Functional Blood Chemistry & CBC Analysis
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1 Functional Blood Chemistry & CBC Analysis Session 11 Immune Markers Immune Dysfunctions Immune Deficiency, Allergies, Immune Over Activity Causes of Immune Dysregulation External Influences Pharmaceutical drugs Toxins Nutrient deficiencies Functional disturbances of the GI tract Systemic infections Poor genetics Hormonal imbalance Stress Poor detoxification and excretion 1
2 Causes of Immune Dysregulation Internal Reserve Capacity Good genetics Optimal digestion, absorption and excretion Optimal nutritional status Optimal liver function Optimal neuro endocrine regulation Structural integrity Free from stress, anxiety and worry Checks and Balances Checks and Balances 2
3 Epstein Barr Virus (EBV) Cytomegalovirus (CMV) Herpes simplex I and II Human Herpes virus VI Candia albicans Other viruses Parasites Bacteria Invading Pathogens Underlying Causative Factors Lifestyle factors GI Dysfunction Liver Toxicity Environmental exposure Dental infections Emotional and Social Factors Underlying Causative Factors: Lifestyle Factors Stress Diet Trans fats Sugar Nutrient deficiencies Smoking Sleep deprivation 3
4 Underlying Causative Factors: GI Dysfunctions Abnormal Mucosal Barrier Function Intestinal Hyperpermeability Secretory IgA dysfunction Dysbiosis Underlying Causative Factors: Others Liver Toxicity Environmental and other influences Dental infections Emotional and Social Factors Immune Dysfunctions Immune Deficiency Chronic Bacterial and Viral Infections, e.g. CFIDS Allergies Immune Disorders Allergic Rhinitis Asthma Eczema 4
5 Immune Deficiency: CFIDS/CFS Symptoms Causes Associated Viruses EBV CMV HSV I & II HHV VI Allergies, Sensitivities, Intolerances Is it that my patient is allergic to particular substances or has the internal environment of my patient s body gotten to a state where it is now reacting to these substances? Common Immune Dysfunctions Allergic Rhinitis Asthma Eczema 5
6 Common Immune Disorders: Functional Diagnostic Medicine Approach Gastrointestinal dysfunction Abnormal intestinal mucosal barrier function Food allergies Nutrient deficiencies Adrenal dysfunction Liver toxicity Environmental toxicity Stress Sleep problems Functional Diagnosis of Immune System and Allergies The Big Ideas to Improve Immune Function Identify and remove the stressors that impact the immune system Strengthen the weaknesses Optimize GI function Optimize digestion and absorption of all nutrients Optimize blood sugar regulation Optimize neuroendocrine function 6
7 Primary FDM Testing Signs and Symptoms Analysis Signs and Symptoms Symptoms Runny or drippy nose Catch colds at the beginning of winter Mucus producing cough Frequent infections Never get sick Acne (adult) Itchy skin / dermatitis Cysts, boils, rashes History of chronic viral conditions Signs Eczema Itchy ears White matter on tympanic membrane Follicular hyperkeratosis Slow wound healing Hang nails and cuticle inflammation White spots on finger nails Conjunctivitis Primary FDM Testing Findings on Blood Chemistry Analysis 7
8 Immune Insufficiency Decreased albumin levels (<4.0 or 40g/L) A decreased total globulin (< 2.0 or 20 g/l) A decreased total white blood cell count (<5.5) Immune Activation An increased level of total globulins (>2.8 or 28 g/l) Decreased albumin/globulin ratio (<1.5) Thymus Abnormality Elevated bilirubin (>1.2 or >20.5 mol/dl) Increased HGB (>14.5 or 145 g/l in women or 15 or 150 g/l in men) Increased HCT (>44 or 0.44 in women and >48 or 0.48 in men) Increased RBCs (>4.5 in women and >4.9 in men) Zinc Deficiency/Insufficiency Decreased levels of Alkaline Phosphatase (<70) have beenassociated with zinc deficiency. Decreased WBC levels (<5.5) You may also see decreased WBC and/or RBC zinc levels Follow up a decreased alkaline phosphatase with a zinc taste test. 8
9 Blood Test Patterns for Infections Acute Bacterial Infection Neutrophils will tend to be increased (>65). Decreased or normal lymphocyte count (<24) Total WBC count may be elevated (>7.5) An increased neutrophils count (>60) and normal lymphocytes = an acute bacterial picture. Blood Test Patterns for Infections Chronic Bacterial Infection An increased neutrophil count (>60) Decreased WBC (<5.5) Lymphocytes may be decreased (<24) Increased monocytes (>7) in the recovery phase. Blood Test Patterns for Infections Acute Viral Infection Lymphocytes willbe increased (>44) Increased total WBC (>7.5) count Possible increased ESR (>5 men, >10 women) Possible increased LDH (>200) Decreased or normal neutrophils (<40) 9
10 Blood Test Patterns for Infections Chronic Viral Infection Increased lymphocytes (>44) Decreased total WBC count (<5.5) 5) Expect to see decreased neutrophils (<40) May see a decreased lymphocyte count (<20) in very chronic infections Recovery Phase of Infection Monocytes will often be elevated (>7) Primary FDM Assessment Allergies, Sensitivities and Intolerances Miscellaneous Symptoms of Food Allergies Arrhythmia Edema Fainting Fatigue Headache Hypoglycemia Itchy nose or throat Migraines Sinusitis Dizziness Canker sores Constipation Hemorrhoids Hypertension Gallbladder pain Colitis Weight gain 10
11 Symptoms Associated with Food Allergies SYSTEM GI Genitourinary Immune Mental/ Emotional SYMPTOMS and DISEASE Canker sores, celiac disease, chronic diarrhea, duodenal ulcer, gastritis, IBS, malabsorption, UC. Bed-wetting, chronic bladder infection, nephrosis Chronic infections, frequent ear infections Anxiety, depression, hyperactivity, inability to concentrate, insomnia, irritability, mental confusion, personality changes, seizures Musculoskeletal Respiratory Skin Bursitis, joint pain, low back pain Asthma, chronic bronchitis, wheezing Acne, eczema, hives, itching, skin rash Nutritional Exam Findings Adult acne and Acne Sores inside the nose rosacea Scars on tympanic Salute sign membrane Intranasal polyps Generalized itching Red rash over nose Discoloration of nails and under eyes Dark circles under eyes Conjunctivitis Geographic tongue Recurrent styes Scalloped tongue Primary FDM Testing Findings on Blood Chemistry Analysis 11
12 Allergies Lab Range Optimal Range Eosinophils 0 7% <3% Basophils 0 2% 0 1% Summary 12
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