Curriculum Vitae Sepehr Sani, MD

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1 Curriculum Vitae Sepehr Sani, MD Education Undergraduate Medical School Internship Residency Chief Residency Fellowships University of California in Los Angeles (UCLA). Bachelor's of Science degree in Physiological Sciences (kinesiology) and Neuroscience. Medical College of Ohio. Doctorate in Medicine degree. Rush University Medical Center, department of Surgery. Rush University Medical Center, department of Neurological Surgery. Rush University Medical Center, department of Neurological Surgery. Roy A. E. Bakay, MD. Section of Stereotactic and Functional Surgery, Department of Neurological Surgery, Rush University Medical Center. Intramural fellowship. Philip A. Starr, MD, PhD. Department of Neurological Surgery, University of California in San Francisco. Appointments Medical Director Neuroscience Institute, Rush-Copley Medical Center. Program Director Movement disorders, stereotactic and functional deep brain stimulation program. Assist. Professor Rush University Medical Center, department of neurosurgery. Honors and Awards American Society of Stereotactic and Functional Neurosurgery (ASSFN) o Best oral presentation award American Association of Neurological Surgeons Section on Stereotactic and Functional Neurological surgery o Philip L. Gildenberg Award Medical College of Ohio o Medical student award in neurological surgery Alpha Omega Alpha o Membership American Federation of Aging 1

2 o Research Scholar UCLA o Summa Cum Laude o College Honors o Department of Physiological Sciences Highest Honors o Department of Neuroscience Honors o Distinguished Scholar Award Professional Memberships American Society of Stereotactic and Functional Neurosurgery Movement Disorders Society Congress of Neurological Surgeons American Association of Neurological Surgeons Alpha Omega Alpha Medical Honor Society American Medical Association Research 2007 present o Identification and characterization of electrophysiological characteristics of single neurons in the basal ganglia nuclei in Parkinson s disease and dystonia present o Rush University Medical Center, department of neurological surgery. Deep brain stimulation for the treatment of obesity in the primate. Effects on weight, nutrition intake, and hormone profile o Rush University Medical Center, department of neurological surgery. Prospective Randomized Study of Incidence and Treatment of Deep Venous Thrombosis in Patients with High Grade Gliomas o Rush University Medical Center, department of neurological surgery. Prospective randomized analysis of time-effectiveness in correcting coagulopathy using common blood products in neurosurgical patients role of recombinant activated factor VII o Harvard Medical School, Beth Israel Deaconess Medical Center, department of neurology. Biochemical and neuropathologic investigations in a Rhesus model of Alzheimer s disease o UCLA School of Medicine, opioid research center. Stereotactic mapping of the endogenous opioid, Orphanin F.Q., responsive sites and microdialysis measurement of catecholeaminergic neurotransmission changes in the rat hypothalamus o UCLA, department of physiological sciences. Locomotor behavioral changes and motor capabilities of the transected spinal cord in the cat. Publications 2

3 Sani S, Traul D, Klink A, Niaraki N, Gonzalo-Ruiz A, Wu CK, and Geula C. Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human. Acta Neuropathologica. 105(2):145-56, Sani S, Ratliff J, and Cooper P. A critical review of cervical laminoplasty. Neurological surgery Quarterly, 14(1):5-16, March Sani S and Byrne RW. Advances in diagnosis and treatment of epilepsy The Rush experience. Rush Annual News Letter; Lopes DK and Sani S. Histological post-mortem study of an internal carotid artery aneurysm treated by the neuroform stent. Neurological surgery. 56(2):E416; Sani S Jobe KW Lopes DK. Treatment of wide-necked cerebral aneurysms with the Neuroform2 Treo stent. A prospective 6-month study. Neurosurgical Focus, 18(2):E4, Sani S, Smith A, Leppla DC, Ilangovan S, Glick R. Epidermoid cyst of the sphenoid sinus with extension into the sella turcica presenting as pituitary apoplexy: case report. Surg Neurol. 63(4):394-7; Sani S and Lopes DK. Treatment of a middle cerebral artery bifurcation aneurysm using a double neuroform stent "Y" configuration and coil embolization: technical case report. Neurological surgery. 57(1 Suppl):E209; Sani S, Boco T, Deutsch H. Cervical stenosis presenting with acute Brown-Sequard syndrome: case report. Spine. 30(16):E481-3; Sani S, Jobe KW, Byrne RW. Successful repair of an intracranial nail-gun injury involving the parietal region and the superior sagittal sinus. Case report. J Neurosurg. 103(3):567-9; Jimenez JC, Sani S, Braverman B, Deutsch H, Ratliff JK. Palsies of the fifth cervical nerve root after cervical decompression: prevention using continuous intraoperative electromyography monitoring. J Neurosurg Spine. 3(2):92-7; Sani S and Medhkour A. Olfactory groove meningiomas: Psychiatric symptoms foster delayed diagnosis. Resident & Staff Physician. 52(2):13-18; Rayport M, Sani S, Ferguson SM. Olfactory Gustatory Responses Evoked by Electrical Stimulation of Amygdalar Region in Man are Qualitatively Modifiable by Interview Content: Case Report and Review. Int Rev Neurobiol. 76:35-42;

4 Musacchio M, Kuchay B, Patel N, Sani S, Lopes D. Long-Term Follow-Up of Quality of Life after Gamma Knife Radiosurgery Treatment for Arteriovenous Malformations. Radiosurgery. 6:211-20; Sani S, Jobe KW, Kordower J, Bakay RAE. Chronic bilateral deep brain stimulation of the rat lateral hypothalamus leads to significant and sustained weight loss. J Neurosurgery. 107(4):809-13; Sani S, Boco T, Lewis SL, Cochran E, Patel AJ and Byrne RW. Post-operative acute disseminated encephalomyelitis after exposure to Avitene a case report. J Neurosurgery. In press. Sani S, Smith AP, Kanner A, Smith M and Byrne RW. Medically Intractable Temporal Lobe Epilepsy in Patients with Normal MRI: Surgical Outcome in twenty four consecutive patients. Neurosurgery. Submitted. Sani S, Verhagen L, Bakay RAE. Single center retrospective analysis of complications in deep brain stimulation surgery Pearls and pitfalls. In preparation. Sani S, Shimamoto S, Turner RS, Levesque N, and Starr PA. Microelectrode Recording in the Posterior Hypothalamic Region in Humans. Operative Neurosurgery. Accepted. Sani S, Ostrem JL, Shimamoto S, Levesque N, and Starr PA, Single Unit Pauser Characteristics of the Globus Pallidus Pars Externa Distinguish Primary Dystonia from Secondary Dystonia and Parkinson s Disease. Experimental Neurology. Submitted. Book Chapters Sani S, Smith, A, Ratliff J. Spinal cord trauma. In: Hyperguide Spinal Surgery; Sani S, Smith, A, Ratliff J. Peripheral nerve injuries, Repair, and Reconstruction. In: Hyperguide Spinal Surgery; Sani S, Smith, A, Ratliff J. Surgical management of spinal cord tumors. In: Hyperguide Spinal Surgery; Sani S. Percutaneous kyphoplasty. In: Perez-Cruet MJ, Khoo LT, Fessler RG, eds. An Anatomic Approach to Minimally Invasive Spine Surgery. St. Louis, MO: Quality Medical Publishing; Oral Abstracts 4

5 Musacchio MJ, Kuchay B, Patel N, Bagan B, Sani S, Lopes DK. Follow-up to cure of intracranial arteriovenous malformations after gamma knife radiosurgery. International Stereotactic Radiosurgery Society Congress; Musacchio MJ, Kuchay B, Patel N, Bagan B, Sani S, Lopes DK. Long-term follow-up of quality of life after gamma knife radiosurgery treatment of arteriovenous malformations. International Stereotactic Radiosurgery Society Congress; Sani S, Musacchio MJ, Lopes DK. Endovascular treatment of wide-neck middle cerebral artery aneurysms. A prospective series with six month follow-up. World Federation of Interventional and Therapeutic Neuroradiology; Wells K, Reeder P, Sani S, Lopes DK. Proposed guidelines for intracranial stenting of ruptured wide neck cerebral aneurysms. World Federation of Interventional and Therapeutic Neuroradiology; Musacchio MJ, Sani S, Badruddin A, Lopes DK. Use of Hydrocoil expandable coils in treatment of cerebral aneurysms. A Prospective study with follow-up. World Federation of Interventional and Therapeutic Neuroradiology; Sani S, Jobe KW, Kordower J, Bakay RAE. Deep brain stimulation for treatment of obesity in the rat. American Association of Neurological Surgeons; 2005 Musacchio MJ, Boco T, Sani S, Ratliff JK, Deutsch H. Graft subsidence with use of cortical allograft versus resorbable implant in anterior cervical fusion. Congress of Neurological Surgeons; Musacchio MJ, Sani S, Wells K, Reeder P, Lopes DK. Endovascular embolization as primary treatment of intracranial vascular malformations: A novel concept. American Society of Neuroradiology; Lopes DK, Musacchio MJ, Sani S. Influence of a remodeling vascular device on MR volume flow measurements in a steady flow phantom. American Society of Neuroradiology; Wells K, Reeder P, Sani S, Lopes DK. Use of Removable Vascular Devices (RVD) for treatment of ruptured wide neck cerebral aneurysms. Results of a pilot study. American Society of Neuroradiology; Sani S, Musacchio MJ, Lopes DK. Treatment of wide-neck middle cerebral artery aneurysms using remodeling vascular devices and coil embolization. American Society of Neuroradiology; Sani S, Nagy AJ, Barbaro NM, Shimamoto S, Raskin NH, Ostrem JL, and Starr PA. Chronic stimulation of the posterior hypothalamic region for cluster headache: Twenty 5

6 Abstracts one month follow up results in eight patients. American Society of Stereotactic and Functional Neurosurgery; 2008; Klink A, Sani S, Daffner KR, Kuznetsov D, Wu C-K and Geula C. Amyloid-beta deposits in the aged rhesus brain: Distribution, progression and chemical Signatures. Society of Neuroscience Abstract 25:2052, Geula C, Sani S, Klink A, Wu C-K and Kuznetsov D. Amyloid-beta deposits in the aged rhesus brain: Pathological effects. Society of Neuroscience Abstract, 25:2052, Geula C, Chen E, Klink A, Sani S and Gonzalo-Ruiz A. Pathologic effects of amyloidbeta deposits in the aged rhesus brain. Neurobiology of Aging 21:S122, Sani S, Jimenez J, Jobe KW, Musacchio M, and Lopes DK. Single center experience with matrix, hydrocoils and neuroform stents on the management of wide neck cerebral aneurysms. Congress of Neurological Surgeons; Sani S, Jobe KW, Musacchio M, and Lopes DK. Initial clinical experience with NOVA on the management of cerebrovascular disease. Congress of Neurological Surgeons; Sani S, Boco T, Jobe KW, Jimenez J, and Lopes DK. Retrospective analysis of widenecked intracranial aneurysms treated by the neuroform stent and coil technique: Review of 30 consecutive cases. Congress of Neurological Surgeons; Sani S and Lopes DK. The Y configuration stent and coil technique for the management of wide neck middle cerebral artery aneurysm. Congress of Neurological Surgeons; Sani S, Jobe KW, Lopes DK. Treatment of wide necked cerebral aneurysms using the neuroform 2 treo TM stent Preliminary experience. American Association of Neurological Surgeons; Sani S and Lopes DK. Treatment of a middle cerebral artery bifurcation aneurysm using a double neuroform stent Y configuration and coil embolization. American Association of Neurological Surgeons; Lopes DK and Sani S. Post-mortem histological analysis of an internal carotid artery aneurysm treated by the neuroform 2 stent. American Association of Neurological Surgeons;

7 Sani S, Ajiboye N, Deutsch H, Ratliff JH. Preliminary experience with use of a composite graft, BioPlex, for anterior cervical fusion. American Association of Neurological Surgeons; Sani S, Jimenez J, Jobe K, Deutsch H, Ratliff JH. Reduction in incidence of postoperative C5 palsy following anterior cervical decompression by using continuous intraoperative electromyographic monitoring A prospective study. American Association of Neurological Surgeons; Sani S, Jimenez J, Deutsch H, Ratliff JH. Minimally invasive posterior lumbar interbody fusion versus transforaminal lumbar interbody fusion A prospective study. American Association of Neurological Surgeons; Sani S, Shimamoto S, Levesque N, and Starr PA. Single Unit Pauser characteristics of the Globus Pallidus Pars Externa in Dystonia: comparison with Parkinson s disease and Normal Non-Human Primate. Movement Disorders Society;

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