DHM 2018, Drug Hypersensitivity Meeting April 2018 Amsterdam, The Netherlands. Scientific Programme
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1 DHM 2018, Drug Hypersensitivity Meeting April 2018 Amsterdam, The Netherlands Scientific Programme Thursday, 19 April :00-13:45 Registration 13:45-14:00 Welcome Address by DHM 2018 Chair Ingrid Terreehorst, The Netherlands, DHM 2018 Local Organising Chair Maria J. Torres, Spain, DHM 2018 Local Organising Secretary Opening lecture Chair: Ingrid Terreehorst, The Netherlands Old and new challenges in drug allergies Maria J. Torres, Spain 14:30-16:00 Controversial and new aspects in drug hypersensitivity Chairs: Ingrid Terreehorst, The Netherlands Knut Brockow, Germany 14:30-14:55 14:55-15:20 15:20-16:00 The neglected role of drug-dose in modifying immune mediated drug reactions James Yun, Australia Role of exosome mediated antigen presentation in antibiotic related allergic reactions Riichiro Abe, Japan Severe drug hypersensitivity are graft versus host diseases: From the basic to the clinic Werner J. Pichler, Switzerland 16:00 16:30 Coffee Break EAACI Headquarters Hagenholzstrasse 111, 3rd Floor, 8050 CH-Zurich Page 1 5
2 16:30-18:00 Lessons from drug induced anaphylaxis Chairs: Jean-Christoph Caubet, Switzerland Ingrid Terreehorst, The Netherlands Beyond T cell in drug hypersensitivity Chairs: Dean Naisbitt, United Kingdom James Yun, Australia 16:30-16:55 16:55-17:20 17:20-17:45 17:45-18:00 Why is drug induced anaphylaxis more dangerous than other forms of anaphylaxis? Oliver Hausmann, Switzerland Perioperative anaphylaxis. Different experiences around the world Lene Heise Garvey, Denmark Differentiating MRGPRX2 receptor from IgE mediated mast cells degranulation Vito Sabato, Belgium O01 Evidence of an IgG-induced neutrophil activation pathway during human drug-induced anaphylaxis Luc De Chaisemartin, France Role of dendritic cells in the evaluation of DH Cristobalina Mayorga, Spain New cell populations involved in DH Marc Vocanson, France Non-IgE mediated mast cell activation: science and Francesca Levi-Schaffer, Israel O02 Oxidative stress and Sulfonylarylamines hypersensitivity reactions: new insights Abdelbaset A Elzagallaai, Canada 18:00-20:00 Welcome Reception and Poster Discussion Session I Skin reactions in drug allergy - Poster Walk 1: P01-P10 Chair: Maja Mockenhaupt, Germany Skin reactions in drug allergy - Poster Walk 2: P11-P20 Chair: Riichiro Abe, Japan Skin reactions in drug allergy - Poster Walk 3: P21-P30 Chair: James Yun, Australia Skin reactions in drug allergy - Poster Walk 4: P31-P41 Chair: Marc Vocanson, France Skin reactions in drug allergy - Poster Walk 5: P42-P52 Chair: Abdelbaset A Elzagallaai, Canada Diagnosis and pathophysiology - Poster Walk 6: P53-P62 Chair: Vito Sabato, Belgium Diagnosis and pathophysiology - Poster Walk 7: P63-P72 Chair: Luc De Chaisemartin, France Diagnosis and pathophysiology - Poster Walk 8: P73-P83 Chair: Francesca Levi-Schaffer, Israel Diagnosis and pathophysiology - Poster Walk 9: P84-P94 Chair: Antonino Romano, Italy Friday, 20 April :45-08:30 Room E103 Breakfast seminar - Meet Expert 1 Room E104 Breakfast seminar - Meet Expert 2 Room E107 Breakfast seminar - Meet Expert 3 Diagnosis in delayed drug hypersensitivity in children Jean-Christoph Caubet, Switzerland Diagnosis of allergic reactions to quinolones and macrolides Maria J. Torres, Spain New aspects in cephalosporin allergy Antonino Romano, Italy 08:30-09:00 Clinical Case 1 Room Clinical Case 2 Differential diagnosis of SCAR Annick Barbaud, France Perioperative drug allergy: the unusual suspects (dyes, disinfectants, bone cement etc.) Lene Heise Garvey, Denmark EAACI Headquarters Hagenholzstrasse 111, 3rd Floor, 8050 CH-Zurich Page 2 5
3 09:00-10:30 Understanding the role of T cells in drug hypersensitivity Chairs: Werner J. Pichler, Switzerland Mariana Castells, United States 09:00-09:30 09:30-10:00 10:00-10:30 What stimulates drug reactive T cells? Daniel Yerly, Switzerland Drug-TCR interactions David Ostrov, United States Tolerance mechanism to small molecules: ignorance, or active tolerance? Dean Naisbitt, United Kingdom 10:30-11:00 Coffee Break 11:00-12:30 Desensitisation or treating through the reaction? Chairs: Annick Barbaud, France Knut Brockow, Germany Genetics of Drug Hypersensitivity Chairs: Munir Pirmohamed, United Kingdom David Ostrov, United States 11:00-11:25 11:25-11:50 11:50-12:15 12:15-12:30 H1-Antihistamine Premedication in NSAID-Associated Urticaria Axel Trautmann, Germany Treating through in drug-associated exanthemas Andreas Bircher, Switzerland Desensitization can we go faster? Mariana Castells, United States O03 Pathways to improved antibiotic allergy practice - The validation of a Beta-Lactam antibiotic allergy assessment tool to aid accurate phenotyping and Jason Anthony Trubiano, Australia Pharmacogenomics in Adverse Drug Reactions Anke-Hilse Maitland-van der Zee, The Netherlands Genetic polymorphisms and epigenetic factors in NSAIDS intolerance Jean-Louis Guéant, France Risk factor of hypersensitivity to allopurinol: beyond HLA- B*58:01 Hye-Ryun Kang, South Korea O04 HLA-B*13:01 To prevent dapsone hypersensitivity syndrome Hong Liu, China Lunch and Poster Discussion Session II Clinical cases - Poster Walk 10: P95-P103 Chair: Daniel Yerly, Switzerland Clinical cases - Poster Walk 11: P104-P112 Chair: Mariana Castells, United States Clinical cases - Poster Walk 12: P113-P121 Chair: Axel Trautmann, Germany Clinical cases - Poster Walk 13: P122-P130 Chair: Kenji Kabashima, Japan Clinical cases - Poster Walk 14: P131-P139 Chair: Jason Anthony Trubiano, Australia Clinical cases - Poster Walk 15: P140-P149 Chair: Xiaoli L. Meng, United Kingdom Clinical cases - Poster Walk 16: P150-P159 Chair: Ricardo Madrigal-Burgaleta, Spain Clinical cases - Poster Walk 17: P160-P169 Chair: Patricia Therese Illing, Australia Clinical cases - Poster Walk 18: P170-P179 Chair: Vincent Descamps, France 14:00-15:30 Immunogenicity vs antigenicity in drug hypersensitivity Chairs: Dean Naisbitt, United Kingdom Cristobalina Mayorga, Spain 14:30-15:00 15:00-15:30 Relevance of hapten-protein conjugates for betalactam specific B and T cell reactions Xiaoli L. Meng, United Kingdom What makes a drug immunogenic, what antigenic? Stefan Martin, Germany Is non-covalent drug binding to proteins sufficient for crosslinking surface bound IgE? Edward Knol, The Netherlands EAACI Headquarters Hagenholzstrasse 111, 3rd Floor, 8050 CH-Zurich Page 3 5
4 15:30-16:00 Coffee Break 16:00-17:30 16:00-16:25 16:25-16:50 16:50-17:15 Drug reactions in malignancy treatment Chairs: Patrizia Bonadonna, Italy Stefan Martin, Germany Adverse reactions in immunotherapy of tumors: diagnosis and Enrico Maggi, Italy Adverse reactions in chemotherapy: diagnosis and Ricardo Madrigal-Burgaleta, Spain O05 COBIOPHAD: Progresses towards in vitro diagnosis of drug allergies by a point-of-care device Luis A. Tortajada-Genaro, Spain Drug hypersensitivity pathomechanisms Chairs: Werner J. Pichler, Switzerland Munir Pirmohamed, United Kingdom Importance of T-cell response to altered peptides in drug hypersensitivity Patricia Therese Illing, Australia Drug hypersentivity and viruses: causal or only amplifying? Vincent Descamps, France Role of T cell subsets in drug eruptions using novel animal models and in vivo live imaging Kenji Kabashima, Japan 17:15-17:30 O06 Characterization Of Penicillin-specific naïve CD8+ T cells: from extracellular to intracellular protein haptenation Rami Jospeh Bechara, Lebanon O07 Characterization of drug-treated hepatocyte-derived exosomes: implications for the mechanistic basis of idiosyncratic drug-induced liver injury Monday Ogaba Ogese, United Kingdom Saturday, 21 April :45-08:30 Room E103 Breakfast seminar - Meet Expert 4 Room E104 Breakfast seminar - Meet Expert 5 Room E107 Breakfast seminar - Meet Expert 6 Radio contrast media hypersensitivity Knut Brockow, Germany Drug provocation tests: acute and late complications Anca Mirela Chiriac, France In vitro test for diagnosing drug allergy in clinical practice Cristobalina Mayorga, Spain 08:30-09:30 Pro/Con Debate: The use of BAT in diagnostics Chairs: Cristobalina Mayorga, Spain Oliver Hausmann, Switzerland Pro: Vito Sabato, Belgium Con: Edward Knol, The Netherlands 09:30-11:00 Factors influencing drug hypersensitivity Chairs: Maria J. Torres, Spain Kenji Kabashima, Japan 09:30-10:00 10:00-10:30 10:30-11:00 Cofactors in pseudo allergic reactions to drugs Joan Bartra, Spain Mast cell disorders and drug hypersensitivity Patrizia Bonadonna, Italy Survey of BL use, allergies and testing in Europe Anca Mirela Chiriac, France 11:00-11:30 Coffee Break EAACI Headquarters Hagenholzstrasse 111, 3rd Floor, 8050 CH-Zurich Page 4 5
5 11:30-13:00 Risk stratification as a tool in drug allergy investigation Chairs: Joan Bartra, Spain Jean-Christoph Caubet, Switzerland Severe cutaneous adverse reactions to drugs Chairs: Annick Barbaud, France Axel Trautmann, Germany 11:30-11:55 11:55-12:20 12:20-12:45 12:45-13:00 Risk as a de-labeling strategy for penicillin allergy Elizabeth Phillips, United States Risk stratification in drug provocation Knut Brockow, Germany Should investigations be drug specific rather than following one size fits all algorithms? Munir Pirmohamed, United Kingdom O08 Direct graded amoxicillin challenges in adults with low risk beta-lactam allergy labels: the West Australian experience Michaela Lucas, Australia Regional differences in SCAR manifestations and elicitors and their explanations Maja Mockenhaupt, Germany Adverse reactions to drugs after SCAR Annick Barbaud, France Autoimmune sequelae in SCAR Yumi Aoyama, Japan O09 MicroRNAs associated with T cell activation are upregulated in plasma exosomes in severe cutaneous reactions Alejandra Monroy Arreola, Mexico 13:00-13:15 Closing and Prize Giving Ceremony EAACI Headquarters Hagenholzstrasse 111, 3rd Floor, 8050 CH-Zurich Page 5 5
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