Fodazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi INGM

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1 E UROPEAN CURRICULUM VITAE FORMAT PERSONAL INFORMATION Name Address GEGINAT, JENS ALBRECHT ERNST VIA FRANCESCO SFORZA 35, MILANO, ITALY Telephone Fax Nationality GERMAN, ITALIAN Date of birth 12 OCTOBER 1968 WORK EXPERIENCE Dates (from to) Name and address of employer Type of business or sector Occupation or position held Main activities and responsibilities present Fodazione Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi INGM Non-profit Research Organization Principal Investigator Head Autoimmunity lab Head FACS facility Dates (from to) Name and address of employer Charité Universitätsmedizin Berlin, DRFZ, Charitéplatz 1, Berlin, Germany Occupation or position held Junior Group Leader Main activities and responsibilities Head Cellular Immunology lab Dates (from to) Name and address of employer Institute for Research in Biomedicine IRB, Via Vela 6, Bellinzona Switzerland Occupation or position held Scientist Main activities and responsibilities Research: Maintenance and generation of memory T-cell subsets Dates (from to) Name and address of employer Basel Institute for Immunology, Grenzacherstrasse 487, Basel, Switzerland Occupation or position held Visiting Scientist Main activities and responsibilities Research: Maintenance of memory T-cell subsets Dates (from to) Name and address of employer San Raffaele Scientific Instiute, Dipartmento Biotecnolgie (DIBIT), Via Olgettina 58, Milano, Italy Occupation or position held Ph.D student Main activities and responsibilities Research: Interdependence between adhesion and proliferation of human T-lymphocytes Page 1 - Curriculum vitae of

2 Dates (from to) Name and address of employer Istituto Tumori, Advanced Biotechnolgy Center, San Martimno Hospital, Genoa, Italy Occupation or position held Diploma student Main activities and Research: Identification of a human thymocyte antigen as a glyco-epitope of CD43 responsibilities EDUCATION AND TRAINING Dates (from to) Name and type of organisation Charité Universitätsmedizin Berlin Principal subjects/occupational Teaching and Research Title of qualification awarded Habilitation in Immunology Level in national classification n/a Dates (from to) Name and type of organisation Freie Universität Berlin Principal subjects/occupational Ph.D research project Title of qualification awarded Ph.D (Dr. rer. nat.) Level in national classification magna cum laude Dates (from to) Name and type of organisation Freie Universität Berlin Principal subjects/occupational Study and experimental thesis Title of qualification awarded Dipl.-Biochem. Level in national classification very Page 2 - Curriculum vitae of

3 PERSONAL SKILLS AND COMPETENCES Acquired in the course of life and career but not necessarily covered by formal certificates and diplomas. MOTHER TONGUE GERMAN OTHER LANGUAGES ENGLISH ITALIAN FRENCH Page 3 - Curriculum vitae of

4 PUBLICATIONS : Author of 36 publications in peer-reviewed Scientific Journals, 27 Research articles (mean IF: 12.5) and 9 Review articles (mean IF: 9.4) ; >4.500 citations, H-Index : 20 (Scopus), Major Publications (as corresponding or senior author): 16. IL-10 producing Foxp3 - regulatory T-cells inhibit B-cell responses and are involved in systemic lupus erythematosus. F. Facciotti, N. Gagliani*, B. Häringer*, J. S. Alfen*, A. Penatti, S. Maglie, M. Paroni, A. Iseppon, M. Moro, M.C. Crosti, K. Stölzel, C. Romagnani, G. Moroni, F. Ingegnoli, S. Torretta, L. Pignataro, A. Annoni, F. Russo, M. Pagani, S. Abrignani, PL. Meroni, R.A. Flavell and J. Geginat. Journal of Allergy and Clinical Immunology (1): (IF ) 15. Immunity to pathogens taught by specialized human dendritic cell subsets J. Geginat, G. Nizzoli, M. Paroni, S. Maglie, J. P. Larghi, S. Pascolo, S. Abrignani Frontiers in Immunology, 2015, 6: Signal strength and metabolic requirements control cytokine-induced Th17 differentiation of uncommitted human T cells. I. Kastirr*, M.C. Crosti*, S. Maglie, M. Paroni, B. Steckel, M. Moro, M. Pagani, S. Abrignani and J. Geginat. The Journal of Immunology, 2015, 195, (8): (IF ) 13. IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells. I. Kastirr, S. Maglie, M. Paroni, J.S. Alfen, G. Nizzoli, E. Sugliano, MC. Crosti, M. Moro, B. Steckel, S. Steinfelder, K. Stölzel, C. Romagnani, F. Botti, F. Caprioli, M. Pagani, S. Abrignani, J. Geginat. The Journal of Immunology 2014, 193(7): (IF ) 12. Plasticity of human CD4 T cell subsets J. Geginat, M. Paroni, S. Maglie, J. S. Alfen, I. Kastirr, P. Gruarin, M. De Simone, M. Pagani, S. Abrignani Frontiers in Immunology, 2014, 5: Human CD1c + dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T cell responses G. Nizzoli, J. Krietsch*, A. Weick*, S. Steinfelder*, F. Facciotti, P.Gruarin, A. Bianco, B. Steckel, M. Moro, M.C. Crosti 1, C. Romagnani, K. Stölzel, S. Torretta, L. Pignataro, C. Scheibenbogen, P. Neddermann, R. DeFrancesco, S. Abrignani, J. Geginat Blood, 2013, 122(6): (IF ) 10. The CD4-centred universe of human T cell subsets J. Geginat, M. Paroni, F. Facciotti, P. Gruarin, I. Kastirr, F. Capriolo, M. Pagani, S. Abrignani. Seminars in Immunology 2013, 25(4): (IF ) 9. Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. S. Steinfelder, S. Floess, U. Baron, L. Rivino, B. Häringer, B. Steckel, A. Gruetzkau, S. Olek, J. Geginat, J. Hühn, and A. Hamann ( equal contributions) Blood, 2011, 117(10): (IF ) 8. CCR6 is expressed on an IL-10 producing, auto-reactive memory T cell population with context-dependent regulatory function Page 4 - Curriculum vitae of

5 L. Rivino, P. Gruarin, B. Häringer, S. Steinfelder, L. Lozza, E. Sugliano, A. Weick, D. Jarrossay, A. Kuehl, C. Loddenkemper, S. Abrignani, F. Sallusto, A. Lanzavecchia and J. Geginat The Journal of Experimental Medicine, 2010, 207(3): (IF ) 7. Biology of Interleukin-10 R. Sabat, G. Grütz, K.Warszawska, S. Kirsch, E.Witte, K. Wolk and J. Geginat. Cytokine and Growth Factor Reviews 2010, 21(5): (IF ) 6. Identification and characterization of IL-10/IFN-γ producing effector-like cells with regulatory function in human blood B. Häringer, L. Lozza, B. Steckel, and J. Geginat The Journal of Experimental Medicine, 2009, 2006(5): (IF ) 5. The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion and lineage commitment of primed human CD4 + IL-7R hi T cells L. Lozza, L. Rivino, F G. Guarda, D. Jarossay, A. Rinaldi,. Bertoni, F. Sallusto, A. Lanzavecchia and J. Geginat European Journal of Immunology (Highlights) (1): (IF ) 4. Chemokine receptor expression identifies pre-th1, pre-th2 and non-polarized cells among human CD4 + central memory T cells. L. Rivino, M. Messi, D. Jarrossay, Antonio Lanzavecchia, Federica Sallusto and J. Geginat The Journal of Experimental Medicine 2004, 200(6): (IF ) 3. T cell fitness determined by signal strength. A. Gett, F. Sallusto, A. Lanzavecchia and J. Geginat Nature Immunology 2003, 4(4): (IF ) 2. Proliferation and differentiation potential of human CD8 + memory T cell subsets in response to antigen or homeostatic cytokines. J. Geginat, A. Lanzavecchia and F. Sallusto Blood 2003, 101(11): (IF ) 1. Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4 + T cells. J. Geginat, F. Sallusto and A. Lanzavecchia The Journal of Experimental Medicine 2001, 194(12): (IF ) Page 5 - Curriculum vitae of