Site Map. Manhica HDSS, Mozambique

Transcription

1 Site Map Manhica HDSS, Mozambique

2 Brief Introduction to Manhiça HDSS The Manhiça Health Research Center (Centro de Investigação em saúde de Manhiça, CISM in Portuguese) was established in 1996 as part of a joint collaborative program between the governments of Spain and Mozambique. It is represented by the National Institute of Health, the Ministry of Health of Mozambique and by the Spanish Agency for International Cooperation, the Fundació Clinic of Barcelona and the University of Barcelona in Spain. The CISM is one of the few research centers located in rural settings in Africa and has become in recent years one of the leading biomedical research organizations in the continent. The Manhiça Health Research Centre is located in the district of Manhiça (Maputo Province) in southern Mozambique, 80 kms north of Maputo City, the capital of Mozambique. Manhiça is a little village located in a plain area, surrounded by Inkomati River, and it has an extension of 2.500km² where near people live. CISM runs a Demographic and Health Surveillance System (HDSS) in Manhica district. This surveillance started with a baseline census carried out in late 1996, which covered at that time an area of 100 km 2 and registered a total of 32,500 inhabitants. In 2002 the DSA was extended to include Mantchiana, Palmeira and Ilha Josina in the North of the original area. In January 2005, the locality of Taninga (north of Palmeira and south of Ilha Josina) was incorporated into the DSA, increasing the area for 500 km 2. In mid 2010, the population under HDSS was about 90,000 inhabitants. Mission: The mission of CISM is to conduct biomedical research in health priority areas to protect and improve the population s health. Vision: The vision is to be a center of excellence in biomedical research that generates evidence to guide public health policy in Mozambique and other countries in the world.

3 Population pyramid, Manhiça HDSS Homens Mulheres Demographic Characteristics 2010 Mortality 2010 Indicator Infant Mortality Rate (IMR) Early neonatal MR Late neonatal MR Neonatal MR Under five mortality (5q0) Maternal Mortality Ratio Crude death rate Rate 58.8 per 1000 live births 17.2 per 1000 live births 4.5 per 1000 live births 21.6 per 1000 live births per 1000 live births 3.6 per 1000 live births 15.3 per 1000 population

4 Rate per 1000 live births Age Life expectancy Life expectancy Males Females Years Mortality Mortality Years Infant mortality rate Under five mortality rate (5q0) Neonatal mortality rate

5 Fertility 2010 Indicator Abortion Ratio Still birth Ratio Crude Birth Rate Total fertility rate Rate of Natural Increase Rate 21.7 per 1000 live births 24.8 per 1000 live births 42.3 per 1000 population 5.5 per woman 27 per 1000 population Age specific fertility rate per 1000 in Age specific fertility rate per Age specific fertility rate per 1000 Migration 2010 Migration Crude external out-migration rate Crude external in-migration rate Crude internal migration rate Rate per 1000 pyrs, 75.7 per 1000 pyrs, 69.8 per 1000 pyrs,

6 Priority Research Areas Malaria HIV/AIDS, Pneumonia and Social Science Tuberculosis, assessment and evaluation Diarrheal diseases Maternal and reproductive health FUNDERS Core funding: Spanish Agency for International Cooperation and development(aecid) Ministry of Health, Mozambique Fundació Clinic - University of Barcelona Other funding bodies: Africa Viva Fundación Agència Catalana de Cooperació al Desenvolupament (ACCD) Bill & Melinda Gates Foundation European and Developing Countries Clinical Trials Partnership (EDCTP) Fondo de Investigación Sanitaria (FIS), Instituto de Salud Carlos III Fundació la Caixa GlaxoSmithKline Biologicals International Union Against Tuberculosis and Lung Disease Malaria Clinical Trials Alliance (MCTA) World Health Organization (WHO) PATH Malaria Vaccine Initiative (MVI) Pathfinder International PneumoADIP The Hib Initiative European Union COLLABORATORS Aeras Global TB Vaccine Foundation (USA) Africa Centre for Health and Population Studies (South Africa) Medical Research Unit Albert Schweitzer Hospital (Gabon) Center for Vaccine Development, University of Maryland School of Medicine (USA) Centers for Disease Control and Prevention CDC (USA) Centre de Recerca en Salut Internacional de Barcelona CRESIB (Spain) Centre for Poverty-Related Communicable Diseases (Holland) Centre Hospitalier Universitaire Vaudois, Division of Immunology and Allergy (Switzerland) Contract Laboratory Services CLS (South Africa)

7 Direcção Provincial de Saúde de Maputo DPS (Mozambique) Division of Infectious Diseases, University of Colorado Health Sciences Center (USA) EuroVacc Foundation (Switzerland) Fundação para o Desenvolvimento da Comunidade FDC (Mozambique) GlaxoSmithKline Biologicals (Belgium) HIV Prevention Research Unit, Medical Research Council South Africa (South Africa) Hospital Central de Maputo (Mozambique) Hospital Clínic (Spain) Ifakara Health Institute (Tanzania) Imperial College London (United Kingdom) Institute for Medical Microbiology and Hygiene, Universität Regensburg (Germany) Institute of Tropical Medicine Antwerp (Belgium) Instituto Nacional de Estadística INE (Mozambique) Instituto Nacional de Saúde INS (Mozambique) Instituto Superior de Ciências de Saúde ISCISA (Mozambique) International Center for Genetic Engineering and Biotechnology (India) International Network of Field Sites with Continuous Demographic Evaluation of Populations INDEPTH (Ghana) International Partnership for Microbicides (USA) Johns Hopkins Bloomberg School of Public Health (USA) CDC/Kenya Medical Research Institute KEMRI (Kenya) KNCV Tuberculosis Foundation

8 KEY PUBLICATIONS Almeida, J., E. Letang, T. Nhampossa, E. Ayala, C. David, C. Menendez, J. Gascon, P. Alonso, and D. Naniche. "Rapid suppression of HIV-RNA is associated with improved control of immune activation in a Mozambican adults initiating antiretroviral therapy with low CD4 counts." AIDS Res Hum Retroviruses (2011): Alonso, P. L., G. Brown, M. Arevalo-Herrera, F. Binka, C. Chitnis, F. Collins, O. K. Doumbo, B. Greenwood, B. F. Hall, M. M. Levine, K. Mendis, R. D. Newman, C. V. Plowe, M. H. Rodriguez, R. Sinden, L. Slutsker, and M. Tanner. A research agenda to underpin malaria eradication. Vol. 8., Bardaji, A., B. Sigauque, S. Sanz, M. Maixenchs, J. Ordi, J. J. Aponte, S. Mabunda, P. L. Alonso, and C. Menendez. "Impact of malaria at the end of pregnancy on infant mortality and morbidity." J Infect Dis (2011): Berthoud, T. K., M. N. Manaca, D. Quelhas, R. Aguilar, C. Guinovart, L. Puyol, A. Barbosa, P. L. Alonso, and C. Dobaño. "Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology." Malar J (2011): 115. Borrmann, S., W. M. Sallas, S. Machevo, R. Gonzalez, A. Bjorkman, A. Martensson, M. Hamel, E. Juma, J. Peshu, B. Ogutu, A. Djimde, D'Alessandro U, A. C. Marrast, G. Lefevre, and S. E. Kern. "The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria." Trop Med Int Health (2010). Menendez, C., A. Bardaji, B. Sigauque, S. Sanz, J. J. Aponte, S. Mabunda, and P. L. Alonso. "Malaria prevention with IPTp during pregnancy reduces neonatal mortality." PLoS One. 5.2 (2010): e9438. Montgomery, C. M., K. Munguambe, and R. Pool. "Group-based citizenship in the acceptance of indoor residual spraying (IRS) for malaria control in Mozambique." Soc Sci Med (2010). Serra-Casas, E., C. Menendez, A. Bardaji, L. Quinto, C. Dobano, B.Sigauque, A. Jimenez, I. Mandomando, V. S. Chauhan, C. E. Chitnis, P. L. Alonso, and A. Mayor. "The Effect of Intermittent Preventive Treatment during Pregnancy on Malarial Antibodies Depends on HIV Status and Is Not Associated with Poor Delivery Outcomes." J Infect Dis (2010):

9 Valles, X., A. Roca, F. Lozano, L. Morais, B. Suarez, F. Casals, I. Mandomando, B. Sigauque, D. Nhalungo, C. Esquinas, L. Quinto, P. L. Alonso, and A. Torres. "Serotypespecific pneumococcal disease may be influenced by MBL-deficiency." Eur Respir J (2010). Guinovart, C., J. J. Aponte, J. Sacarlal, P. Aide, A. Leach, Q. Bassat, E. Macete, C. Dobano, M. Lievens, C. Loucq, W. R. Ballou, J. Cohen, and P. L. Alonso. "Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children." PLoS ONE. 4.4 (2009): e5165. Roca, A., Q. Bassat, L. Morais, S. Machevo, B. Sigauque, C. O'Callaghan, T. Nhamposa, E. Letang, I. Mandomando, D. Nhalungo, L. Quinto, and P. Alonso. "Surveillance of acute bacterial meningitis among children admitted to a district hospital in rural Mozambique." Clin Infect Dis. 48 Suppl 2 (2009): S Sacarlal, J., A. Q. Nhacolo, B. Sigauque, D. A. Nhalungo, F. Abacassamo, C. N. Sacoor, P. Aide, S. Machevo, T. Nhampossa, E. V. Macete, Q. Bassat, C. David, A. Bardaji, E. Letang, F. Saute, J. J. Aponte, R. Thompson, and P. L. Alonso. "A 10 year study of the cause of death in children under 15 years in Manhica, Mozambique." BMC Public Health. 9 (2009): 67. Sigauque, B., A. Roca, I. Mandomando, L. Morais, L. Quinto, J. Sacarlal, E. Macete, T. Nhamposa, S. Machevo, P. Aide, Q. Bassat, A. Bardaji, D. Nhalungo, M. Soriano-Gabarro, B. Flannery, C. Menendez, M. M. Levine, and P. L. Alonso. "Community-Acquired Bacteremia Among Children Admitted to a Rural Hospital in Mozambique." Pediatr Infect Dis J (2009): Bassat, Q.; Mulenga, M.; Tinto, H.; Piola, P.; Borrmann, S.; Menendez, C.; Nambozi, M.; Valea, I.; Nabasumba, C.; Sasi, P.; Bacchieri, A.; Corsi, M.; Ubben, D.; Talisuna, A.; D'Alessandro U (2009) 'Dihydroartemisinin-Piperaquine and Artemether-Lumefantrine for Treating Uncomplicated Malaria in African Children: A Randomised, Non-Inferiority Trial'. PLoS One 4(11):e7871. Grobusch, M.P.; Gabor, J.J.; Aponte, J.J.; Schwarz, N.G.; Poetschke, M.; Doernemann, J.; Schuster, K.; Koester, K.B.; Profanter, K.; Borchert, L.B.; Kurth, F.; Pongratz, P.; Issifou, S.; Lell, B.; Kremsner, P.G. (2009) 'No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon'. J Infect Dis 200(11):

10 Manhiça Field Supervisors 2008 Field worker collecting data from a household member