Acknowledgements Table of Contents About CIPHER CIPHER Paediatric Cohort Consultation Consultation Objectives...
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2 ACKNOWLEDGEMENTS
3 TABLE OF CONTENTS Acknowledgements... 1 Table of Contents... 2 About CIPHER... 4 CIPHER Paediatric Cohort Consultation... 5 Consultation Objectives... 5 Overview: Research Gaps... 5 Cohort Summaries... 7 Médecins sans Frontières Epicentre... 7 Baylor International Pediatric AIDS Initiative (BIPAI)... 8 Pediatric AIDS Clinical Trials Group (PACTG)/International Maternal Adolescent AIDS Clinical Trials Group (IMPAACT)... 9 Pediatric HIV/AIDS Cohort Study (PHACS) Optimal Models for HIV Care in Africa European Pregnancy and Paediatric HIV Cohort Collaboration [EPPICC] EPPICC: Eastern Europe International Epidemiological Databases to Evaluate AIDS (IeDEA) IeDEA Southern Africa IeDEA Central Africa IeDEA West Africa IeDEA East Africa TREAT Asia Paediatric HIV Observational Database: TApHOD IeDEA Asia-Pacific Caribbean, Central and South America Network for HIV Epidemiology (CCASAnet) Chair s Summary Research Priorities Research Priorities: Breakout Group Research Priorities: Breakout Group Research Priorities: Breakout Group Consensus Research Priorities Mechanism for Addressing Research Priorities... 23
4 Proposed Mechanism: Breakout Group Proposed Mechanism: Breakout Group Consensus: Collaborative Mechanism CIPHER Online Database Next Steps Annex 1: Paediatric Cohort Consultation Participants Annex 2: Breakout Group Participants Bibliography... 31
5 ABOUT CIPHER
6 CIPHER PAEDIATRIC COHORT CONSULTATION CONSULTATION OBJECTIVES OVERVIEW: RESEARCH GAPS
7 Retention and transition to adult-based care: 1 Two ART regimens (PI+2 NRTIs or an NNRTI + 2 NRTIs) and two VL switch thresholds (>1,000 copies/mm 3 or >30,000 copies/mm 3 ) comprised the four arms of this study.
8 COHORT SUMMARIES MÉDECINS SANS FRONTIÈRES EPICENTRE
9 BAYLOR INTERNATIONAL PEDIATRIC AIDS INITIATIVE (BIPAI)
10 PEDIATRIC AIDS CLINICAL TRIALS GROUP (PACTG)/INTERNATIONAL MATERNAL ADOLESCENT AIDS CLINICAL TRIALS GROUP (IMPAACT)
11 PEDIATRIC HIV/AIDS COHORT STUDY (PHACS) OPTIMAL MODELS FOR HIV CARE IN AFRICA
12 o o o EUROPEAN PREGNANCY AND PAEDIATRIC HIV COHORT COLLABORATION [EPPICC]
13 EPPICC: EASTERN EUROPE INTERNATIONAL EPIDEMIOLOGICAL DATABASES TO EVALUATE AIDS (IEDEA)
14 IEDEA SOUTHERN AFRICA
15 IEDEA CENTRAL AFRICA IEDEA WEST AFRICA
16 IEDEA EAST AFRICA TREAT ASIA PAEDIATRIC HIV OBSERVATIONAL DATABASE: TAPHOD IEDEA ASIA-PACIFIC
17 CARIBBEAN, CENTRAL AND SOUTH AMERICA NETWORK FOR HIV EPIDEMIOLOGY (CCASANET) CHAIR S SUMMARY
18
19 RESEARCH PRIORITIES RESEARCH PRIORITIES: BREAKOUT GROUP 1
20 RESEARCH PRIORITIES: BREAKOUT GROUP 2
21
22 RESEARCH PRIORITIES: BREAKOUT GROUP 3 CONSENSUS RESEARCH PRIORITIES
23
24 MECHANISM FOR ADDRESSING RESEARCH PRIORITIES PROPOSED MECHANISM: BREAKOUT GROUP 1 PROPOSED MECHANISM: BREAKOUT GROUP 2
25 CONSENSUS: COLLABORATIVE MECHANISM
26
27 CIPHER ONLINE DATABASE
28 NEXT STEPS
29 ANNEX 1: PAEDIATRIC COHORT CONSULTATION PARTICIPANTS Last Name First Name Affiliation Abrams Elaine Columbia University, Mailman School of Public Health, USA Ananworanich Jintanat Thai Red Cross AIDS Research Centre, Thailand Bekker Linda-Gail Desmond Tutu HIV Centre, University of Cape Town, South Africa Calles Nancy Baylor International Pediatric AIDS Initiative, USA Collins Jeannie Medical Research Council Clinical Trials Unit, UK Cotton Mark Stellenbosch Children's Hospital, South Africa Dabis François INSERM, Université Victor Segalen Bordeaux, France Davies Mary-Ann University of Cape Town, South Africa Duong Trinh Medical Research Council, Clinical Trials Unit, UK Essajee Shaffiq Clinton Health Access Initiative, USA Giaquinto Carlo Department of Paediatrics, Padua University, Italy Gibb Diana Medical Research Council, Clinical Trials Unit, UK Hazra Rohan US National Institutes of Health, NICHD, USA Heidari Shirin International AIDS Society, Switzerland Judd Ali Medical Research Council Clinical Trials Unit, UK Kort Rodney Consultant, Canada Leroy Valériane INSERM, Université Victor Segalen Bordeaux, France
30 Mofenson Lynne US National Institutes of Health, NICHD, USA Paul Mary Baylor International Pediatric AIDS Initiative, USA Pinto Jorge School of Medicine, Federal University of Minas Gerias, Brasil Seage George Harvard School of Public Health, USA Sohn Annette TREAT Asia/amfAR, Thailand Sorensen Carina International AIDS Society, Switzerland Szumilin Elisabeth Médecins Sans Frontières, France Thorne Claire Medical Research Council Centre of Epidemiology for Child Health, UK Turkova Anna PENTA, Medical Consultant Coordinator for Eastern Europe, UK Van Dyke Russel Tulane University Health Sciences Center, USA Vicari Marissa International AIDS Society, Switzerland Wools- Kaloustian Kara Indiana University School of Medicine, USA Yotebieng Marcel University of North Carolina at Chapel Hill, School of Global Public Health, USA
31 ANNEX 2: BREAKOUT GROUP PARTICIPANTS * Group chair
32 BIBLIOGRAPHY
33
Intira Jeannie Collins, Ruth Goodall, Colette Smith and Kara Wools-Kaloustian for the CIPHER Duration of First-Line Project Team.
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