Space amputation in neglect?

Transcription

1 Space amputation in neglect? Bisiach & Luzzatti, Cortex 14:129-33, 1978 Space amputation in neglect? Revisited!? 71% 29% Visual only Imaginal + visual Bartolomeo, D Erme & Gainotti, Neurology 44:1710-4,

2 Space compression in neglect? Halligan & Marshall, Cortex 27:623-9, 1991 Space compression in neglect? Halligan & Marshall, Cortex 27:623-9,

3 Space compression in neglect? Halligan & Marshall, Cortex 27:623-9, 1991 Space compression in neglect? Halligan & Marshall, Cortex 27:623-9,

4 Space compression in neglect? Halligan & Marshall, Cortex 27:623-9, 1991 Space compression in neglect?

5 Space compression in neglect? Bartolomeo, Urbanski, Chokron, Chainay, Moroni, Siéroff, Belin, Halligan, Neuropsychologia, 2004 Space compression in neglect? I I I I I I I I I I I I Bartolomeo, Urbanski, Chokron, Chainay, Moroni, Siéroff, Belin, Halligan, Neuropsychologia,

6 Space compression in neglect? Bartolomeo, Urbanski, Chokron, Chainay, Moroni, Siéroff, Belin, Halligan, Neuropsychologia, 2004 Results N- NUMBERS LINES I I I I I I I I I (left) DEV. (right) CTR (n=8) BLANK -4-6 (left) POSITION (right) 16 N-H- (n=5) 16 N-H+ (n=3) (left) DEV. (right) (left) DEV. (right) (left) POSITION (right) (left) POSITION (right) 6

7 Results N+ (left) DEVIATION (right) (mm) N+H+ (n=5) NUMBERS LINES BLANK y = -1.06x y = -1.00x y = -0.43x (left) POSITION (right) N+H- (n=5) y = -0.57x y = -0.40x y = -0.36x (left) POSITION (right) Left hemispace Right hemispace LH - RH Kinsbourne, Trans Am Neurol Assoc, 95:143-6,

8 Left hemispace Right hemispace LH - RH Kinsbourne, Trans Am Neurol Assoc, 95:143-6, 1970 Left hemispace Right hemispace LH - RH Kinsbourne, Trans Am Neurol Assoc, 95:143-6,

9 Left hemispace Right hemispace LH - RH Kinsbourne, Trans Am Neurol Assoc, 95:143-6, 1970 Left hemispace Right hemispace LH RH Heilman & Van Den Abell, Neurology, 30:327-30,

10 Left hemispace Right hemispace LH RH Heilman & Van Den Abell, Neurology, 30:327-30, 1980 Left hemispace Right hemispace LH RH Heilman & Van Den Abell, Neurology, 30:327-30,

11 Left hemispace Right hemispace LH RH Heilman & Van Den Abell, Neurology, 30:327-30, 1980 Left Right Left RTs LH - RH Right Severity of neglect Left Right Left Right RTs LH RH 11

12 Left neglect or right hyperattention? RTs (ms) y = x y = x Severity of neglect (λ score) Left Right Bartolomeo & Chokron, Neurology 53:2023-7, 1999 valid cue target TIME Posner, Walker, Friedrich, & Rafal, J Neurosci 4: ,

13 invalid cue target TIME Posner, Walker, Friedrich, & Rafal, J Neurosci 4: , 1984 EXOGENOUS ENDOGENOUS BENEFIT SOA (ms) 1,000 COST IOR Müller & Findlay, Acta Psychol 69: ,

14 Exp. 1: 50% Valid Trials CONTROLS NEGLECT 600 VALID INVALID 1000 RT (ms) LEFT SOA (ms) RIGHT LEFT SOA (ms) RIGHT Bartolomeo, Siéroff, Decaix & Chokron, Exp Brain Res 137:424-31, 2001 Exp. 3: 20% Valid Trials CONTROLS NEGLECT 600 VALID INVALID RT (ms) LEFT SOA (ms) RIGHT LEFT SOA (ms) RIGHT Bartolomeo, Siéroff, Decaix & Chokron, Exp Brain Res 137:424-31,

15 Corbetta & Shulman, Nat Rev Neurosci 3:201-15, 2002 Corbetta & Shulman, Nat Rev Neurosci 3:201-15,

16 The anatomy of neglect Vallar, Corbetta Neuroimage & Shulman, 14:S52-8, Nat Rev 2001 Neurosci 3:201-15, 2002 Mishkin, Ungerleider & Macko, Trends Neurosci 6:414-7, 1983 Milner & Goodale, The Visual Brain in Action, 1995 Mort, Malhotra, Mannan, Rorden, Pambakian, Kennard & Husain, Brain, 120: ,

17 NeuroReport 14: , 2003 The lesion overlap method has problems Lack of spatial resolution coarse boundaries of vascular lesions lesions plotted on a standard brain Vascular lesions may reflect differences in vascular territories rather than true functional organization of the brain In case of multiple lesions, the region of overlap may be identified as the crucial region, whereas the deficit may in fact result from the co-occurrence of distinct lesions Relies on a phrenological view of anatomofunctional relationships: each brain region is dedicated to, and crucial for, a particular function Bartolomeo, Arch Neurol 63: ,

18 Which framework for clinico-anatomical correlations? TOPOLOGICAL approach neurological deficit HODOLOGICAL approach neurological deficit a b c a b c Catani & Mesulam, Cortex 2008 Science 309:2226-8,

19 Patient CAL rstg cstg SMG FEF * * Others LEFT < Deviation (mm) > RIGHT Patient SB cstg SMG Others 1 O-FF 1 Others 2 O-FF 2 Others 3 Day +5 * v * * ** ** LEFT < Deviation (mm) > RIGHT

20 Thiebaut de Schotten, Urbanski, Duffau & Bartolomeo, Science 309:2226-8, 2005 Schmahmann & Pandya, Fiber Pathways of the Brain, 2006 Parietal component perceptual salience of extrapersonal objects Frontal component production of an appropriate response to behaviorally relevant stimuli online retention of spatial information focusing of attention on salient items through reciprocal connections to more posterior regions Bartolomeo, Arch Neurol 63: ,

21 Neglect as a disconnection syndrome Bartolomeo, Thiebaut de Schotten & Doricchi, Cereb Cortex 45: , 2007 Bartolomeo, Thiebaut de Schotten & Doricchi, Cereb Cortex 45: ,

22 N+ N- Inferior Longitudinal Fasciculus Déjerine, Anatomie des Centres Nerveux, 1895 Catani, Jones, Donato & ffytche, Brain 126: ,

23 Superior Longitudinal Fasciculus SLF II SLF III Thiebaut de Schotten,... & Bartolomeo, Visualization of disconnection syndromes in humans, Cortex 2008 lateral medial Inferior Fronto-Occipital Fasciculus Frontal regions Temporal region Inferior fronto-occipital fasciculus Occipital region Inferior longitudinal fasciculus Uncinate Catani et al, in preparation 23

24 Urbanski, Thiebaut de Schotten, Rodrigo, Catani & Bartolomeo, J Neurol Neurosurg Psychiatry, in press Case 1 Urbanski, Thiebaut de Schotten, Rodrigo, Catani & Bartolomeo, J Neurol Neurosurg Psychiatry, in press 24

25 ROI A ILF touches ROI A & C ROI B ROI C IFOF touches ROIs B & C ROI D SLF touches ROI D Urbanski, Thiebaut de Schotten, Rodrigo, Catani & Bartolomeo, J Neurol Neurosurg Psychiatry, in press SLF ILF IFOF Urbanski, Thiebaut de Schotten, Rodrigo, Catani & Bartolomeo, J Neurol Neurosurg Psychiatry, in press 25

26 Urbanski, Thiebaut de Schotten, Rodrigo, Catani & Bartolomeo, J Neurol Neurosurg Psychiatry, in press Towards a hodological approach to visual neglect? N+ N- 26

27 SLF II SLF III IFOF 27