Key words : Chlamydia trachomatis, Tonsillitis, Rokitamycin
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1 Key words : Chlamydia trachomatis, Tonsillitis, Rokitamycin
2 Table 1 Distribution of the study population
3 Table 2 Clinical details of patients with tonsillitis *LT =Lingering tonsillitis, RT = Recurrent tonsillitis, CT = Chronic tonsillitis No. 8, : Ricamycin R Tablets administered cases
4 Table 3 The lengths of period from the start of treatment till the disappearance of C. trachomatis No. 8, : Ricamycin R Tablets administered cases
5 Table 4 Clinical efficacy of Rokitamycin therapy in the treatment of tonsillitis due to C. trachomatis Table 5 Serovars and detected immunoglobulins of serum antibodies to C. trachomatis in patients
6 1) Dowson, C.R. & Schachter, J.: TRIC AGENT INFECTION OF THE EYE AND GENITAL TRACT. Am. J. Ophthalmol., 63: , ) Schachter, J. & Atwood, G.: Chlamydial pharyngitis? J. Am. Vener. Dis. Assoc., 2 : 12, ) Watanakunakorn, C. & Levy, D.H. : Pharyngitis and urethritis due to Chlamydia tra- chomatis. J. Infect. Dis., 147 : 364, ) McDonald, C.J., Tierney, W.M., Hui, S.L., French, M.L.V., Leland, D.S. & Jones, R.B. : A controlled trial of erythromycin in adults with nonstreptococcal pharyngitis. J. Infect. Dis., 152 : , ) Gerber, M.A., Ryan, R.W., Tilton, R.C. & Watson, J.E. : Role of Chlamydia trachomatis in acute pharyngitis in young adults. J. Clin. Microbiol., 20 : , 1984.
7 6) Huss, H., Jungkind, D., Amadio, P. & Rubenfeld, I.: Frequency of Chlamydia trachomatis as the cause of pharyngitis. J. Clin. Microbiol., 22 : , ) Bowie, W.R., Alexander, E.R. & Holmes, K.K. : Chlamydial pharyngitis? Sex. Trans. Dis., , ) Neinstein. L.S. & Inderlied, C.: Low prevalence of Chlamydia trachomatis in the oropharynx of adolescents. Pediatr. Infect. Dis., 5 : 660 9) Grayston, J.T., Kuo, C.-C., Wang, S.-P. & Altman, J.: A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N. Eng. J. Med., 315 : , ) Huovinen, P., Lahtonen, R., Ziegler, T., Meurman, O., Hakkarainen, A., Miettinen, Arstila, P., Eskola, J. & Saikku, P.: Pharyngitis in adults : The presence and coexistence of vir- 12) Ogawa, H., Yamazaki, Y. & Hashiguchi, K.: 19) Grayston, J.T., Kuo, C.-C., Campbell, L.A. & Chlamydia trachomatis : A currently recognized Wang, S.-P. : Chlamidia pneumoniae sp. nov. pathogen of tonsilltis. Acta Otolaryngol. Suppl., 454 : , for Chlamydia sp. strain TWAR. Int. J. Systematic Bacteriol., 39 : 88-90, ) Sakakibara, H., Okekawa, o., Fujiwara, T., 20) Saikku, P., Wang, S.-P., Kleemola, M., Brander, Otani, M. & Omura, S.: Acyl derivatives of E., Rusanen, E. & Grayston, J.T.: An 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A5 (TMS-19-Q). J. Antibiotics, 34 : , ) Kuo, C.-C., Wang, S.-P., Wentworth, S. & Grayston, J.T.: Primary isolation of TRIC organisms in HeLa 229 cells treated with DEAE-dextran. J. Infect. Dis., 125: , ) Wang, S.-P., Grayston, J.T., Alexander, E.R. & Holmes, K.K. : Simplified microimmunofluorescence test with trachomalymphogranuloma venereum (chlamydia trachomatis) antigens for use as a screenig test for antibody. J. Clin. Microbiol., 1 : , ) Reeve, P., Owen, J. & Oriel, J.D. : Laboratory procedures for the isolation of Chlamydia trachomatis from the human genital tract. J. Clin. Pathol., 28 : , ) Hammerschlag, M.R., Chandler, J.W., Alexander, E.R., English, M. & Koutsky, L.: Longitudinal studies on chlamydial infection in the first uses and bacterial organisms. Ann. Inter. Med., 110 : , year of life. Pediatr Infect. Dis., 1 : , epidemic of mild pneumonia due to unusual strain of Chlamydia psittaci. J. Infect. Dis., 151 : , Tonsillitis Associated with Chlamydia trachomatis and Antimicrobial Therapy with Rokitamycin Hiroshi OGAWA & Kazuhiro HASHIGUCHI Division of Otorhinolayngology, Kitasato Institute Hospital Yukimasa KAZUYAMA Research and Development Center of Hygienic Science, Kitasato University Tonsillitis is the most common disease in the otorhinolaryngeal location. For most patients, tonsillitis is attributed to a group A streptoccal infection if the throat culture is positive for that organism or to a viral infection if the throat culture is negative. However, recent studies have shown that Chlamydia trachomatis can produce tonsillar infection. In this study, we evaluated the efficacy of Rokitamycin, a 16-membered ring macrolide antibiotic agent, in the treatment of tonsillitis associated with C. trachomatis. In 26 of 28 (92.9%) patients from whom C. trachomatis was isolated, the organism was eradicated by antimicrobial treatment with Rokitamycin of five days to three weeks' duration. In 25 of the 26 patients, they were totally free of tonsillar symptoms.
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