Date 27/03/2013 Iscription to The Board of Physicians, Surgeons and Orthodontists of Milan Iscription code: 43176

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1 Curriculum Vitae Personal information First name / Surname Federico Pane Address Via Mercanti 4, Catanzaro (CZ); domiciled in Via Staro 5, Milano (MI) Phone Mobile: Fax federico.pane@aliceposta.it Nationality Italy Place and date of birth Catanzaro, Profession Medical Doctor Work experience Occupation or position held Principal subjects / occupational skills covered Postgraduate school Name and type of organisation providing educational and training Date 08/08/ /09/2018 Medical Doctor undergoing specialised training in Pneumology, fifth year Clinical activity in pneumology ward, active participation to frontal lessons and clinical meetings Respiratory diseases University of Milan Bicocca, Monza (MB). Via Pergolesi n33 Monza (MB) O.U. of Pneumology, Ospedale S. Gerardo, Monza (MB). Director Prof. Alberto Pesci Education and training Date 27/03/2013 Iscription to The Board of Physicians, Surgeons and Orthodontists of Milan Iscription code: Date University 07/02/2013, II session of 2012 License to practice the Medical profession Università Vita-Salute San Raffaele Final degree mark University Thesis title Date 25/10/ /S Second level degree class in Medicine and Surgery 110/110 cum Laude Università Vita-Salute San Raffaele Risk stratification for recurrence in resected stage I Non-small cell lung cancer using new PET-derived parameters. Supervisor: Prof. Piero Zannini. Assistant supervisor: Dr. Giulio Melloni Internship O.U. of Thoracic Surgery, Ospedale San Raffaele, Milan (MI), Italy From November 2010 to October 2012 Director: Prof. Piero Zannini Tutor: Dr. Carlopietro Voci

2 Date 2006 High school diploma Classical studies Mark 100/100 Institute Liceo Classico Statale Pasquale Galluppi, Catanzaro (CZ), Italy Postgraduate formative activity Traineeship to obtain the license to the medical profession practice Clinic of General Medicine, Lavanderie di Segrate (MI), Italy Tutor: Dr. Massimo Zavaglia 02/01/ /02/2013 Final mark: 30/30 Department of General Surgery, O.U. of Gastroenterological Surgery, Tutor: Dr. Andrea Marco Tamburini 03/12/ /12/2012 Final mark: 28/30 Department of Internal Medicine, O.U. of Internal Medicin specialising in diabetes and endocrinologic diseases Tutor: Dott. Marco Federico Manzoni 02/11/ /11/2012 Final mark: 30/30 Voluntary formative activity Voluntary medical attender, O.U. of Thoracic Surgery Date(s) From October 2012 to May 2013 Personal capacities and Linguistic knowledge Mother tongue Italian Second language English Self-assessment Understanding Speaking Writing Listening Reading Spoken interaction Spoken production B2 C2 B2 B2 B2 Technical skills and Execution and interpretation of the most common respiratory exams: - Pulmonary function tests - Six minutes walking test - MIP and MEP - Mantoux test - Arterial blood gas analysis

3 Interpretation of the main instrumental exams for respiratory diseases: - Thoracic RX, CT, RM, Echography and Positron emission tomography - ECG and echocardiogram - Right heart catheterization Active participation to clinical and therapeutic management of patients affected by respiratory diseases with multidisciplinary discussion of clinical problems Supervisor(s): Prof. Alberto Pesci / Dr. Francesco Morganti / Dott. Stefano Polti Active participation to clinical and therapeutic management of patients with pulmonary hypertension; management of specific therapies for PAH and CTEPH Supervisor(s): Prof. Alberto Pesci / Dr. Giuseppe Paciocco Active participation to clinical and therapeutic management of patients with severe asthma undergoing therapy with Omalizumab Supervisor(s): Prof. Alberto Pesci / Dr. Stefano Polti Active participation to clinical, psicological and therapeutic management of patients undergoing pharmacological anti-smoking treatment O.U. of Pneumology, Ospedale S.Gerardo, Monza (MB), Italy Supervisor(s): Prof. Alberto Pesci / Dr. Stefano Polti Active participation to clinical and therapeutic management of patients with OSAS O.U. of Pneumology, Ospedale San Gerardo, Monza (MB), Italy Supervisor(s): Prof. Alberto Pesci / Dott.ssa Anna Monzani Active Participation to clinical and therapeutic management of patient wit diffuse lung diseases and interstitial lung disease O.U. of Pneumology, Ospedale San Gerardo, Monza (MB), Italy Supervisor(s): Prof. Alberto Pesci / Dott. Almerico Marruchella Active participation to clinical and therapeutic management of patients recovered in Sub-Intensive Care Unit Management of Non-Invasive Ventilation O.U. of Pneumology, Ospedale San Gerardo, Monza (MB), Italy Supervisor(s): Prof. Alberto Pesci / Dott.ssa Grazia Messinesi Active participation in Respiratory Endoscopy; execution by first or second operator of flexible fibrobronchoscopy, bronchial aspirate, bronchoalveolar lavage, transbronchial or endobronchial biopsies, transbronchial-needle biopsies with or without using ultrasound guide O.U. of Respiratory Endoscopy, Ospedale San Gerardo, Monza (MB), Italy Supervisor(s): Prof. Alberto Pesci / Dott. Almerico Marruchella Active participation in Respiratory Endoscopy c/o Azienda Ospedaliera Treviglio- Caravaggio (May-June 2018) Supervisor: Dott. Rinaldo Salvi Active participation in pneumology ward and management of the patient undergoing lung transplantation O.U. of Pneumology Ospedale Papa Giovanni XXIII Bergamo (BG) Supervisor(s): Dott. G. Michetti Dott. P. Parigi Active participation to sponsored clinical studies in regard to respiratory disease, expecially Pulmonary Hypertension, PAH and CTEPH Cooperation in clinical and therapeutic management of patients operated for lung cancer O.U. of Thoracic Surgery, Supervisor(s): Prof. Piero Zannini / Dr. Carlopietro Voci Active participation to experimental applied studies in regard to the use of new

4 PET-derived parameters (SUVmax, SUVindex, MTV, TLG) for recurrence risk stratification in resected stage I non-small cell lung cancer O.U. of Thoracic Surgery, Supervisor(s): Prof. Piero Zannini / Dr. Carlopietro Voci Computer skills and Most common operating systems (MAC and Windows XP/Vista), Internet browsers (Internet Explorer, Mozilla Firefox, Google Chrome), Microsoft Office, clinical softwares (Galileo, Impax, Elefante, Careline), statistics analysis software (SPSS), Medidata Rave ecrf, study specific EDC trainings Other skills and Temporary replacement of General Physician in his doctor s office Upgrade courses, conferences e and elective formative activity Respir Med Oct;119: Characterization of bronchiectasis in the elderly. Bellelli G, Chalmers JD, Sotgiu G, Dore S, McDonnell M, Goeminne P, Dimakou K, Skrbic D, Lombi A, Pane F, Obradovic D, Fardon T, Rutherford RM, Pesci A, Aliberti S. Participation as speaker in numerous updating courses on Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Veno-Occlusive disease and PH-related to respiratory diseases. Scientific responsible: Prof. Alberto Pesci Dott. Giuseppe Paciocco November 11 th, 2016, Milan, Italy Updating course in thoracic ultrasound Scientific responsible: Dott. Paolo Banfi Dott. Gino Soldati October 27 th, 2016, Milan, Italy Updating course on Chronic Thromboembolic Pulmonary Hypertension Scientific responsible: Prof. AM D'Armini, Dott. S.Ghio April 22 th, 2016, Milan, Italy Pleural-Hub Scientific responsible: Prof. G.Marchetti May 21 th -24 th, 2015, Isola d'elba (LI), Italy Interventional Pneumology Course Scientific responsible: Dott. G.Menconi, Dott.ssa B.Pastori, Dott.ssa R.Vincenti October 16 th -17 th, 2014, Naples, Italy June 14 th, 2014, Roma, Italy Updating on Pulmonary Hypertension Scientific responsible: Dott. M.D'Alto June 14 th, 2014, Rome, Italy IPHNET Workshop on Pulmonary Hypertension Scientific responsible: Prof. Dario Vizza May 13 th 14 th, 2014, IRCCS Policlinico San Matteo, Pavia, Italy Updating course on pulmonary hypertension Scientific responsible: Dr. Stefano Ghio October 25 th 26 th, 2013, Centro Anti-Tabacco - ASL3 Genova, Italy ECM Stage on the medical treatment of tobacco addiction Smoking cessation in clinical practice Scientific responsible: Dr. Piero Clavario November 7 th 8 th, 2013, Firenze, Italy 3 th Meeting of respiratory allergology task forces AAITO AIPO SIAIC - SIMeR December 13 th - 15 th, 2012, The 5 th International Congress of Aortic Surgery and Anesthesia Scientific responsible: Prof. Roberto Chiesa

5 May 12 th - 14 th, 2011, International Hands-on Dissection course: Surgery of cerebello-pontine angle tumors Scientific responsible: Prof. Pietro Mortini May 21 st, 2010, San Raffaele Transplant meeting: organ transplant from living donors Scientific responsible: Prof. Antonio Secchi, Prof. Carlo Staudacher March 2010 June 2010 Elective course: Invasive diagnostic techniques in Pneumology: the bronchoscopy Responsible: Dr. Giampiero Negri November 2008 January 2009 Elective course: Neck and thorax surgical anathomy Responsible: Dr. Carlopietro Voci I authorize the processing of my personal data persuant to Legislative Decree 30 June 2003, No.196, code regarding the protection of personal data. Milano, In fede Dott. Federico Pane