Trade Name: ZINC CHLORIDE, MOLECULAR BIOLOGY REAGENT, Z0173 MSDS Date: 01/01/1999 Tech Review:

Transcription

1 Trade Name: ZINC CHLORIDE, MOLECULAR BIOLOGY REAGENT, Z0173 MSDS Date: 01/01/1999 Tech Review: General Information Company: SIGMA CHEMICAL CO PO Box: City: ST LOUIS State: MO Zip: Country: US Info Phone Number: Emergency Phone Number: Other company information: Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: City: ST LOUIS State: MO Zip: Country: US Info Phone Number: Other information: Ingredients Cas: RTECS #: ZH Name: ZINC CHLORIDE = Wt: 100. Other REC Limits: N/K (FP N) OSHA PEL: 1 MG/M3 OSHA STEL: N/K (FP N) ACGIH TLV: 1 MG/M3 ACGIH STEL: 2 MG/M3 EPA Rpt Qty: 1000 LBS DOT Rpt Qty: 1000 LBS Health Hazards Data

2 LD50 LC50 Mixture: SEE TOXICOLOGICAL INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Health Hazards Acute And Chronic: ACUTE: HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED/ABSORBED THRU SKIN. MATL IS EXTREMELY DESTRUCTIVE TO TISS OF MUC MEMBS & UPPER RESP TRACT, EYES & SKIN. INHAL MAY RSLT IN SPASM, INFLAMM & PULM E DEMA. SYMPS OF EXPOS MAY INCL BURNING SENSATION, COUGHING, WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HDCH, NAUS & VOMIT. CHRONIC: POSS RISK OF CONGENITAL MALFORMATION IN FETUS. TO THE BEST OF MFR'S K NOWLEDGE, THE CHEM, PHYSICAL, & TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THORO INVESTIGATED. ADDNL INFO: ZINC CHLORIDE & ITS AQUEOUS SOLNS ARE CORR TO EYES & SKIN. (EFTS OF OVEREXP) Signs And Symptions Of Overexposure: HLTH HAZ: THEY CAUSE CONJUNCTIVITIS & CORNEAL BURNS IN EYE & PRODUCE CHEM BURNS, PARTICULARLY ON AREAS WHERE SKIN IS BROKEN. INGEST PRODUCES CORROSIVE ACTION TO MOUTH, THROAT & DIGESTIVE TRACT WHICH C AN INCLUDE SYMPS OF STOMACH PAIN, NAUS, VOMIT, BLOODY DIARRHEA, SWELLING OF THROAT, BLOOD IN URINE & SHOCK. INHAL IRRITATES NOSE & THROAT PRODUCING COUGH, CHEST PAIN, BLUISH SKIN, FEVER, NAUS & VOMIT, SHORTNESS OF BREATH, DIFFICULTY IN BREATHING (ONSET MAY BE DELAYED BY SEVERAL HOURS) & PNEUMONIA. FATALITIES HAVE OCCURRED BY INHAL & INGEST. First Aid: EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE EYELIDS WITH FINGERS. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE. DISCARD CONTAMINATED SHOES. Spill Release Procedures: EVACUATE AREA. WEAR NIOSH APPROVED SELF- CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINER AND HOLD FOR WASTE DIS POSAL. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF THIS MATERIAL. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

3 Other Precautions: LABEL PRECAUTIONARY STATEMENTS: CORR. CAUSES BURNS. HARMFUL IF SWALLOWED. POSS RISK OF HARM TO UNBORN CHILD. IN CASE OF CONT W/EYES, RINSE IMMEDIATELY W/PLENTY OF WATER & SEEK MEDICAL ADVICE. TAKE OFF IMMEDIATELY ALL CONTAMINATED CLOTHING. WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES & EYE/FACE PROT. D O NOT BREATHE DUST. Fire and Explosion Hazard Information Extinguishing Media: NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. Control Measures Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES AND FULL LENGTH FACESHIELD (FP N). Other Protective Equipment: ANSI APPROVED EMERGENCY EYEWASH AND DELUGE SHOWER (FP N). WEAR OTHER PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: MF: CL*2ZN. EC NUMBER: TOX INFO: ENDOCRINE (CHANGE IN LH, CHANGE IN GONADOTROPINS); PATERNAL EFTS (OTHER EFTS ON MALE); EFTS ON FERTILITY (FEMALE FERTILITY INDEX, POST-IMPLANTATION MORTALIT Y); SPECIFIC DEVEL ABNORMS (MUSCULOSKELETAL SYS); TUMORIGENIC EFTS (TESTICULAR TUMORS); (OTHER INFO) Physical Chemical Properties Melt/Freeze Pt: =293. C, 559.4F Vapor Pres: 1 428C Spec Gravity: Appearance and Odor: WHITE CRYSTALS. Reactivity Data

4 Stability Indicator: YES Stability Condition To Avoid: PROTECT FROM MOISTURE. Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: HYDROGEN CHLORIDE GAS, METAL OXIDES. Toxicological Information Toxicological Information: RTECS # ZH ZINC CHLORIDE. TOXICITY DATA: ORL-RAT LD50: 350 MG/KG; FOREAE 7, 313, IPR-RAT LD50: 58 MG/KG; VHTODE 30, 224, IVN-RAT LD50: 3690 UG/KG; INJPD2 23, 153, ORL-MUS LD 50: 329 MG/KG; INJPD2 23, 153, IPR-MUS LD50: 24 MG/KG; TXAPA9 63, 461, SCU-MUS LD50: 330 MG/KG; OYYAA2 8, 1067, IVN-MUS LD50: 9090 UG/KG; INJPD2 23, 153, ORL-GPG LD50: 200 MG/K G; FOREAE 7, 313, TARGET ORGAN DATA: SENSE ORGANS & SPECIAL SENSES (MIOSIS); VASCULAR (BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION); LUNGS, THORAX/RESP (DYSPNAE); GI (COLON TUMORS); (SUP DAT) Ecological Information Ecological: DATA NOT YET AVAILABLE. MSDS Transport Information Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. Regulatory Information Sara Title III Information: THIS PRODUCT IS SUBJECT TO SARA SECTION 313 REPORTING REQUIREMENTS. OTHER INFO: TWA 1 MG/M3 (FUME) JAN OEL-AUSTRALIA, OEL-BELGIUM, OEL-UNITED KINGDOM: TWA 1 MG/M3; STEL 2 MG/M3 (FUME) JAN OEL-DENMARK: TWA 0.5 MG/M3 (FUME) JAN OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA, NEW ZEALAND, SINGAPORE, & VIETNAM, CHECK ACGIH TLV. NIOSH REL TO ZINC CHLORIDE FUME-AIR: 10H TWA 1 MG/M3; STEL 2 M G/M3; NIOSH* DHHS #92-100, NOHS 1974: HZD 77150; NIS 192; TNF 20416; NOS 84; TNE NOES 1983: HZD 77150; NIS 172; TNF 22612; NOS 115; TNE ; TFE (STATE REGS) Federal Regulatory Information: EUROPEAN INFO: EC INDEX #: CORR. R 34: CAUSES BURNS. S 7/8: KEEP CONTR TIGHTLY CLSD & DRY. S 28:

5 AFTER CONT W/WKIN, WASH IMMED W/PLENTY OF WATER. S 45: IN CASE OF ACCIDENT/IF YOU FEEL UN WELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSS). REVIEWS, STDS, & REGS: OEL=MAK. ACGIH TLV- STEL: 2 MG/M3, VAP; DTLVS* TLV/BEI, ACGIH YLV-TWA: 1 MG/M3, FUME; DTLVS* TLV/BEI, EPA FIFRA PESTICIDE SUBJECT TO REGISTRATION/RE-REGISTRATION; FEREAC 54, 7740, MSHA STD- AIR:TWA 1 MG/ M3 (FUME); DTLVS* 3, 283, OSHA PEL (GEN INDU): 8H TWA 1 MG/M3, FUME; CFRGBR 29, , (OTHER INFO) State Regulatory Information: N/P -- SARA REGS: EPA GENETOX PROGRAM 1988, POS: CELL TRANSFORMATION-SA7/SHE; HOST-MEDIATED ASSAY. EPA GENETOX PROGRAM 1988, POS: HISTIDINE REVERSION/AMES TEST. EPA GENETOX PROGRAM 1988: NEG: IN VITRO CYTOGENETICS-HUMAN LYMPHOCYTE. EPA GENETOX PROGRAM 1988, NEG: B SUBTILIS REC ASSAY; SPERM MORPHOLOGY-MOUSE. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY. EPA TSCA SECTION 8 (D) UNPUBLISHED HEALTH/SAFETY STUDIES. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE OSHA ANALYTICAL METHOD #ID-125G. Other Information Other Information: SUP DAT: NUTRITUINAL & GROSS METABOLIC (WT LOSS/DECRD WT GAIN); TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA). ONLY SELECTED REGISTRY TO TOX EFTS OF CHEM SUBSTANCES (RTECS) DATA IS PRESE NTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFO. FED REGS: OSHA PEL (CONSTRUC): 8H TWA 1 MG/M3, FUME; CFRGBR 29, , OSHA PEL (SHIPYARD): 8H TWA 1 MG/M3, FUME; CFRGBR 29, , OSHA PEL (FED CONT): 8H TWA 1 MG/M3, FUME; CFRGBR 41, , OEL-ARAB REPUBLIC OF EGYPT, OEL-FINLAND, OEL-FRANCE, OEL-THE NETHERLANDS, OEL-THE PHILIPPINES, OEL-SWEDEN, OEL-SWITZERLAND, OEL-THAILAND, OEL- TURKEY: (SARA REGS) HAZCOM Label Trade Name: ZINC CHLORIDE, MOLECULAR BIOLOGY REAGENT, Z0173 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST PO Box: City: ST LOUIS State: MO Zipcode: Country: US Health Emergency Info Phone Number: Label Required IND: Y

6 Date Of Label Review: 12/22/1999 Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: DANGER Respiratory Protection IND: YES Health Hazard: Severe Contact Hazard: Severe Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: CORROSIVE. ACUTE: HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED/ABSORBED THROUGH SKIN. MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUES OF MUCOUS MEMBRANESS & UPPER RESPIRATORY TRACT, EYES & SKIN. INHAL ATION MAY RESULT IN SPASM, INFLAMMATION& PULMONARY EDEMA. SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING, WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA & VOMITING. CHRONIC: POSSIBLE RISK OF CONGENITAL MALFORMATION IN FETUS. === === Return to Index