Research progress of adult stem cells and clinical applications

Transcription

1 Chinese Bulletin of Life Sciences Vol. 18, No. 4 Aug., (2006) Q831 A Research progress of adult stem cells and clinical applications XI Jia-Fei, WANG Yun-Fang, PEI Xue-Tao* (Department of Stem Cell Biology, Beijing Insititute of Transfusion Medcine, Beijing , China) Abstract: The objective of adult stem cell research is to cure the intractable diseases. Nowadays there are much data about the basic and clinical research about the adult stem cells. More and more information about the stem cells plasticity have been declared, and studies about the applications of stem cell therapy for various diseases are increasingly carried out. Despite of so many problems should be solved, people are still giving a great hope for adult stem cell therapy in regenerative medicine. Key words: adult stem cells; plasticity; cell therapy [1~2] (hematopoietic stem cells, HSC) HSC (2005AA219010); (Z ) (1981 ) (1972 ) (1962 ) *

2 329 1 HSC Blay [3] [4] [5] [6] [7] ( ) HSC [8] I 50 HSC HSC HSC [9] Krause [10] HSC HSC [11] ( HSC) [12] [13] [14~15] [16] 2 ( ) Victor Dzau Anversa [17]

3 % 0.08% [18] ; [19] ; [20] Y [21] [22] [23~24] ( ); 2.2 [25] [26] [27]

4 [28] (bone marrow stroma stem cells, BMSCs) [29] BMSCs FGF-2 FGF-2 BMSCs BMSCs / Farber [30~31] [32] [33] NOD/SCID (nonobese diabetic/ severe combined immunodeficiency disease) [34] HSCs [35] HSCs [36] 3 FDA SFDA I 12 ( )

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