EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy

Transcription

1 Annual Meeting, Milan 8-11 h February 2016 EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy Roger Harrison (Chair), on behalf of WG9

2 WG9 Objectives Develop & harmonise dosimetry techniques in radiotherapy Measure out-of-field doses for input to secondary malignancy risk models and epidemiological studies of late effects Facilitate development and application of novel dosimeters Investigate dosimetric aspects of proton radiotherapy, including patient dosimetry and the measurement and modelling of ambient neutron and proton fields Development of the complete dose specification from all sources of radiation to all parts of the body, delivered as part of radiotherapy planning & treatment (collaboration with WG12)

3 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

4 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

5 Meetings 2015 Medical Physics Department, Portuguese Institute of Oncology, th October 2015 Plenary meeting and experimental investigation of extremity doses in brachytherapy HDR MicroSelectron with a single iridium-192 source (~ 370 GBq) Complete treatment (~ 15 to 20 Gy) Several applicator types

6 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

7 Photon radiotherapy: Paediatric treatments Measuring out-of-field doses from a paediatric brain tumour treatment (photons) Institute of Nuclear Physics (IFJ) and Centre of Oncology, Krakow Ruđer Bošković Institute, Clinical Hospital for Tumours & Clinical Hospital Centre, Zagreb

8 Photon radiotherapy: Paediatric treatments Measuring out-of-field doses from a paediatric craniospinal treatment (photons) Cranio-spinal irradiation at the Clinical Hospital for Tumours, Zagreb Passive detectors (TLD, RPL) positioned inside 5y and 10y old phantoms.

9 Photon radiotherapy: Paediatric treatments Measuring out-of-field doses from a paediatric brain tumour treatment using Gamma knife (stereotactic radiosurgery) Ruđer Bošković Institute & Clinical Hospital Centre Zagreb 2014

10 Photon radiotherapy: Paediatric treatments Paediatric brain tumour treatment (photons) Head Body Dose (mgy) Dose comparison for 5y phantom Total target dose = 40 Gy 3D-CRT (TLD) IMRT (RPL) 10 1 Organ / tissue

11 Photon radiotherapy: Paediatric treatments Paediatric brain tumour treatment (photons) Dose (mgy) IMRT: total target dose = 40 Gy 10 year 5 year organ / tissue

12 Analysis of experimental campaigns: Trento, Krakow, Zagreb Paediatric brain tumour treatment (photons and protons) 3D-CRT IMRT GK PT * * PT Neutrons PT Total µsv/gy * * * * * * * * * * 0,1 Organ / tissue

13 Analysis of experimental campaigns: Trento, Krakow, Zagreb Paediatric brain tumour treatment (photons and protons) * 3D-CRT IMRT GK PT * PT Neutrons PT Total Photon doses: 10 msv/gy - < 1 msv/gy µsv/gy * * * * * * * * * * 0,1 Organ / tissue

14 Analysis of experimental campaigns: Trento, Krakow, Zagreb Paediatric brain tumour treatment (photons and protons) * 3D-CRT IMRT GK PT * PT Neutrons PT Total Photon doses: 10 msv/gy - < 1 msv/gy µsv/gy ,1 * * * * * * * * * * Secondary photon doses from proton RT Organ / tissue

15 Analysis of experimental campaigns: Trento, Krakow, Zagreb Paediatric brain tumour treatment (photons and protons) µsv/gy ,1 * * * 3D-CRT IMRT GK PT * * * * * * PT Neutrons PT Total * * * Photon doses: 10 msv/gy - < 1 msv/gy Total proton therapy doses, inc. neutron dose Secondary photon doses from proton RT Organ / tissue

16 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

17 Out-of-field measurements for verification of analytical models Paediatric brain tumour treatment (photons) Dose (mgy) D-CRT (TLD) IMRT (RPL) 1 Organ / tissue

18 Measurements for verification of analytical models A very large number of possible treatment configurations

19 Measurements for verification of analytical models A very large number of possible treatment configurations Limited time and resources for measurement

20 Input to analytical models Collaboration with Prof. Wayne Newhauser, Louisiana State University Measured and calculated relative absorbed doses for 6 MV beam and 10 cm depth in water from the EURADOS dataset, following training of the model A simple, descriptive, and broadly applicable model of therapeutic and stray absorbed dose from 6 MV to 25 MV photon beams Christopher Schneider, Wayne D Newhauser, Lydia Jagetic, Uwe Schneider, Robert Kaderka, Saveta Miljanić, Željka Knežević, Liliana Stolarcyzk, Marco Durante, Roger Harrison (submitted for publication to Phys. Med. Biol)

21 Input to analytical models Photon dosimetry: water tank experiments Commissariat à l'énergie Atomique (CEA, LIST, LNE/LNHB) Saclay, 2010, Dose (mgy) Distance (mm) Depth (mm)

22 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

23 Future work: complete dose specification Total dose from radiotherapy and imaging: the complete dose specification (WG9/12 collaboration) Out-of-field measurements for validation of analytical models Objective: Neutron benchmarking Measure total dose for out-of-field organs in selected paediatric RT treatments (CT dose + OBI dose + RT dose) Determine the fractional contribution of each component in the total Inter-centre proton dose intercomparisons & mailed organ dosimetry and tissue audits dose of proton dosimetry Experiments planned for late 2016: Anthropomorphic phantoms (10y + 5y) + several dosimeter types (RPL, TLDs, OSLs) + + CT OBI Linac

24 Future work: validation of analytical models Out-of-field measurements for validation of analytical models Objective: model validation and development +

25 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

26 EURADOS Working Group 9: Sub-Group WG9.2 Hadron Radiotherapy Topics of interest: In phantom dosimetry of secondary and scattered radiation in hadron therapy Environmental neutron and gamma radiation dosimetry in hadron therapy facilities (patient oriented) Participating institutions: CEA, Sacley HZ, Neuherberg IFJ PAN. Krakow NPI, Prague RBI Zagreb SCK, Brussels UB, Barcelona

27 Sub-Group WG9.2 Hadron Radiotherapy Meetings 1. Series of Skype meetings in 2015 Evaluation of results from experiments in proton therapy center in Krakow Preparation of draft paper describing experiment in Trento 2. WG 9.2 editorial meeting, Brussels, June 15-17, 2015 (together with WG9 meeting) Secondary radiation in water phantom (measurements) Secondary radiation in water phantom (simulations) Measurements with TEPC Environmental measurements Secondary radiation spectra 3. WG 9.2 meeting, Porto, October 22, 2015 (together with WG9 meeting)

28 1. Publications Sub-Group WG9.2 Hadron Radiotherapy Results Paper of Farah et al. Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems. Published in Med. Phys (5), Paper of Mares et al. A comprehensive spectrometry study of stray neutron radiation field in scanning proton therapy Submitted to Physics in Medicine and Biology Paper by Adamek at al. Measurement of secondary neutron variation with beam energy, field size, modulation width and air gap size in scanning proton therapy In preparation Paper by Stolarczyk at al. Dose distribution of scattered radiation in water phantom for proton pencil beam - EURADOS WG9 inter-comparison exercise on passive dosimetry systems In preparation 2. Presentations at conferences 5 oral presentations 2 posters

29 From: Farah et al Neutron fluence spectra using two Bonner sphere systems 4

30 From: Farah et al Comparative performance of active detectors 4 4 H*(10) (µsv/gy) TEPC IFJ TEPC NPI TEPC IRSN Berth Rad- Wendi Wendi BSS UAB Eye IFJ IRSN HMGU H*(10) (µsv/gy) BSS UAB NM2B NM2B 495Pb 458 Elect Dosim H*(10) (µsv/gy) TEPC IFJ TEPC NPI TEPC IRSN Berth UAB Rad- Eye Wendi Wendi BSS IFJ IRSN HMGU BSS UAB NM2B NM2B 495Pb 458 Elect Dosim 0 TEPC IFJ TEPC NPI TEPC IRSN Berth UAB Rad- Eye Wendi Wendi BSS IFJ IRSN HMGU BSS UAB NM2B NM2B 495Pb 458 Elect Dosim Farah, J., Mares, V., Romero-Expósito, M., Trinkl, S., Domingo, C., Dufek, V., Klodowska, M., Kubancak, J., Knežević, Ž., Liszka, M., Majer, M., Miljanić, S., Ploc, O., Schinner, K., Stolarczyk, L., Trompier, F., Wielunski, M., Olko, P., Harrison, R. M. Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems. Med. Phys (5),

31 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Summary

32 Sub-Group WG9.2 Hadron Radiotherapy Plans for future 1. System for mailed dosimetry audits of proton therapy radiotherapy beams EURADOS Young Scientist Grant awarded to Marijke De Saint-Hubert (SCK-CEN) PhD thesis of Jenny Kunst (IFJ PAN) Experiments in Bronowice Cyclotron Center IFJ PAN in Kraków TL detectors RPL detectors Alanine detectors OSL detectors (?)

33 Future work: neutron benchmarking Neutron benchmarking WG9,6,11 collaboration Objective: To validate computational and measurement methods at high energies o for low energies (e.g. for neutrons below 20 MeV) evaluated cross-sections are available, and are validated against experimental data o for higher energies (e.g. for neutrons above 20 MeV) cross-sectional data are scarce.

34 Summary of future work Total dose from radiotherapy and imaging: the complete dose specification (WG9/12 collaboration) Out-of-field measurements for validation of analytical models Inter-centre proton dose intercomparisons & mailed dosimetry audits of proton dosimetry Neutron benchmarking (WG 9, 6 and 11)

35 Outline 1. Meetings Brussels June 2015: Data analysis of previous experimental campaigns Porto October 2015: Plenary meeting + brachytherapy experiments 2. Photon radiotherapy programme Out-of-field dosimetry for: o paediatric brain tumour treatments o validation of analytical models Future work 3. Hadron radiotherapy programme (Sub-Group 9.2, Pawel Olko) In phantom dosimetry of secondary and scattered radiation in proton therapy Environmental neutron and gamma radiation dosimetry in proton therapy facilities (patient oriented) Future work 4. Publications and presentations

36 Publications Farah, J., Mares, V., Romero-Expósito, M., Trinkl, S., Domingo, C., Dufek, V., Klodowska, M., Kubancak, J., Knežević, Ž., Liszka, M., Majer, M., Miljanić, S., Ploc, O., Schinner, K., Stolarczyk, L., Trompier, F., Wielunski, M., Olko, P., Harrison, R. M. Measurement of stray radiation within a scanning proton therapy facility: EURADOS WG9 intercomparison exercise of active dosimetry systems. Med. Phys (5),

37 Conference presentations Željka Knežević (on behalf of EURADOS WG9). Measurements of secondary radiation doses inside a paediatric anthropomorphic phantom exposed to scanning proton radiotherapy, using different passive dosimetry systems: Activity within EURADOS WG9 (SG2). 10th International Workshop on Ionizing Radiation Monitoring (IWIRM10), March 2015, Oarai, Japan Saveta Miljanić (on behalf of EURADOS WG9). Dose distribution measurements inside children anthropomorphic phantoms in photon radiotherapy. 10th International Workshop on Ionizing Radiation Monitoring (IWIRM10), March 2015, Oarai, Japan J Farah, V. Mares, M. Romero-Expósito, C. Domingo, M. Klodowska, O. Ploc, L. Stolarczyk, S. Trinkl, F. Trompier, P. Olko and R. Harrison. EURADOS' experimental mapping of neutron environment in scanning proton therapy facilities. 54th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG), May 21st to 23rd, 2015 San Diego, California. Liliana Stolarczyk, Pawel Olko and 25 coauthors. Dosimetry outside the treatment field from scattered radiation produced by a proton scanning beam results of a EURADOS study. 54th Annual Conference of the Particle Therapy Co-operative Group (PTCOG), May 21st to 23rd, 2015 San Diego, California.

38 Conference presentations Marija Majer, Željka Knežević and Saveta Miljanić (on behalf of EURADOS Working Group 9). Out-of-field dose measurements for radiotherapy of brain tumors in paediatric patients. Proc. of the 10th Symposium of the Croatian Radiation Protection Association (CRPA), Šibenik, Croatia, April 15-17, 2015 (in Croatian) Željka Knežević, Marija Majer and Saveta Miljanić (on behalf of EURADOS Working group 9). Secondary radiation in proton radiotherapy - preliminary results for measurements with passive dosimeters. Proc. of the 10th Symposium of the Croatian Radiation Protection Association (CRPA), Šibenik, Croatia, April 15-17, 2015 (in Croatian) Natalia Adamek, Liliana Stolarczyk, Marzena Bakoniak, Eleonora Góra, Damian Kabat, Željka Knežević, Małgorzata Liszka, Marija Majer, Saveta Miljanić, Katarzyna Skowrońska, Paulina Wilusz, Paweł Olko, Roger Harrison. Secondary Radiation Doses Received by Paediatric Patients During Brain Tumour Radiotherapy Using 3DCRT and Proton Spot Scanning Technique. Second Central European Symposium on Radiation Oncology (CESARO): Technological and Biological Sunrise for Radiation Oncology. 8-9 May, 2015 Kraków, Poland.

39 Conference presentations Saveta Miljanić on behalf of EURADOS WG9 Peripheral doses in radiotherapy an overview of activity of EURADOS Working Group 9. Proc. xxviii DZZSCG Symp (in Croatian), Vršac, Sep-Oct Roger Harrison on behalf of EURADOS WG9. Out-of-field dosimetry in radiotherapy for input to epidemiological studies. 7th MELODI Workshop, Munich, 9 11 November 2015 Saveta Miljanić on behalf of EURADOS WG9 Whole body doses from photon and proton radiotherapy of brain tumors in paediatric patients 11th International Workshop on Ionizing Radiation Monitoring, (IWIRM11) Oarai, Japan, December 2015

40 Thank you