Host-pathogen interactions in Multidrug-Resistant Tuberculosis
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1 Host-pathogen interactions in Multidrug-Resistant Tuberculosis Study of the Molecular Epidemiology, Host Immune responses and Genome Based prediction and Early Identification of MDR-TB in High Tuberculosis Burden Settings MDR-TBNet Consortium
2 Oportunity Problem ERANET-LAC Determination
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5 Contributing to the control of a problem that affects a large part of the world population, generating a positive impact on the population. Establish collaboration, scientific and technological exchange. Research and learning
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7 Coordinator Our Research Consortium Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales, Peru IRCCS Ospedale San Raffaele, Italy Universidade Federal de Minas Gerais, Brazil Hospital Sant Joan de Déu, Spain Research Center Borstel, Germany BIOASTER, France
8 Network strengths IRCCS Ospedale San Raffaele (Milano, Italy) Research hospital in Molecular Medicine WHO Collaborating Centre in Tuberculosis Laboratory Strengthening WHO Supranational Reference Laboratory for TB Research Center Borstel (Borstel, Germany) National Mycobacterium Reference Laboratory WHO Supranational Reference Laboratory CITBM (Callao, Peru) First peruvian RDI oriented center of excellence Strong molecular epidemiology background Universidade Federal de Minas Gerais (Belo Horizonte, Brazil) Top10 university Latin America Molecular and gentyping reference Hospital Sant Joan de Déu (Barcelona, Spain) Europeanwide renknown research and technology facility Bioaster (Lyon, France) Technology Research Institute dedicated to infectious diseases and microbiology in health
9 Introduction High prevalence of MDR-TB in Peru and Brazil Conventional diagnostic methods are time consuming Limit knowledge of immune response to MDR-TB MDR-TB host pathogen interactions not well defined
10 Goal Early detection Host-pathogen factors in MDR-TB MDR-TB Prevention
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12 Cohort study Molecular epidemiology study Enrolment patients = 24 TB-MDR (n = 5) TB Sensible (n = 10) Control (n = 9) MODS Culture Baciloscopy
13 Technological transference 2017 Nurse training in sample collection and patient enrolment at UNIDEC CITBM and Hospital Dos de Mayo. TB molecular typing, sequencing and data analysis. Molecular and Experimental Mycobacteriology Group. Forschungszentrum Borstel - Germany, June Mycobacterial small regulatory RNAs. Emerging Bacterial Pathogens Unit., S. Raffalele Scientific Institute. Milán Italy, May June Fellow research at CITBM.
14 First steps
15 Coordinator Coordinator oordinator Our team Moisés Paolo Miotto Daniella Huamán (OSR, Italy) Bartolomeu (CITBM, Perú) Daniella Bartholomeu (UFMG, Brazil) Moises Huaman; Leading Paolo Miotto, (IRCCS Daniella (Universidade Bartholomeu Federal de Huaman; Scientist Leading (CITBM, Peru) Paolo Ospedale Miotto, San (IRCCS Raffaele, Italy) (Universidade Daniella Minas Bartholomeu Gerais, Federal Brazil) de tist uaman; (CITBM, Leading Peru) Ospedale Paolo Miotto, San Raffaele, (IRCCS Italy) (Universidade Minas Gerais, Federal Brazil) de t (CITBM, Peru) Ospedale San Raffaele, Italy) Minas Gerais, Brazil) Laia Alsina (Hospital Sant Stefan Niemann (Research Joan de Déu, Spain) Center Borstel, Germany) sina (Hospital Sant Stefan Niemann (Research na de (Hospital Déu, Spain) Sant Stefan Center Niemann Borstel, (Research Germany) de Déu, Spain) Center Borstel, Germany) BIOASTER, France BIOASTER, France BIOASTER, France
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