At a Glance. Our teaching. Our accolades. Connect with us. bostonchildrens.org. Spring Summer 2014

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At a Glance Our accolades Top-ranked pediatric hospital nationwide by U.S.News & World Report in 2013 2014 in all rated subspecialty areas: Cancer Cardiology and Heart Surgery Diabetes and Endocrinology Gastroenterology Neonatology Nephrology Neurology and Neurosurgery Orthopedics Pulmonology Urology Four Gold Beacon Awards for Critical Care Excellence Magnet status for excellence in nursing Named a Leapfrog Group Top Children s Hospital for safety and quality One of few pediatric hospitals nationwide named a Stage 7 Hospital by the Healthcare Information Management Systems Society Named one of Hospital & Health Network s Most Wired hospitals for information technology Honored by American Heart Association and American Stroke Association with Silver Resuscitation Award Connect with us 300 Longwood Avenue Boston, MA 02115 Make a referral or request a second opinion For international physicians +1-617-355-5209 /internationalreferral international.resources@childrens.harvard.edu Our teaching is a Harvard Medical School teaching hospital. We are dedicated to training the top pediatric clinicians of tomorrow not only as leaders in their respective fields, but also as practitioners of compassionate, child- and family-centered care. Highlights of our teaching initiatives include: 38 (37 ACGME and 1 ADA) accredited training programs with 432 interns, residents, and clinical fellows One of the nation s most competitive pediatric residency programs, with 1,670 medical students applying for only 42 spots in 2014 A Department of Nursing that trained more than 700 nursing students during the 2013 2014 academic year Observerships in more than 20 clinical programs Explore our fellowship and training opportunities /teaching Spring Summer 2014

at a glance Hospital is proud to collaborate with you to provide the full spectrum of diagnostics, therapies and long-term support services to all children from babies in the womb to young adults, here in New England and around the world. Fiscal Year 2013 249 specialized clinical programs 24,758 inpatient and observation discharges 580,418 outpatient visits 6.79 average length of stay The care we work with you to provide to patients at the bedside is driven by our basic, translational and clinical research. With more than 1,600 scientists, in excess of $272 million in annual funding and more than 877,000 square feet of state-of-the-art laboratory space, Boston Children s is home to the largest and best-funded research enterprise based at a pediatric medical center. 58,588 emergency department visits 26,920 inpatient and day surgical cases 2.42 average case mix index Our faculty and staff 398 active medical and dental staff 747 associate scientific staff 421 residents, clinical fellows and interns 1,112 full-time nursing staff Our clinical care Our research 570 volunteers 9,869 total employees Here are some of our medical offerings: and some of our surgical innovations: Gene therapy Novel agents Clinical trials Induced hypothermia protocol for the treatment of newborns with hypoxic-ischemic encephalopathy Co-founding member of the Transatlantic Gene Therapy Consortium Home to one of the country s largest cystic fibrosis centers First pediatric center for rehabilitating and repairing congenital heart valve anomalies, and the largest and most experienced fetal cardiac intervention program in the United States, with a 90 percent technical success rate Discovered regenerative agents capable of restoring heart muscle growth and cardiac function after a heart attack Led the successful first clinical trial in history of a potential drug for progeria, a rare, fatal genetic premature aging syndrome Comprehensive pediatric transplant programs for kidney, lung, heart, liver and other organs Development of the staged left ventricle recruitment approach for treating children born with hypoplastic left heart syndrome Omegaven therapy to protect and preserve the livers of children receiving parenteral nutrition Hallmark neurosurgical techniques, including pial synangiosis for moyamoya disease, programmable shunts for hydrocephalus and vagus nerve stimulation for epilepsy Sole U.S. site for active gene therapy trial in Wiskott-Aldrich syndrome Developing drugs that treat obesity by regulating leptin levels Use of the serial transverse enteroplasty procedure to lengthen the bowels of children with short bowel syndrome Genetics and genomics Clinical and scientific innovations Launched the CLARITY Challenge, an international genomics challenge to set best practices for the growing field of clinical genomics Development of injectable oxygen microparticles that could potentially save the life of patients unable to breathe Nation s first program dedicated to caring for infants, children and adolescents with gender identity disorder or disorders of sexual differentiation Successful adaptation of the Foker process for lengthening the esophagus in children with esophageal atresia Make a referral Call us at Visit us online at Lead U.S. site for an active gene therapy trial in X-linked severe combined immunodeficiency and upcoming trial in adrenoleukodystrophy Conducted clinical trials of drugs aimed at reversing autistic and cognitive symptoms in several known genetic disorders Completed genomic profiling of medulloblastoma, typing it into four different subtypes and raising the possibility of customized treatments Exploring urinary biomarkers that may help make or rule out a diagnosis, as in appendicitis or Kawasaki disease, and monitor patients with brain tumors for recurrence Identified, using blood tests, a 55-gene signature that may help determine a child s risk of autism Developed a pediatric vision scanner to measure the eyes alignment and focusing ability in an effort to detect amblyopia earlier in young children Found that low-glycemic diets offer the best balance of metabolic benefits and reduced risk of heart disease, rather than traditionally recommended low-fat and low-carb diets Launched a clinical trial that targets the basic biology of relapsed acute lymphoblastic leukemia and its resistance to therapy Learn more about our research /research Our leadership Sandra Fenwick President and Chief Executive Officer Kevin Churchwell, MD Executive Vice President of Health Affairs and Chief Operating Officer

at a glance Hospital is proud to collaborate with you to provide the full spectrum of diagnostics, therapies and long-term support services to all children from babies in the womb to young adults, here in New England and around the world. Fiscal Year 2013 249 specialized clinical programs 24,758 inpatient and observation discharges 580,418 outpatient visits 6.79 average length of stay The care we work with you to provide to patients at the bedside is driven by our basic, translational and clinical research. With more than 1,400 scientists, in excess of $272 million in annual funding and more than 877,000 square feet of state-of-the-art laboratory space, Boston Children s is home to the largest and best-funded research enterprise based at a pediatric medical center. 58,588 emergency department visits 26,920 inpatient and day surgical cases 2.42 average case mix index Our faculty and staff 398 active medical and dental staff 747 associate scientific staff 421 residents, clinical fellows and interns 1,112 full-time nursing staff Our clinical care Our research 570 volunteers 9,869 total employees Here are some of our medical offerings: and some of our surgical innovations: Gene therapy Novel agents Clinical trials Induced hypothermia protocol for the treatment of newborns with hypoxic-ischemic encephalopathy Co-founding member of the Transatlantic Gene Therapy Consortium Home to one of the country s largest cystic fibrosis centers First pediatric center for rehabilitating and repairing congenital heart valve anomalies, and the largest and most experienced fetal cardiac intervention program in the United States, with a 90 percent technical success rate Discovered regenerative agents capable of restoring heart muscle growth and cardiac function after a heart attack Led the successful first clinical trial in history of a potential drug for progeria, a rare, fatal genetic premature aging syndrome Comprehensive pediatric transplant programs for kidney, lung, heart, liver and other organs Development of the staged left ventricle recruitment approach for treating children born with hypoplastic left heart syndrome Omegaven therapy to protect and preserve the livers of children receiving parenteral nutrition Hallmark neurosurgical techniques, including pial synangiosis for moyamoya disease, programmable shunts for hydrocephalus and vagus nerve stimulation for epilepsy Sole U.S. site for active gene therapy trial in Wiskott-Aldrich syndrome Developing drugs that treat obesity by regulating leptin levels Use of the serial transverse enteroplasty procedure to lengthen the bowels of children with short bowel syndrome Genetics and genomics Clinical and scientific innovations Launched the CLARITY Challenge, an international genomics challenge to set best practices for the growing field of clinical genomics Development of injectable oxygen microparticles that could potentially save the life of patients unable to breathe Nation s first program dedicated to caring for infants, children and adolescents with gender identity disorder or disorders of sexual differentiation Successful adaptation of the Foker process for lengthening the esophagus in children with esophageal atresia Make a referral Call us at Visit us online at Lead U.S. site for an active gene therapy trial in X-linked severe combined immunodeficiency and upcoming trial in adrenoleukodystrophy Completed genomic profiling of medulloblastoma, typing it into four different subtypes and raising the possibility of customized treatments Identified, using blood tests, a 55-gene signature that may help determine a child s risk of autism Conducted clinical trials of drugs aimed at reversing autistic and cognitive symptoms in several known genetic disorders Exploring urinary biomarkers that may help make or rule out a diagnosis, as in appendicitis or Kawasaki disease, and monitor patients with brain tumors for recurrence Developed a pediatric vision scanner to measure the eyes alignment and focusing ability in an effort to detect amblyopia earlier in young children Found that low-glycemic diets offer the best balance of metabolic benefits and reduced risk of heart disease, rather than traditionally recommended low-fat and low-carb diets Launched a clinical trial that targets the basic biology of relapsed acute lymphoblastic leukemia and its resistance to therapy Learn more about our research /research Our leadership Sandra Fenwick President and Chief Executive Officer Kevin Churchwell, MD Executive Vice President of Health Affairs and Chief Operating Officer

At a Glance Our accolades Top-ranked pediatric hospital nationwide by U.S.News & World Report in 2013 2014 in all rated subspecialty areas: Cancer Cardiology and Heart Surgery Diabetes and Endocrinology Gastroenterology Neonatology Nephrology Neurology and Neurosurgery Orthopedics Pulmonology Urology Four Gold Beacon Awards for Critical Care Excellence Magnet status for excellence in nursing Named a Leapfrog Group Top Children s Hospital for safety and quality One of few pediatric hospitals nationwide named a Stage 7 Hospital by the Healthcare Information Management Systems Society Named one of Hospital & Health Network s Most Wired hospitals for information technology Honored by American Heart Association and American Stroke Association with Silver Resuscitation Award Connect with us 300 Longwood Avenue Boston, MA 02115 Make a referral or request a second opinion For international physicians +1-617-355-5209 /internationalreferral international.resources@childrens.harvard.edu Our teaching is a Harvard Medical School teaching hospital. We are dedicated to training the top pediatric clinicians of tomorrow not only as leaders in their respective fields, but also as practitioners of compassionate, child- and family-centered care. Highlights of our teaching initiatives include: 38 (37 ACGME and 1 ADA) accredited training programs with 432 interns, residents, and clinical fellows One of the nation s most competitive pediatric residency programs, with 1,670 medical students applying for only 42 spots in 2014 A Department of Nursing that trained more than 700 nursing students during the 2013 2014 academic year Observerships in more than 20 clinical programs Explore our fellowship and training opportunities /teaching Spring Summer 2014

at a glance Hospital is proud to collaborate with you to provide the full spectrum of diagnostics, therapies and long-term support services to all children from babies in the womb to young adults, here in New England and around the world. Fiscal Year 2013 249 specialized clinical programs 24,758 inpatient and observation discharges 580,418 outpatient visits 6.79 average length of stay The care we work with you to provide to patients at the bedside is driven by our basic, translational and clinical research. With more than 1,600 scientists, in excess of $272 million in annual funding and more than 877,000 square feet of state-of-the-art laboratory space, Boston Children s is home to the largest and best-funded research enterprise based at a pediatric medical center. 58,588 emergency department visits 26,920 inpatient and day surgical cases 2.42 average case mix index Our faculty and staff 398 active medical and dental staff 747 associate scientific staff 421 residents, clinical fellows and interns 1,112 full-time nursing staff Our clinical care Our research 570 volunteers 9,869 total employees Here are some of our medical offerings: and some of our surgical innovations: Gene therapy Novel agents Clinical trials Induced hypothermia protocol for the treatment of newborns with hypoxic-ischemic encephalopathy Co-founding member of the Transatlantic Gene Therapy Consortium Home to one of the country s largest cystic fibrosis centers First pediatric center for rehabilitating and repairing congenital heart valve anomalies, and the largest and most experienced fetal cardiac intervention program in the United States, with a 90 percent technical success rate Discovered regenerative agents capable of restoring heart muscle growth and cardiac function after a heart attack Led the successful first clinical trial in history of a potential drug for progeria, a rare, fatal genetic premature aging syndrome Comprehensive pediatric transplant programs for kidney, lung, heart, liver and other organs Development of the staged left ventricle recruitment approach for treating children born with hypoplastic left heart syndrome Omegaven therapy to protect and preserve the livers of children receiving parenteral nutrition Hallmark neurosurgical techniques, including pial synangiosis for moyamoya disease, programmable shunts for hydrocephalus and vagus nerve stimulation for epilepsy Sole U.S. site for active gene therapy trial in Wiskott-Aldrich syndrome Developing drugs that treat obesity by regulating leptin levels Use of the serial transverse enteroplasty procedure to lengthen the bowels of children with short bowel syndrome Genetics and genomics Clinical and scientific innovations Launched the CLARITY Challenge, an international genomics challenge to set best practices for the growing field of clinical genomics Development of injectable oxygen microparticles that could potentially save the life of patients unable to breathe Nation s first program dedicated to caring for infants, children and adolescents with gender identity disorder or disorders of sexual differentiation Successful adaptation of the Foker process for lengthening the esophagus in children with esophageal atresia Make a referral Call us at Visit us online at Lead U.S. site for an active gene therapy trial in X-linked severe combined immunodeficiency and upcoming trial in adrenoleukodystrophy Conducted clinical trials of drugs aimed at reversing autistic and cognitive symptoms in several known genetic disorders Completed genomic profiling of medulloblastoma, typing it into four different subtypes and raising the possibility of customized treatments Exploring urinary biomarkers that may help make or rule out a diagnosis, as in appendicitis or Kawasaki disease, and monitor patients with brain tumors for recurrence Identified, using blood tests, a 55-gene signature that may help determine a child s risk of autism Developed a pediatric vision scanner to measure the eyes alignment and focusing ability in an effort to detect amblyopia earlier in young children Found that low-glycemic diets offer the best balance of metabolic benefits and reduced risk of heart disease, rather than traditionally recommended low-fat and low-carb diets Launched a clinical trial that targets the basic biology of relapsed acute lymphoblastic leukemia and its resistance to therapy Learn more about our research /research Our leadership Sandra Fenwick President and Chief Executive Officer Kevin Churchwell, MD Executive Vice President of Health Affairs and Chief Operating Officer

At a Glance Our accolades Top-ranked pediatric hospital nationwide by U.S.News & World Report in 2013 2014 in all rated subspecialty areas: Cancer Cardiology and Heart Surgery Diabetes and Endocrinology Gastroenterology Neonatology Nephrology Neurology and Neurosurgery Orthopedics Pulmonology Urology Four Gold Beacon Awards for Critical Care Excellence Magnet status for excellence in nursing Named a Leapfrog Group Top Children s Hospital for safety and quality One of few pediatric hospitals nationwide named a Stage 7 Hospital by the Healthcare Information Management Systems Society Named one of Hospital & Health Network s Most Wired hospitals for information technology Honored by American Heart Association and American Stroke Association with Silver Resuscitation Award Connect with us 300 Longwood Avenue Boston, MA 02115 Make a referral or request a second opinion For international physicians +1-617-355-5209 /internationalreferral international.resources@childrens.harvard.edu Our teaching is a Harvard Medical School teaching hospital. We are dedicated to training the top pediatric clinicians of tomorrow not only as leaders in their respective fields, but also as practitioners of compassionate, child- and family-centered care. Highlights of our teaching initiatives include: 38 (37 ACGME and 1 ADA) accredited training programs with 432 interns, residents, and clinical fellows One of the nation s most competitive pediatric residency programs, with 1,670 medical students applying for only 42 spots in 2014 A Department of Nursing that trained more than 700 nursing students during the 2013 2014 academic year Observerships in more than 20 clinical programs Explore our fellowship and training opportunities /teaching Spring Summer 2014