Lymphoproliferative Diseases

Transcription

1 Lymphoproliferative Diseases

2 IMMUNOLOGY AND MEDICINE SERIES Immunology of Endocrine Diseases Editor: A. M. McGregor Clinical Transplantation: Current Practice and Future Prospects Editor: G. R. D. Catto Complement in Health and Disease Editor: K. Whaley Immunological Aspects of Oral Diseases Editor: L. Ivanyi Immunoglobulins in Health and Disease Editor: M. A. H. French Immunology of Malignant Diseases Editors: V. S. Byers and R. W. Baldwin Lymphoproliferative Diseases Editors: D. B. Jones and D. H. Wright Phagocytes and Disease Editors: M. S. Klempner, B. Styrt and J. Ho HLA and Disease Authors: B. Bradley, P. T. Klouda, J. Bidwell and G. Laundy Immunology of Sexually Transmitted Diseases Editor: D. J. M. Wright Lymphocytes in Health and Disease Editors: G. Janossy and P. L. Amiot Mast Cells, Mediators and Disease Editor: S. T. Holgate Immunodeficiency and Disease Editor: A. D. B. Webster Immunology of Pregnancy and its Disorders Editor: C. M. M. Stern Immunotherapy of Disease Editor: T. J. Hamblin Immunology of Prophylactic Immunization Editor: A. J. Zuckerman Immunology of Eye Diseases Editor: S. Lightman Immunology of Renal Diseases Editor: C. D. Pusey Biochemistry of Inflammation Editors: J. T. Whicher and S. W. Evans Immunology of ENT Disorders Editor: G. Scadding Immunology of Infection Editors: J. G. P. Sissons, J. Cohen and L. K. Borysiewicz

3 IMMUNOLOGY SERIES SERIES SERIES SERIES AND SERIES. SERIES SERIES SERIES MEDICINE Volume 15 Lymphoproliferative Diseases Edited by D. B. Jones and D. H. Wright University Department of Pathology Series Editor: K. Whaley KLUWER ACADEMIC PUBLISHERS DORDRECHT/BOSTON/LONDON

4 Distributors for the United States and Canada: Kluwer Academic Publishers, PO Box 358, Accord Station, Hingham, MA , USA for all other countries: Kluwer Academic Publishers Group, Distribution Center, PO Box 322, 3300 AH Dordrecht, The Netherlands British Library Cataloguing in Publication Data Lymphoproliferative diseases. 1. Man. Reticuloendothelial system. Malignant tumours. Immunological aspects I. Jones, D. B. II. Wright, Dennis H. (Dennis Howard), III. Series ' ISBN-13: DOl: / e-isbn -13: by Kluwer Academic Publishers Softcover reprint of the hardcover 1st edition 1990 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers, Kluwer Academic Publishers BV, PO Box 17,3300 AA Dordrecht, The Netherlands. Published in the United Kingdom by Kluwer Academic Publishers, PO Box 55, Lancaster,. Kluwer Academic Publishers BV incorporates the publishing programmes of D. Reidel, Martinus Nijhoff, Dr W. Junk and MTP Press. Typeset by Witwell Ltd, Southport. iv

5 Contents Series Editor's Note List of Contributors vii ix Introduction D. B. Jones and D. H. Wright 2 Diagnosis of leukaemia 5 1. M. Davies and J. C. Cawley 3 The diagnosis and classification of malignant lymphomas 15 D. H. Wright 4 Analysis of immunoglobulin changes in lymphoproliferative diseases 31 J. L. Smith and F. K. Stevenson 5 Immunoenzymatic analysis of haematological and cytological preparation 53 A. K. Ghosh and W. N. Erber 6 Cell-mediated immunity in lymphomas 73 P. L. AmIot 7 The origin of the Reed-Sternberg cell 91 D. B. Jones 8 Chronic-type B-lymphocytic leukaemias lo7 P. Richardson and J. Gordon 9 Malignant lymphoma of mucosa-associated lymphoid tissue 123 P. G. Isaacson and J. Spencer lo T-cell neoplasia 145 A. D. Ramsay and W. J. Smith v

6 11 12 LYMPHOPROLIFERATIVE DISEASES Tumours of the macrophage series Su-Ming Hsu Immunostaining methods for frozen and paraffin sections B. L. Mepham and K. J. M. Britten Index vi

7 Series Editor's Note The interface between Clinical Immunology and other branches of medical practice is frequently blurred and the general physician is frequently faced with clinical problems with an immunological basis and is often expected to diagnose and manage such patients. The rapid expansion of basic and clinical immunology over the past two decades has resulted in the appearance of increasing numbers of immunology journals and it is impossible for a nonspecialist to keep apace with this information overload. The Immunology and Medicine series is designed to present individual topics of immunology in a condensed package of information which can be readily assimilated by the busy clinician or pathologist. K Whaley, Glasgow March,1990 vii

8 List of Contributors P.LAMLOT Department of Immunology Royal Free Hospital, School of Medicine Pond Street London NW32QG K. J. M. BRITTEN University Department of Pathology Level E, S Block J.C.CAWLEY University Department of Haematology Duncan Building Royal Liverpool Hospital Prescot Street P.O. Box 147 Liverpool L69 3BX J.M.DAVIES University Department of Haematology Duncan Building Royal Liverpool Hospital Prescot Street P.O. Box 147 Liverpool L69 3BX W.N.ERBER Haematology Department Royal North Shore Hospital St Leonards Sydney New South Wales 2065 Australia A. K. GHOSH Immunology Department Paterson Institute for Cancer Research Christie Hospital and Holt Radium Institute Wilmslow Road Manchester M20 9BX J.GORDON Department of Immunology University of Birmingham Medical School Vincents Drive Birmingham B15 2T J SU-MING'HSU Department of Pathology P.O. Box University of Texas Houston Texasn225 USA P. G. ISAACSON Department of Histopathology University College and Middlesex School of Medicine University Street London WC1 E 6JJ D.B.JONES University Pathology Level E, South Block HantS094XY ix

9 LYMPHOPROLIFERATIVE DISEASES B. L. MEPHAN University Pathology Level E, South Block A.D. RAMSAY Department of Histopathology P. RICHARDSON Department of Immunology University of Birmingham Medical School Vincents Drive Edgbaston Birmingham B15 2T J J. L.SMITH Regional Immunology Service Tenovus Research Laboratory W. J. SMITH Department of Histopathology University College and Middlesex School of Medicine University Street London WC1 E 6JJ J.SPENCER Department of Histopathology University College and Middlesex School of Medicine University Street London WC1 E 6JJ F. K. STEVENSON Regional Immllnology Service Tenovus Research Laboratory HantS094XY D.H. WRIGHT University Department of Pathology x