseases Immunological Aspects of Infectious Diseases EDITED BY GEORGE DICK Professor of Pathology, London University Honorary Consultant, Institute of Child Health
More informationRADIOISOTOPE STUDIES IN CARDIOLOGY
RADIOISOTOPE STUDIES IN CARDIOLOGY DEVELOPMENTS IN NUCLEAR MEDICINE Series editor Peter H. Cox Cox, P.H. (ed.): Cholescintigraphy. 1981. ISBN 90-247-2524-0 Cox, P.H. (ed.): Progress in radiopharmacology
More informationErin Lawson Mark S. Wallace Editors. Fibromyalgia. Clinical Guidelines and Treatments
Fibromyalgia Erin Lawson Mark S. Wallace Editors Fibromyalgia Clinical Guidelines and Treatments Editors Erin Lawson, MD Voluntary Faculty Department of Anesthesiology Center for Pain Medicine University
More informationBones and Joints in Diabetes Mellitus
Bones and Joints in Diabetes Mellitus Series in Radiology Volume 4 Bones and Joints in Diabetes Mellitus by S. Forgacs Semmelweis University Medical School Budapest : ~. : 1982 Martinus Nijhoff Publishers
More informationBrighton Polytechnic Eastbourne
Brighton Polytechnic Eastbourne Welkin Library Please return this book to the library on or before the last date stamped below An Introduction to Medical Manipulation An Introduction to Medical Manipulation
More informationWater-soluble Vitamin Assays in Human Nutrition
Water-soluble Vitamin Assays in Human Nutrition Water-soluble Vitamin Assays in Human Nutrition G.F.M. Ball SPRINGER-SCIENCE+BUSINESS MEDIA, B.V. First edition 1994 1994 Springer Science+Business Media
More informationAlcoholism and Clinical Psychiatry
Alcoholism and Clinical Psychiatry Alcoholism and Clinical Psychiatry Edited by Joel Solomon Downstate Medical Center Brooklyn, New YorK Plenum Medical Book Company New York and London Main entry under
More informationHERPESVIRUS DISEASES OF CATTLE, HORSES, AND PIGS
HERPESVIRUS DISEASES OF CATTLE, HORSES, AND PIGS Yechiel Becker, Series Editor Julia Hadar, Managing Editor DEVELOPMENTS IN VETERINARY VIROLOGY Payne, L.N. (ed.) Marek's Disease (1985) Burny, A. and Mammerickx,
More informationANALYZING T CELL RESPONSES
ANALYZING T CELL RESPONSES How to Analyze Cellular Immune Responses Analyzing T Cell Responses against Tumor Associated Antigens Edited by DIRK NAGORSEN Charité University Medicine Berlin, Berlin, Germany
More informationDevelopmental Tasks: Towards a Cultural Analysis of Human Development
Developmental Tasks: Towards a Cultural Analysis of Human Development Developtnental Tasks: Towards a Cultural Analysis of Human Development Edited by Jan J.F. ter Laak: Peter G. Heymans Department of
More informationImmunology for the Practicing Physician
Immunology for the Practicing Physician Immunology for the Practicing Physician Edited by Jon R. Schmidtke and Ronald M. Ferguson Departments of Surgery and Microbiology University of Minnesota Medical
More informationMANAGEMENT OF PATIENTS WITH CHRONIC PAIN
MANAGEMENT OF PATIENTS WITH CHRONIC PAIN MANAGEMENT OF PATIENTS WITH CHRONIC PAIN Edited by STEVEN F. BRENA, M.D. Department of Rehabilitation Medicine and Anesthesiology Director, Pain Control Center
More informationBiochemistry of Inflammation
Biochemistry of Inflammation IMMUNOLOGY AND MEDICINE SERIES Immunology of Endocrine Diseases Editor: A. M. McGregor Clinical Transplantation: Current Practice and Future Prospects Editor: G. R. D. Catto
More informationNeurobiology of Exceptionality
Neurobiology of Exceptionality Neurobiology of Exceptionality Edited by Con Stough Swinburne University of Technology, Hawthorn, Victoria, Australia Kluwer Academic / Plenum Publishers New York, Boston,
More informationChapman and Hall Animal Behaviour Series
ANIMAL MOTIVATION Chapman and Hall Animal Behaviour Series SERIES EDITORS D.M.Broom Colleen Macleod Professor of Animal Welfare, University of Cambridge, UK P.W. Colgan Professor of Biology and Psychology,
More informationContemporary Psychological Approaches to Depression THEORY, RESEARCH, AND TREATMENT
Contemporary Psychological Approaches to Depression THEORY, RESEARCH, AND TREATMENT Contemporary Psychological Approaches to Depression THEORY, RESEARCH, AND TREATMENT Edited by Rick E. Ingram San Diego
More informationProgress in Experimental Tumor Research
COX-2 Progress in Experimental Tumor Research Vol. 37 Series Editor Joseph R. Bertino, New Brunswick, N.J. Basel Freiburg Paris London New York Bangalore Bangkok Singapore Tokyo Sydney COX-2 A New Target
More informationTRACE ELEMENTS ANO IRON IN HUMAN METABOLISM
TRACE ELEMENTS ANO IRON IN HUMAN METABOLISM TOPICS IN HEMATOLOGV Series Editor: Maxwell M. Wintrobe, M.D. University of Utah, Salt Lake City THE RESPIRATORY FUNCTIONS OF BLOOD Lars Garby, M.D. and Jerry
More informationPATHOPHYSIOLOGY OF SEVERE ISCHEMIC MYOCARDIAL INJURY
PATHOPHYSIOLOGY OF SEVERE ISCHEMIC MYOCARDIAL INJURY Developments in Cardiovascular Medicine VOLUME 104 PATHOPHYSIOLOGY OF SEVERE ISCHEMIC MYOCARDIAL INJURY edited by Hans Michael Piper Institute of Physiology
More informationClinical Policy: Sarilumab (Kevzara) Reference Number: CP.PHAR.346 Effective Date: Last Review Date: 11.18
Clinical Policy: (Kevzara) Reference Number: CP.PHAR.346 Effective Date: 07.18.17 Last Review Date: 11.18 Line of Business: Medicaid Revision Log See Important Reminder at the end of this policy for important
More informationViral Hepatitis. Diagnosis, Therapy, and Prevention EDITED BY. Steven Specter. College of Medicine University of South Florida, Tampa
Viral Hepatitis Viral Hepatitis Diagnosis, Therapy, and Prevention EDITED BY College of Medicine University of South Florida, Tampa * Springer Science+Business Media, LLC 01999 Springer Science+Business
More informationThe Use and Misuse of. Sleeping Pills. -A Clinical Guide-
The Use and Misuse of Sleeping Pills -A Clinical Guide- Head of Hypnos (Photograph courtesy of the British Museum) The Use and Misuse of Sleeping Pills --A Clinical Guide-- Wallace B. Mendelson, M. D.
More informationin Asthmology Methods Luigi Allegra. Pier Carlo Braga Roberto Dal Negro (Eds.)
Luigi Allegra. Pier Carlo Braga Roberto Dal Negro (Eds.) Methods in Asthmology With 107 Figures and 53 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
More informationHormonal Regulation of Fluid and Electrolytes. Environmental Effects
Hormonal Regulation of Fluid and Electrolytes Environmental Effects Hormonal Regulation of Fluid and Electrolytes Environmental Effects Edited by John R. Claybaugh TripIer Army Medical Center, Hawaii and
More informationVasilis Vasiliou. Q. Max Guo. Alcohol and Cancer
Alcohol and Cancer Samir Zakhari Editors Vasilis Vasiliou Q. Max Guo Alcohol and Cancer Editors Samir Zakhari, Ph.D. Director Division of Metabolism and Health Effects National Institute on Alcohol Abuse
More informationCurrent Topics in Pathology
Current Topics in Pathology Continuation of Ergebnisse der Pathologie 71 Editors c. L. Berry E. Grundmann W. H. Kirsten Advisory Board H.-W. Altmann, K. Benirschke, A. Bohle, H. Cottier M. Eder, P. Gedigk,
More informationTHE CEREBROSPINAL FLUID
THE CEREBROSPINAL FLUID THE CEREBROSPINAL FLUID Editors: ROBERT M. HERNDON, M.D. Chief of Neurology Good Samaritan Hospital and Professor of Neurology Oregon Health Sciences University Portland, Oregon
More informationCancer Pain Relief. A Practical Manual SPRINGER SCIENCE+BUSINESS MEDIA, B.V. F. DE CONNO, MD DEREK DOYLE, MD CARL JOHAN FURST K.
Cancer Pain Relief Cancer Pain Relief A Practical Manual Edited by: F. DE CONNO, MD Istituto Nazionale per 10 Studio e la Cura dei Tumori Milan, Italy K. FOLEY, MD Memorial Sioan Kettering New York, New
More informationKEY FACTS IN ANAESTHESIA AND INTENSIVE CARE
KEY FACTS IN ANAESTHESIA AND INTENSIVE CARE Alcira Serrano Gomez MD Fellow John Farman Intensive Care Unit Addenbrooke s NHS Trust Cambridge, UK Gilbert R Park MD DMed Sci FRCA Director of Intensive Care
More informationAttention-Deficit Hyperactivity Disorder (ADHD) in Adults
Attention-Deficit Hyperactivity Disorder (ADHD) in Adults Key Issues in Mental Health Vol. 176 Series Editors A. Riecher-Rössler Basel M. Steiner Hamilton Attention-Deficit Hyperactivity Disorder (ADHD)
More informationIntroduction to Virology
Introduction to Virology Introduction to Virology K. M. SMITH C.B.E., D.Se., Ph.D., F.R.S. Formerly Director, Virus Research Unit, Agricultural Council, Cambridge Chapter 9, The replication of viruses
More informationEncyclopedia of Women s Health
Encyclopedia of Women s Health Encyclopedia of Women s Health Edited by Sana Loue, JD, PhD, MPH and Martha Sajatovic, MD University Hospitals of Cleveland Core Editors Keith B. Armitage, MD University
More informationFREUD MODERN PSYCHOLOGY AND VOLUME 2: THE EMOTIONAL BASIS OF HUMAN BEHA VIOR
FREUD AND MODERN PSYCHOLOGY VOLUME 2: THE EMOTIONAL BASIS OF HUMAN BEHA VIOR EMOTIONS, PERSONALITY, AND PSYCHOTHERAPY Series Editors Carroll E. Izard, University of Delaware, Newark, Delaware and Jerome
More informationNutrition and Behavior
Nutrition and Behavior New Perspectives Robin B. Kanarek Robin Marks-Kaufman Tufts University Medford, Massachusetts An (\Vi Book Published by Van Nostrand Reinhold New York An AVI book. (A VI is an imprint
More informationAlcohol and Drug Problems
Research Advances in Alcohol and Drug Problems Volume 8 RESEARCH ADVANCES IN ALCOHOL AND DRUG PROBLEMS Series Editors Reginald G. Smart Howard D. Cappell Frederick B. Glaser Yedy Israel Harold Kalant Robert
More informationANESTHESIA AND THE LUNG
ANESTHESIA AND THE LUNG DEVELOPMENTS IN CRITICAL CARE MEDICINE AND ANESTHESIOLOGY Prakash, O. (ed.): Applied Physiology in Clinical Respiratory Care. 1982. ISBN 90-247-2662-X. McGeown, Mary G.: Clinical
More informationSeries Editors Samuel J. Black, University of Massachusetts, Amherst, MA, US.A. J. Richard Seed, University of North Carolina, Chapel Hill, NC, US.A.
LEISHMANIA World Class Parasites VOLUME 4 Volumes in the World Class Parasites book series are written for researchers, students and scholars who enjoy reading about excellent research on problems of global
More informationClinical Echocardiography
Clinical Echocardiography Michael Y. Henein Editor Mary Sheppard John R. Pepper Michael Rigby Associate Editors Clinical Echocardiography Second Edition Editor Michael Y. Henein, M.D. Department of Public
More informationFrom Psycho-Analysis to Culture-Analysis
From Psycho-Analysis to Culture-Analysis Also by Marwan Dwairy COUNSELING AND PSYCHOTHERAPY WITH ARABS AND MUSLIMS: A Culturally Sensitive Approach CROSS-CULTURAL COUNSELLING: The Arab Palestinian Case
More informationCHILDREN AND ARSON. America's Middle Class Nightmare
CHILDREN AND ARSON America's Middle Class Nightmare CHILDREN AND ARSON America's Middle Class Nightmare Wayne S. Wooden and Martha Lou Berkey PLENUM PRESS NEW YORK AND LONDON Wooden, Wayne S. Children
More informationSteroid Hormone Action and Cancer
Steroid Hormone Action and Cancer CURRENT TOPICS IN MOLECULAR ENDOCRINOLOGY Series Editors: Bert W. O'Malley and Anthony R. Means Department of Cell Biology Baylor College of Medicine Houston, Texas Volume
More informationUnderstanding Incontinence
Understanding Incontinence Understanding Incontinence A GUIDE TO THE NATURE AND MANAGEMENT OF A VERY COMMON COMPLAINT Dorothy Mandelstam MCSP DipSocSc With illustrations by Brenda Naylor SPRINGER-SCIENCE+BUSINESS
More informationIMMUNOLOGICAL ASPECTS OF NEOPLASIA THE ROLE OF THE THYMUS
IMMUNOLOGICAL ASPECTS OF NEOPLASIA THE ROLE OF THE THYMUS Cancer Growth and Progression Volume 17 Series Editor: Hans E. Kaiser, D.Sc. Professor, Department of Pathology, School of Medicine, University
More informationDEPRESSION. The disorder and its associations
DEPRESSION The disorder and its associations DEPRESSION The disorder and its associations by B. Mahendra Consultant Psychogeriatrician, Hope Hospital (University of Manchester School of Medicine) Salford
More informationInflammatory Bowel Disease
Inflammatory Bowel Disease Experience and Controversy A Teaching Seminar on Inflammatory Bowel Disease Sponsored by (New York) and the American College of Gastroenterology Edited by BURTON I. KORELITZ,
More informationLow and Lower Fertility
Low and Lower Fertility Ronald R. Rindfuss Minja Kim Choe Editors Low and Lower Fertility Variations across Developed Countries Editors Ronald R. Rindfuss Department of Sociology and Carolina Population
More informationAIDS Testing Methodology and Management Issues
AIDS Testing Gerald Schochetman J. Richard George Editors AIDS Testing Methodology and Management Issues Foreword by Walter R. Dowdle With 38 Illustrations Springer-Verlag New York Berlin Heidelberg London
More informationClinical Policy: Baricitinib (Olumiant) Reference Number: CP.PHAR.135 Effective Date: Last Review Date: 11.18
Clinical Policy: (Olumiant) Reference Number: CP.PHAR.135 Effective Date: 07.24.18 Last Review Date: 11.18 Line of Business: Medicaid Revision Log See Important Reminder at the end of this policy for important
More informationDrug-Related Problems in the Elderly
Drug-Related Problems in the Elderly Patrik Midlöv Tommy Eriksson Annika Kragh Drug-Related Problems in the Elderly 123 Dr. Patrik Midlöv Lund University Faculty of Medicine SE-221 00 Lund Sweden Patrik.Midlov@skane.se
More informationSupportive Cancer Care with Chinese Medicine
Supportive Cancer Care with Chinese Medicine William C.S. Cho Editor Supportive Cancer Care with Chinese Medicine 123 Editor Dr. William Chi-Shing Cho Department Clinical Oncology Queen Elizabeth Hospital
More informationCommunication in Cognitive Behavioral Therapy
Communication in Cognitive Behavioral Therapy Michela Rimondini Editor Communication in Cognitive Behavioral Therapy Editor Michela Rimondini Department of Public Health and Community Medicine University
More informationFoundations of Cognitive Therapy. Theoretical Methods and Practical Applications
Foundations of Cognitive Therapy Theoretical Methods and Practical Applications Foundations of Cognitive Therapy Theoretical Methods and Practical Applications Edited by Nicolas Hoffmann The Free University
More informationNeurobiology of Drug Abuse
Neurobiology of Drug Abuse Monographs in Neural Sciences Vol. 13 Series Editor Maynard M. Cohen, Chicago, Ill. KARGER Basel Miinchen. Paris London New York New Delhi Singapore Tokyo Sydney Neurobiology
More informationTOPICS IN DIETARY FIBER RESEARCH
TOPICS IN DIETARY FIBER RESEARCH TOPICS IN DIETARY FIBER RESEARCH Edited by Gene A. Spiller Syntex Research Palo Alto, California With the assistance of Ronald J. Amen Syntex Research Palo Alto, California
More informationWilliam A. Yost and George Gourevitch Editors. Directional Hearing. With 133 Figures. Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
Directional Hearing William A. Yost and George Gourevitch Editors Directional Hearing With 133 Figures Springer-Verlag New York Berlin Heidelberg London Paris Tokyo William A. Yost Director Parmly Hearing
More informationRespiratory Medicine Series Editor: Sharon I.S. Rounds. Marc A. Judson Editor. Pulmonary Sarcoidosis A Guide for the Practicing Clinician
Respiratory Medicine Series Editor: Sharon I.S. Rounds Marc A. Judson Editor Pulmonary Sarcoidosis A Guide for the Practicing Clinician Respiratory Medicine Series Editor: Sharon I.S. Rounds For further
More informationPrinciples of Renal Physiology. 4th Edition
Principles of Renal Physiology 4th Edition Principles of Renal Physiology 4th Edition Chris Lote Professor of Experimental Nephrology, University of Birmingham, UK SPRINGER SCIENCE+BUSINESS MEDIA, B.V.
More informationCancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention Cancer Metastasis Biology and Treatment VOLUME 1 Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention
More informationAntioxidant-Rich Phytochemicals
Analysis of Antioxidant-Rich Phytochemicals EDITED BY ZHIMIN XU LUKE R. HOWARD Analysis of Antioxidant-Rich Phytochemicals Analysis of Antioxidant-Rich Phytochemicals Edited by Zhimin Xu and Luke R.
More informationX-RAY FLUORESCENT SCANNING OF THE THYROID
X-RAY FLUORESCENT SCANNING OF THE THYROID DEVELOPMENTS IN NUCLEAR MEDICINE Series editor Peter H. Cox Other titles in this series Cox, P.H. (ed.): Cholescintigraphy. 1981. ISBN 90-247-2524-0 Cox, P.H.
More informationThe Viruses CATALOGUE, CHARACTERIZATION, AND CLASSIFICATION
The Viruses CATALOGUE, CHARACTERIZATION, AND CLASSIFICATION THE VIRUSES Series Editors HEINZ FRAENKEL-CONRAT, University of California Berkeley, California ROBERT R. WAGNER, University of Vizginia School
More informationClinical Policy: Anakinra (Kineret) Reference Number: ERX.SPA.135 Effective Date:
Clinical Policy: (Kineret) Reference Number: ERX.SPA.135 Effective Date: 10.01.16 Last Review Date: 05.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationAntidepressants lor Elderly People
Antidepressants lor Elderly People Antidepressants for Elderly People Edited by KARABI CHOSE Honorary Consultant in Geriatrie Medieine University o[ Wales College o[ Medicine S Springer-Science+Business
More informationFIBER DEFICIENCY AND COLONIC DISORDERS
FIBER DEFICIENCY AND COLONIC DISORDERS FIBER DEFICIENCY AND COLONIC DISORDERS Edited by Richard W. Reilly and Joseph B. Kirsne.r Department of Medicine The Pritzker School of Medicine The University of
More informationPocket Reference to Alzheimer s Disease Management
Pocket Reference to Alzheimer s Disease Management Pocket Reference to Alzheimer s Disease Management Anna Burke, MD Geriatric Psychiatrist, Dementia Specialist Geri R Hall, PhD, ARNP, GCNS, FAAN Advanced
More informationClinical Policy: Tocilizumab (Actemra) Reference Number: ERX.SPMN.44
Clinical Policy: (Actemra) Reference Number: ERX.SPMN.44 Effective Date: 10/16 Last Review Date: 09/16 Coding Implications Revision Log See Important Reminder at the end of this policy for important regulatory
More informationClassic DMARD s, biologic drugs and cancer risk
Classic DMARD s, biologic drugs and cancer risk Prof. Dr. António M. F. Araújo Head of the Service of Medical Oncology Centro Hospitalar do Porto Instituto de Ciências Biomédicas de Abel Salazar Disclosure
More informationAdvances in. Clinical Child. Psychology. Volume 16
Advances in Clinical Child Psychology Volume 16 ADVANCES IN CLINICAL CHILD PSYCHOLOGY Advisory Editors ELAINE BLECHMAN, University of Colorado-Boulder SUSAN B. CAMPBELL, University of Pittsburgh JUDITH
More informationEfim Benenson. Rheumatology. Clinical Scenarios. Syndrome or disease?
Rheumatology Efim Benenson Rheumatology Clinical Scenarios Syndrome or disease? Author Efim Benenson, MD Professor of Medicine Department of Internal Medicine University of Cologne Cologne Germany The
More informationFebrile Neutropenia Jean A Klastersky
Febrile Neutropenia Febrile Neutropenia Jean A Klastersky Consultant, Medical Oncology Institut Jules Bordet Centre des Tumeurs de l Universite Libre de Bruxelles Brussels Belgium Published by Springer
More informationFAMILIAL BRAIN TUMOURS. A Commented Register
FAMILIAL BRAIN TUMOURS A Commented Register DEVELOPMENTS IN ONCOLOGY 9 Other titles in this series: 1. Cleton F.J. and Simons J.W.I.M. (eds): Genetic Origins of Tumor Cells. 1980. ISBN 90-247- 2272-1 2.
More informationFast Facts: Multiple Sclerosis
Fast Facts Fast Facts: Multiple Sclerosis George D Perkin and Jerry S Wolinsky Second edition 2006 Health Press Ltd. www.fastfacts.com Fast Facts Fast Facts: Multiple Sclerosis Second edition George D
More information