Strategic Research Agenda of EURADOS, highlighting synergies

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Bošković Institute On behalf of EURADOS Workshop on

1 Strategic Research Agenda of EURADOS, EURADOS WORKING GROUP 12 highlighting synergies Željka Knežević Ruđer Bošković Institute On behalf of EURADOS Workshop on synergies of SRA of EURAMED, MELODI and EURADOS, Helsinki 2017

2 EURADOS (European Radiation Dosimetry Group e.v.) Mission: Promote research and development in the field of the dosimetry of ionizing radiation Activities: Coordination of working groups Promote technical development and its implementation in routine work Contribute to compatibility within Europe and conformance with international practice Organization of scientific meetings and training activities Organization of intercomparisons and bench mark studies Financial resources Sponsoring institutions Levies raised for activities organized by EURADOS Projects funded by the European Commission EURADOS is an independent platform which includes experts, reference and research laboratories, industry and dosimetry services. Workshop on synergies of SRA of EURAMED, MELODI and EURADOS, Helsinki 2017

EURADOS (as of January 2017) Voting Member Status (January 2017) 67 Voting Members from 30 countries EURADOS Board of Officers Chair: W. Rühm (Helmholtz Munich, Germany) Vice-Chair: F.

3 EURADOS (as of January 2017) Voting Member Status (January 2017) 67 Voting Members from 30 countries EURADOS Board of Officers Chair: W. Rühm (Helmholtz Munich, Germany) Vice-Chair: F. Vanhavere (SCK-CEN, Belgium) Secretary: JF. Bottollier (IRSN, France) Treasurer: H. Schumacher (PTB, Germany) EURADOS EURADOS Office operated by HMGU (W. Rühm, J. Brehme, (H. Schuhmacher)) EURADOS Council J. Alves, J.F. Bottollier, M. Caresana, I. Clairand, E. Fantuzzi, P. Fattibene, M.A. Lopez, P. Olko, W. Rühm, H. Schuhmacher, H. Stadtmann, F. Vanhavere EURADOS Workshop on synergies of SRA of EURAMED, MELODI and EURADOS, Helsinki 2017

EURADOS Working Groups Associate Members Almost 500 scientists contributing to the overall EURADOS objectives 8 EURADOS Working Groups WG2 - Harmonization of Individual Monitoring (P.

4 EURADOS Working Groups Associate Members Almost 500 scientists contributing to the overall EURADOS objectives 8 EURADOS Working Groups WG2 - Harmonization of Individual Monitoring (P. Gilvin, UK) WG3 - Environmental Dosimetry (A. Vargas, Spain) WG6 - Computational Dosimetry (R. Tanner, UK) WG7 - Internal Dosimetry (M. A. Lopez, Spain) WG9 - Radiation Dosimetry in Radiotherapy (R. Harrison, UK) EURADOS WG10 - Retrospective Dosimetry (C. Woda, Germany) WG11 - High-Energy Radiation Fields (JF Bottollier, France) WG12 - Dosimetry in Medical Imaging (Ž. Knežević, Croatia) Workshop on synergies of SRA of EURAMED, MELODI and EURADOS, Helsinki

EURADOS Annual Meetings 350 300 Number of participants - History 282 313

5 EURADOS Annual Meetings Number of participants - History

6 EURADOS Workshops and Winterschools Winter Schools: Workshops with Proceedings 1) Dosimetry for epidemiological cohorts (AM2016) The Fukushima Daiichi nuclear accident the role of dosimetry in assessing the consequences (AM2015) RBE, radiation weighting factor and quality factor (AM2014) Status and Future Perspectives of Computational Micro- and Nanodosimetry (AM2013) Radiation Protection for Medical Staff (AM2011) Radiological Emergencies Internal exposures (AM2010) Low-Dose Radiation Effects (AM2009) Retrospective Dosimetry (AM2008) Related to research topics where EURADOS Working Groups are involved Dosimetry for second cancer risk estimation in radiotherapy (AM2012) Accelerator radiation protection and shielding (AM2010) Cosmic Radiation and Aircrew Exposure (AM2009) Dosimetric Issues in the Medical Use of Ionizing Radiation (AM2008) Characterization of Workplaces for the Assessment of the Doses to Individuals (AM2007) 1) : in RPD; 2012: in Rad Meas

7 Intercomparisons / Training

EURADOS SRA History and Current Status October 2012 Council initiates SRA discussion and stimulates input from Working Groups February 2013, Council Meeting- SRA Task Group established SRA-WG: W.

8 EURADOS SRA History and Current Status October 2012 Council initiates SRA discussion and stimulates input from Working Groups February 2013, Council Meeting- SRA Task Group established SRA-WG: W. Rühm, E. Fantuzzi, R. Harrison, H. Schuhmacher, F. Vanhavere July 2013, Council Meeting Discussion of collected material and future actions Draft prepared with input from all EURADOS WGs February 2014, General Assembly SRA presented to Voting Members and input stimulated June 2014:EURADOS Report 2014/01 finished and published Publication as EURADOS report

9 EURADOS SRA History and Current Status Spring 2015: Summary of SRA published in Rad. Prot. Dosim. SRA presented at OPERRA, January 2014, Rome (W. Rühm) German Radiat Prot Association, April 2014, Munich (W. Rühm) IRPA 2014, June, Geneva (F. Vanhavere) MELODI 2014, October, Barcelona (JF. Bottollier, M. Ginjaume) Melodi 2014 E&T (J. Alves) MELODI 2014, October, Barcelona (W. Rühm)

EURADOS SRA is a Moving Target EURADOS Stakeholder Workshop June 30, 2016, Neuherberg, Germany Meeting of 24 international organisations Commenting on EURADOS SRA Identifying missing topics 1) Which

10 EURADOS SRA is a Moving Target EURADOS Stakeholder Workshop June 30, 2016, Neuherberg, Germany Meeting of 24 international organisations Commenting on EURADOS SRA Identifying missing topics 1) Which vision or challenge included in the EURADOS SRA needs further improvement? Expressing interest (or not) in future cooperations 2) Are there any important topics missing? Participating organisations ALLIANCE, 3) What are EANM, the 5 most EFOMP, important ENISS, challenges ESR, in the EURADOS SRA ESTRO, (please EURAMET, give rank)? HERCA, IAEA, IARC, ICRP, ICRU, ILO, IRPA, ISO, ISSDO, MELODI, NEA, NERIS, 4) In which NUGENIA, field should PTCOG, your RENEB, organization SSH. and EURADOS collaborate in the future? Meeting Next Steps was very successful and positively accepted Publication by all of Workshop organisations Report (final draft) Update of EURADOS SRA

11 Vision 1 Towards Updated Dose Concepts and Quantities Absorbed dose does not always provide an adequately detailed description of an irradiation to allow predicting biological consequences Therefore, the present system of limiting and operational quantities in radiation protection dosimetry needs improvement This Vision includes 4 Challenges To improve understanding of spatial correlations of radiation interaction events (micro and nano dosimetry, numerical simulations,...) To quantify correlations between track structure and radiation damage (microbeam experiments, modelling,...) To improve understanding of biokinetics of internal emitters (spatially and temporally inhomogeneous dose distributions,...) To update operational quantities for external exposure (energy range and particle type,...)

12 Vision 2 - Towards Improved Radiation Risk Estimates Deduced from Epidemiological Cohorts The purpose of radio-epidemiological studies is primarily the deduction of risk coefficients > Effect (y-axis) per dose (x-axis) (slope) > Dosimetry essential This Vision includes 2 Challenges To explore exposure pathways not yet considered or validated in epidemiological studies (specific organs, doses to substructures, micro-distribution of doses, out-of-field doses in radiotherapy, SPEs for air crew, ) To improve retrospective dosimetry for historical cohorts (e.g., confouding by other stressors, assessment of internal dose uncertainties, improvement of organ dosimetry e.g. for eye lens, brain, heart arteries and walls, α-emitters in lung)

13 Vision 3 - Towards an Efficient Dose Assessment in Case of Radiological Emergencies Radiological emergencies are considered a major challenge of modern societies (e.g. nuclear accidents, terroristic attacks, lost radiation sources) This Vision includes 3 Challenges To identify and and characterize new markers of exposure (use of daily life materials as dosimeters, protein biomarkers, computational techniques, ) To develop strategies and methods to increase measurement capacity (automatisation, web-based scoring, networking of laboratories,...) To quantify doses after accidental internal contamination (reliable biological end-points, decorporation strategies,...) 13

14 Vision 4 - Towards an Integrated Personalized Dosimetry in Medical Applications Modern medical therapy includes a number of diagnostic procedures involving ionizing radiation (X-Ray, CTs, PET, etc.). Additionally radiotherapy is a major treatment modality in cancer therapy This Vision includes 5 Challenges To establish out-of-field dosimetry for photon and particle therapy (focus on pediatrics) (scattered primary beam, secondary photons and neutrons, imaging procedures; development of suitable detectors and phantoms) - WG9 To optimize dose estimations in interventional radiology (determination of skin doses, patient specific, skin doses,...) WG12 To establish reliable patient dosimetry in CT examinations (automatic dose mapping and collection of patient doses, quantities,... ) WG12 To improve dosimetry in modern external beam radiotherapy (in-vivo for QA, new radiotherapy techniques, calibration aspects,...) WG9 To include internal microdosimetry in radiotherapy and medical imaging procedures (alpha and auger emittors, nanoparticles,...)

15 Vision 5 - Towards an Improved Radiation Protection of Workers and the Public This Vision includes 5 Challenges To refine, validate and implement new ICRP biokinetic models (including how to use ICRP models, differences healthy persons and patients, validation of these models) To develop calibration procedures for partial body counters (person specific, biokinetic models,...) To develop accurate and on-line personal dosimetry for workers (including real-time monitoring of wholebody dose, eye lens, extremities, development of suitable active dosemeters) To improve neutron dosimetry techniques (e.g., for high-energy and pulsed neutron fields, including the photon component that is always present; note: a high-energy quasi-monoenergetic neutron reference field will soon be missing in Europe!) To include nuclide-specific information in doserate measurements in the environment (e.g., environmental monitoring with suitable spectrometric instrumentation)

16 Additionally, the SRA includes Separate Chapter on Training and Education Implementation of EC directives and technical recommendations into practice Training courses on novel or improved dosimetric methods Winter schools, workshops and scientific symposia Separate Chapter on Harmonisation and Practice Intercomparison for dosemeters used in individual monitoring Intercomparison for early-warning systems used in environmental monitoring Intercomparison for codes and simulations Surveys on practical dosimetry (to document quality of dosimetric practices) Separate Chapter on Importance of Computational Dosimetry Monte Carlo method dominant in many fields of radiation protection and dosimetry Include representations of human body at macroscopic, microscopic, nanometric level

17 EURADOS Strategic Research Agenda Future Present SRA is based on input from Council, working Groups, Voting members also the priorities are identified by Council members and EURADOS voting members Answers received from 40/61 voting members Priorities identified from EURADOS SRA N 1: To quantify correlations between track structure and radiation damage N 2: To improve neutron dosimetry techniques N 3: To quantify doses after accidental internal contamination N 4: To develop accurate and on-line personal dosimetry for workers N 5: To improve the measurement of out-of-field radiotherapy and imaging doses in photon and particle radiotherapy, for input to epidemiological studies N 6: To improve dosimetry in modern external beam radiotherapy

Synergies witih medical platforms EURADOS - EFOMP Main focus of EFOMP includes individualized dosimetry in all fields of medical dosimetry Three major visions

applications, Vision 5 - Improved radiation protection of workers and public. Another major filed of common interest is in the field of education and training.

18 Synergies witih medical platforms EURADOS - EFOMP Main focus of EFOMP includes individualized dosimetry in all fields of medical dosimetry Three major visions representing common interests Vision 3 - Efficient dose assessment for radiological emergencies, Vision 4 - Integrated personalized dosimetry in medical applications, Vision 5 - Improved radiation protection of workers and public. Another major filed of common interest is in the field of education and training. WG 12 collaborates with EFOMP WG12 SG 2 (Patient dosimetry) participate in activities of EFOMP group related to dosimetry in CBCT SG2 prepared contribution for the EFOMP document

Synergies witih medical platforms EURADOS - ESTRO The topics presented by ESTRO are in compliance with EURADOS SRA Vision 4 - Integrated personalized dosimetry in medical applications, To establish

19 Synergies witih medical platforms EURADOS - ESTRO The topics presented by ESTRO are in compliance with EURADOS SRA Vision 4 - Integrated personalized dosimetry in medical applications, To establish out-of-field dosimetry for photon and particle therapy (focus on pediatrics) To improve dosimetry in modern external beam radiotherapy To optimize dose estimations in interventional radiology To establish reliable patient dosimetry in CT examinations Vision 2 -Towards improved radiation risk estimates deduced from epidemiological cohorts Another important area of interest between ESTRO and EURADOS is education and training

20 Synergies witih medical platforms EURADOS - ICRP ICRP goals for R&D in dosimetry are in compliance with EURAODS SRA, Visions 4 and Vision 5. Vision 4 - Integrated personalized dosimetry in medical applications Vision 5 -Towards an Improved Radiation Protection of Workers and the Public ICRP C3 (on doses from medical radiation exposures) and ESR the most important are in Vision 1 the challenge of updating operational quantities for external exposure; all topics addressed in Vision 4 and in Vision 5 the topic on developing accurate and on-line personal dosimetry for workers. ICRP/EURADOS common areas i. Skin dose maps with peak skin dose estimation ii. Transitioning from dose to a phantom to patient dose and to a specific patient WG 9/ WG 12

Synergies witih medical platforms EURADOS - EURAMET Topics arising out of EURADOS SRA stakeholder meeting EURAMET and EURADOS should collaborate in the future on the

21 Synergies witih medical platforms EURADOS - EURAMET Topics arising out of EURADOS SRA stakeholder meeting EURAMET and EURADOS should collaborate in the future on the following dosimetric challenges: providing traceability and comparability bringing the findings into practice harmonization in practice standardisation education and training

22 Synergies witih medical platforms EURADOS - MELODI Major links in the research on the impact of radiation exposure characteristics and the research on the effects associated with internal exposures, due to different radiation qualities and inhomogeneous radionuclide distributions within the human body. Always need for high standard of radiation dosimetry for cell culture systems, model organisms and a range of radiation qualities Also link needed with biological dosimetry Link with priority 5 (out of field doses radiotherapy) and generally vision 2 From the MELODI point of view, most relevant challenges are covered by EURADOS SRA Visions 1 Towards Updated Dose Concepts and Quantities Visions 2 Towards Improved Radiation Risk Estimates Deduced from Epidemiological Cohorts Visions 3 Towards an Efficient Dose Assessment in Case of Radiological Emergencies Visions 5 Towards an Improved Radiation Protection of Workers and the Public

Synergies witih medical platforms EURADOS - IARC Main visions of interest in relation to IARC activities- commom areas with EURADOS Vision 2: Toward improved radiation risk estimates deduced from

23 Synergies witih medical platforms EURADOS - IARC Main visions of interest in relation to IARC activities- commom areas with EURADOS Vision 2: Toward improved radiation risk estimates deduced from epidemiological cohorts Vision 4: Toward integrated personnalized dosimetry in medical applications (Need for improved paediatric phantoms, In real time organ dose estimation (both CT and IC, To improve out-of-field dosimetry for charge particle therapy...) Vision 5: Toward improved radiation protection of the workers and the public (for the activities of nuclear workers neutron dosimetry should be improved (recorded doses are currently not integrated in the cumulative doses of workers), and tritium doses should also be taken into consideration in whole body doses.)

24 Cooperation EURADOS - EANM Vision 1 Towards Updated Dose Concepts and Quantities (Short-ranged - and -emitters show high levels of inhomogeneity at both cellular and tissue level and are increasingly used Vision 2 Towards Improved Radiation Risk Estimates Deduced from Epidemiological Cohorts (e.g.dose-effect relations after radionuclide therapy not well characterized Vision 3 Towards an Efficient Dose Assessment in Case of Radiological Emergencies (e.g. SPECT / PET imaging for quantification and localisation of internalised radionuclides Vision 4 Toward integrated personalized dosimetry in medical applications (Pediatric dosimetry is mostly based on the adult pharmacokinetics applied in pediatric mathematical phantoms) Vision 5 Towards an Improved Radiation Protection of Workers and the Public (NM patients form a source of exposure and possible contamination, uniform rules needed for restrictions of daily-life activities, patient care, family Among EANM are interested: Dosimetry Committee: EANM Radiation Protection Committee Among EURADOS are interested: 17 institutions Mainly from WG6, WG7, WG10, WG12 First joint meetings At EURADOS AM2016, AM2017 At EANM Annual Meeting, Oct 2016,

25 Working groups collaborating with the medical sector Vision 4. Towards an integrated personalized in medical applicationsdosimetry WG 9 Radiation Dosimetry in Radiotherapy &WG 12 Dosimetry in Medical Imaging SG 2 Patient Dosimetry The measurements and MC simulation of out-of-field doses in paediatric radioththerapy treatments, using various photon/proton radiotherapy techniques Environmental neutron dosimetry in proton therapy facilities To generate a database of out of-field dose measurements which can be used for the development and validation of dose algorithms and analytical models To build and test a systems for auditing of proton therapy centers Vision 5: Towards an Improved Radiation Protection of Workers and the Public WG 12 Dosimetry in Medical Imaging SG1 Staff Dosimetry Eye lens dosimetry, APDs in hospitals Skin dose measurement in clinical settings + alert thresholds in interventional radiology and cardiology European RLs for interventional cardiology Skin dose mapping software-validation of existing solutions Cone beam CT, (Dental, On board imaging)

26 Links with common SRA for Radiation Protection in Medicine Research topics-summarized Measurements and quantification in the field of ionising radiation Measurement of exposure: improve methods for quantification Calibration of radiotherapy dosemeters: EURADOS Priority 6 Real-time measurements to staff: EURADOS Priority 4 Correct determination of doses within patients for different types of radiation: EURADOS priority 2 and 5 Knowledge on track structure and microdosimetry: EURADOS priority 1 Alternative quantities for dose distributions in organs: EURADOS priority 1 Peripheral doses: EURADOS priority 5 Individual dosimetry/quality metrics for imaging and therapy: vision 4 Optimisation of radiation exposure: vision 4, vision 5

EURADOS Strategic Research Agenda Future The SRA is not a fixed document: it needs revisions at regular periods Present SRA represents view of EURADOS community

..) In next period SRA, needs updates also with renewed input from EURADOS members and WGs View of stakeholders needs to be included Priority list together with the

27 EURADOS Strategic Research Agenda Future The SRA is not a fixed document: it needs revisions at regular periods Present SRA represents view of EURADOS community (Council, WGs, VMs) (many EURADOS members are also involved in other organisations (ICRP, ICRU, medical associations,...) In next period SRA, needs updates also with renewed input from EURADOS members and WGs View of stakeholders needs to be included Priority list together with the other research platforms needs to be discussed and developed. Synergetic topics with other platforms needs to be clearly identified and defined: EURAMED Melodi, Alliance, Neris... EURADOS, EURAMED, MELODI..should work closely together

28 THANK YOU!

Task 2.4 Develompment of SRA, roadmap and priorities for research on dosimetry

Task 2.4 Develompment of SRA, roadmap and priorities for research on dosimetry EJP CONCERT Kick-Off Meeting Oberschleißhei m, Germany 8. June 2015 W. Rühm Institute for Radiation Protection Helmholtz Zentrum