Supplementary Figure S1A
|
|
- Daniella Blake
- 5 years ago
- Views:
Transcription
1 Supplementary Figure S1A-G. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Genes up to 500 kb on either side of each new index SNP are shown. All variants nominally associated (P < 0.05) with every cancer type contributing to the corresponding cross-cancer meta-analysis are plotted regardless of the direction of effect across cancers. Supplementary Figure S1A 1
2 Supplementary Figure S1B 2
3 Supplementary Figure S1C 3
4 Supplementary Figure S1D* * The index variant at the new 9q31 breast and ovarian cancer risk locus rs (gray dot), was a deletion/insertion polymorphism for which no linkage disequilibrium data were available in LocusZoom for the regional association plot. Therefore, the next most significantly associated SNP rs , was used for this plot. 4
5 Supplementary Figure S1E 5
6 Supplementary Figure S1F 6
7 Supplementary Figure S1G 7
8 Supplementary Figure S2A-B. Box plots showing eqtl associations between (A) rs and L3MBTL3 in normal breast and prostate tissues and (B) rs and RCCD1 in normal breast and ovarian tissues. Supplementary Figure S2A L3MBTL3 and rs Alleles (Ref/Alt): C/T Supplementary Figure S2B RCCD1 and rs Alleles (Ref/Alt): T/C 8
9 Supplementary Figure S3. Interactions between BCL2L11 and the 32 Biocarta Death Pathway genes. Interactions were identified using the GeneMania server. Circles contain gene names, lines represent interactions, and the color of the line indicates a specific type of interaction as listed in the legend. Supplementary Methods Published Breast, Ovarian, and Prostate Cancer Index SNPs We compiled a list of the most significantly associated SNP, referred to as the index SNP, in every region known to be associated with ovarian, breast and/or prostate cancer risk at genome-wide significance (P < 5 x 10-8 ) in populations of European ancestry. The SNPs were obtained from the publications that reported the largest and most recent genome-wide association meta-analysis for susceptibility to each cancer (1 3). The list included 18 SNPs associated with all invasive and/or serous invasive epithelial ovarian cancer, 92 SNPs associated with overall, ER-positive and/or ER-negative breast cancer, and 100 SNPs associated with prostate cancer (Supplementary Table S1). The ovarian cancer risk SNP rs was associated with ovarian cancer risk only in BRCA1 mutation carriers (4). Of the 100 prostate cancer risk SNPs, rs636291, was associated specifically with early-onset prostate cancer risk and seven SNPs had been identified at genome-wide significance only after a multi-ancestry meta-analysis that included data from populations of European ancestry (3). These seven SNPs were associated with prostate cancer at P < 6.8 x 10-4 in European ancestry populations (3). For SNPs discovered before the latest publication in each cancer, index SNPs obtained from the most recent publication were identical to those reported in the original publications. The only exception was at the 2q33 breast cancer susceptibility locus where the original SNP (5), rs , was not replicated even at a P < 10-4 threshold in the latest combined analysis (1). This SNP was replaced with rs (r 2 = 0.05 with rs in 1000 Genomes 9
10 European populations, distance between the two SNPs = 32 kb), which did reach genome-wide significance in the same analysis. Overall, the list contained 207 unique index SNPs after accounting for two cross-cancer SNPs (rs and rs8170) that were both associated with ER-negative breast and serous ovarian cancer risk and one SNP (rs ) sharing an association with breast and prostate cancer risk. Sixty of the 207 SNPs were located in 21 1-Mb regions containing index SNPs associated with more than one of the three cancers (Supplementary Table S2). References 1. Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ, et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015;47: Kuchenbaecker KB, Ramus SJ, Tyrer J, Lee A, Shen HC, Beesley J, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 2015;47: Olama AA Al, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014;46: Couch FJ, Wang X, McGuffog L, Lee A, Olswold C, Kuchenbaecker KB, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet. 2013;9:e Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MWR, Pooley KA, et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet. 2007;39:
Supplementary Figure 1. Quantile-quantile (Q-Q) plot of the log 10 p-value association results from logistic regression models for prostate cancer
Supplementary Figure 1. Quantile-quantile (Q-Q) plot of the log 10 p-value association results from logistic regression models for prostate cancer risk in stage 1 (red) and after removing any SNPs within
More informationThe lymphoma-associated NPM-ALK oncogene elicits a p16ink4a/prb-dependent tumor-suppressive pathway. Blood Jun 16;117(24):
DNA Sequencing Publications Standard Sequencing 1 Carro MS et al. DEK Expression is controlled by E2F and deregulated in diverse tumor types. Cell Cycle. 2006 Jun;5(11) 2 Lassandro L et al. The DNA sequence
More informationA systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk
Indian Academy of Sciences RESEARCH ARTICLE A systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk YINLIANG ZHANG 1, WEI LI 1,2,YIHONG 1,2, GUOYING WU
More informationSupplementary Figure 1: Attenuation of association signals after conditioning for the lead SNP. a) attenuation of association signal at the 9p22.
Supplementary Figure 1: Attenuation of association signals after conditioning for the lead SNP. a) attenuation of association signal at the 9p22.32 PCOS locus after conditioning for the lead SNP rs10993397;
More informationCorporate Medical Policy
Corporate Medical Policy Common Genetic Variants to Predict Risk of Nonfamilial Breast File Name: Origination: Last CAP Review: Next CAP Review: Last Review: common_genetic_variants_to_predict_risk_of_nonfamilial_breast_cancer
More informationSupplementary webappendix
Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Hartman M, Loy EY, Ku CS, Chia KS. Molecular
More information2) Cases and controls were genotyped on different platforms. The comparability of the platforms should be discussed.
Reviewers' Comments: Reviewer #1 (Remarks to the Author) The manuscript titled 'Association of variations in HLA-class II and other loci with susceptibility to lung adenocarcinoma with EGFR mutation' evaluated
More informationCS2220 Introduction to Computational Biology
CS2220 Introduction to Computational Biology WEEK 8: GENOME-WIDE ASSOCIATION STUDIES (GWAS) 1 Dr. Mengling FENG Institute for Infocomm Research Massachusetts Institute of Technology mfeng@mit.edu PLANS
More informationPolygenes, Risk Prediction, and Targeted Prevention of Breast Cancer
T h e n e w e ng l a nd j o u r na l o f m e dic i n e special article Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer Paul D.P. Pharoah, Ph.D., Antonis C. Antoniou, Ph.D., Douglas
More informationBreast and ovarian cancer risk assessment using multigene panel tests Prof Antonis Antoniou
Breast and ovarian cancer risk assessment using multigene panel tests Prof Antonis Antoniou Department of Public Health and Primary Care University of Cambridge, U.K. Cancer risk prediction in the era
More informationLarge-scale genotyping identifies 41 new loci associated with breast cancer risk
Large-scale genotyping identifies 41 new loci associated with breast cancer risk Kyriaki Michailidou, Per Hall, Anna Gonzalez-Neira, Maya Ghoussaini, Joe Dennis, Roger L Milne, Marjanka K Schmidt, Jenny
More informationSupplementary Online Content
Supplementary Online Content Hartwig FP, Borges MC, Lessa Horta B, Bowden J, Davey Smith G. Inflammatory biomarkers and risk of schizophrenia: a 2-sample mendelian randomization study. JAMA Psychiatry.
More informationLarge-scale identity-by-descent mapping discovers rare haplotypes of large effect. Suyash Shringarpure 23andMe, Inc. ASHG 2017
Large-scale identity-by-descent mapping discovers rare haplotypes of large effect Suyash Shringarpure 23andMe, Inc. ASHG 2017 1 Why care about rare variants of large effect? Months from randomization 2
More informationAccepted Preprint first posted on 15 August 2016 as Manuscript ERC
Page 1 of 28 Accepted Preprint first posted on 15 August 2016 as Manuscript ERC-16-0277 1 Modifiers of breast and ovarian cancer risks for BRCA1 and BRCA2 mutation carriers. 2 3 Roger L. Milne 1,2 and
More informationOvarian cancer variant rs is associated with HOXD1 and HOXD3 gene expression
/, 2017, Vol. 8, (No. 61), pp: 103410-103414 Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression Liyuan Guo 1,*, Yan Peng 2,*, Lei Sun 3,*, Xia Han 4, Juan Xu 4 and Dongwei
More informationNature Genetics: doi: /ng Supplementary Figure 1
Supplementary Figure 1 Replicability of blood eqtl effects in ileal biopsies from the RISK study. eqtls detected in the vicinity of SNPs associated with IBD tend to show concordant effect size and direction
More informationTen modifiers of BRCA1 penetrance validated in a Norwegian series
Hereditary Cancer in Clinical Practice This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Ten
More informationIntroduction to Genetics and Genomics
2016 Introduction to enetics and enomics 3. ssociation Studies ggibson.gt@gmail.com http://www.cig.gatech.edu Outline eneral overview of association studies Sample results hree steps to WS: primary scan,
More informationCancer risk prediction via algorithms: identifying individuals at high-risk of breast and ovarian cancer
Cancer risk prediction via algorithms: identifying individuals at high-risk of breast and ovarian cancer Antonis C. Antoniou Department of Public Health and Primary Care University of Cambridge, U.K. No
More informationindicated in shaded lowercase letters (hg19, Chr2: 217,955, ,957,266).
Legend for Supplementary Figures Figure S1: Sequence of 2q35 encnv. The DNA sequence of the 1,375bp 2q35 encnv is indicated in shaded lowercase letters (hg19, Chr2: 217,955,892-217,957,266). Figure S2:
More informationGene-Environment Interactions
Gene-Environment Interactions What is gene-environment interaction? A different effect of an environmental exposure on disease risk in persons with different genotypes," or, alternatively, "a different
More informationDOES THE BRCAX GENE EXIST? FUTURE OUTLOOK
CHAPTER 6 DOES THE BRCAX GENE EXIST? FUTURE OUTLOOK Genetic research aimed at the identification of new breast cancer susceptibility genes is at an interesting crossroad. On the one hand, the existence
More informationAdditional Disclosure
Additional Disclosure The Genetics of Prostate Cancer: Clinical Implications William J. Catalona, MD Collaborator with decode genetics, Inc. Non-paid consultant with no financial interest or support Northwestern
More informationDownloaded from:
Orr, N; Cooke, R; Jones, M; Fletcher, O; Dudbridge, F; Chilcott- Burns, S; Tomczyk, K; Broderick, P; Houlston, R; Ashworth, A; Swerdlow, A (2011) Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13,
More informationThe Genetics of Breast and Ovarian Cancer Prof. Piri L. Welcsh
The Genetics of Breast Piri L. Welcsh, PhD Research Assistant Professor University of Washington School of Medicine Division of Medical Genetics 1 Genetics of cancer All cancers arise from genetic and
More informationGlobal variation in copy number in the human genome
Global variation in copy number in the human genome Redon et. al. Nature 444:444-454 (2006) 12.03.2007 Tarmo Puurand Study 270 individuals (HapMap collection) Affymetrix 500K Whole Genome TilePath (WGTP)
More informationUpdate on BRCA testing thresholds NICE guidance changes
Update on BRCA testing thresholds NICE guidance changes D Gareth R Evans Christie and St Mary s Hospital Manchester UK London July 2014 Guideline Development Group Familial Breast Cancer Any woman with
More informationBST227 Introduction to Statistical Genetics. Lecture 4: Introduction to linkage and association analysis
BST227 Introduction to Statistical Genetics Lecture 4: Introduction to linkage and association analysis 1 Housekeeping Homework #1 due today Homework #2 posted (due Monday) Lab at 5:30PM today (FXB G13)
More informationUse of Genetics to Inform Drug Development of a Novel Treatment for Schizophrenia
Use of Genetics to Inform Drug Development of a Novel Treatment for Schizophrenia March 21, 2012 Institute of Medicine: New Paradigms in Drug Discovery Workshop Laura K. Nisenbaum, PhD Translational Medicine,
More informationAssociation-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis
Supplementary Material Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis Kwangwoo Kim 1,, So-Young Bang 1,, Katsunori Ikari 2,3, Dae
More informationGWAS of HCC Proposed Statistical Approach Mendelian Randomization and Mediation Analysis. Chris Amos Manal Hassan Lewis Roberts Donghui Li
GWAS of HCC Proposed Statistical Approach Mendelian Randomization and Mediation Analysis Chris Amos Manal Hassan Lewis Roberts Donghui Li Overall Design of GWAS Study Aim 1 (DISCOVERY PHASE): To genotype
More informationGenetic Testing for BRCA1 and BRCA2 Genes
Genetic Testing for BRCA1 and BRCA2 Genes MP9478 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria below Yes as shown below Pre and post-test genetic counseling
More informationWhite Paper Guidelines on Vetting Genetic Associations
White Paper 23-03 Guidelines on Vetting Genetic Associations Authors: Andro Hsu Brian Naughton Shirley Wu Created: November 14, 2007 Revised: February 14, 2008 Revised: June 10, 2010 (see end of document
More informationThis is the author s final accepted version.
Kar, S. P. et al. (2016) Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types. Cancer Discovery,
More informationWhole-genome detection of disease-associated deletions or excess homozygosity in a case control study of rheumatoid arthritis
HMG Advance Access published December 21, 2012 Human Molecular Genetics, 2012 1 13 doi:10.1093/hmg/dds512 Whole-genome detection of disease-associated deletions or excess homozygosity in a case control
More informationRESEARCH ARTICLE. Abstract. Introduction
DOI:http://dx.doi.org/10.7314/APJCP.2014.15.19.8311 RESEARCH ARTICLE 8q24 rs4242382 Polymorphism is a Risk Factor for Prostate Cancer among Multi-Ethnic Populations: Evidence from Clinical Detection in
More informationIdentification of heritable genetic risk factors for bladder cancer through genome-wide association studies (GWAS)
BCAN 2014 August 9, 2014 Identification of heritable genetic risk factors for bladder cancer through genome-wide association studies (GWAS) Ludmila Prokunina-Olsson, PhD Investigator Laboratory of Translational
More informationCONTENT SUPPLEMENTARY FIGURE E. INSTRUMENTAL VARIABLE ANALYSIS USING DESEASONALISED PLASMA 25-HYDROXYVITAMIN D. 7
CONTENT FIGURES 3 SUPPLEMENTARY FIGURE A. NUMBER OF PARTICIPANTS AND EVENTS IN THE OBSERVATIONAL AND GENETIC ANALYSES. 3 SUPPLEMENTARY FIGURE B. FLOWCHART SHOWING THE SELECTION PROCESS FOR DETERMINING
More informationAssessment and Management of Genetic Predisposition to Breast Cancer. Dr Munaza Ahmed Consultant Clinical Geneticist 2/7/18
Assessment and Management of Genetic Predisposition to Breast Cancer Dr Munaza Ahmed Consultant Clinical Geneticist 2/7/18 Overview The role of the Cancer Genetics team NICE guidelines for Familial Breast
More informationGenetic Testing for BRCA1 and BRCA2 Genes
Genetic Testing f BRCA1 and BRCA2 Genes MP9478 Covered Service: Pri Authization Required: Additional Infmation: Yes when meets criteria below Yes--as shown below Pre and post-test genetic counseling is
More informationMendelian Randomization
Mendelian Randomization Drawback with observational studies Risk factor X Y Outcome Risk factor X? Y Outcome C (Unobserved) Confounders The power of genetics Intermediate phenotype (risk factor) Genetic
More informationGenetics and Pharmacogenetics in Human Complex Disorders (Example of Bipolar Disorder)
Genetics and Pharmacogenetics in Human Complex Disorders (Example of Bipolar Disorder) September 14, 2012 Chun Xu M.D, M.Sc, Ph.D. Assistant professor Texas Tech University Health Sciences Center Paul
More informationAssociation mapping (qualitative) Association scan, quantitative. Office hours Wednesday 3-4pm 304A Stanley Hall. Association scan, qualitative
Association mapping (qualitative) Office hours Wednesday 3-4pm 304A Stanley Hall Fig. 11.26 Association scan, qualitative Association scan, quantitative osteoarthritis controls χ 2 test C s G s 141 47
More informationSupplementary note: Comparison of deletion variants identified in this study and four earlier studies
Supplementary note: Comparison of deletion variants identified in this study and four earlier studies Here we compare the results of this study to potentially overlapping results from four earlier studies
More informationTITLE: A Genome-wide Breast Cancer Scan in African Americans. CONTRACTING ORGANIZATION: University of Southern California, Los Angeles, CA 90033
Award Number: W81XWH-08-1-0383 TITLE: A Genome-wide Breast Cancer Scan in African Americans PRINCIPAL INVESTIGATOR: Christopher A. Haiman CONTRACTING ORGANIZATION: University of Southern California, Los
More informationSupplementary Figure 1. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations.
Supplementary Figure. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations. a Eigenvector 2.5..5.5. African Americans European Americans e
More informationSupplementary Figures
Supplementary Figures Supplementary Fig 1. Comparison of sub-samples on the first two principal components of genetic variation. TheBritishsampleisplottedwithredpoints.The sub-samples of the diverse sample
More informationMRC-Holland MLPA. Description version 18; 09 September 2015
SALSA MLPA probemix P090-A4 BRCA2 Lot A4-0715, A4-0714, A4-0314, A4-0813, A4-0712: Compared to lot A3-0710, the 88 and 96 nt control fragments have been replaced (QDX2). This product is identical to the
More informationSupplementary Figure 1
Supplementary Figure 1 Supplementary Figure 1: The chromosome 2p23.2 and 13q22 regions. Manhattan Plot for the 2p23.2 (a) and 13q22 (b) loci displaying the strength of genetic association (-log 10 P) versus
More informationFONS Nové sekvenační technologie vklinickédiagnostice?
FONS 2010 Nové sekvenační technologie vklinickédiagnostice? Sekvenování amplikonů Sequence capture Celogenomové sekvenování FONS 2010 Sekvenování amplikonů Amplicon sequencing - amplicon sequencing enables
More informationUniversity of Groningen. Metabolic risk in people with psychotic disorders Bruins, Jojanneke
University of Groningen Metabolic risk in people with psychotic disorders Bruins, Jojanneke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationLESSON 3.2 WORKBOOK. How do normal cells become cancer cells? Workbook Lesson 3.2
For a complete list of defined terms, see the Glossary. Transformation the process by which a cell acquires characteristics of a tumor cell. LESSON 3.2 WORKBOOK How do normal cells become cancer cells?
More informationFellow GU Lecture Series, Prostate Cancer. Asit Paul, MD, PhD 02/20/2018
Fellow GU Lecture Series, 2018 Prostate Cancer Asit Paul, MD, PhD 02/20/2018 Disease Burden Screening Risk assessment Treatment Global Burden of Prostate Cancer Prostate cancer ranked 13 th among cancer
More informationSupplementary Figures
Supplementary Figures Supplementary Figure 1. Heatmap of GO terms for differentially expressed genes. The terms were hierarchically clustered using the GO term enrichment beta. Darker red, higher positive
More informationDan Koller, Ph.D. Medical and Molecular Genetics
Design of Genetic Studies Dan Koller, Ph.D. Research Assistant Professor Medical and Molecular Genetics Genetics and Medicine Over the past decade, advances from genetics have permeated medicine Identification
More informationMultifactorial Susceptibility to Common Diseases: common and rare variants Walter Bodmer and Carolina Bonilla
Multifactorial Susceptibility to Common Diseases: common and rare variants Walter Bodmer and Carolina Bonilla Supplementary Table 1. Distribution of mutation types in BRCA1 and BRCA2 A. BRCA1 mutation
More informationHeritability and genetic correlations explained by common SNPs for MetS traits. Shashaank Vattikuti, Juen Guo and Carson Chow LBM/NIDDK
Heritability and genetic correlations explained by common SNPs for MetS traits Shashaank Vattikuti, Juen Guo and Carson Chow LBM/NIDDK The Genomewide Association Study. Manolio TA. N Engl J Med 2010;363:166-176.
More informationGenomic structural variation
Genomic structural variation Mario Cáceres The new genomic variation DNA sequence differs across individuals much more than researchers had suspected through structural changes A huge amount of structural
More informationGenome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
Supplementary Online Material Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. John C Chambers, Weihua Zhang, Yun Li, Joban Sehmi, Mark N Wass, Delilah Zabaneh,
More informationSUPPLEMENTARY INFORMATION
SUPPLEMENTRY INFORMTION Supplementary Figure 1. Q-Q plot of RE/NIMH autism family TDT results. The quantile-quantile plot of the expected and observed P-values is shown. The blue circles represent the
More informationSupplementary information. Supplementary figure 1. Flow chart of study design
Supplementary information Supplementary figure 1. Flow chart of study design Supplementary Figure 2. Quantile-quantile plot of stage 1 results QQ plot of the observed -log10 P-values (y axis) versus the
More informationBreast cancer risk prediction using a polygenic risk score in the familial setting: a
Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kconfab Hongyan Li 1 MSc, Bingjian Feng 2 PhD, Alexander
More informationReview Article Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk
BioMed Research International, Article ID 648137, 9 pages http://dx.doi.org/10.1155/2014/648137 Review Article Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk Cunzhong Yuan,
More informationVariation in linkage disequilibrium patterns between populations of different production types VERONIKA KUKUČKOVÁ, NINA MORAVČÍKOVÁ, RADOVAN KASARDA
Variation in linkage disequilibrium patterns between populations of different production types VERONIKA KUKUČKOVÁ, NINA MORAVČÍKOVÁ, RADOVAN KASARDA AIM OF THE STUDY THE COMPARISONS INCLUDED DIFFERENCES
More informationFULL TITLE: Incorporating Truncating. Variants in PALB2, CHEK2 and ATM into. the BOADICEA Breast Cancer Risk. SHORT TITLE: Rare Variants in the
FULL TITLE: Incorporating Truncating Variants in PALB, CHEK and ATM into the BOADICEA Breast Cancer Risk Model SHORT TITLE: Rare Variants in the BOADICEA Breast Cancer Risk Model Authorship Andrew J. Lee
More informationLeveraging Interaction between Genetic Variants and Mammographic Findings for Personalized Breast Cancer Diagnosis
Leveraging Interaction between Genetic Variants and Mammographic Findings for Personalized Breast Cancer Diagnosis Jie Liu, PhD 1, Yirong Wu, PhD 1, Irene Ong, PhD 1, David Page, PhD 1, Peggy Peissig,
More informationGENETIC VARIATION AND PROSTATE CANCER
UMEÅ UNIVERSITY MEDICAL DISSERTATIONS New series No. 1114 ISSN 0346 6612 ISBN 978 91 7264 367 3 GENETIC VARIATION AND PROSTATE CANCER Population based association studies in Sweden SARA LINDSTRÖM Umeå
More informationAssociation between interleukin-17a polymorphism and coronary artery disease susceptibility in the Chinese Han population
Association between interleukin-17a polymorphism and coronary artery disease susceptibility in the Chinese Han population G.B. Su, X.L. Guo, X.C. Liu, Q.T. Cui and C.Y. Zhou Department of Cardiothoracic
More informationMP Use of Common Genetic Variants (Single Nucleotide Variants) to Predict Risk of Nonfamilial Breast Cancer
Medical Policy Use of Common Genetic Variants (Single Nucleotide Variants) to Predict Risk of Nonfamilial Breast Cancer BCBSA Ref. Policy: 2.04.63 Last Review: 10/18/2018 Effective Date: 10/18/2018 Section:
More informationDeliverable 2.1 List of relevant genetic variants for pre-emptive PGx testing
GA N 668353 H2020 Research and Innovation Deliverable 2.1 List of relevant genetic variants for pre-emptive PGx testing WP N and Title: WP2 - Towards shared European Guidelines for PGx Lead beneficiary:
More informationForward Looking Statements
Forward Looking Statements Some of the information presented here today may contain projections or other forward-looking statements regarding future events or the future financial performance 15M Patient
More informationTITLE: Unique Genomic Alterations in Prostate Cancers in African American Men
AD Award Number: W81XWH-12-1-0046 TITLE: Unique Genomic Alterations in Prostate Cancers in African American Men PRINCIPAL INVESTIGATOR: Michael Ittmann, M.D., Ph.D. CONTRACTING ORGANIZATION: Baylor College
More informationMassoud Houshmand National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
QUID 2017, pp. 669-673, Special Issue N 1- ISSN: 1692-343X, Medellín-Colombia NON-GENE REGION AND INFLUENCES TUMOR CHARACTERISTICS BY LOW-RISK ALLELES IN BREAST CANCER (Recibido el 21-06-2017. Aprobado
More informationBRCA1 & BRCA2: CANCER RISK & GENETIC TESTING IAP ID 2013 NAIR HOSPITAL, MUMBAI
BRCA1 & BRCA2: CANCER RISK & GENETIC TESTING IAP ID 2013 NAIR HOSPITAL, MUMBAI DR KIRTI CHADHA MD (Path), PDCC (Oncopath & Oncohemat) CONSULTANT SURGICAL PATHOLOGIST NATIONAL COORDINATOR,SURGICAL PATHOLOGY
More informationLinkage analysis: Prostate Cancer
Linkage analysis: Prostate Cancer Prostate Cancer It is the most frequent cancer (after nonmelanoma skin cancer) In 2005, more than 232.000 new cases were diagnosed in USA and more than 30.000 will die
More informationModifiers of Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: A Systematic Review and Meta-Analysis
DOI:10.1093/jnci/dju091 First published online May 14, 2014 The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. Review
More informationInvestigating causality in the association between 25(OH)D and schizophrenia
Investigating causality in the association between 25(OH)D and schizophrenia Amy E. Taylor PhD 1,2,3, Stephen Burgess PhD 1,4, Jennifer J. Ware PhD 1,2,5, Suzanne H. Gage PhD 1,2,3, SUNLIGHT consortium,
More informationBRCA Precertification Information Request Form
BRCA Precertification Information Request Form Failure to complete this form in its entirety may result in the delay of review. Fax to: BRCA Precertification Department Fax number: 1-860-975-9126 Section
More informationTwo Susceptibility Loci Identified for Prostate Cancer Aggressiveness
Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Citation
More informationPhenotype analysis in humans using OMIM
Outline: 1) Introduction to OMIM 2) Phenotype similarity map 3) Exercises Phenotype analysis in humans using OMIM Rosario M. Piro Molecular Biotechnology Center University of Torino, Italy 1 MBC, Torino
More information# For the GWAS stage, B-cell NHL cases which small numbers (N<20) were excluded from analysis.
Supplementary Table 1a. Subtype Breakdown of all analyzed samples Stage GWAS Singapore Validation 1 Guangzhou Validation 2 Guangzhou Validation 3 Beijing Total No. of B-Cell Cases 253 # 168^ 294^ 713^
More informationThe common CARD14 gene missense polymorphism rs (c.c2458t/p. Arg820Trp) is associated with psoriasis: a meta-analysis
The common CARD14 gene missense polymorphism rs11652075 (c.c2458t/p. Arg820Trp) is associated with psoriasis: a meta-analysis G. Shi 1 *, S.J. Li 1 *, T.T. Wang 1 *, C.M. Cheng 2, Y.M. Fan 1 and K.J. Zhu
More informationUse of Common Genetic Variants (Single Nucleotide Variants) to Predict Risk of Nonfamilial Breast Cancer
Use of Common Genetic Variants (Single Nucleotide Variants) to Predict Risk of Nonfamilial Breast Cancer Policy Number: 2.04.63 Last Review: 12/2018 Origination: 12/2013 Next Review: 12/2019 Policy Blue
More informationImaging Genetics: Heritability, Linkage & Association
Imaging Genetics: Heritability, Linkage & Association David C. Glahn, PhD Olin Neuropsychiatry Research Center & Department of Psychiatry, Yale University July 17, 2011 Memory Activation & APOE ε4 Risk
More informationIntroduction to the Genetics of Complex Disease
Introduction to the Genetics of Complex Disease Jeremiah M. Scharf, MD, PhD Departments of Neurology, Psychiatry and Center for Human Genetic Research Massachusetts General Hospital Breakthroughs in Genome
More informationGENETIC TESTING FOR HEREDITARY BREAST AND OVARIAN CANCER SYNDROME BRCA1 BRCA2
SYNDROME BRCA1 BRCA2 Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices and drugs
More informationNIH Public Access Author Manuscript Obesity (Silver Spring). Author manuscript; available in PMC 2013 December 01.
NIH Public Access Author Manuscript Published in final edited form as: Obesity (Silver Spring). 2013 June ; 21(6): 1256 1260. doi:10.1002/oby.20319. Obesity-susceptibility loci and the tails of the pediatric
More informationNature Genetics: doi: /ng Supplementary Figure 1
Supplementary Figure 1 LD (r 2 ) between the A3AB deletion and all markers in a 400-kb APOBEC3 region in 1000 Genomes Project populations. Populations: CEU, individuals of European ancestry from Utah,
More informationRelationship between genomic features and distributions of RS1 and RS3 rearrangements in breast cancer genomes.
Supplementary Figure 1 Relationship between genomic features and distributions of RS1 and RS3 rearrangements in breast cancer genomes. (a,b) Values of coefficients associated with genomic features, separately
More informationNature Genetics: doi: /ng Supplementary Figure 1
Supplementary Figure 1 Illustrative example of ptdt using height The expected value of a child s polygenic risk score (PRS) for a trait is the average of maternal and paternal PRS values. For example,
More informationSUPPLEMENTARY DATA. 1. Characteristics of individual studies
1. Characteristics of individual studies 1.1. RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) The RISC study is based on unrelated individuals of European descent, aged 30 60
More informationNature Biotechnology: doi: /nbt.1904
Supplementary Information Comparison between assembly-based SV calls and array CGH results Genome-wide array assessment of copy number changes, such as array comparative genomic hybridization (acgh), is
More informationMulti-clonal origin of macrolide-resistant Mycoplasma pneumoniae isolates. determined by multiple-locus variable-number tandem-repeat analysis
JCM Accepts, published online ahead of print on 30 May 2012 J. Clin. Microbiol. doi:10.1128/jcm.00678-12 Copyright 2012, American Society for Microbiology. All Rights Reserved. 1 2 Multi-clonal origin
More informationCompound heterozygosity Yurii S. Aulchenko yurii [dot] aulchenko [at] gmail [dot] com. Thursday, April 11, 13
Compound heterozygosity Yurii S. Aulchenko yurii [dot] aulchenko [at] gmail [dot] com 1 Outline Recessive model Examples of Compound Heterozygosity Compound Double Heterozygosity (CDH) test 2 Recessive
More informationGenetics update and implications for (General) Practice
Genetics update and implications for (General) Practice May 12 th 2018 Women s Health Symposium Clearwater Estate Dr Kate Gibson MB BCh, MRCP, FRACP Topics NZ Clinical Genetics delivery New Technologies
More informationHaplotype allelic classes in the lactase persistence locus
Haplotype allelic classes in the lactase persistence locus Robert Cedergren Colloquium november 3 rd 28 Julie Hussin 1,2, Philippe Nadeau 1,2, Jean-François Lefebvre 2 and Damian Labuda 1-3 1 Bioinformatics
More informationSupplementary Materials to
Supplementary Materials to The Emerging Landscape of Epidemiological Research Based on Biobanks Linked to Electronic Health Records: Existing Resources, Analytic Challenges and Potential Opportunities
More informationBRCA Testing in Ovarian cancer Arabic Approach
BRCA Testing in Ovarian cancer Arabic Approach Khalid El Khalfaoui Departement of Gynecology and Gyn Oncology Wermelskirchen Hospital 25.04.2018 Krankenhaus Wermelskirchen GmbH I 1 Development of cancer
More informationSupplementary Figure 1. Nature Genetics: doi: /ng.3736
Supplementary Figure 1 Genetic correlations of five personality traits between 23andMe discovery and GPC samples. (a) The values in the colored squares are genetic correlations (r g ); (b) P values of
More informationNew evidence of TERT rs polymorphism and cancer risk: an updated meta-analysis
JBUON 2016; 21(2): 491-497 ISSN: 1107-0625, online ISSN: 2241-6293 www.jbuon.com E-mail: editorial_office@jbuon.com ORIGINAL ARTICLE New evidence of TERT rs2736098 polymorphism and risk: an updated meta-analysis
More information