HS:$Biology$$ $ BPS!Science!CWA!materials!2016!!

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Griselda Cannon
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1 CommonWritingAssignment:Science GeneticsCWA TheGeneticsCWAisdesignedtobeanopenargument.Theoverarchingquestionis:What shouldsuzannedo?shouldshebetested?thefollowinghandoutsareincluded: Prompt:GeneticsCERR Alzheimer scasestudy: Rubric SampleStudentResponse Studentsshouldbeprovidedthe GeneticsCERR handout.thishandoutincludestheprompt, data,andaresponsesection.inadditiontoprovidingaspecificcerrrubricthatcorresponds tothistopic,asamplestudentresponseisincluded. HS:Biology BPSScienceCWAmaterials2016

2 GeneticsCERR Readthescenariobelowaboutawomanfacedwithdecisionaboutwhethertogetgenetictesting. Living With Her Genes: Early Onset Familial Alzheimer s Disease" Lynne H. Gildensoph, Biology Department, The College of St. Catherine, St. Paul, MN Alice M. Stanford, Division of Science and Mathematics, University of the Virgin Islands, St. Thomas, VI Deborah D. Wygal, Biology Department, The College of St. Catherine, St. Paul, MN Adapted From: sciencecases.lib.buffalo.edu: Part I - Confronting the Future Suzanne, a woman in her early 30s, has learned the devastating news that her 38-yearold sister, Karen, has been diagnosed with early-onset familial Alzheimer s disease EOFAD) through the use of a genetic screen. Karen started experiencing symptoms such as progressive memory loss, confusion, poor judgment, and language problems in her late 30s. Karen is no longer able to care for her two children and is in a nursing home, where she may live another 10 or more years, although her state will deteriorate with time. This is similar to what Suzanne s dad experienced before he died of EOFAD complications when he was just 42. Furthermore, one of her dad s parents his mother) also had EOFAD. Suzanne s mother did not have EOFAD. Suzanne is distraught, both by the thought of losing her sister and by the fact that she may be carrying the gene for this disease herself. Since she is a genetic counselor, she understands the pattern of inheritance of the gene for this autosomal dominant hereditary disease, and its implications for her own life. Scientists working on the Human Genome Project have identified three gene mutations responsible for EOFAD. Clinical testing for these mutations is available, and tests on Karen revealed that she has one of these mutations, called APP. APP is a dominant gene. This is a relatively rare mutation, affecting only 5% of people diagnosed with EOFAD. She and her husband, David, are struggling with the decision of whether Suzanne should be tested, since they know that no effective treatment or cure for EOFAD exists and the probability of having inherited the gene and remaining unaffected is very small. In addition, there are implications for insurance coverage, potential discrimination by employers, and the likelihood that family and social interactions will change. And, if Suzanne carries the gene, if she had children, they could potentially inherit it. Suzanne and David have been considering having a child of their own.

3 Question: Should Suzanne be tested for APP? Makeaclaimandsupportitwithevidenceandreasoning.Yourreasoningshouldincludebiological conceptsyouhavelearnedaswellasotherethicalconisderations.thereisnorightanswer;what mattersishowyoujustifyyourchoice. Don tforgetto... Planyourwritingusinganoutline,weborgraphicorganizer.Asyouwriteeachdraftofyourassignment, it simportanttousewhatyouknowasawritertocommunicateyourideaseffectively. Provideaclearclaimthatanswersthequestion. Includeevidenceusingdatafromclassactivities,experimentsandotherresources. Includereasoningtoshowhowyourevidencesupportsyourclaim. Usevocabularythatyouhavelearnedinscienceclass. Correctgrammar,punctuation,andspellingerrors. Claim:Writeastatementthatanswersthequestionabove. Evidence:StatetheevidenceincludingrelevantdataaboutEOFADforSuzanne sfamily.

4 Reasoning:Explainwhytheevidencesupportstheclaim.Yourreasoningshouldincludebiological conceptsyouhavelearnedaswellasethicalconisderations. Rebuttal:Addressanargumentthatsomeonewhodisagreeswithyoumightmake.Don tforgetto arguewhyyourclaimisstronger.

5 GeneticsCERRRubric Exemplary Proficient NeedsImprovement CriticalArea Claim: Accuratelystateswhetherornot Suzanneshouldbetestedbased onhis/heranalysisofthe evidence,usingpreciselanguage thatcorrespondstothequestion Writtenincomplete,easyto understandsentences) Accuratelywhetherornot Suzanneshouldbetested,using languagethatgenerally correspondstothequestion Writtenincomplete,easyto understandsentences) Answersthequestionbutuses vagueorunclearlanguage. Inaccuratelyorincompletely answersthequestion,and/or Notwrittenincomplete,easyto understandsentences) Doesnotmakeaclaim,ormakes acompletelyinaccurateclaim. Evidence: weightedx2 Providesspecific,appropriate, andampleevidencethat supportsclaim,including: PhenotypicpatternofEOFAD insuzanne sfamily Suzanne sriskofhaving allele sforeofad RiskforSuzanne schildrento haveeofad Providesspecific,appropriate, andsufficientevidencethat supportsclaim.mayinclude someinappropriateevidence PhenotypicpatternofEOFAD insuzanne sfamily Suzanne sriskofhaving allele sforeofad RiskforSuzanne schildrento haveeofad Providesappropriate,but insufficientorunclearevidence tosupportclaim.mayinclude someinappropriateevidence Addresses1N2ofbulletpoints fromexemplary Doesnotprovideevidence,or onlyprovidesinappropriate evidenceevidencethatdoes notsupportclaim) Reasoning: weightedx2 Correctlyandclearlyconnects theevidencetotheclaim, showinghowitsupports whetherornotsuzanneshould betested Identifiesandappliesscientific conceptsaboutdominance Discussesethicalanalysis, consideringsuzanne schildren andqualityoflife Appliesconceptsthatgo beyondtheprompt,as appropriate Correctlyandadequately connectstheevidencetothe claim,showinghowitsupports whetherornotsuzanneshould betested Identifiesandappliesscientific conceptsaboutdominance Discussesoneethicalissue concerningsuzanne sdecision Correctlyconnectstheevidence totheclaim,butleavesout importantdetails,and/or Partiallyidentifiesandapplies geneticsconceptsand/or Doesnotapplyethicalanalysis Restatestheevidencewithout connectingittotheclaim Doesnotprovidereasoning,or onlyprovidesreasoningthat doesnotconnectevidenceto theclaim,and/or Providesanincomplete generalization,ordoesnot applyappropriatescientific concepts Rebuttal: Correctlyidentifiestheopposite choiceasacounternargument totheclaim. Explains,inyourownwords, whyyourclaimisabetter claim, Correctlyidentifiestheopposite choiceasacounternargument Explains,mostlyinyourown words,whyyourclaimisa betterclaimthanthecountern argumentusingsomeevidence Identifiestheotherchoiceasa possiblecounternargument,but includesevidencebutnot reasoningorreasoningbutnot evidencetoshowwhyyour claimisbetterthanthe Doesnotidentifyappropriate counterarguments,and/or Doesnotprovidesufficient evidencetoaddresscounter arguments,orprovidesmore supportforthecountern

6 Givesevidenceand reasoningwhysomeone mightmakeoppositeclaim Explains,inyourownwords, whyyourclaimisabetter claim,usingevidenceand reasoning andincompletereasoning counternargument argumentthentheoriginal claim Writing: Useappropriate structure, grammar,and mechanicsto communicateyour argument. Writingcontainsno grammaticalorspellingerrors Writingisclear,concise,and persuasive Writingcontainsveryfew grammaticalorspellingerrors Writingisclear,mostlyconcise, andwelldeveloped Writingisfairlyclear,with somegrammaticalorspelling errors Writingcouldbemoreconcise Writingisdifficulttofollow, withmanygrammaticalerrors andnoclearstructure Writingiseithertoowordyor tooincomplete

7 GeneticsCERRSampleResponse:Yes Claim: Yes,Suzanneshouldgettestedbecauseoftheimplicationsforherchildren. Evidence: Suzanne smotherdidnothaveeofad,thereforeshecouldnothavepassedonadiseaseallele tosuzanne.suzanne sdadhadeofad.consequently,shehasa50%chanceofgettingeofad.if SuzannehasthealleleforEOFAD,herchildrenhavea50%chanceofhavingthedisease. Reasoning: ThereasonSuzannehasa50%chanceofgettingthediseaseisbecauseEOFADisdominant.For adominantgene,anindividualonlyneedstohaveonecopyoroneallele)tohavethedisorder.since Suzanne smotherdidnothaveeofad,thismeansshedidnothaveanalleletopassontosuzanne.on theotherhand,sincesuzanne sdaddidhaveeofad,thatmeanshehadoneallele,whichsuzannehasa 50%changeofreceiving. SinceSuzannehasa50%chanceofhavingEOFADandofpassingitontopotentialchildren,she shouldgettested.suzanneandherhusbandshouldknowwhethersuzannehasachanceofpassingon thisdisordertotheirchildrensinceitisadominantdisorder.thedegenerativenatureofthedisorder andimpactonfamilymembersforcare,etc.areimportantconsiderations.inadditiontothepossibility ofpassingonthedisorder,suzanneandherhusbandshouldthinkabouttheimpactonpotential childrenofhavingaparentwhomaydevelopthedisorder,needcare,losetheabilitytorecognizeher children,andprobablydieprematurely.althougheofadismoregeneticallydeterminedthanregular Alzehimer sandmanydiseases,knowingsuzanne sriskmayhelpherandherhusbandmakelife decisionsaswellasexploreresearch,etc.itispossiblethatresearchwillhelptodeveloptreatmentsor preventativemeasuresbeforesuzanneisaffected.earlydetectionorpreventivemeasurescould possiblyhelpatthatpoint. Rebuttal: SomeethicistsandmedicalprofessionalsmightarguethatSuzanneshouldnotgettestedsince knowingwhetherornotsheisatriskwillnotchangeherlifeoutcomes,astreatmentsarecurrently unavailable.havingtheinformationmightalsoinfluenceinsurancecompaniestochargemoreorviolate privacyinsharingherinformation.suzanneandherhusbandshouldnotbethejudgeofwhoshould live/comeintoexistenceorjudgethatthelifeofsomeonewhowilldevelopeofadisnotworthliving. Despitethesedifficultissuestoconsider,Suzannehasanobligationtobetestedandfindoutherrisk becauseoftheimpactonpotentialchildren.herhusbandshould,attheveryleast,havetheinformation astheymakethisdecisionaboutpossibilitiesforanother slife.

GRADING RUBRIC (TOTAL POINTS

GRADING RUBRIC (TOTAL POINTS Lesson 6.9a Disorder Pamphlet Due Date: FRIDY, Feb 24th Name: Date: Period: ssigned Disorder: disorders are hereditary conditions caused by defective genes. You will be assigned a genetic disorder. Once