A brief look at the herbal medicine within our TNT therapy

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1 A brief look at the herbal medicine within our TNT therapy The best sourced herbs from around the world Targeted Nutritional Therapy is a therapeutic approach using low dosages of the most safe and efficacious natural ingredients, enhanced by a unique delivery system to increase absorption and bioavailability. TNT has been designed by Sanesco to elicit specific metabolic responses for the restoration of function in the HPA-T (Hypothalamus-Pituitary-Adrenal-Thyroid) axis. Griffonia simplicifolia (5-HTP) 5-HTP is the direct precursor in the biosynthesis of serotonin. Mucuna pruriens Multiple studies have found that Mucuna pruriens contains a large amount of L-DOPA, the precursor to dopamine. Siberian Ginseng The extract of Siberian Ginseng roots, eleutheroside, has shown to be an excellent adaptogen. Prolent Tranquilent Procite-D Contegra Adaptacin Ashwagandha (root) Ashwagandha root demonstrates multiple ways to combat the effects of the stress response. Slimaluma Slimaluma, also known as Caralluma fimbriata, is an edible catcus known to surpress hunger and enhance endurance. Garcinia cambogia Extract An extract harvested from the dried fruit rinds of Garcinia cambogia, also known as Brindall Berry, which is native to Indonesia. Adaptacin Plenus Plenus Tus magnis ese dis nullatum qui doluptatium Tus magnis ese dis nullatum qui sectore BEST PRICE Repudaerum sit volores exped que repro Repudaerum sit volores exped que magnis Spedi sectore ctecus int que repro Spedi sectore ctecus int que repro doluptatium

2 06 01 Lentra 30/60 capsules Lentra GABA Receptor Formula SYNOPSIS AND REVIEW Lentra is a natural anxiolytic formula which supports inhibitory neurotransmission by aiding in the potentiating optimal GABA-A reception function. Lentra activates inhibitory neurotransmission and induces relaxation and restfulness, without inducing sedation. Now available in 30ct and 60ct bottles. Lentra Recommended Dosage Take one (1) capsule daily or as directed by your clinician. Lentra Indications Use when support is needed for the inhibitory system, particularly GABA. Research shows GABA deficiency may contribute to restlessness, irritability, and PMS symptoms. Lentra may be recommended for mood support and to support a full night of sleep. GABA functions synergistically with progesterone for a balanced and calming effect during PMS and menopause. GABA levels may elevate to compensate for low serotonin. When serotonin increases due to supplementation, GABA levels often normalize. Lentra contributes, along with Prolent or Tranquilent, to rebalancing and supporting the inhibitory system. Lentra may be recommended in combination with SomniTR or Tranquilent to promote sleep. Lentra Contraindications No specific contraindications known other than for individuals hypersensitive to any of its ingredients.

3 Prolent 60 capsules Prolent Inhibitory & Serotonin Support Formula SYNOPSIS AND REVIEW Prolent supports inhibitory neurotransmission by functioning to primarily rebuild serotonin stores, while supporting GABA receptors and glycine. Prolent Recommended Dosage Take one (1) capsule daily or as directed by your clinician. Prolent Indications Prolent is used in Initial, Restoration, and Maintenance phases to rebuild or maintain the inhibitory system of neurotransmitters or to continue inhibitory support while rebuilding the excitatory system. Use when serotonin function is inadequate to control elevated excitatory neurotransmitters, particularly norepinephrine and glutamate. Helps maintain relaxation and mood support. In the scientific literature, insufficient serotonin is associated with conditions such as carbohydrate cravings, menopausal symptoms, poor sleep and nervousness. Serotonin helps restore GABA inhibitory function. When GABA is elevated and serotonin is low, raising serotonin can help to normalize GABA. Prolent may be combined with Lentra, SomniTR, or Tranquilent for added inhibitory support. In conjunction with excitatory support, Prolent helps prevent over-excitation. Prolent Contraindications No specific contraindications are known other than for individuals hypersensitive to any of the Prolent ingredients. Building up for a week or two with smaller doses is advisable to avoid loose stools that occur in about 10% of cases upon initial contact with 5-HTP.

4 Tranquilent 30 tablets Tranquilent - Chewable Nutritional Support Formula for Relaxation Tranquilent is a unique, chewable, raspberry-flavored formula providing inhibitory support for both serotonergic and GABAergic neurotransmission. Tranquilent may be used for acute situations as well as for rebalancing the inhibitory system. Doses are appropriate for use in the pediatric population. Tranquilent Recommended Dosage Chew one (1) or more tablets daily or as directed by your clinician. Tranquilent Indications Inositol and 5-HTP can be used to support inhibitory pathways in pediatric or adult populations. Suntheanine has earned FDA structure/function claims for promoting relaxation, reducing stress and nervous tension, relieving occasional insomnia and poor sleep as well as decreasing symptoms of PMS. The low doses of 5-HTP and Suntheanine are absorbed quickly and may help reduce stress or tension. May be suggested for adults when serotonin levels are elevated due to medications or receptor insensitivity but symptoms of inhibitory insufficiency are present. For pediatric patients, Tranquilent may be suggested when inhibitory support is necessary. Tranquilent Contraindications Avoid when taking Lithium for bipolar disorder due to counteracting effects.

5 Procite-D 60 capsules Procite-D - Catecholamine Formula Procite-D is a catecholamine support formula specifically targeting Dopamine while also supporting Norepinephrine, Epinphrine, and Beta-endorphin pathways. It supplies, in coenzymatic and/or phosphorylated/methylated form, B vitamins critical for proper neurotransmitter conversions. Procite-D Recommended Dosage Take one (1) capsule daily or as recommended by your practitioner. Procite-D Indications Procite-D supports excitatory neurotransmission through rebuilding catecholamine pathways, particularly dopamine. Catecholamine deficiencies have been associated with apathy, lack of focus, poor memory, and decreased stamina. When optimized, catecholamines increase energy, focus, and a sense of well-being. Use Procite-D in the rebalancing process to increase dopamine/catecholamines after inhibitory support has begun. Special attention should be paid to ensuring optimal serotonin levels while using Procite-D, because increasing catecholamine levels can suppress serotonin. As a potent excitatory formula, Procite-D may be recommended in conjunction with Adaptacin or MethylMax for balancing the function of the catecholamine pathway and up-regulating the HPA-T axis. Procite-D Contraindications Caution should be exercised when used in patients with a history of hypertension, bipolar, mania, or psychosis. It is contraindicated in Phenylketonuria (PKU).

6 Contegra 60 tablets Contegra - HPA-T Balancing Formula Contegra is a broad system support formula for the wired and tired, supporting inhibitory and excitatory neurotransmitter production, adrenal and thyroid function, and methylation pathways. It also supplies crucial B vitamins, in coenzymatic and/or phosphorylated form, critical for proper neurotransmitter function. Contegra Recommended Dosage Take one (1) tablet daily or as recommended by your practitioner. Contegra Indications Contegra is formulated for reestablishing HPA-T axis balance. Its ingredients allow for beginning excitatory support while continuing support for inhibitory function. Contegra may be recommended when beginning excitatory support prior to more aggressive support to reduce restlessness and stress. Contegra is used to support patients with non-chronic symptoms of poor memory and focus, apathy, agitation and decreased stamina. The addition of methylation support in Contegra helps prevent over-excitation as excitatory support is added to the patient s protocol. As balanced support for HPA-T axis function, it is often suggested after inhibitory support has begun (Prolent, Lentra, Tranquilent ) but prior to more potent excitatory support (Procite-D ). Contegra Contraindications No specific contraindications other than for individuals hypersensitive to any of the Contegra ingredients.

7 Adaptacin 60 tablets Adaptacin - Comprehensive Adrenal Support A formula for patients in need of adrenal support. This product utilizes the highest quality, most scientifically-validated compounds currently available. All botanicals are standardized for maximum efficacy and are classified as adaptogens. The most bioavailable forms of nutrients are utilized. Adaptacin Recommended Dosage Take two (2) tablets daily or as directed by your clinician. Adaptacin Indications Adaptacin merges adaptogens and adrenal cortex glandulators to tonify the adrenal gland and support adrenal function. Adaptogens are a class of herbs used to support adrenal imbalance and symptoms of decreased stamina, salt cravings, sugar cravings, lack of energy, lack of focus and concentration, and other signs and symptoms of adrenal stress. Adaptacin is typically recommended once inhibitory support (Prolent, Lentra, Tranquilent ) begins, and in conjunction with excitatory support (Contegra and Procite-D ) to help reduce stress and tension, and provide support for stamina and other adrenal insufficiency symptoms. Adaptacin Contraindications No specific contraindications known other than for individuals hypersensitive to any of the Adaptacin ingredients. Licorice may be of concern in some individuals with hypertension. However, Adaptacin s glycyrrhizic acid content falls within the safety profile of licorice in hypertension, at a maximum dosage of 6 tablets per day.

8 MethylMax 60 tablets MethylMax - Comprehensive Methylation Support MethylMax is a full-spectrum methylation formula for the support of all major methylation pathways. Methylmax is commonly recommended for patients with an elevated norepinephrine/epinephrine ratio and for patients who exhibit decreased stamina and/or low energy. MethylMax is an enteric-coated tablet designed to protect SAMe from oxidative damage when exposed to air. This product is packaged in a protective sealed bottle containing a desiccate pack to prevent moisture damage. MethylMax Recommended Dosage Take two (2) tablets daily or as directed by your clinician. MethylMax Indications SAMe has been used as a primary or adjunctive therapy in patients with physical and mental tiredness, and to help alleviate the occasional blue feeling everyone experiences from time to time. MethylMax is therefore a useful adjunct to Prolent in strengthening the inhibitory system, particularly serotonin. Methylation support is also necessary where norepinephrine is poorly converted into epinephrine (elevated norepinephrine/epinephrine ratio), promoting norepinephrine elevations and epinephrine depletions. MethylMax Contraindications No specific contraindications known other than for individuals hypersensitive to any of its ingredients. Caution should be exercised, however, when using SAMe in patients with a known history of bipolar disorder or any form of manic depression, schizophrenia or psychosis.[18] These conditions may involve hypermethylation at the level of gene expression. Quatrefolic is a registered trademark of Gnosis Spa

9 SomniTR 30 tablets SomniTR - Delayed-Release Sleep Formula SomniTR is a delayed-released formula, designed to release 1 mg of melatonin initially and 1 mg three hours later, to help promote the ability to stay asleep. SomniTR supports melatonin production and levels through multiple steps in the serotonin-to-melatonin pathway, and also influences inhibitory GABAergic activity. SomniTR Recommended Dosage Take one (1) tablet daily, before bedtime or as directed by your clinician. Allow for a full 8 hours of sleep. SomniTR Indications A deficiency in melatonin levels can be the cause of prolonged sleep latency, inability to stay asleep, circadian rhythm disorders, and jet lag. Disordered circadian rhythm is hypothesized to be another cause for increased appetite and weight gain. Melatonin also has the capability to reduce ACTH-stimulated cortisol production that may interrupt sleep. The melatonin in SomniTR is delayed-release to provide sustained levels for up to eight hours. Besides melatonin, SomniTR combines support for GABA-A receptor sites. GABA-A agonists have shown to improve quality of sleep. Lactium for GABA support is used to improve the quality of sleep. Other ingredients in SomniTR are used for melatonin synthesis. SomniTR provides support for patients with sleeping problems. It may be taken in conjunction with Lentra and/or Tranquilent. SomniTR Contraindications History of major depressive disorder.

10 Plenus 60/120 capsules Plenus - Nutritional Support for Satiety Plenus is an advanced satiety product to address overeating and weight loss. It represents the forefront of satiety research by addressing hunger through several distinct pathways, including gastric messaging to the brain, neural catecholamine function, hypothalamic hunger areas, and fatty acid synthesis. Plenus is free of stimulants such as methylxanthines (caffeine, theophylline, theobromine, etc.) as well as any hidden botanical or other source of ephedrine and synephrine. Plenus utilizes dosages of ingredients used in clinical studies. Plenus Recommended Dosage Two (2) capsules twice daily, 30 minutes before 2 heaviest meals. Plenus Indications When appetite and weight issues are self-reported by the patient, it is recommended for neuroendocrine balancing. Patients with excessive appetite often have imbalanced dopamine, serotonin, and/or low adrenal function. In attempting to bring these patients back into neuroendocrine balance, beneficial strategies include: supporting serotonin levels to help control carbohydrate cravings, using Plenus to support appetite control and to possibly help increase lean body mass, and implementing an insulin-sparing diet. A complete Healthy Weight Management program may require Prolent, Lentra, Procite-D and/or Adaptacin, depending on the patient s individual biochemical needs. Plenus Contraindications No specific contraindications other than for individuals hypersensitive to any of the Plenus ingredients. BEST PRICE

11 Sanesco International, Inc. All Rights Reserved 2016

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