Gene-Environment Interaction in Allergic Asthma
|
|
|
- Isaac Arnold
- 5 years ago
- Views:
Transcription
1 Gene-Environment Interaction in Allergic Asthma Renz, von Mutius, et al. Nature Immunology 211;12: Renz H, Autenrieth IB, Brandtzeag P, Cookson WO, Holgate S, von Mutius E, et al. JACI 211;128(6):25-49.
2 Pre- and postnatal environment opportunity for early immuno-education and programming
3 Loss of clinical and immunological tolerance Hygiene hypothesis Lack of infectious microbes in early childhood Altered exposure to environmental microbes Examples: having older siblings frequent viral infections anthroposophical life style early day care traditional farming
4 Traditional farming and early immuno-education Courtesy: Erika von Mutius ALEX-Study ( ) EU-6FWP PASTURE (22 27) EU-7FWP PRO-IMMUNE (28 211)
5 Traditional farming environment and atopic/allergic phenotypes - studies worldwide - n=5 n=3 n=4 n=1 n=1 n= n=1 6 4 n=6 n=6 n=2 n=6 n=4 n=1 n=4 n = 33 studies
6 Effect of childhood farm exposure on allergic phenotypes Protective effect Phenotype Number of studies Risk reduction Significant Trend (n =) (n =) % (n =) % rhinitis/ conjunctivitis 16 (12) 75 % (4) 25 % atopic sensitization 14 (1) 71 % (4) 29 % asthma 28 (18) 64 % (1) 36 % wheezing 17 (9) 53 % (7) 41 % * atopic dermatitis 14 (3) 21 % (1) 72 % Total study number : n = 33 * In one study a slight increase in risk was observed von Mutius and Vercelli, 21; Roduit et al., 21
7 Adj. Prevalence of Hay Fever (%) Adj. Prevalence of Hay Fever Symptomes (%) Adj. Prevalence of Atopic Sensitization (%) Inverse relationship between endotoxin-load and atopic phenotypes Adj. Prevalence of Hay Fever (%) Adj. Prevalence of Hay Fever Symptoms (%) Adj. Prevalence of Atopic Sensitization (%) Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 2 ] Braun-Fahrländer et al. NEJM, 22
8 CD14 mrna / 18s rrna TLR2 mrna / 18s rrna TLR4 mrna / 18s rrna Farmers express higher levels of CD14 and TLR-2, but not TLR-4 CD14 TLR-2 TLR p <.5.21 p <.1.55 ns non farmer farmer. non farmer farmer.2 non farmer farmer Lauener et al, Lancet 22
9 IFN [pg/1 6 lymphocytes] IL-1 [pg/1 IL-1 [pg/1 6 lymphocytes] ] Inverse relationship between in-vitro IFN- and IL-1 production and in-door endotoxin load IFN IL-1 1 IFN [pg/1 6 lymphocytes] Endotoxin Load in Mattress [EU/m 1 2 ] Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m²] stimulation of PBMC with 1 µg/ml LPS collection of supernatants after 24 h Braun-Fahrländer et al. NEJM, 22
10 TNFα [pg/1 6 lymphocytes] 6 lymphocytes] IL-12 [pg/1 6 lymphocytes] Braun-Fahrländer et al. NEJM, 22 Inverse relationship between in-vitro TNF-a and IL-12 production and in-door endotoxin load TNF a [pg/ TNFα IL-12 [pg/1 6 lymphocytes] IL Endotoxin Load in Mattress [EU/m 2 ] Endotoxin Load in Mattress [EU/m 1 2 ] Endotoxin Load in Mattress [EU/m²]
11 Selection of study population RS SRS = random selection = stratified random selection Ege MJ et al. Allergy 212;67:
12 Examples of bacterial species inversly related to childhood asthma and atopy Health outcome Physician s diagnosis of asthma Bacterium Corynebacterium sp Jeotgalicoccus sp Gardnerella vaginalis Lactobacillus curvatus, saker Atopic sensitization Staphylococcus sciuri Lactobacillus iners Acinetobacter lwoffii modified from Ege MJ et al. Allergy 212;67:
13
14 Mouse model of prenatal immuno-modulation - proof of principle - Mother A. lwoffii F78 exposure Mating Pregnancy Birth days -1 2 sensitization aerosol challenge Offspring days Phenotype
15 Prenatal A. lwoffii F78 exposure prevents the allergic phenotype Goblet cells Eosinophils Airway reactivity Conrad et al, J Exp Med, 29
16
17 Toll-like receptors and their ligands Peptidoglycan (G+) Lipoprotein Zymosan (Yeast) dsrna LPS (G-) Flagellin MALP-2 ssrna R848 CpG DNA??? CD14 MD-2
18 Intact maternal TLR-signalling is required for allergy protection Conrad et al, J Exp Med, 29
19 Intranasal A. lwoffii administration suppressed placental cytokine production X. Conrad et al, JEM 29
20 Commensal bacteria promote development of respiratory mucosal immune system Renz et al. Nat Rev Immunol 211 Dec 9;12(1):9-23.
21
22 MCh5 (mg/ml) pg/ml inflammation score V mucin/sbm (µm 3 /µm 2 ) % of goblet cells per basal membrane length (µm/µm) Asthma protection by prenatal A. lwoffii exposure is IFN dependent B Prenatal exposure Inflammation *** * A.lwoffii A.lwoffii A.lwoffii 7 6 Mucin 8 * A.lwoffii A.lwoffii A.lwoffii * Goblet cells 55 *** * A.lwoffii A.lwoffii A.lwoffii Sensitization Challenge Antibody treatment IgG a IFN IgG a IFN IgG a IFN C Airway reactivity 1 ** * Prenatal exposure A.lwoffii A.lwoffii A.lwoffii D IL-5 * * A.lwoffii A.lwoffii A.lwoffii Sensitization Challenge Antibody treatment IgG a IFN IgG a IFN Brand et al., JACI 211
23 % Methylation % Methylation % Methylation % Methylation % Methylation % Prenatal A. lwoffii exposure has no significant effect on DNA methylation of cytokine promotors / 1 9 IL-4 promoter IL-4 promoter 1 9 IL-5 promoter IL-5 promoter / 8 8 A. lwoffi/ A. lwoffi/ / / ACI/ ACI/ IFN promoter IFN- promoter CNS-1 1 ** 9 * ** CNS % Methylation % Methylation Brand et al, 211 JACI 28(3)
24 Epigenetic regulation - Histone modifications Transcription no Transcription TF Open chromatin: active state closed chromatin: inactive state H3 Ac Ac K79 K27 K23 Ac Me Me K18 Me R17 K14 Ac K9 Ac Me Me K4 Ac H4 K2 Me Ac K16 Ac K8 R3 Me Histone modifications: Acetylation Methylation Phosphorylation Ubiquination Sumoylation
25 % Input % Methylation Epigenetic regulation of the IFN promotor by prenatal A. lwoffii exposure DNA methylation / / Aci/ Aci/ / / A. lwoffi/ A. lwoffi/ 25 ** 2 Histone acetylation 15 1 ** 5 ns IgG H4ac H3K27me3 Brand et al, 211 JACI 28(3)
26 % Input % Input % Input % Input Epigenetic regulation of cytokine promotors by prenatal A. lwoffii exposure / / IFN promoter IL-4 promoter A. lwoffi/ ** ** / / A.lwoffii/ lwoffi/ A.lwoffii/ lwoffi/ ** A. lwoffi/ ns 5 ns H4ac H3K27me3 H4ac H3K27me3 IL-5 promoter CNS ns 1 ns 5 ns 5 ns H4ac H3K27me3 H4ac H3K27me3
27 Histone Acetyltransferase Inhibitor Garcinol Histone Acetyltransferase p3 Potent inhibitor of HAT p3 (IC 5 = 7µM) and PCAF (IC 5 = 5µM) Histone-Binding-Site Acetyl-CoA-Binding-Site Inhibits histone acetylation, no effect on deacetylation of histones Acetylation of H4 >> H3 Garcinol Arif et al., J.Med.Chem., 29 Balasubramanyam et al., JBC, 24
28 MHC5 pg/ml inflammation score % of goblet cells per basal membrane length (µm/µm) Garcinol inhibits histone acetylation and abolishes A. lwoffii mediated asthma protection in the progeny B Prenatal exposure Inflammation ** * A.lwoffii A.lwoffii A.lwoffii Goblet cells * ** A.lwoffii A.lwoffii A.lwoffii Sensitization Challenge Treatment Gar Gar C AHR AHR 9 *** ** Prenatal exposure A.lwoffii A.lwoffii A.lwoffii D Prenatal exposure IFN *** ** A.lwoffii A.lwoffii A.lwoffii Sensitization Sensitization Challenge Challenge Treatment Gar Treatment Gar Brand et al, JACI 212
29 The Team PASTURE study team Erika von Mutius, Munich, D Charlotte Braun-Fahrländer, Basel, CH Roger Lauener, Zürich, CH Josef Riedler, Salzburg, A Juha Pekannen, Kuopio, Fi Jean-Charles Dalphin, Besancon, F Dept of Clinical Chemistry and Molecular Diagnostics, Marburg Holger Garn Petra Ina Pfefferle Stefanie Brandt Dörthe Kesper Christoph Hudemann Ayse Kilic Ulrich Purath SFB/TR22 study team Otto Holst, Borstel Kai Vogel, Borstel Johann Bauer, Munich Melanie Korthals, Munich
Gene-Environment Interaction in Chronic Inflammatory Disease
Gene-Environment Interaction in Chronic Inflammatory Disease Renz H, von Mutius E, et al. Nature Immunology 2011;12:273-7. Renz H, Autenrieth IB, Brandtzeag P, Cookson WO, Holgate S, von Mutius E, et al.
Eat Dirt: Why Cleanliness is Bad for Asthma
Eat Dirt: Why Cleanliness is Bad for Asthma Joel N. Kline MD MSc Professor, Pulmonary Medicine Director: UI Adult Asthma Center Director, Clinical Research ICTS University of Iowa Iowa City, IA 1 Disclosures:
Pro/Con: Pets Prevent Allergies and Asthma
Slide 1 Pro/Con: Pets Prevent Allergies and Asthma Slide 2 Special thanks to: n Dr. Dennis Ownby n Dr. Matt Perzanowski n Dr. Erica von Mutius and Dr. Charlotte Braun-Fahrlander n Dr. Andy Liu n Colleagues
Epigene'cs, Hygiene Theory & the Origins of Asthma. Molecular Basis for Health & Disease: We are our genes. Health Protein.
Epigene'cs, Hygiene Theory & the Origins of Asthma Andy Liu, MD Pulmonary Section The Breathing Institute Children s Hospital Colorado National Jewish Health University of Colorado Denver School of Medicine
The Link Between Viruses and Asthma
The Link Between Viruses and Asthma CATHERINE KIER, MD Professor of Clinical Pediatrics Division Chief, Pediatric Pulmonary, and Cystic Fibrosis Center Director, Pediatric Sleep Disorders Center SUNY Stony
Paediatric Food Allergy. Introduction to the Causes and Management
Paediatric Food Allergy Introduction to the Causes and Management Allergic Reactions in Children Prevalence of atopic disorders in urbanized societies has increased significantly over the past several
ABIMMUNE Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections
ABIMMUNE Repurposing disused antibiotics with immune modulators as antimicrobial strategy for respiratory tract infections Jean-Claude Sirard Christophe Carnoy Fiordiligie Casilag Delphine Cayet The partners
Allergy prevention by raw cow s milk - Epidemiological evidence and possible involved mechanisms
Allergy prevention by raw cow s milk - Epidemiological evidence and possible involved mechanisms Agnes Wold Professor of Clinical Bacteriology University of Gothenburg Senior Consultant, Sahlgrenska University
Host cell activation
Dept. of Internal Medicine/Infectious and Respiratory Diseases Stefan Hippenstiel Epigenetics as regulator of inflammation Host cell activation LPS TLR NOD2 MDP TRAF IKK NF-κB IL-x, TNFα,... Chromatin
Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
Br ief Definitive Repor t Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78 Melanie L. Conrad, 1 Ruth Ferstl, 2 René Teich, 1 Stephanie
Mikrobiom und Ernährung. Ruth Ferstl
Mikrobiom und Ernährung Ruth Ferstl 18.09.2017 Gemeinsamkeiten? Zellen: - 10% Mensch - 90% Bakterien Gene: - 1% Mensch - 99% Bakterien Everything that we eat, drink, touch, and breathe is reflected in
The New England. Copyright 2002 by the Massachusetts Medical Society
The New England Journal of Medicine Copyright 02 by the Massachusetts Medical Society VOLUME 347 S EPTEMBER 19, 02 NUMBER 12 ENVIRONMENTAL EXPOSURE TO ENDOTOXIN AND ITS RELATION TO ASTHMA IN SCHOOL-AGE
Defining Asthma: Clinical Criteria. Defining Asthma: Bronchial Hyperresponsiveness
Defining Asthma: Clinical Criteria Atopy 34% Recent wheeze 20% Asthma 11% AHR 19% n = 807 From: Woolcock, AJ. Asthma in Textbook of Respiratory Medicine, 2nd ed. Murray, Nadel, eds.(saunders:philadelphia)
Defining Asthma: Bronchial Hyperresponsiveness. Defining Asthma: Clinical Criteria. Impaired Ventilation in Asthma. Dynamic Imaging of Asthma
Defining Asthma: Clinical Criteria Defining Asthma: Bronchial Hyperresponsiveness Atopy 34% Recent wheeze 20% Asthma 11% AHR 19% n = 807 From: Woolcock, AJ. Asthma in Textbook of Respiratory Medicine,
Perinatal Nutrition. Disclosure Statement. Annual Meeting of the NASPGHAN. Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned
Annual Meeting of the NASPGHAN Chicago, ILL October 10-13, 2013 Keynote Lecture: Nutrients in the Perinatal Environment: Lessons Learned Allan Walker, M.D. Boston, MA Disclosure Statement Dr. Allan Walker
Allergy in young children
APAPARI TRAINING COURSE Allergy in young children Hugo Van Bever National University Singapore Phnom Penh, 26 May 2007 APAPARI 2005 Seoul, S-Korea APAPARI JACIN MEETING, JAKARTA APRIL 2006 APAPARI - Education
Environmental factors influencing the development and progression of pediatric asthma
Environmental factors influencing the development and progression of pediatric asthma Erika von Mutius, MD Munich, Germany Recent data underscore the importance of environmental factors in the sensitization
1/30/2016 RESPIRATORY INFECTIONS AND ASTHMA NO DISCLOSURES NO FINANCIAL INTEREST INFORMATION OBTAINED JACI AJRCCM
RESPIRATORY INFECTIONS AND ASTHMA NO DISCLOSURES NO FINANCIAL INTEREST INFORMATION OBTAINED JACI AJRCCM 1 2 year old male HISTORY -Daycare since 9 months of age -Recurrent symptoms since 10 months of age:
International Symposium of Environmental Medicine
International Symposium of Environmental Medicine Including Asthma, Rhinitis Eczema, Uti Urticaria i (hives) Drug, Food, and Insect allergy Asthma: ~3 3 10 8 patients in the world 250,000 asthma deaths
Allergy and Immunology Pearls for Clinical Practice 2017
Allergy and Immunology Pearls for Clinical Practice 2017 Nothing to declare No discussion of non-fda approved medication use Katherine Gundling, MD FACP Professor, Section Chief Allergy and Immunology
Feed those babies some peanut products!!!
Disclosures Feed those babies some peanut products!!! No relevant disclosures Edward Brooks Case presentation 5 month old male with severe eczema starting at 3 months of age. He was breast fed exclusively
Immunology Part II. Innate Immunity. 18. April 2018, Ruhr-Universität Bochum Marcus Peters,
Immunology Part II Innate Immunity 18. April 2018, Ruhr-Universität Bochum Marcus Peters, marcus.peters@rub.de Conserved structures of pathogens PAMPs are detected by Pattern Recognition Receptors PRRs
Innate immune regulation of T-helper (Th) cell homeostasis in the intestine
Innate immune regulation of T-helper (Th) cell homeostasis in the intestine Masayuki Fukata, MD, Ph.D. Research Scientist II Division of Gastroenterology, Department of Medicine, F. Widjaja Foundation,
Diet during pregnancy. and atopic disease
Diet during pregnancy and atopic disease 1. Elimination diet 2. Probiotics 3. LCPUFA 4. Conclusions Maternal elimination diet during pregnancy? NO! Prescription of of an an antigen avoidance diet to to
Defining Asthma: Clinical Criteria. Defining Asthma: Bronchial Hyperresponsiveness
Defining Asthma: Clinical Criteria Atopy 34% Recent wheeze 20% Asthma 11% AHR 19% n = 807 From: Woolcock, AJ. Asthma in Textbook of Respiratory Medicine, 2nd ed. Murray, Nadel, eds.(saunders:philadelphia)
Running head: MICROBIAL EXPOSURE AND ASTHMA 1. Microbial Exposure and Asthma. Elisabeth Campbell
Running head: MICROBIAL EXPOSURE AND ASTHMA 1 Microbial Exposure and Asthma Applying Strachan s Hygiene Hypothesis to Nursing Practice Elisabeth Campbell A Senior Thesis submitted in partial fulfillment
Current Asthma Therapy: Little Need to Phenotype. Phenotypes of Severe Asthma. Cellular Phenotypes 12/7/2012
Subbasement Membrane Thickness(µm) 12/7/212 Current Asthma Therapy: Little Need to Phenotype Phenotypes of Severe Asthma Most mild and to some degree moderate asthmatics respond well to currently available
Vitamina D: un ormone multifunzione
Vitamina D: un ormone multifunzione Introduction And Infections Diego Peroni Clinica Pediatrica Universita di Ferrara Food Allergy Asthma Conclusions diego.peroni@unife.it Holick, M. F. J. Clin. Invest.
Innate Immunity & Inflammation
Innate Immunity & Inflammation The innate immune system is an evolutionally conserved mechanism that provides an early and effective response against invading microbial pathogens. It relies on a limited
Toll-like Receptor Signaling
Toll-like Receptor Signaling 1 Professor of Medicine University of Massachusetts Medical School, Worcester, MA, USA Why do we need innate immunity? Pathogens multiply very fast We literally swim in viruses
Essential fatty acids, asthma and allergies in children A summary of epidemiological evidence
Essential fatty acids, asthma and allergies in children A summary of epidemiological evidence Joachim Heinrich heinrich@helmholtz-muenchen.de Helmholtz Zentrum München Institute of Epidemiology I München,
Inflammation in the clinic
Inflammation in the clinic Stephen T. Holgate MRC Clinical Professor of Immunopharmacology ILSI Europe Workshop, Seville, May 14-15 2012 The immune system acts in four general ways to ensure host defence
Too Much, Too Early or Too Late
Too Much, Too Early or Too Late Prenatal & Perinatal Exposures Charles (Chip) Webb, M.D. The Allergy Group 1 Disclosure I have no relevant disclosures 2 1. Hygiene Hypothesis 2. Epigenetics 3. Climate
Allergy and Immunology Review Corner: Chapter 75 of Middleton s Allergy Principles and Practice, 7 th Edition, edited by N. Franklin Adkinson, et al.
Allergy and Immunology Review Corner: Chapter 75 of Middleton s Allergy Principles and Practice, 7 th Edition, edited by N. Franklin Adkinson, et al. Chapter 75: Approach to Infants and Children with Asthma
Twenty years of the hygiene hypothesis. David P Strachan Community Health Sciences St George s, University of London
Twenty years of the hygiene hypothesis David P Strachan Community Health Sciences St George s, University of London A little dirt never does any harm... Hay fever, birth order & social class H a y fe v
Identifying Biologic Targets to Attenuate or Eliminate Asthma Exacerbations
Identifying Biologic Targets to Attenuate or Eliminate Exacerbations exacerbations are a major cause of disease morbidity and costs. For both children and adults, viral respiratory infections are the major
FOOD ALLERGY AND WHEEZING
FOOD ALLERGY AND WHEEZING Jarungchit Ngamphaiboon Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand The pattern of allergy in developed countries has been changing
Persistent food allergy might present a more challenging situation. Patients with the persistent form of food allergy are likely to have a less
Iride Dello Iacono Food allergy is an increasingly prevalent problem in westernized countries, and there is an unmet medical need for an effective form of therapy. A number of therapeutic strategies are
Clinical and Experimental Allergy
ORIGINAL PAPER Clinical and Experimental Allergy, 36, 489 494 c 2006 Blackwell Publishing Ltd Do parents with an atopic family history adopt a prudent lifestyle for their infant? (KOALA Study) I. Kummeling,
Toll-like receptor 2 as a major gene for asthma in children of European farmers
Toll-like receptor 2 as a major gene for asthma in children of European farmers Waltraud Eder, MD, a,b Walt Klimecki, PhD, a Lizhi Yu, MD, a Erika von Mutius, MD, b Josef Riedler, MD, c Charlotte Braun-Fahrländer,
Immunology of Asthma. Kenneth J. Goodrum,Ph. Ph.D. Ohio University College of Osteopathic Medicine
Immunology of Asthma Kenneth J. Goodrum,Ph Ph.D. Ohio University College of Osteopathic Medicine Outline Consensus characteristics/incidence data Immune/inflammatory basis Etiology/Genetic basis Hygiene
DNA vaccine, peripheral T-cell tolerance modulation 185
Subject Index Airway hyperresponsiveness (AHR) animal models 41 43 asthma inhibition 45 overview 41 mast cell modulation of T-cells 62 64 respiratory tolerance 40, 41 Tregs inhibition role 44 respiratory
Pediatric Asthma. Fernando D. Mar,nez, M.D. Asthma and Airways Disease Research Center The University of Arizona
Pediatric Asthma Fernando D. Mar,nez, M.D. Asthma and Airways Disease Research Center The University of Arizona Disclosure Grant from Johnson and Johnson to study use of Amish dust to prevent asthma Advisor
Immunological Tolerance
Immunological Tolerance Definition: Making sure antibodies or T cells recognizing self components are either eliminated or brought under tight control. Failure of tolerance can lead to autoimmunity. (Also
Thorax Online First, published on October 21, 2005 as /thx
Thorax Online First, published on October 21, 2005 as 10.1136/thx.2005.049403 1 Inhalation of stable-dust extract prevents allergen-induced airway inflammation and hyperresponsiveness Marcus Peters 1*,
Early life nutrition and Inflammation
Early life nutrition and Inflammation Harry J McArdle and Graham Devereux Rowett institute of Nutrition and Health, University of Aberdeen. Aberdeen Royal Infirmary. The process of development Critical
Commensal Bacteria, Toll-like Receptors and Intestinal Injury. Journal Club December 16, 2004
Commensal Bacteria, Toll-like Receptors and Intestinal Injury Journal Club December 16, 2004 Gut-Commensal Interactions Nutrient metabolism Tissue development Resistance to colonization with pathogens
Allergic rhinitis (Hay fever) Asthma Anaphylaxis Urticaria Atopic dermatitis
Hypersensitivity Disorders Hypersensitivity Disorders Immune Response IgE Disease Example Ragweed hay fever IgG Cytotoxic Immune complex T Cell Hemolytic anemia Serum sickness Poison ivy IgE-mediated Diseases
Allergen Immunotherapy in Asthma: Now and in the Future
Allergen Immunotherapy in Asthma: Now and in the Future Young-Il Koh, M.D. Chonnam National University Medical School, Gwangju, Korea 2017-03-25 CHONNAM NATIONAL UNIVERSITY MEDICAL SCHOOL 1 Management
TD-BF01: Innate immunity to microorganisms
TD-BF01: Innate immunity to microorganisms I. Toll receptors (adapted from Takeuchi, O. et al. (1999) Immunity 11:443; Kawai, T. et al. (1999) Immunity 11:115; Hemmi, H. et al. (2000) Nature 408:740; Muzio,
D2 inhibits TLR2- initiated 12p40 transcription (-) TLR2 PGN MDP. MyD88 IRAK ECSIT TRAF6 NIK. Smallest unit of PGN muramyl dipeptide IKK.
D2 inhibits TLR2- initiated 12p40 transcription CARD CARD NOD2 LRR RICK/Rip2 NIK MDP TRAF6 PGN TLR2 MyD88 IRAK ECSIT (-) IKK Smallest unit of PGN muramyl dipeptide IκB NF-κB atanabe et al, 2004 NF-κB IL-12p40
Airway macrophages in health and disease Tracy Hussell
Prof. Airway Macrophages in Health and Disease Director, Manchester Collaborative Centre for Inflammation Research (MCCIR), Professor of Inflammatory Disease University of Manchester Manchester, M13 9PT
Allergic Disorders. Allergic Disorders. IgE-dependent Release of Inflammatory Mediators. TH1/TH2 Paradigm
Allergic Disorders Anne-Marie Irani, MD Virginia Commonwealth University Allergic Disorders IgE-mediated immune reactions Clinical entities include: asthma allergic rhinitis atopic dermatitis urticaria
Allergic Disorders. Allergic Disorders. IgE-dependent Release of Inflammatory Mediators. TH1/TH2 Paradigm
Allergic Disorders Anne-Marie Irani, MD Virginia Commonwealth University Allergic Disorders IgE-mediated immune reactions Clinical entities include: asthma allergic rhinitis atopic dermatitis urticaria
The Skinny of the Immune System
The Skinny of the Immune System Robert Hostoffer, DO, FACOP, FAAP Associate Professor of Pediatrics Case Western Reserve University, Cleveland, Ohio Overview 1. Immune system of the skin 2. Immune Players
University of Nottingham, UK. Addis Ababa University, Ethiopia
The role of paracetamol and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study Alemayehu Amberbir 1, 2, GirmayMedhin 2, AtalayAlem 2, John Britton 1, Gail Davey
Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis
Atopic dermatitis and skin disease Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis Caroline Roduit, MD, MPH, a Johanna Wohlgensinger,
Developing the potential of prebiotics and probiotics as immune health ingredients
Developing the potential of prebiotics and probiotics as immune health ingredients ARTHUR OUWEHAND ACTIVE NUTRITION DUPONT NUTRITION & HEALTH 20 th November 2014, The gut microbiome The gut microbiota
Recurrent Wheezing in Preschool Children. William Sheehan, MD Associate Professor of Pediatrics Division of Allergy and Immunology
Recurrent Wheezing in Preschool Children William Sheehan, MD Associate Professor of Pediatrics Division of Allergy and Immunology Disclosure I have nothing to disclose related to this talk. Background
Evolution of asthma from childhood. Carlos Nunes Center of Allergy and Immunology of Algarve, PT
Evolution of asthma from childhood Carlos Nunes Center of Allergy and Immunology of Algarve, PT allergy@mail.telepac.pt Questionnaire data Symptoms occurring once or several times at follow-up (wheeze,
Innate Immunity. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples Chapter 3. Antimicrobial peptide psoriasin
Know Differences and Provide Examples Chapter * Innate Immunity * kin and Epithelial Barriers * Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive
DNA methylation and a biomarker panel to predict asthma development
Accepted Manuscript DNA methylation and a biomarker panel to predict asthma development Harald Renz, MD PII: S0091-6749(19)30483-X DOI: https://doi.org/10.1016/j.jaci.2019.04.002 Reference: YMAI 13961
How the Innate Immune System Profiles Pathogens
How the Innate Immune System Profiles Pathogens Receptors on macrophages, neutrophils, dendritic cells for bacteria and viruses Broad specificity - Two main groups of bacteria: gram positive, gram-negative
Neonatal Exposure to Microbial Phosphorylcholine Modulates the Development of House Dust Mite Allergy During Adult Life
Neonatal Exposure to Microbial Phosphorylcholine Modulates the Development of House Dust Mite Allergy During Adult Life J. Sides SEM Preeyam Patel Mentor: Dr John Kearney 015 CAMBAC Research Day 9/18/15
Mechanisms of allergen-specific immunotherapy
2012 KAAACI/EAAS Spring Mechanisms of allergen-specific immunotherapy Woo-Jung Song, MD Division of Allergy and Clinical Immunology Department of Internal Medicine Seoul National University Hospital, Seoul,
Is there an allergy epidemic and what are the possible causes?
Is there an allergy epidemic and what are the possible causes? Professor Michael Gold Department of Allergy and Immunology Women s and Children s Health Network Discipline of Paediatrics University of
Searching for Targets to Control Asthma
Searching for Targets to Control Asthma Timothy Craig Distinguished Educator Professor Medicine and Pediatrics Penn State University Hershey, PA, USA Inflammation and Remodeling in Asthma The most important
Innate Immunity. Chapter 3. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples. Antimicrobial peptide psoriasin
Chapter Know Differences and Provide Examples Innate Immunity kin and Epithelial Barriers Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive Immunity
Immunology of Asthma. Kenneth J. Goodrum,Ph. Ph.D. Ohio University College of Osteopathic Medicine
Immunology of Asthma Kenneth J. Goodrum,Ph Ph.D. Ohio University College of Osteopathic Medicine Outline! Consensus characteristics! Allergens:role in asthma! Immune/inflammatory basis! Genetic basis!
DOWNLOAD OR READ : LIPOPOLYSACCHARIDE ENDOTOXIN INDUCES IL 18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO PDF EBOOK EPUB MOBI
DOWNLOAD OR READ : LIPOPOLYSACCHARIDE ENDOTOXIN INDUCES IL 18 VIA CD14 IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS IN VITRO PDF EBOOK EPUB MOBI Page 1 Page 2 lipopolysaccharide endotoxin induces il 18
9/26/2012. Too Clean or Not Too Clean? What is the Hygiene Hypothesis? History Immunological Mechanisms Case study Helminthic Therapy
Too Clean or Not Too Clean? What is the Hygiene Hypothesis? History Immunological Mechanisms Case study Helminthic Therapy There has been a steep increase in the diagnosis of autoimmune diseases and allergies
Allergen and Environment in Severe Asthma
Allergen and Environment in Severe Asthma Hye-Ryun Kang MD., PhD. Department of Internal Medicine, Seoul National University Hospital Role of Allergen in Asthma Pathogenesis Early response of allergen
Infant feeding and atopic eczema risk. Possible allergy prevention by nutritional intervention
Note: for non-commercial purposes only Infant feeding and atopic eczema risk Sibylle Koletzko Possible allergy prevention by nutritional intervention Maternal diet during pregnancy and breast-feeding Dr.
Innate Immunity and the Paradoxes of Viral Pathogens and Tissue Injury in Gene Therapy
Innate Immunity and the Paradoxes of Viral Pathogens and Tissue Injury in Gene Therapy Daniel R. Salomon, M.D. Department of Molecular and Experimental Medicine The Scripps Research Institute Tissue and
R. Masekela. Paediatric Pulmonologist and Allergist
R. Masekela Paediatric Pulmonologist and Allergist Outline Definitions i i Biomass fuels Atopy Respiratory tract Environmental tobacco smoke (ETS) Respiratory tract. HIV Atopy Traffic related air pollutants
2. Innate immunity 2013
1 Innate Immune Responses 3 Innate immunity Abul K. Abbas University of California San Francisco The initial responses to: 1. Microbes: essential early mechanisms to prevent, control, or eliminate infection;
Epigenetics: The Future of Psychology & Neuroscience. Richard E. Brown Psychology Department Dalhousie University Halifax, NS, B3H 4J1
Epigenetics: The Future of Psychology & Neuroscience Richard E. Brown Psychology Department Dalhousie University Halifax, NS, B3H 4J1 Nature versus Nurture Despite the belief that the Nature vs. Nurture
Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology
Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology Allan Linneberg, MD, PhD, a Jacob B. Simonsen, MSc, b Janne Petersen, MSc, a Lone G. Stensballe,
Intestinal Microbiota in Health and Disease
Intestinal Microbiota in Health and Disease February 27, 2015 Master s Course in Gastroenterology Prof. Kathy McCoy 1 Overview Overview of Gut Microbiota Microbiota in Health Microbiota in Disease 2 Gut
Asthma in Pediatric Patients. DanThuy Dao, D.O., FAAP. Disclosures. None
Asthma in Pediatric Patients DanThuy Dao, D.O., FAAP Disclosures None Objectives 1. Discuss the evaluation and management of asthma in a pediatric patient 2. Accurately assess asthma severity and level
Clinical & Experimental Allergy
EC doi: 10.1111/j.1365-2222.2009.03428.x Clinical & Experimental Allergy, 40, 786 794 ORIGINAL ARTICLE Epidemiology of Allergic Disease c 2009 Blackwell Publishing Ltd Maternal vitamin D intake during
Identification of Microbes
Identification of Microbes Recognition by PRR (pattern recognition receptors) Recognize conserved molecular patterns on microbes called pathogen associated molecular patterns (PAMPs) which are not present
COPD and Asthma: Similarities and differences Prof. Peter Barnes
and Asthma: Similarities and Differences and Asthma: 1 Imperial College Peter Barnes FRS, FMedSci, National Heart & Lung Institute Imperial College, London, UK p.j.barnes@imperial.ac.uk Royal Brompton
Table 1: Summary of studies of raw milk with health outcomes,
[This summary document and copies of all cited articles were presented to the B.C. Government on Feb 26 2018] Peer-reviewed scientific studies demonstrating health benefits of unprocessed milk, 2001-2018
EARN 3 FREE CPD POINTS
EARN 3 FREE CPD POINTS asthma and allergy Leader in digital CPD for Southern African healthcare professionals Asthma and allergy: Influence of EARLY LIFE RISK EXPOSURE Professor Peter Sly Director: World
Carsten Flohr ISAAC Steering Committee 2011
Carsten Flohr Industrialised countries 20% asthma 20% eczema 30% allergic rhinitis Developing countries less allergy rural-urban gradient big cities similar prevalence levels to industrialised countries
Good Bugs Bad Bugs: The Role of the Microbiome on Human Health
Good Bugs Bad Bugs: The Role of the Microbiome on Human Health S Shahzad Mustafa, MD Rochester Regional Health Clinical Associate Professor of Medicine University of Rochester School of Medicine and Dentistry
The role of mucosal innate immunity in allergic rhinitis Ji-Hwan Ryu
The role of mucosal innate immunity in allergic rhinitis Ji-Hwan Ryu Research Center for Human Natural Defense system College of Medicine Yonsei University Mucosal epithelium in innate immunity Mucosal
Asthma diagnosis and. treatment. rather than with atopic sensitization. (J Allergy Clin Immunol 2004;113:860-7.)
Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health Robert Theodoor van Strien, PhD, a Regina Engel,
Increases Circulation Immune Complexes, Increased Fibrin Activation and Fibrosis
Inflammation Inflammation is a complex biological process in which the body s white blood cells and chemicals provide protection from infection and foreign substances, such as bacteria, yeast, and viruses
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore
Allergy and Breast Feeding CON (?) Hugo Van Bever Department of Pediatrics NUHS Singapore WAC, Cancun, December 2011 As a pediatrician are you crazy? Breast milk is the best! 1. Nutritional 2. Psychological
Outcome, classification and management of wheezing in preschool children Paul L.P. Brand
Outcome, classification and management of wheezing in preschool children Paul L.P. Brand Princess Amalia Children s Clinic Isala klinieken, Zwolle the Netherlands p.l.p.brand@isala.nl Valle de la Luna,
Effector T Cells and
1 Effector T Cells and Cytokines Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School 2 Lecture outline Cytokines Subsets of CD4+ T cells: definitions, functions, development New
Evaluation of in utero sensitization by screening antigenspecific immunoglobulin E levels in umbilical cord blood
Original paper Evaluation of in utero sensitization by screening antigenspecific immunoglobulin E levels in umbilical cord blood Tamay Gürbüz, Burcu Karakol, Zehra Esra Önal, Yonca Tabak, Çağatay Nuhoğlu,
Necrotizing Enterocolitis: The Role of the Immune System
Necrotizing Enterocolitis: The Role of the Immune System Patricia Denning, M.D. Associate Professor in Pediatrics Division of Neonatology Emory University School of Medicine What is NEC? What is NEC? Necrotizing
3/10/14. Ultrastructural organization. Gram Stain. Infection leads to production of inducers of inflammation. Gram negative.
Infection leads to production of inducers of inflammation or dendritic cell Inflammatory mediators: Complex and many, but include: Lipids and Proteins (cytokines/chemokines) TNF Others Ultrastructural
Development of atopic dermatitis according to age of onset and association with early-life exposures
Atopic dermatitis and skin disease Development of atopic dermatitis according to age of onset and association with early-life exposures Caroline Roduit, MD, MPH, a Remo Frei, PhD, b Georg Loss, PhD, c
Gifu University Graduate School of Medicine, Gifu Asahi University School of Dentistry, Gifu Sakihai Institute, Gifu
2 3 2 3 Chisato NAGATA, Naoyoshi TAKATSUKA, Noriyuki TAKEDA 2 and Hiroyuki SHIMIZU 3 Gifu University Graduate School of Medicine, Gifu 50-94 2 Asahi University School of Dentistry, Gifu 50-0296 3 Sakihai
Rino Ragno Rome Center for Molecular Design Department of Chemistry and Phamaceutical Technology Faculty of Pharmacy and Medicine
Rino Ragno Rome Center for Molecular Design Department of Chemistry and Phamaceutical Technology Faculty of Pharmacy and Medicine HDAC Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction
Distinction and Overlap. Allergy Dpt, 2 nd Pediatric Clinic, University of Athens
Asthma Phenotypes: Distinction and Overlap Nikos Papadopoulos Allergy Dpt, 2 nd Pediatric Clinic, University of Athens Asthma as a syndrome From the Iliad to ADAM 33 and back again Bronchoconstriction,