Dr Muzaffer Kaser MD PhD MPhil MRCPsych

Transcription

1 Dr Muzaffer Kaser MD PhD MPhil MRCPsych Bahcesehir University Ciragan Caddesi No: Besiktas Istanbul/TURKEY Positions Held / Education Affiliated Lecturer Bahcesehir University Medical Faculty, Department of Psychiatry March Current PhD, Department of Psychiatry, University of Cambridge Effects of Modafinil on Cognition in Patients with Remitted Depression Supervisor: Professor Barbara J Sahakian Cambridge-IDB International Scholarship October 2012 June 2016 (Degree awarded in February 2017, conferred in formal ceremony in July 2017) Double-blind, randomised, placebo-controlled study on the effects of modafinil to improve cognitive functions in people with remitted depression (Clinical Research Network Portfolio ID: 17355) Set up the study including funding application, ethics application, Clinical Research Network adoption, pharmacy/randomisation arrangements, established collaborations with clinical teams across East of England. Completed 120 sessions including neuropsychological testing of participants. Baseline sessions were at local mental health trusts, intervention sessions were completed at NIHR/Wellcome Trust Clinical Research Facility at Addenbrooke s Hospital. MPhil in Clinical Science, Translational Medicine and Therapeutics Clinical School, University of Cambridge Investigation of the Relationship Between Mismatch Negativity and CANTAB Performance in Patients with Schizophrenia Degree awarded in September 2012 Taught course on aspects of drug development, experimental medicine, research methodology Experimental research on a candidate EEG biomarker (Mismatch Negativity) and cognition in patients with schizophrenia EEG data analysis, neuropsychological data analysis Medical School, Istanbul University Cerrahpasa Medical Faculty Degree awarded: Medical Doctor (M.D. equivalent to MB BChir) July 2005 Scholarships and Awards Best Trainee Presentation Prize 6th Biannual International Conference on Mental Health, September 2017, Cambridge, UK Guarantors of Brain Travel Grant to attend Society of BIological Psychiatry Meeting, May 2017, San Diego, USA

2 Travel Fellowship for Clinical Trials Workshop American Society of Clinical Psychopharmacology April 2017, New York, USA ECNP Travel Award for 29th Annual Congress, Vienna September 2016 One of the 50 awards selected among 650 applications Research funding awarded by Wellcome Trust/MRC Behavioural and Clinical Neuroscience Institute after peer-review for the Project entitled Effects of Modafinil on Cognitive Functioning and Emotional Processing in Patients with Remitted Depression (Reference ) ( 12,600) October 2013 Cambridge-IDB International Scholarship by Cambridge Overseas Trust for 3 years PhD (tuition and maintenance) - October 2012 Post-doctoral research grant by Scientific and Technological Research Council of Turkey (TUBITAK) for work at University of Cambridge May 2011 Research travel grant by Brain Research Society of Turkey (BAD) for work at University of Cambridge - February 2010 Eczacibasi Promotion Award for Medical Students The effects of tianeptine pre-treatment on emotional activity and spatial memory under acute and chronic restraint stress - May 2004 Clinical Training/Experience Specialty Training in Psychiatry Bakirkoy Research & Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul/Turkey Dissertation: Decision-Making Cognition and Symptom Dimensions in Patients with Obsessive-Compulsive Disorder November 2005 March 2011 (Title Awarded: Specialist in Psychiatry) Publications Kaser M, Deakin JB, Michael A, Zapata C, Bansal R, Ryan D, Cormack F, Rowe JB, Sahakian BJ. Modafinil Improves Episodic Memory and Working Memory in Patients with Remitted Depression: A Double-Blind, Randomized, Placebo-Controlled Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2017; 2(2); (Set up the study, conducted the testing for all patients, did the data analysis, wrote the manuscript) Ramakrishnan R, Kaser M, Guloksuz S. The Link Between the Immune System, Environment, and Psychosis. Schizophrenia Bulletin, Volume 43, Issue 4, 1 July 2017, ( ) Vaghi MM, Hampshire A, Fineberg NA, Kaser M, Brühl AB, Sahakian BJ, Chamberlain SR, Robbins TW. Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2017; (Completed the clinical assessment of patients)

3 Kaser M, Zaman R, Sahakian BJ. Cognition as a Treatment Target in Depression Psychological Medicine, 2017; 47; Hacioglu Yildirim M, Yildirim EA, Kaser M, Guduk M, Fistikci N, Cinar O, Yuksel S. The relationship between adulthood traumatic experiences and psychotic symptoms in female patients with schizophrenia. Comprehensive Psychiatry, 2014; 55(8): (Collected data in patient interviews and contributed to data analysis) Gillan CM, Morein-Zamir S, Kaser M, Fineberg NA, Sule A, Sahakian BJ, Cardinal RN, Robbins TW. Counterfactual processing of economic action-outcome alternatives in obsessive-compulsive disorder: Further evidence of impaired goal-directed behavior. Biological Psychiatry, 2014; 75(8), (Collected data via neuropsychological testing of patients and healthy volunteers) Caglar E, Kaser M. Mental Health Law in Turkey: legislation pending. International Psychiatry, 2014; 11(1); Kaser M, Soltesz F, Lawrence P, Miller S, Dodds C, Croft R, Dudas RB, Zaman R, Fernandez-Egea E, Müller U, Dean A, Bullmore ET, Nathan PJ. Oscillatory Underpinnings of Mismatch Negativity and Their Relationship with Cognitive Function in Patients with Schizophrenia. PloS one, 2013; 8(12), e (Completed the data analysis for neurocognitive tests, wrote the manuscript) Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH. Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials. The Journal of Clinical Psychiatry 2013; 74(11), (joint first author) Yildirim EA, Kasar M, Guduk M, Ates E, Kucukparlak I, Ozalmete O. Investigation of reliability of Reading Mind in the Eyes Test in a Turkish population. Turkish Journal of Psychiatry 2011; 22(3): (Collected data for the reliability study via testing heatlhy volunteers) Kasar M, Gleichgerrt E, Keskinkilic C, Tabo A, Manes FF. Decision Making in people who relapsed to Driving Under Influence of Alcohol. Alcoholism: Clinical and Experimental Research 2010; Vol.34 No.12, 1-7. (Collected data via neuropsychological testing of DUI offenders and healthy volunteers) Kasar M, Mengi M, Yildirim EA, Yurdakos E. Different effects of tianeptine pretreatment in rats exposed to acute stress and repeated severe stress. Methods and Findings in Experimental and Clinical Pharmacology 2009; 31(3), (Collected data at the lab including animal handling and behavioural testing and analysed data) Kasar M, Saatcioglu O, Kutlar T. ECT use during pregnancy. J ECT 2007 Sep;23(3): Surname Correction: Surname was corrected from Kasar to Kaser for cultural reasons in accordance with Turkish official procedures. Abstracts (Last three years) Kaser M, Bland A, Deakin JB, Michael A, Zapata C, Bansal R, Ryan D, Cormack F, Rowe JB, Sahakian BJ. Effects of Modafinil on Emotional Processing in Patients with Remitted Depression 72nd Annual Meeting of the SOBP, San Diego (2017)

4 Kaser M, Deakin JB, Michael A, Zapata C, Bansal R, Ryan D, Cormack F, Rowe JB, Sahakian BJ. Modafinil improves spatial working memory in patients with remitted depression. 29th ECNP Congress, Vienna (2016) Kaser M, Cormack F, Deakin JB, Sahakian BJ. Cognitive Dysfunction in Patients with Remitted Depression. BAP Summer Meeting, Bristol (2015) Gottwald J, Apergis-Schoute A, Morein-Zamir S, Kaser M, Sule A, Conway-Morris A, Limmer W, Robbins TW, Sahakian BJ. Cognitive Function in Adolescent OCD: Does age matter? European Neuropsychopharmacology (25), S574-S th ECNP Congress, Amsterdam (2015) Apergis-Schoute AM, van der Flier FE, Whitaker KJ, Vaghi MM, Kaser M, Sule A, Fineberg NA, Robbins TW, Sahakian BJ. A neurocognitive and white matter profile of behavioral flexibility in obsessivecompulsive disorder. Society for Neuroscience Meeting, Washington (2014) Kaser M, Hacioglu M, Yildirim EA, Saatcioglu O. Comparison of neurocognitive performance in patients with early onset and late onset obsessive compulsive disorder. European Neuropsychopharmacology, (24), S623-S th ECNP Congress, Berlin (2014) van der Flier FE, Apergis-Schoute AM, Vaghi MM, Kaser M, Robbins TW, Sahakian BJ. Cognitive Flexibility in OCD: Findings From a Novel Reversal Learning Task. Journal of Psychopharmacology Supplement: Volume 28, Issue 8, August BAP Summer Meeting, Cambridge (2014) Kaser M, Hacioglu M, Yildirim EA, Saatcioglu O. Are there gender differences in neurocognitive functions of patients with obsessive-compulsive disorder? Journal of Psychopharmacology Supplement: Volume 28, Issue 8, August BAP Summer Meeting, Cambridge (2014) Kaser M, Soltesz F, Lawrence P, Miller S, Dodds C, Croft R, Dudas RB, Zaman R, Fernandez-Egea E, Müller U, Dean A, Bullmore ET, Nathan PJ. Mismatch Negativity Deficits are Associated with Reduced Theta Power in Patients with. Schizophrenia Organisation for Human Brain Mapping Conference, Hamburg (2014) Conferences/Talks Improving Cognition in Patients with Remitted Depression: Is Modafinil a Feasible Option? Speaker at Post-doc symposium in BAP Annual Summer Meeting, Harrogate, 25/07/2017 Clinical Aspects of Cognitive Enhancement Panel Speaker at the event The Ethics and Science of Students Use of Cognitive Enhancing Drugs, Edinburgh University Neurological Society, Edinburgh, 06/04/2017 Cognitive Dysfunction in Depression: Testing the potential of modafinil as a treatment. Talk at CPFT & Department of Psychiatry Lunchtime Seminar, 02/03/2017 Adulthood Trauma in Schizophrenia Talk at Royal College of Psychiatrists Eastern Division Meeting, Cambridge, 10/11/2016 Modafinil improves working memory in patients with remitted depression Rapid-fire poster session talk at 29th ECNP Congress, Vienna, Austria, 20/09/2016

5 Cognitive Dysfunction in Depression: Preliminary Results from a Sample of Remitted Depressed Patients Conference Talk in Cambridge & Bedford International Conference on Mental Health, Cambridge, 11/09/2015 Tackling the Black Dog: On Brain and Depression Graduate Seminar at Sidney Sussex College, University of Cambridge 01/12/2014 Neurophysiological and Neurocognitive Biomarkers of Schizophrenia 12th National Neuroscience Congress, Istanbul, Turkey, 2014 Mismatch Negativity as a Potential Translational Biomarker Oral Presentation in Cambridge Luton International Conference on Mental Health, Cambridge, 2013 Teaching Formal Teaching Training I completed the course by Clinical School, University of Cambridge on medical students teaching. The course (Integrated Foundations of Medical Education IFME) is a pioneering initiative and followed the standards of Higher Education Academy. I am awarded with Associate Fellowship of Higher Education Academy (AFHEA). July 2017 Medical Students Teaching, Clinical School, University of Cambridge Group Teaching Coordinator for medical students during their psychiatry placements. In my role as coordinator, I set up an interactive teaching programme using non-didactical approach. I started a stigma teaching session in collaboration with peer worker colleagues from Recovery College CPFT. Group teaching sessions have received consistently good feedback from students. April 2014 April 2016 Affiliated Lecturer Bahcesehir University, Istanbul Classroom-based and online lectures at medical school, undergraduate psychology course and clinical psychology masters course on cognition, mood disorders and neural basis of behaviour. December 2011 current Reviewer for Academic Journals Psychological Medicine (February 2014 Current) International Journal of Psychopharmacology (October 2012 Current) International Journal of Psychiatry in Clinical Practice (April 2012 Current) Turkish Journal of Psychiatry (November 2013 Current) Public Engagement Guest speaker on Depression in Chris Mann s Drive Time Programme, BBC Cambridgeshire 19/01/2017 Some Drugs are Smarter Than Others Talk at Pint of Science event 25/05/2016 Depression: All in mind? Talk at Cambridge Science Festival - 19/03/2016

6 Panel speaker at theatre play Pictures of You Cambridge Science Festival 18/03/2016 Report on the National Academy of Sciences Workshop on Cognitive Dysfunction in Depression: Challenges and Future Directions, Washington, DC, USA for BAP website. 19/01/ From Stem Cells to Mind: Our Journey through Life - A short play involving conversations between scientists and artists on human development, brain and mind. Performed at Cambridge Science Festival - 14/03/2015: Co-authored the script, acted in the play. Panel speaker at Cambridge Science Festival Event How to get the best out of life: resilience and stress management - 12/03/2015 Audience was around 220 people. Event feedback: 90% rated the panel as good or very good. Completed Rising Stars public engagement course by University of Cambridge (2015)