The New Frontier of Precision Medicine - Program International Summer School University of Pavia - Department of Molecular Medicine
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1 The New Frontier of Precision Medicine - Program International Summer School University of Pavia - Department of Molecular Medicine 3 September - Introduction to the concepts of the Precision Medicine 9:00-9:20 Welcome and presentation of the course (Luca Arcaini and Orsetta Zuffardi 9:20-10:00 How whole exome and genome sequencing are changing the management of patients (Raoul Hennekam University of Amsterdam) 10:00-10:40 Some lessons from autoinflammatory diseases (Alberto Martini University of Genoa) 10:40-11:20 Next generation sequencing: new diagnostic approaches in red blood cell disorders (Achille Iolascon University of Naples Federico II) 11:40-12:20 What about GMO Humans? (Francesca Forzano Guy s and Saint Thomas NHS Foundation Trust London) 12:20 13:00 New therapeutic approaches in red blood disorders (Maria Domenica Cappellini University of Milan) 14:00-14:40 Between laboratory and clinic: a continuous conversation (Orsetta Zuffardi 14:40-15:20 The Medicine inside the databases (Edoardo Errichiello 15:40-16:00 European Reference Network (ERN): what are and what are the advantages for patients (Achille Iolascon University of Naples Federico II) 16:00-16:40 From clinical to molecular diagnosis in nephropathies (Paola Romagnani University of Florence) 16:40-17:20 New therapeutic approaches in nephropathies (Sabrina Giglio University of Florence) 17:20-18:00 Summary of the day
2 4 September - Precision Medicine and Oncology 9:00-10:20 Hematological malignancies: from genetics to the clinic (Luca Arcaini University of Pavia) 10:40-12:00 From clinical to molecular diagnosis in myelodysplastic syndromes and their treatment (Luca Malcovati 13:00-13:40 Monoclonal antibodies and precision medicine (Ermanno Gherardi University of Pavia) 13:40-14:20 Benefits and obstacles of immunotherapy in solid tumours (Vincenzo Russo San Raffaele University) 14:20-15:00 The role of epigenetics and epigenetic drugs in cancer (Andrea Mattevi 15:20-16:00 Liquid biopsy: non invasive monitoring in oncological patients (Giulia Siravegna Candiolo Cancer Institute Turin) 16:00-16:40 Personalized approach to advanced NSCLC (Giulia Stella 17:00-18:00 CDx diagnostic companion in personalized therapy of solid tumours (Matteo Dionisi Roche Diagnostic) 5 September - Precision Medicine, Neurology and Neurodegenerative diseases 9:00-9:40 Parkinson s disease: from genetic diagnosis to genetic treatment (Enza Maria Valente 9:40-10:20 Huntington disease: from genetic diagnosis to genetic treatment (Mario Pata Roche) 10:40-11:20 Spinal Muscular Atrophy: from hopeless disease to new therapies (Stefania Corti University of Milan)
3 11:20-12:00 Duchenne muscular dystrophy and genetic therapy (Angela Berardinelli Mondino Neurological Institute of Pavia) 14:00-14:40 Epilepsies: from molecular diagnosis to precision medicine (Emilio Perucca 14:40 15:00 The epileptic encephalophaty from prenatal development to postnatal diagnosis: a paradigmatic case (A mother accompanied by Dott.ssa Arossa Policlinico San Matteo of Pavia) 15:20-16:00 New treatments for Alzheimer s disease (Stefano Govoni 16:00-18:00 Practises on Databases (Orsetta Zuffardi and Why ethics : a case based training (Maria Giovanna Ruberto 6 September - Immunology and Transplantations NIPT lecture 9:00-10:00 New approaches to re-establish tolerance in autoimmune diseases (Silvia Gregori San Raffaele University) 10:00-11:00 Novel approaches in (xeno)transplantation: CRISPR/Cas9 and genetic engineering for humanized organs, back to the future? (Roberto Giovannoni University of Milan-Bicocca) Coffee Break 11:20-12:00 Transplantation ethics (Maria Giovanna Ruberto 14:00-15:00 Non Invasive Prenatal Testing (NIPT): a revolution in prenatal diagnosis (Ioris Vermeesch Katholieke Universiteit Leuven) 16:00-18:00 Practises on Databases (Orsetta Zuffardi and Why ethics : a case based training (Maria Giovanna Ruberto
4 7 September - Hereditary Metabolic Diseases and Precision Medicine Ethics and Precision Medicine 9:00-9:40 The diagnostic approach to inborn errors of metabolism in the era of genomic sequencing (Nicola Brunetti Pierri University of Naples Federico II) 9:40-10:20 Novel therapies for inborn errors of metabolism (Nicola Brunetti Pierri University of Naples Federico II) 10:40-12:00 Neonatal whole exome sequencing and genetic manipulation : possible related discrimination issues (Maria Giovanna Ruberto 14:00-16:00 Practises on Databases (Orsetta Zuffardi and Why ethics : a case based training (Maria Giovanna Ruberto 8 September - Journal Club for PhD students and Researchers Participants will discuss some published articles analyzing their strengths and weaknesses. The articles will be selected by the Scientific Committee in order to follow the major Magazines on a wide spectrum, with particular attention to the most relevant works in translational research. This activity is optional for participants who will attend both weeks or who will choose the variant "Autonomous project version" September - Workshops Methodological approaches to genome for M.D. Division of participants into small groups according to their main interests in order to prepare a paper the will be presented during the week. Titles and relevant literature will be proposed by the teachers or chosen directly by the students. Each presentation will be moderated by a professor with the aim of stimulating the discussion among the participants. The best paper will be rewarded with one of the scholarships made available by the school. Lectures and exercises on methodological approaches to genome analysis and functional pathogenicity tests, in order to teach how to move into the translational medicine (under the responsibility of Orsetta Zuffardi. 10 September
5 9:00-13:00 Lecture on methodologic approaches to genome analysis and functional tests: how moving into the translational medicine (Orsetta Zuffardi 14:00-18:00 Workshop activities 11 September 9:00-13:00 Lecture on methodologic approaches to genome analysis and functional tests: how moving into the translational medicine (Orsetta Zuffardi 14:00-18:00 Workshop activities 12 September 9:00-13:00 Workshop activities 14:00-18:00 Presentations and discussions 13 September 9:00-13:00 Workshop activities 14:00-18:00 Presentations and discussions 14 September 9:00-13:00 Presentations and discussions
The New Frontier of Precision Medicine - Program International Summer School University of Pavia - Department of Molecular Medicine
The New Frontier of Precision Medicine - Program International Summer School University of Pavia - Department of Molecular Medicine 3 September - Introduction to the concepts of the Precision Medicine
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