Herpetic Eye Diseases

Transcription

1 Herpetic Eye Diseases

2 Documenta Ophthalmologica Proceedings Series volume 44 Editor H. E. Henkes

3 Herpetic Eye Diseases Proceedings of the International Symposium at the Katholieke Universiteit Leuven, Leuven, Belgium, May 17-19, 1984 P.C. Maudgal and L. Missotten (Editors) 1985 DR W. JUNK PUBLISHERS a member of the KLUWER ACADEMIC PUBLISHERS GROUP DORDRECHT / BOSTON / LANCASTER

4 Distributors for the United States and Canada: Kluwer Academic Publishers, 190 Old Derby Street, Hingham, MA 02043, USA for the UK and Ireland: Kluwer Academic Publishers, MTP Press Limited, Falcon House, Queen Square, Lancaster LAI lrn, UK for all other countries: Kluwer Academic Publishers Group, Distribution Center, P.O. Box 322, 3300 AH Dordrecht, The Netherlands Library of Congress Cataloging in Publication Data Main entry under title: Herpetic eye diseases. (Documenta ophthalmo1ogica. Proceedings series ; v. 44) 1. Keratitis--Congresses. 2. Herpes simplex virus- Congresses. I. Maudgal, P. C. II. Missotten, Luc. [DNLM: 1. Keratitis, Dendritic--congresses. 2. Herpesvirus Hominis--pathogenicity--eongresses. W3 Do637 v.44 / WW 220 H J RE338.H ' ISBN-13: DOl: / e-isbn-13: Copyright 1985 by Dr W. Junk Publishers, Dordrecht. Softcover reprint of the hardcover 15t edition 1985 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publishers, Dr W. Junk Publishers, P.O. Box 163, 3300 AD Dordrecht, The Netherlands.

5

6 VII CONTENTS Welcome address P.De Somer XIII SESSION I : Virology, Pathogenesfs Chairman: D.L.Easty (Bristol) Pathogenesis of herpes virus infections H.J.Field Herpes simplex virus infection of corneal cells in vitro C:Carter, H.Dyson and D.L.Easty Cytopathogenic effects of herpes simplex virus on corneal epithelium P.C.Maudgal and L.Missotten Superior cervical ganglion in experimental herpes simplex virus eye disease C.R.Dawson, W.-h.Zhang and O.Briones Recurrent and non-recurrent HSV-1 strains Effect of temperature Y.Centifanto-Fitzgerald Herpes simplex virus cycle : Model of mechanism of acute disease, latency and reactivation A.Romano and D.Gamus SESSION II : Pathology, Immunology Chairman: C.R.Dawson (San Francisco) Spread of herpes simplex virus to the eye following cutaneous inoculation in the snout of the mouse C.Shimeld, D.L.Easty, A.B.Tullo, W.A.Blythand T.J.Hill Light microscopic evaluation of rabbit corneal nerves: Comparison of the normal with dendritic herpetic keratitis P.A.Asbell and R.Beuerman Isolation of herpes simplex virus from corneal discs of patients with chronic stromal keratitis A.B.Tullo, D.L.Easty, C.Shimeld, P.E.Stirling and J.M.Darville

7 VIII Genetic influence from chromosome 12 on murine susceptibility to herpes simplex C.S.Foster, R.Wetzig, D.Knipe andm.i.greene Systemic immune responses after ocular antigen encounter C.S.Foster The role of virus-infected mononuclear leukocytes in the pathogenesis of herpetic chorioretini tis of newborn rabbits Y.Ohashi, J.O.Oh and K.-H. Tung-ou SESSION III : Immunology,Vaccination Chairman: C. S. Foster (Boston) The influence of prednisolone on external eye disease, virus proliferation and latent infection in an animal model of herpes simplex keratitis D.L.Easty, A.B.Tullo, C.Shimeld, T.J.Hill and W.A.Blyth Suppressive effect of cyclosporine on the induction of secondary herpes simplex uveitis J.O.Oh, P.Minasi, G.Grabner and Y.Ohasi T-cell subsets in herpes zoster cyclitis T.M.Radda, J.Funder, U.M.Klemen and U.Koller Experimental and clinical preliminary study of immunomodulators in the treatment of ocular herpes J.Denis, T.Hoang-Xuan, J.F.Bonissent, K.Dogbe, C.Clay, D.Viza, F.Rosenfeld,J.Phillips and J.M.Vich Subunit vaccine compared with infection as protection against experimental herpes simplex keratitis B.A.Harney, D.L.Easty and G.R.B.Skinner Immunological aspects and thymic hormone therapy of herpetic keratitis P.Pivetti-Pezzi, P.De Liso, W.Calcatelli,M.C.Sirianni, M.Fiorilli, I.Mezzaroma and L.Palmisano SESSION IV : Clinical Disease Chairman : P. Wright (London) Primary ocular HSV infections in adults C.Ameye, P.C.Maudgal and L.Missotten A case of bilateral herpes simplex eye disease of long duration A.A.Tye

8 IX Differential diagnosis of herpetic keratitis by means of a new electronic optical aesthesiometer J.Draeger, R.Winter and G.Krolzig Lacrimal secretion after herpetic keratitis J.G.Orsoni, M.Bonacini, A.Piccioni andm.c.tomba A computer -based method to provide subspecialist expertise on the management of herpes simplex infections of the eye C.R.Dawson, J Kastner, S.Weiss and C.Kulikowski SESSION V: Antiviral Agents-I Chairman: L.M.T.Collum(Dublin) New antiviral drugs for the treatment of herpesvirus infections E.De Clercq Ocular herpesvirus infections and the development of virus-drug resistance H.J.Field Relevance of viral thymidine kinase for clinical resistance to anti viral drugs when treating herpes simplex eye infections A.R.Karlstrom, C.F.R.Kallander, J.S.Gronowitz and P.J.Wistrand A rapid micromethod for evaluating the sensitivity of ocular herpes simplex strains to anti viral drugs M.Langlois, J.Denis, J.Ph.Allard and M.Aymard A review of acyclovir in the management of herpes simplex infections of the eye P.J.Rees A comparison of the antiherpes activi ties in vi tro and in vivo of foscarnet and mono- and dihydroxybutylguanine "R":"Datema,A.-C.Ericson, A.Larsson, K.Stenberg, A.Nyqvist Mayer, F.Y.Aoki, N.-G.Johansson and B.Oberg SESSION VI : Anti viral Agents-II Chairman: O.P.van Bijsterveld (Utrecht) Acyclovir treatment in stromal herpetic kerati tis R. van Ganswijk, J.A.Oosterhuis and J. Versteeg Antiviral treatment of herpes simplex stromal disease J. I. McGill

9 x Treatment of herpetic kerato-uvei tis; Comparative action of vidarabine, trifluorothymidine and acyclovir in combination with corticoids J.Colin, D.Mazetand C.Chastel Oral acyclovir (Zovirax R ) in herpetic keratitis L. M. T. Collum, P. MacGerrtick, J. Akhtar and P. J Rees A double-blind, dual-centre comparative trial of acyclovir (ZoviraxR) and adenine arabinoside in the treatment of herpes simplex amoeboid ulcers S. O. Hung, A. Patterson, L.M. T. Collum, P. Logan and P.Rees SESSION VII; Antiviral Agents-III Chairman ; E. De Clercq (Leuven) Topical bromovinyldeoxyuridine treatment of herpes simplex keratitis P.C.Maudgal, M.Dieltiens, E.De Clercqand L.Missotten Permeabili ty of the cornea to (1251 ) IVDU, an analogue of bromoviny.ldeoxyuridine A. M. Verbruggen, E. De Clercq, P. C. Maudgal, C. Ameye, R.Busson, R.Bernaerts, M.De Roo and L.Missotten Use of ara-a in herpetic eye diseases ; A review C.Ameye Trifluridine induced corneal epithelium dysplasia P.C.Maudgal, B.VanDamme and L.Missotten Steroid addiction; A complication of use and abuse of steroids in herpes simplex keratitis I.S.Jain, A.Gupta and M.R.Dogra Management of herpetic keratitis by instillation of citreous honey M.H.Emarah SESSION VIII ; Keratoplasty Chairman ;.H.-J.Thiel (TUbingen) Severe herpes simplex keratitis, frequency of complicating cataract, results of corneal grafting M.Rydberg Penetrating keratoplasty in herpetic corneal diseases with perforation or severe stromal keratitis E.G.Weidle, H.-J.Thiel and W.Lish Keratoplasty in herpetic corneal disease H. Knobel, E. N. Hinzpeter and G. O. H. Naumann

10 XI Prevention and treatment of herpes recurrence in the corneal graft with acyclovir C. C. Kok-van Alphen and H. J M. Volker-Dieben The influence of prospective HLA-A and -B matching in 288 penetrating keratoplasties for herpes simplex keratitis H. J. Volker-Dieben, C. C. Kok-van Alphen, J.D'Amaro and P.De Lange SESSION IX : Interferon Chairman: J. Colin (Brest) Interferon treatment of herpetic keratitis G. Smolin Lymphoblast and fibroblast-interferon in a combination therapy of kerati tis dendri tica Chr.Fellinger, M.E.Reich and H.Hofmann Beta interferon cream therapy in periocular herpetic infections A.Romano, M.Revel and T.Doerner Human leukocyte interferon plus trifluorothymidin versus recombinant alpha 2 arg interferon plus trifluorothymidin for therapy of dendri tic keratitis. A controlled clinical study R.Sundmacher, D.Neumann-Haefelin, A.Mattes, W.Merk, G.Adolf and K.Cantell Acyclovir and recombinant human alpha 2 arg interferon treatment for dendritic keratitis P.J.Meurs and O.P.van Bijsterveld SESSION X : Herpes Zoster, Cytomegalovirus Chairman: R.Sundmacher (Freiburg) The acute retinal necrosis syndrome and retinal necrosis associated wi th encephali tis A. Leys, B.De Cnodder and L.Missotten Clinical comparison between herpes simplex and herpes zoster ocular infections R.Ahonen and A.Vannas Corneal complications of herpes zoster ophthalmicus T.J.Liesegang Oral bromovinyldeoxyuridine treatment of herpes zoster ophthalmicus P.C.Maudgal, M.Dieltiens, E.De Clercqand L.Missotten

11 XII Herpes zoster treatment J.I.McGill 413 SESSION XI : General Discussion Chairman: R.Sundmacher (Freiburg) General discussion on the management of herpetic eye diseases P.C.Maudgal Closing remarks P.C.Maudgal List of participants xv

12 XIII WELCOME ADDRESS Ladies and Gentlemen, I feel honoured and proud that you came from so many countries to our university to exchange your cl inical and laboratory experience on herpes virus. This is a mixed meeti ng of ophthalmologists and virologists, clinicians asking questions and learning from people working in the laboratory, and laboratory people looking to the problems expressed by the cl inicians - an example of mutual fecundation of appl ied and fundamental medical science. We owe this meeting to an enthousiastic young man, Dr. Maudgal, who for the first time brought together the Department of Ophthalmology of Dr. Missotten and the Laboratory of Virology of Dr. De Clercq in a collaborative study of herpes infections and who organised this gathering as an extension of this intiative. He is entitled to your gratitude and also to your criticism. Our university wi II be your host for these few days you will spend with us. We have no luxury to offer you in this medieval city, I hope you wi II be able to adapt to its quiet atmosphere and its poor accomodations, that you will relax, far from your own laboratories and clinics, in this old university where for more than 5 centuries scholars from all countries gathered together, just I ike you, to find inspiration to solve their problems. I wish to all of you that your stay with us will be interesting and pleasant. The progress of science is based on the communication of knowledge and communication depends on good relations between people. The contribution of this meeting to a better knowledge of what herpes virus is and does, will depend as much on the friendship that you will develop from living together for three days, as on the quality of the work that will be presented.

13 XIV I hope that you will be successful in realising both and that Leuven will remain an important date for your future work. As a virologist myself, got lost in university administration. I regret very much that cannot stay with you to learn about the latest news in herpes research, it would be more exciting than to run a university. My best wishes for a successfu I meet i ng Professor P. DE SOMER, R e c K.U.Leuven. ~ r