Application of neural stem cells in curing traumatic brain injury(tbi)
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1 Chinese Bulletin of Life Sciences Vol. 20, No.4 Aug., (2008) (neural stem cells, NSCs) NSCs NSCs NSCs NSCs NSCs Q813 R745.1 A Application of neural stem cells in curing traumatic brain injury(tbi) ZHANG Peng-yue 1,2, SHA Hong-ying 3, PENG Gang 3, CHENG Guo-xiang 1,2 * (1 Life Science and Technology College of Tongji University, Shanghai , China; 2 Shanghai Transgenic Center, Shanghai , China; 3 Department of Neurosurgery, Huasha Hospital, Fudan University, Shanghai , China) Abstract: Neural stem cells (NSCs) are cell populations which can self-renew and give rise to neurons, astrocytes and oligodendrocytes in center neural system. In vitro, they can maintain proliferation potency, and differentiate into neural cells-like cells through conditional induction. NSCs transplantation experiments show that grafts can differentiate into neural cells in the transplanted site and integrate into the host nervous system, rebuild the injured nervous system, and alleviate the injured symptom at a certain extent. In addition, it has been paid more attention that activating endogenous NSCs cure traumatic brain injury (TBI). So application of NSCs in curing TBI has been hot spot in neurobiology and clinic. This review introduces briefly the latest advances about NSCs curing TBI. Key words: central nervous system; neural stems cells; neural injury; transplantation (traumatic brain injury, TBI) ( ) / / (NSCs) NSCs NSCs NSCs (06dj14001) * chenggx@cngenon.com
2 647 NSCs NSCs NSCs (MHC MHC ) [1] NSCs NSCs NSCs NSCs 1 NSCs 1.1 NSCs NSCs NSCs ( ) Englund [2] NSCs Cummings [3] NSCs NSCs NSCs NSCs ( GABA ) NSCs [4] NSCs ( BDNF) [5] NSCs NSC NSCs ( ) NSCs NSCs NSCs [6] NSCs slit-2 slit-2 NSCs [7] NSCs NSCs NSCs NSCs Blesch [8] RT-PCR NSCs nestin (NSCs ) NSCs [9] NSCs NSCs NSCs
3 648 (PET) NSCs NSCs NSCs NSCs [10,11] NSCs NSCs [12] 1.2 NSCs NSCs NSCs NSCs [6] Maurer [13] VEGF 1.8 VEGF NSCs [14] NSCs SV40tsA58 NSCs SV40 T NSCs NSCs NSCs NSCs NSCs [8] 1.3 NSCs NSCs NSCs [15] NSCs (G-CSF) G-CSF G-CSF G-CSF NSCs [16,17] NSCs NSCs / NSCs NSCs [18] 2 NSCs NSCs
4 649 MPTT( ,2,3,6- ) NSCs (TH) NSCs [5] NSCs NSCs NSCs( ) [19-23] 90% [24,25] Milosevic [26] 25% 30% caspase-3 ( ) ( A) NSCs [27-30] NSCs [6] NSCs 3 NSCs NSC NSC ( ) NSCs [1]. [M]. :, 2005: [2] Englund U, Bjorklund A, Wictorin K, et al. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc Natl Acad Sci USA, 2002, 99(26) : [3] Cummings BJ, Tamaki SJ, Tamaki SJ. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci USA, 2005, 102(39): [4] Yan J, Xu LY, Welsh AM, et al. Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. PLoS Med, 2007, 4 (2): e39 [5] Redmond D, Bjugstad Ki, Teng Y, et al. Behavioral improvement in a primate Parkinson s model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci USA, 2007, 104 (29): [6] Aboody K, Najbauer J,Schmidt N, et al. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neurol Oncol, 2006, 8(2): [7] Guan CB, Xu HT, Jin M, et al. Long-Range Ca 2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2. Cell, 2007, 129(2): [8] Blesch A, Lu P, Tuszynski MH. Neurotrophic factors,gene therapy,and neural stem cells for spinal cord repair. Brain Res Bull, 2002, 57(6): [9],,,.., 2001, 27(3) : [10] Zhu JH, Zhou LF, Wu X, et al. Tracking neural stem cells in patients with brain trauma. N Engl J Med, 2006, 355(22): [11] Guzman R, Uchida N, Bliss TM. Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc Natl Acad Sci USA, 2007, 104(24):
5 650 [12] Scharfman H, Hen R. Is more neurogenesis always better? Science, 2007, 315(5810): [13] Maurer M, Thomas C, Bürgers H, et al. Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain. Int J Biol Sci, 2008, 4(1): 1-7 [14],.., 2005, 36(5): [15] Nakatomi H, Kuriu T, Okabe S, et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell, 2002, 110(4): [16] Schneider A, Krüger C, Steigleder T, et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest, 2005, 115(8): [17] Shyu WC, Lin SZ, Lee CC, et al. Granulocyte colony-stimulating factor for acute ischemic stroke: a randomized controlled trial. CMAJ, 2006, 174(7): [18] Scharfman HE. Functional implications of seizure-induced neurogenesis. Adv Exp Med Biol, 2004, 548: [19] Armstrong RJ, Watts C, Svendsen CN, et al. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington s disease. Cell Transplant, 2000, 9 (1): [20] Svendsen CN, Clarke DJ, Rosser AE, et al. Survival and differentiation of rat and human epidermal growth factorresponsive precursor cells following grafting into the lesioned adult central nervous system. Exp Neurol, 1996, 137(2): [21] Englund U, Bjorklund A, Wictorin K. Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain. Brain Res, 2002, 134(1-2): [22] Wu P, Tarasenko YI, Gu YP, et al. Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat. Nat Neurosci, 2002, 5(12): [23] Hurelbrink CB, Armstrong RJ, Dunnett SB, et al. Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS. Eur J Neurosci, 2002, 15(7): [24] Freeman TB, Sanberg PR, Nauert GM, et al. The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts. Cell Transplant, 1995, 4(1): [25] Zawada WM, Zastrow DJ, Clarkson ED, et al. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res, 1998, 786 (1-2): [26] Milosevic J, Storch A, Schwarz J. Spontaneous apoptosis in murine free-floating neurospheres. Exp Cell Res, 2004, 294(1): 9-17 [27] Micci MA, Pattillo MT, Kahrig KM, et al. Caspase inhibition increases survival of neural stem cells in the gastrointestinal tract. Neurogastroenterol Motil, 2005, 17(4): [28] Hansson O, Castilho RF, Kaminski Schierle GS, et al. Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Exp Neurol, 2000, 164(1): [29] Karlsson J, Petersén A, Gidö G, et al. Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient. Cell Transplant, 2005, 14(5): [30] Micci M, Pasricha PJ. Neural stem cells for the treatment of disorders of the enteric nervous system: strategies and challenges. Dev Dyn, 2007, 236(1): ( ) ( )
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