Gambling distortions and the brain reward system Dr Luke Clark
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1 Gambling distortions and the brain reward system Dr Luke Clark Department of Psychology University of Cambridge, U.K.
2 Impulsive choice in PG as possible index of vmpfc dysfunction Functional imaging of gambling near-misses Gambling distortions following brain injury (ventromedial PFC vs insula damage)
3 Impulsive Choice in PG: the Cambridge Gamble Task -well-established neuropsychology probe of vmpfc function (Clark et al 2008 Brain) vmpfc Insula Lesion Controls Healthy Controls 65 % Bet to1 8to2 7to3 6to4 Chances of Winning
4 Impulsive Choice in PG: the Cambridge Gamble Task -Lawrence et al (2009 Addiction) elevated betting & more bankruptcy in community problem gamblers (and alcohol-dep) -Sharman, Bowden-Jones, Clark: Clinical PG: 86 male PG vs45 healthy controls Choice of Likely Colour Betting Behaviour Proportion Majority Choice PG Controls Majority Colour Bet Amount (%) PG Controls Ascend Condition Descend Condition
5 Cognitive Approach to Gambling Gamblers experience distorted processing of chance and skill, causing over-estimated chances of winning Elevated in PG and correlated with impulsivity (delay discounting) Gambling-Related Cognitions Scale ** PG Controls Discounting Rate (ln k) Gambling-Related Cognitions Scale r=0.64, p<.001 Michalczuk et al (2011 Psychol Med)
6 Near-Misses A special kind of failure to reach a goal, one that comes close to being successful (Reid 1986) WIN NEAR-MISS
7 Near Misses are Aversive but Enhance Motivation to Play Z score of rating "Continue to play?" "Pleased with outcome?" -0.6 NearMiss FullMiss Clark et al (2009 Neuron)
8 Arousal Responses to Wins and Near-Misses SCR Change from Baseline (log + 1) Participant - WINS All Non-Wins Time post-outcome (2s bins) SCR Change from Baseline (log + 1) Participant - NEAR Participant - FULL Time post-outcome (2s bins) Clark et al (2012 JoGS)
9 A fmri Responses to Wins and Near-Misses WINNING OUTCOMES minus ALL NON-WIN OUTCOMES Dopaminergic Midbrain B Anterior Insula Ventral Striatum mpfc NEAR-MISS OUTCOMES minus FULL-MISS OUTCOMES P<.05 FWE P<.001 uncorr Clark et al (2009 Neuron)
10 Gambling Involvement and Near-Misses Clark et al (2009): Insula response to near misses and trait gambling cognitions Chase & Clark (2010): in regular players, midbrain response to near misses predicts PG symptoms 1.5 Percent Signal Change Gambling Related CognitionScale Percent Signal Change South Oaks Gambling Screen
11 Near Misses and Skill Near misses are falsely interpreted as signals of skill acquisition, and thus fuel the illusion of control. 3 lines of evidence Near miss effect needs personal choice of play icon (Clark et al 2009) Individual differences in skill-oriented cognitions predict the potency of near misses (Billieux et al 2012 Brit J Psychol) Learning consequences on trials after a near-miss predict persistent play (Clark et al 2013 J BehavDec Making)
12 The Gambler s Fallacy Wins Losses P (Same as last) Run Length Binary choice guessing: RED or BLACK on roulette Further effect of prior feedback (win-stay / lose-shift) Limbrick-Oldfield, Aitken & Clark, in progress
13 Gambling Distortions following Brain Injury Injury to ventromedialpfc n=18 Insulan=12 Amygdala n=7 Healthy controls n=16 Clark, Studer, Bechara, in prep
14 Gambling Distortions following Brain Injury 0.65 vmpfc 6 Insula Amygdala Healthy Controls "Continue to Play" Run Length -8 Healthy vmpfc Insula Amygdala Effect of Run Length = Gambler s Fallacy Abolished in Insula lesion group Clark, Studer, Bechara, in prep Motivational Effect of Near Misses vs Full Misses Abolished in Insula lesion group
15 Conclusions Two gambling distortions: Motivational effects of near-misses Sequential biases in random choice (Gambler s Fallacy) These biases: exist in healthy people and are enhanced in problem gamblers are abolishedin patients with damage to the insula, plausibly via damaged representations of bodily excitement Ongoing work: fmri of these biases in PG, unaffected relatives, alcohol abuse Near-misses: more realistic simulations; vs near-losses(eeg); vs Losses Disguised as Wins
16 Laboratory for Affect, Risk and Gambling Experiments (LARGE) Mike Aitken Bettina Studer(now ICN) Rosanna Michalczuk Roseline Porchet Steve Sharman Eve Limbrick Oldfield Yin Wu Sophie Miller Acknowledgements Funding support: Medical Research Council Imperial College, London Henrietta Bowden-Jones Paul Stokes Anne Lingford-Hughes Antoine Bechara(USC / McGill) Barney Dunn (Exeter) Joel Billieux (UC Louvain) Antonio Verdejo(U Granada) MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute
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