Appendix C: Search strategies

Transcription

1 Appendix C: Search strategies Overview of search strategies This appendix details the search strategies used in the identification of relevant studies for the guideline on diagnosis, prevention and management of delirium. All searches were conducted on the following databases: Medline (OVID), Embase (OVID), PsycINFO (Silverplatter/OVID) Cinahl (EBSCO) and the Cochrane Library. Searches were initially performed for articles published since 199, the publication date of the Diagnostic and Statistical Manual IV (DSM IV) which is the reference standard for the diagnosis of delirium. Following guidance from the Guideline Development Group (GDG), a further search back to 198 was carried out in order to retrieve studies using the earlier Diagnostic and Statistical Manual III (Revised) (DSMIII-R) as the reference standard. Search filters were applied where appropriate, including filters for randomised controlled trials (RCT) and systematic reviews (SR). The RCT filter used was based on that recommended by Cochrane (Higgins 00). An exclusions filter was designed to remove irrelevant results such as letters and editorials. The search strategies for each review are reproduced below. Note that the searches make use of the controlled vocabulary which varies between databases and between search interfaces. Amendments were made where necessary in order to take these variations into account. Where possible, searches were restricted to articles written in English. All searches were updated on August 1 th 009. Hand searching was not undertaken by the NCC-NSC following NICE advice that exhaustive searching on every guideline review topic is not practical (Mason 00). Reference lists of articles were checked for further articles of potential relevance. Page 1 of 0

2 Clinical questions and literature search Diagnosis Question wording What are the symptoms that indicate a person may have delirium? What is the diagnostic accuracy of practical diagnostic tests compared with the reference standard DSM IV, to identify delirium in people in hospital and long-term care settings? What are the diagnostic criteria that must be fulfilled to identify that a person has delirium? Prognosis What are the risk factors for delirium? What are the precipitating factors for delirium? What are the consequences of delirium in terms of morbidity and mortality in a person in hospital or long-term care? Interventions Prevention of delirium in a hospital setting What are the most clinical and cost effective and safe pharmacological interventions for the prevention of delirium in people in hospital? What are the most clinical and cost effective singlecomponent, non-pharmacological interventions for the prevention of delirium in people in hospital? What are the most clinical and cost effective multicomponent interventions for the prevention of delirium in people in hospital? Prevention of delirium in a long-term care setting What are the most clinical and cost effective and safe pharmacological interventions for the prevention of delirium in people in long-term care? What are the most clinical and cost effective singlecomponent, non-pharmacological interventions for the prevention of delirium in people in long-term care? What are the most clinical and cost effective multicomponent interventions for the prevention of delirium in people in longterm care? Treatment of delirium in a hospital setting What are the most clinical and cost effective and safe pharmacological interventions for treating people with delirium in hospital? What are the most clinical and cost effective singlecomponent, non-pharmacological interventions for treating people with delirium in hospital? What are the most clinical and cost effective multicomponent interventions for treating people with delirium in hospital? Study type / filters used All study types All study types All study types All study types All study types Database and years Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Page of 0

3 Question wording Study type / filters used Database and years Treatment of delirium in a long-term care setting What are the most clinical and cost effective and safe pharmacological interventions for treating people with delirium in long-term care? What are the most clinical and cost effective singlecomponent, non-pharmacological interventions for treating people with delirium in long-term care? What are the most clinical and cost effective multicomponent interventions for treating people with delirium in long-term care? Patient information What information should be given to people at risk of developing delirium, or people with delirium, and their families or carers? Other What is the prevalence of delirium in different hospital settings and in long-term care? All study types All study types All study types Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Medline Embase Cochrane Cinahl PsycINFO Delirium Patient Filter The following patient filters were developed in consultation with the GDG chair. These patient filters were initially combined with filters for randomized controlled trials (RCTs) and systematic reviews (SRs) (see below). It was then combined with an exclusions filter to remove unwanted references. The results were sifted for relevant studies. The searches were then performed with no additional filters and again sifted for studies relevant to the guideline. Page of 0

4 Medline 1 deliri$.ti,ab. (acute adj (confusion$ or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).mp. (terminal$ adj restless$).mp. toxic confus$.mp. delirium/ confusion/ or/1-8 *psychoses, alcoholic/ or *alcohol withdrawal delirium/ 9 *substance withdrawal syndrome/ 10 8 or 9 11 not 10 Embase 1 delirium/ (acute adj (confusion$ or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).mp. deliri$.ti,ab. (terminal$ adj restless$).mp. toxic confus$.mp. or/1- *alcohol psychosis/ 8 *delirium tremens/ 9 *withdrawal syndrome/ 10 or 8 or 9 11 not 10 PsycINFO (Silverplatter) #1 # not #11 #11 ("delirium-tremens" in mj) or ("alcoholic-psychosis" in mj) or ("alcohol-withdrawal" in mj) or ("drug-withdrawal" in mj) #10 "delirium-tremens" in mj #9 "alcoholic-psychosis" in mj #8 "alcohol-withdrawal" in mj # "drug-withdrawal" in mj # (toxic confus* in ti,ab,mj,mn) or ((terminal* adj restless*) in ti,ab,mn,mj) or ((acute near (confusion* or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")) in ti,ab,mj,mn) or (deliri* in ti,ab) or ("delirium-" in mj,mn) # toxic confus* in ti,ab,mj,mn # (terminal* adj restless*) in ti,ab,mn,mj # (acute near (confusion* or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")) in ti,ab,mj,mn # deliri* in ti,ab #1 "delirium-" in mj,mn Page of 0

5 PsycINFO (OVID) Cinahl 1 exp delirium/ deliri$.ti,ab. (acute adj (confusion* or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).ti,ab,sh. (terminal* adj restless*).ti,ab,sh. toxic confus*.ti,ab,sh. or/1- *drug withdrawal/ 8 *alcohol withdrawal/ 9 *alcoholic psychosis/ 10 *delirium tremens/ 11 or/-10 1 not 11 S1 S1 S1 S1 S1 S1 S11 S10 S9 S8 S S S S S S S1 s1 not s1 s1 or s1 or s1 (mh "psychoses, substance-induced+") (mh "alcohol withdrawal delirium") (mh "substance withdrawal syndrome") s11 or s10 or s9 or s8 or s or s or s or s or s or s or s1 toxic n1 confus* terminal* n1 restless* acute n "organic psycho?syndrome" acute n "psycho-organic syndrome" acute n "brain failure" acute n "brain syndrome acute n confusion* deliri* (mh "delirium management (iowa nic)") (mh "confusion") (mh "delirium") The Cochrane Library #1 deliri*:kw,ti,ab # (acute near/ (confusion* or brain syndrome or brain failure or psycho*organic syndrome* or organic psycho*syndrome*)):kw,ti,ab # (terminal* next restless*):kw,ti,ab # toxic next confus*:kw,ti,ab # (#1 OR # OR # OR #) Page of 0

6 8 RCT Filters Medline 1 randomized controlled trial$.pt,sh. clinical trial$.pt,sh. random allocation/ double blind method/ single blind method/ ((clin$ or control$) adj trial$).ti,ab. ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).ti,ab. 8 placebos/ 9 placebo$.ti,ab. 10 random$.ti,ab. 11 (volunteer$ or "control group" or controls or prospective$).ti,ab. 1 research design/ 1 or/1-1 1 animals/ not humans/ 1 1 not 1 Embase 1 exp randomized controlled trial/ (random$ or placebo$).ti,ab. ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).ti,ab. (clin$ adj trial$).ti,ab. exp comparative study/ exp evaluation/ exp follow up/ 8 exp prospective study/ 9 (control$ or prospective$ or volunteer$).ti,ab. 10 or/ exp human/ 1 10 and 11 PsycINFO 1 placebo.sh. clinical trials.sh. random sampling.sh. mental health program evaluation.sh. treatment effectiveness evaluation.sh. exp treatment outcomes/ or treatment outcome$.md. (clinical adj trial$).tw. 8 (crossover or cross over).tw. 9 (((single$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$ or dummy)) or (singleblind$ or doubleblind$ or trebleblind$)).tw. Page of 0

7 Cinahl 10 (placebo$ or random$).tw. 11 (animal not (animal and human)).po. or (animals not (animals and (human females or human males))).sh. 1 or/1-10 not 11 S11 (s10 or s9 or s8 or s or s or s or s or s or s or s1) S10 control* or prospective* or volunteer* S9 (mh "quantitative studies") S8 (mh "placebos") S (mh "random assignment") S random* or placebo* S (singl* n mask*) or (doubl* n mask*) or (trebl* n mask*) or (tripl* n mask*) S (singl* n blind*) or (doubl* n blind*) or (trebl* n blind*) or (tripl* n blind*) S (clin* n trial*) S pt clinical trial S1 (mh "clinical trials+") SR Filters 8 Medline / Embase 1 review.pt. or review.ti. or "review"/ (systematic$ or evidence$ or methodol$ or quantitativ$ or analys$ or assessment$).ti,sh,ab. 1 and meta-analysis.pt. meta-analysis/ meta-analysis as topic/ "systematic review"/ 8 (meta-analy$ or metanaly$ or metaanaly$ or meta analy$).ti,ab. 9 ((systematic$ or evidence$ or methodol$ or quantitativ$) adj (review$ or survey$ or overview$)).ti,ab,sh. 10 ((pool$ or combined or combining) adj (data or trials or studies or results)).ti,ab. 11 or/-10 PsycINFO 1 (meta analysis or systematic review).sh,md. literature review.sh,md. (metaanal$ or meta anal$ or metasynthes$ or meta synthes$).tw. ((systematic or quantitative or methodologic$) adj (overview$ or review$)).tw. ((quantitativ$ or data) adj (extraction or synthesis)).tw. ((bids or cinahl or cochrane or embase or index medicus or isi citation or medlars or psyclit or psychlit or scisearch or science citation or (web adj science)) and review$).tw. Page of 0

8 Cinahl (pooled or pooling).tw. 8 (research adj (review$ or integration)).tw. 9 (handsearch$ or ((hand or manual) adj search$)).tw. 10 ((electronic or bibliographic) adj database$).tw. 11 (mantel haenszel or peto or dersimonian or der simonian).ti,ab. 1 (fixed effect$ or random effect$).ti,ab. 1 reference list$.ab. 1 bibliograph$.ab. 1 published studies.ab. 1 relevant journals.ab. 1 selection criteria.ab. 18 or/1-1 S1 S1 S11 S10 S9 S8 S S S S S S S1 S1 or S11 or S10 or S9 or S8 or S or S (pool* N data) or (combined N data) or (combining N data) or (pool* N trials) or (combined N trials) or (combining N trials) or (pool* N studies) or (combined N studies) or (combining N studies) or (pool* N results) or (combined N results) or (combining N results) (systematic* N overview*) or (evidence* N overview*) or (methodol* N overview*) or (quantitativ* N overview*) (systematic* N survey*) or (evidence* N survey*) or (methodol* N survey*) or (quantitativ* N survey*) (systematic* N review*) or (evidence* N review*) or (methodol* N review*) or (quantitativ* N review*) (meta-analy* or metanaly* or metaanaly* or meta analy*) (MH "Meta Analysis") S and S S or S or S1 (systematic* or evidence* or methodol* or quantitativ* or analys* or assessment*) TI review (MH "Systematic Review") PT review 8 Exclusions Filter The following filter was designed to remove irrelevant results from searches. If used it was combined into search strategies using the NOT operator Medline / Embase / Cinahl 1 letter.pt. letter/ letter$/ editorial.pt. historical article.pt. Page 8 of 0

9 anecdote.pt. commentary.pt. 8 note.pt. 9 case report/ 10 case report$.pt. 11 case study/ 1 case study.pt. 1 exp animal/ not human/ 1 nonhuman/ 1 exp animal studies/ 1 animals, laboratory/ 1 exp experimental animal/ 18 exp animal experiment/ 19 exp animal model/ 0 exp rodentia/ 1 exp rodents/ exp rodent/ or/1- Page 9 of 0

10 Adverse Effects The following searches were combined with the delirium patient filter to identify studies reporting pharmacological adverse effects Medline 1 haloperidol/ae, to risperidone/ae, to diazepam/ae, to flunitrazepam/ae, to meperidine/ae, to or/1- (donepezil$ or aricept or rivastigmine or amisulpride or sultopride or olanzapine or quetiapine or valium or rohypnol or rohipnol or pethidine).mp. 8 (ae or to).fs. 9 and 8 10 or 9 Embase 1 haloperidol/ae, to donepezil/ae, to rivastigmine/ae, to exp amisulpride/ae, to olanzapine/ae, to quetiapine/ae, to risperidone/ae, to 8 diazepam/ae, to 9 flunitrazepam/ae, to 10 pethidine/ae, to 11 or/1-10 PsycINFO Cinahl 1 "side effects".id. S S1 AND S Page 10 of 0

11 S S1 (haloperidol or risperidone or diazepam or flunitrazepam or meperidine or donepezil* or aricept or rivastigmine or amisulpride or sultopride or olanzapine or quetiapine or valium or rohypnol or rohipnol or pethidine) MW "adverse effects" 8 The Cochrane Library #1 (haloperidol or risperidone or diazepam or flunitrazepam or meperidine or donepezil* or aricept or rivastigmine or amisulpride or sultopride or olanzapine or quetiapine or valium or rohypnol or rohipnol or pethidine):ti,ab,kw Patient Information The following searches were combined with the delirium patient filter and the exclusions filter to identify papers for the review on information for patients Medline 1 ((client$ or patient$ or user$ or carer$ or consumer$ or customer$) adj (attitud$ or priorit$ or perception$ or preferen$ or expectation$ or choice$ or perspective$ or view$ or satisfact$ or inform$ or experience$ or opinion$)).mp. (information adj need$).mp. (information adj requirement$).mp. (information adj support$).mp. (patient$ adj information$).mp. (service$ adj acceptab$).mp. (service$ adj unacceptab$).mp. 8 psycho?social.mp. 9 (patient$ adj (complian$ or adheren$ or concordan$)).mp. 10 patient education/ 11 exp attitude to health/ 1 exp patient acceptance of health care/ 1 or/1-1 Embase 1 ((client$ or patient$ or user$ or carer$ or consumer$ or customer$) adj (attitud$ or priorit$ or perception$ or preferen$ or expectation$ or choice$ or perspective$ or view$ or satisfact$ or inform$ or experience$ or opinion$)).mp. (information adj need$).mp. (information adj requirement$).mp. (information adj support$).mp. (patient$ adj information$).mp. Page 11 of 0

12 (service$ adj acceptab$).mp. (service$ adj unacceptab$).mp. 8 psycho?social.mp. 9 (patient$ adj (complian$ or adheren$ or concordan$)).mp. 10 patient education/ 11 exp attitude/ 1 exp patient attitude/ 1 or/1-1 PsycINFO 1 ((client$ or patient$ or user$ or carer$ or consumer$ or customer$) adj (attitud$ or priorit$ or perception$ or preferen$ or expectation$ or choice$ or perspective$ or view$ or satisfact$ or inform$ or experience$ or opinion$)).mp. (information adj need$).mp. (information adj requirement$).mp. (information adj support$).mp. (patient$ adj information$).mp. (service$ adj acceptab$).mp. (service$ adj unacceptab$).mp. 8 psycho?social.mp. 9 (patient$ adj (complian$ or adheren$ or concordan$)).mp. 10 client education/ 11 exp client attitudes/ or exp consumer attitudes/ or exp health attitudes/ 1 health care delivery/ 1 or/1-1 Cinahl S1 S11 S10 S9 S8 S S S S S S S1 S1 or S or S or S or S or S or S or S8 or S9 or S10 or S11 (MH "Attitude to Health+") (MH "Patient Education") psychosocial or psycho-social patient* and (complian* or adheren* or concordan*) service* N unacceptab* service* N acceptab* patient* N1 information* information N1 support* information N1 requirement* information N1 need* ((client* or patient* or user* or carer* or consumer* or customer*) and (attitud* or priorit* or perception* or preferen* or expectation* or choice* or perspective* or view* or satisfact* or inform* or experience* or opinion*)) The Cochrane Library #1 (client* or patient* or user* or carer* or consumer* or customer*) near/ (attitud* or priorit* or Page 1 of 0

13 8 9 perception* or preferen* or expectation* or choice* or perspective* or view* or satisfact* or inform*) # information NEXT need* # information NEXT requirement* # information NEXT support* # service* near/ attribute* # service* near/ acceptab* # service* near/ unacceptab* #8 impact* OR psycholog* OR emotion* OR experience* OR subjective* OR status OR perception* OR consequence* OR sequelae OR meaning* OR rating* OR complian* OR adheren* OR concordan* #9 (psycho-social OR psychosocial) OR (psycho NEXT social) #10 patient NEXT education #11 (#1OR #OR #OR #OR #OR #OR #OR #8OR #9OR #10) Economics The delirium patient filter was combined with the following filters for health economics and quality of life studies. Searches for health economics were performed on Medline, Embase, the Health Technology Appraisals (HTA) database and the NHS Economic Evaluations Database (NHSEED). The latter two databases were searched via the Cochrane Library using the delirium patient filter Medline 1 exp "costs and cost analysis"/ economics/ exp economics, hospital/ exp economics, medical/ exp economics, nursing/ exp economics, pharmaceutical/ exp "fees and charges"/ 8 exp budgets/ 9 ec.fs. 10 (economic$ or pharmacoeconomic$ or price$ or pricing$ or cost$ or budget$).ti,ab. 11 (value adj (money or monetary)).ti,ab. 1 (expenditure not energy).ti,ab. 1 or/1-1 1 ((metabolic or energy or oxygen) adj1 cost$).ti,ab. 1 1 not 1 1 exp quality-adjusted life years/ 1 quality adjusted life.tw. 18 exp "quality of life"/ 19 value of life/ 0 (qaly$ or qald$ or qale$ or qtime$).tw. 1 disability adjusted life.tw. daly$.tw. Page 1 of 0

14 health status indicators/ (sf or sf or short form or shortform or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. (sf or sf or short form or shortform or sf six or sfsix or shortform six or short form six).tw. (sf1 or sf 1 or short form 1 or shortform 1 or sf twelve or sftwelve or shortform twelve or short form twelve).tw. (sf1 or sf 1 or short form 1 or shortform 1 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. 8 (sf0 or sf 0 or short form 0 or shortform 0 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. 9 (euroqol or euro qol or eqd or eq d).tw. 0 (hql or hqol or h qol or hrqol or hr qol).tw. 1 (hye or hyes).tw. health$ year$ equivalent$.tw. health utilit$.tw. (hui or hui1 or hui or hui).tw. disutili$.tw. rosser.tw. quality of well?being.tw. 8 qwb.tw. 9 willingness to pay.tw. 0 standard gamble$.tw. 1 time trade off.tw. time tradeoff.tw. tto.tw. or/1-1 or Embase 1 health economics/ exp economic evaluation/ exp health care cost/ exp pharmacoeconomics/ exp fee/ budget/ (economic$ or pharmacoeconomic$ or cost$ or price$ or pricing$ or budget$).ti,ab. 8 (value adj (money or monetary$)).ti,ab. 9 (expenditure not energy).ti,ab. 10 or/ ((metabolic or energy or oxygen) adj1 cost$).ti,ab not 11 1 quality adjusted life year/ 1 quality of life/ 1 (qaly$ or qald$ or qale$ or qtime$).tw. 1 daly$.tw. 1 quality adjusted life.tw. 18 disability adjusted life.tw. 19 (sf or sf or short form or shortform or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw. 0 (sf or sf or short form or shortform or sf six or sfsix or shortform six or short form six).tw. 1 (sf1 or sf 1 or short form 1 or shortform 1 or sf twelve or sftwelve or shortform twelve or Page 1 of 0

15 short form twelve).tw. (sf1 or sf 1 or short form 1 or shortform 1 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw. (sf0 or sf 0 or short form 0 or shortform 0 or sf twenty or sftwenty or shortform twenty or short form twenty).tw. (euroqol or euro qol or eqd or eq d).tw. (hql or hqol or h qol or hrqol or hr qol).tw. (hye or hyes).tw. health$ year$ equivalent$.tw. 8 health utilit$.tw. 9 (hui or hui1 or hui or hui).tw. 0 disutili$.tw. 1 rosser.tw. quality of well?being.tw. qwb.tw. willingness to pay.tw. standard gamble$.tw. time trade off.tw. time tradeoff.tw. 8 tto.tw. 9 or/ or 9 Epidemiology The epidemiology searches are presented here in full with the exception of that for Cinahl (see note below). 8 Medline 1 incidence/ prevalence/ epidemiology/ ep.fs. deliri$.ti,ab. (acute adj (confusion$ or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).mp. (terminal$ adj restless$).mp. 8 toxic confus$.mp. 9 delirium/ 10 confusion/ 11 or/-10 1 *psychoses, alcoholic/ or *alcohol withdrawal delirium/ 1 *substance withdrawal syndrome/ 1 1 or not 1 1 delirium/ep Page 1 of 0

16 1 confusion/ep 18 or/-8 19 or/ and or 1 or 1 11 and 19 1 or not 1 Embase 1 incidence/ prevalence/ exp epidemiology/ ep.fs. delirium/ (acute adj (confusion$ or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).mp. deliri$.ti,ab. 8 (terminal$ adj restless$).mp. 9 toxic confus$.mp. 10 or/-9 11 *alcohol psychosis/ 1 *delirium tremens/ 1 *withdrawal syndrome/ 1 or/ not 1 1 delirium/ep 1 or/-9 18 or/ and or and 18 or not 1 PsycINFO 1 exp delirium/ deliri$.ti,ab. (acute adj (confusion* or "brain syndrome" or "brain failure" or "psycho-organic syndrome" or "organic psychosyndrome")).ti,ab,sh. (terminal* adj restless*).ti,ab,sh. toxic confus*.ti,ab,sh. or/1- *drug withdrawal/ 8 *alcohol withdrawal/ 9 *alcoholic psychosis/ 10 *delirium tremens/ Page 1 of 0

17 Cinahl 11 or/-10 1 not 11 1 exp epidemiology/ 1 (inciden* or prevalen* or frequency or occurence* or outbreak*).ti,ab,sh. 1 1 or and 1 The following search strategy was combined with the delirium patient filter. S S S S1 S1 or S or S MH "Incidence" MW "Epidemiology" MH "Prevalence" Consequences Top level searches were carried out to provide evidence for the review of the health consequences of delirium. Searches were restricted by date to studies published since 1990 unless there was a more recently published NICE clinical guideline. Where this was the case searches were performed from the last search date of the relevant guideline. Searches were performed on Medline, Embase, the Health Technology Appraisals (HTA) database and the NHS Economic Evaluations Database (NHSEED). The searches on Medline and Embase were combined with the health economics filters detailed above. 1 1 Medline 1 *accidental falls/ limit 1 to yr="00-009" *pressure ulcer/ limit to yr="00-009" *cognition disorders/ limit to yr=" " *dementia/ 8 limit to yr=" " 9 *stress disorders, post-traumatic/ 10 limit 9 to yr="00-009" 11 *stroke/ 1 limit 11 to yr=" " 1 ((extrapyramidal or extra-pyramidal) adj (symptom$ or disorder$)).ti,ab. 1 limit 1 to yr=" " 1 *long-term care/ Page 1 of 0

18 1 *nursing homes/ 1 *homes for the aged/ 18 or/ limit 18 to yr=" " 0 (persist$ and deliri$).tw. 1 limit 0 to yr=" " or or or 8 or 10 or 1 or 1 or 19 or 1 Embase 1 *falling/ limit 1 to yr="00-009" *decubitus/ limit to yr="00-009" *cognitive defect/ limit to yr=" " *dementia/ 8 limit to yr=" " 9 *posttraumatic stress disorder/ 10 limit 9 to yr="00-009" 11 *stroke/ 1 limit 11 to yr=" " 1 *extrapyramidal symptom/ 1 limit 1 to yr=" " 1 *long term care/ 1 *home for the aged/ 1 *nursing home/ 18 or/ limit 18 to yr=" " 0 (persist$ and deliri$).tw. 1 limit 0 to yr=" " or or or 8 or 10 or 1 or 1 or 19 or 1 The Cochrane Library NHSEED and HTA database were searched via The Cochrane Library #1 ((fall or falls or falling or faller* or fallen or slip or trip or trips or tripped):ti,ab) or (fall*):kw, from 00 to 009 # ((pressure next ulcer*) or (pressure next wound*) or (pressure next damag*) or (pressure next injur*)):ti,kw,ab # MeSH descriptor Pressure Ulcer, this term only # (# OR #), from 00 to 009 # ((cognition OR cognitive* OR intellectual* OR neurological*) AND (impair* OR problem)):ti,ab,kw # ((cognition OR cognitive) AND (disorder* OR defect*)):ti,ab,kw # (# OR #), from 1990 to 009 Page 18 of 0

19 #8 dementia:ti,ab,kw, from 1990 to 009 #9 ((ptsd) or (posttraumatic or post-traumatic) or (post next traumatic)):ti,ab,kw #10 MeSH descriptor Stress Disorders, Post-Traumatic, this term only #11 (#9 OR #10), from 00 to 009 #1 stroke:ti,ab,kw, from 008 to 009 #1 ((extrapyramidal or extra-pyramidal) near/ (symptom* or disorder*)):ti,ab,kw, from 1990 to 009 #1 (long term care or long-term care):ti,kw,ab #1 MeSH descriptor Long-Term Care, this term only #1 MeSH descriptor Nursing Homes, this term only #1 MeSH descriptor Homes for the Aged, this term only #18 (#1 OR #1 OR #1 OR #1), from 1990 to 009 #19 (persist* and deliri*):ti,kw,ab, from 1990 to 009 #0 (#1 OR # OR # OR #8 OR #11 OR #1 OR #1 OR #18 OR #19) Page 19 of 0

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