FDM Training Program: Mod 3: FDMT 521A-Dysfunctions of the Immune System Wayne L. Sodano, D.C., D.A.B.C.I. & Ron Grisanti, D.C., D.A.B.C.O., M.S.

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1 Functional Diagnostic Medicine Training Program Module 3 * FDMT 521A Dysfunctions of the Immune System Dr. Wayne L. Sodano, D.C., D.A.B.C.I. & Dr. Ron Grisanti, D.C., D.A.B.C.O., M.S. Th1/Th2 Balance T Helper Cell Th1 Th2 Cytotoxic T Cell B Cell IgG Macrophage Eosinophil Mast Cell Basophil B Cell lge, IgA, IgG, IgM 1

2 Substances That Balance the Immune System Nutrients and other orthomolecular substances that modify (balance)the immune system: Melatonin DHEA (dehydroepiandrosterone) Progesterone Selenium Zinc Probiotics Phytochemial: Phytosterols and Sterolins Essential Fatty Acids See Insiders Guide Article: Th1/Th2 Balance: The Hypothesis, its Limitations, and Implications for Health & Disease Categories of Immune Dysfunction Two categories of immune dysfunction have been described: underactive overactive Causes of Immune Dysfunction Deleterious external influences on the immune system Nutritional deficiencies Pharmaceuticals Gastrointestinal dysbiosis Environmental toxins Food sensitivity, food allergy, food intolerance Liver dysfunction Systemic infections Elevated stress levels Lack of exercise Free radical damage Hormonal imbalances 2

3 Signs and Symptoms of Immune Dysfunction Chronic Runny Nose (indications) Frequent colds Chronic lung congestion Itchy skin/dermatitis/cysts/boils/rashes Chronic infections History of: autoimmune disease chronic fatigue syndrome fibromyalgia chronic fatigue and immune deficiency syndrome (CFIDS) Adverse Food Reactions Food allergies have the potential for contributingto immune dysfunction and well as being the resultof a dysfunctional immune system. Food allergies cause immune dysfunction by the following mechanisms: Stimulation of cytokine release Immune complex formation and deposition Damage to the intestinal lining Molecular mimicry (structures similar to human molecules cause a cross-reacting immune response) See Insiders Guide article: Food Allergies and Other Food Sensitivities Dysbiosis Some of the mechanisms of disease induced by microorganisms are: Molecular mimicry Endotoxins from bacteria Immune-complex formation and deposition Damage to the intestinal lining 3

4 Conditions that Suggest Dysbiosis Food allergies Ankylosing Spondylitis Crohn s disease IBS Rheumatoid arthritis Eczema Psoriasis Colon cancer External Toxins Can Cause Immune Dysregulation Food additives Pesticides Prescription drugs Herbicides Toxic metals Petrochemicals Out gassing from plastics Chemotherapy GMO (genetically modified foods) The Important Role of Zinc Stabilizes DNA-binding protein Synthesis of collagen Needed for thymic hormone Reproduction, taste,vision and vitamin A metabolism Needed for serotonin, sex hormone and insulin production Needed for some digestive enzymes See Insiders Guide article: Thymulin and zinc contents of the thymus glands of malnourished children 4

5 Zinc Taste Test Finding Grade Interpretation No taste (tastes like water) 1 Marked zinc deficiency No immediate taste though a vague taste develops over time Slight initial taste that becomes stronger over time: may be unpleasant Very strong, unpleasant and immediate taste 2 Moderate zinc deficiency 3 Mild zinc deficiency 4 Zinc sufficient Next Lesson Secretory IgA 5